US23046A
(en)
*
|
|
1859-02-22 |
|
Joseph saxton |
US11222A
(en)
*
|
|
1854-07-04 |
|
Machine |
US120522A
(en)
*
|
|
1871-10-31 |
|
Improvement in hoisting-buckets |
US2081136A
(en)
*
|
1936-08-10 |
1937-05-25 |
Iuglio Frank Di |
Shirt collar
|
US3710795A
(en)
*
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
US4302386A
(en)
|
1978-08-25 |
1981-11-24 |
The Ohio State University |
Antigenic modification of polypeptides
|
FR2303890A1
(fr)
*
|
1975-03-14 |
1976-10-08 |
Ciba Geigy Ag |
Procede en continude teinture dans des vapeurs de solvants organiques et matieres fibreuses synthetiques teintes par ce procede
|
US4105776A
(en)
*
|
1976-06-21 |
1978-08-08 |
E. R. Squibb & Sons, Inc. |
Proline derivatives and related compounds
|
AU531759B2
(en)
|
1978-04-17 |
1983-09-08 |
Ici Ltd. |
Electrostatic spraying
|
US4316906A
(en)
*
|
1978-08-11 |
1982-02-23 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyl derivatives of substituted prolines
|
IL58849A
(en)
*
|
1978-12-11 |
1983-03-31 |
Merck & Co Inc |
Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
US4508729A
(en)
*
|
1979-12-07 |
1985-04-02 |
Adir |
Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
|
US4444784A
(en)
*
|
1980-08-05 |
1984-04-24 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
MX7065E
(es)
*
|
1980-06-06 |
1987-04-10 |
Sankyo Co |
Un procedimiento microbiologico para preparar derivados de ml-236b
|
US4344949A
(en)
*
|
1980-10-03 |
1982-08-17 |
Warner-Lambert Company |
Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
|
ZA817261B
(en)
*
|
1980-10-23 |
1982-09-29 |
Schering Corp |
Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
|
US4337201A
(en)
*
|
1980-12-04 |
1982-06-29 |
E. R. Squibb & Sons, Inc. |
Phosphinylalkanoyl substituted prolines
|
US4410520A
(en)
|
1981-11-09 |
1983-10-18 |
Ciba-Geigy Corporation |
3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
|
US4739073A
(en)
*
|
1983-11-04 |
1988-04-19 |
Sandoz Pharmaceuticals Corp. |
Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
|
JPS6038490A
(ja)
*
|
1983-08-11 |
1985-02-28 |
Toshiba Corp |
白色発光混合螢光体及びこれを用いた陰極線管
|
US5387413A
(en)
*
|
1985-06-14 |
1995-02-07 |
The Research Foundation Of State University Of New York |
Method of inhibiting thrombus formation by the 7E3 monoclonal antibody
|
US4816463A
(en)
*
|
1986-04-01 |
1989-03-28 |
Warner-Lambert Company |
Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
|
US4940727A
(en)
*
|
1986-06-23 |
1990-07-10 |
Merck & Co., Inc. |
Novel HMG-CoA reductase inhibitors
|
US5116870A
(en)
*
|
1986-06-23 |
1992-05-26 |
Merck & Co., Inc. |
HMG-CoA reductase inhibitors
|
CA1334092C
(fr)
|
1986-07-11 |
1995-01-24 |
David John Carini |
Imidazoles bloquant les recepteurs de l'angiotensine ii
|
US4799156A
(en)
*
|
1986-10-01 |
1989-01-17 |
Strategic Processing Corporation |
Interactive market management system
|
US4772684A
(en)
*
|
1987-01-20 |
1988-09-20 |
Triton Biosciences, Inc. |
Peptides affecting blood pressure regulation
|
US5091378A
(en)
*
|
1987-05-22 |
1992-02-25 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
|
US5017716A
(en)
*
|
1987-05-22 |
1991-05-21 |
E.R. Squibb & Sons, Inc. |
Phosphorous-containing HMG-CoA reductase inhibitors, new intermediates and method
|
US4997837A
(en)
*
|
1987-09-08 |
1991-03-05 |
Warner-Lambert Company |
6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
|
US4906624A
(en)
*
|
1987-09-08 |
1990-03-06 |
Warner-Lambert Company |
6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
|
US5008853A
(en)
*
|
1987-12-02 |
1991-04-16 |
Xerox Corporation |
Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment
|
US4929620A
(en)
*
|
1987-12-10 |
1990-05-29 |
Warner-Lambert Company |
5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis
|
US5001128A
(en)
*
|
1987-12-21 |
1991-03-19 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
HMG-COA reductase inhibitors
|
US4939143A
(en)
*
|
1987-12-21 |
1990-07-03 |
Rorer Pharmaceutical Corporation |
Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
|
US4994494A
(en)
*
|
1987-12-21 |
1991-02-19 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
HMG-COA reductase inhibitors
|
US4900754A
(en)
*
|
1987-12-21 |
1990-02-13 |
Rorer Pharmaceutical Corp. |
HMG-COA reductase inhibitors
|
US5001144A
(en)
*
|
1987-12-21 |
1991-03-19 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
|
US5081127A
(en)
*
|
1988-01-07 |
1992-01-14 |
E. I. Du Pont De Nemours And Company |
Substituted 1,2,3-triazole angiotensin II antagonists
|
US4946864A
(en)
*
|
1988-02-01 |
1990-08-07 |
Merck & Co., Inc. |
Novel HMG-CoA reductase inhibitors
|
EP0403503A4
(en)
|
1988-02-09 |
1992-06-24 |
Memorial Blood Center Of Minneapolis |
Nucleic acid isolation
|
DE68914495T2
(de)
|
1988-03-02 |
1994-10-27 |
Merck & Co Inc |
Antihypercholesterolemisches Mittel.
|
US5021453A
(en)
*
|
1988-03-02 |
1991-06-04 |
Merck & Co., Inc. |
3-keto HMG-CoA reductase inhibitors
|
US4920109A
(en)
*
|
1988-04-18 |
1990-04-24 |
Merck & Co., Inc. |
Antifungal compositions and method of controlling mycotic infections
|
US5166171A
(en)
|
1988-05-13 |
1992-11-24 |
Hoechst Aktiengesellschaft |
6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia
|
US4897402A
(en)
*
|
1988-06-29 |
1990-01-30 |
Merck & Co., Inc. |
5-oxa, 5-thia, 5-aza HmG-CoA reductase inhibitors
|
US4963538A
(en)
|
1988-06-29 |
1990-10-16 |
Merck & Co., Inc. |
5-oxygenated HMG-CoA reductase inhibitors
|
IT1226726B
(it)
*
|
1988-07-29 |
1991-02-05 |
Zambon Spa |
Composti attivi come inibitori della biosintesi del colesterolo.
|
US5196440A
(en)
*
|
1988-07-29 |
1993-03-23 |
Zambon Group S.P.A. |
Compounds active as inhibitors of the cholesterol biosynthesis
|
DE3832570A1
(de)
*
|
1988-09-24 |
1990-03-29 |
Hoechst Ag |
7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
|
JPH0547647Y2
(fr)
*
|
1988-10-03 |
1993-12-15 |
|
|
US4950675A
(en)
*
|
1988-12-21 |
1990-08-21 |
Warner-Lambert Company |
Pyridine di-mevalono-lactones as inhibitors of cholesterol biosynthesis
|
US4906657A
(en)
*
|
1988-12-21 |
1990-03-06 |
Warner-Lambert Company |
Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis
|
US4957940A
(en)
*
|
1988-12-21 |
1990-09-18 |
Warner-Lambert Company |
Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis
|
US4923861A
(en)
*
|
1989-02-07 |
1990-05-08 |
Warner-Lambert Company |
6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
|
US5130306A
(en)
*
|
1989-03-13 |
1992-07-14 |
Merck & Co., Inc. |
5-Oxygenated HMG-COA reductase inhibitors
|
US5132312A
(en)
*
|
1989-03-27 |
1992-07-21 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
|
US5064825A
(en)
|
1989-06-01 |
1991-11-12 |
Merck & Co., Inc. |
Angiotensin ii antagonists
|
US5102911A
(en)
*
|
1989-06-09 |
1992-04-07 |
Merck & Co, Inc. |
4-Substituted HMG-CoA reductase inhibitors
|
US4970231A
(en)
|
1989-06-09 |
1990-11-13 |
Merck & Co., Inc. |
4-substituted HMG-CoA reductase inhibitors
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
US4992429A
(en)
*
|
1989-08-24 |
1991-02-12 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Novel HMG-COA reductase inhibitors
|
US5098931A
(en)
*
|
1989-08-31 |
1992-03-24 |
Merck & Co., Inc. |
7-substituted HMG-CoA reductase inhibitors
|
US4946860A
(en)
*
|
1989-11-03 |
1990-08-07 |
Rorer Pharmaceutical Corporation |
Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors
|
US5073566A
(en)
|
1989-11-30 |
1991-12-17 |
Eli Lilly And Company |
Angiotensin ii antagonist 1,3-imidazoles and use thereas
|
IT1237793B
(it)
*
|
1989-12-21 |
1993-06-17 |
Zambon Spa |
Composti attivi come inibitori dell'enzima hmg-coa reduttasi
|
US5025000A
(en)
*
|
1990-03-02 |
1991-06-18 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing HMG-CoA reductase inhibitor compounds
|
US5622985A
(en)
*
|
1990-06-11 |
1997-04-22 |
Bristol-Myers Squibb Company |
Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
|
US5085992A
(en)
*
|
1990-07-19 |
1992-02-04 |
Merck & Co., Inc. |
Microbial transformation process for antihypertensive products
|
US5112857A
(en)
*
|
1990-09-04 |
1992-05-12 |
Merck & Co., Inc. |
Hmg-coa reductase inhibitor metabolites
|
US5087634A
(en)
*
|
1990-10-31 |
1992-02-11 |
G. D. Searle & Co. |
N-substituted imidazol-2-one compounds for treatment of circulatory disorders
|
AU1580292A
(en)
|
1991-03-13 |
1992-10-21 |
United States of America, as represented by the Secretary, U.S. Department of Commerce, The |
Increasing the therapeutic efficiency of macrophage-targeted therapeutic agents by up-regulating the mannose lectin on macrophages
|
US5182298A
(en)
*
|
1991-03-18 |
1993-01-26 |
Merck & Co., Inc. |
Cholesterol lowering agents
|
US5256689A
(en)
|
1991-05-10 |
1993-10-26 |
Merck & Co., Inc. |
Cholesterol lowering compounds
|
US5135935A
(en)
*
|
1991-05-17 |
1992-08-04 |
Merck & Co., Inc. |
Squalene synthetase inhibitors
|
US5250435A
(en)
|
1991-06-04 |
1993-10-05 |
Merck & Co., Inc. |
Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
|
US5202327A
(en)
*
|
1991-07-10 |
1993-04-13 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing hmg-coa reductase inhibitors
|
HU9203780D0
(en)
|
1991-12-12 |
1993-03-29 |
Sandoz Ag |
Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
|
FR2686899B1
(fr)
*
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
US5260332A
(en)
|
1992-02-07 |
1993-11-09 |
Merci & Co., Inc. |
Cholesterol lowering compounds
|
US5262435A
(en)
|
1992-02-10 |
1993-11-16 |
Merck & Co., Inc. |
Cholesterol lowering compounds
|
US5286895A
(en)
*
|
1992-02-19 |
1994-02-15 |
Merck & Co., Inc. |
Cholesterol lowering compounds
|
US5302604A
(en)
*
|
1992-03-09 |
1994-04-12 |
Merck & Co., Inc. |
Cholesterol lowering compounds produced by directed biosynthesis
|
FR2690022B1
(fr)
*
|
1992-03-24 |
1997-07-11 |
Bull Sa |
Circuit a retard variable.
|
US5369125A
(en)
|
1992-07-17 |
1994-11-29 |
Merck & Co., Inc. |
Cholesterol-lowering agents
|
US5283256A
(en)
*
|
1992-07-22 |
1994-02-01 |
Merck & Co., Inc. |
Cholesterol-lowering agents
|
US5279940A
(en)
*
|
1992-08-03 |
1994-01-18 |
Eastman Kodak Company |
Chemiluminescent composition containing cationic surfactants or polymers and 4'-hydroxyacetanilide, test kits and their use in analytical methods
|
US5661125A
(en)
*
|
1992-08-06 |
1997-08-26 |
Amgen, Inc. |
Stable and preserved erythropoietin compositions
|
US5317031A
(en)
*
|
1992-10-19 |
1994-05-31 |
Merck & Co., Inc. |
Cholesterol lowering compounds
|
GB9225098D0
(en)
*
|
1992-12-01 |
1993-01-20 |
Coffee Ronald A |
Charged droplet spray mixer
|
US5543297A
(en)
*
|
1992-12-22 |
1996-08-06 |
Merck Frosst Canada, Inc. |
Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity
|
US6105571A
(en)
*
|
1992-12-22 |
2000-08-22 |
Electrosols, Ltd. |
Dispensing device
|
US5276995A
(en)
*
|
1993-02-08 |
1994-01-11 |
Johnson Steven L |
Net trap
|
US5474995A
(en)
|
1993-06-24 |
1995-12-12 |
Merck Frosst Canada, Inc. |
Phenyl heterocycles as cox-2 inhibitors
|
EP0739340A1
(fr)
|
1994-01-10 |
1996-10-30 |
Merck Frosst Canada Inc. |
Heterocycles phenyliques utilises comme inhibiteurs de cox-2
|
GB9406255D0
(en)
*
|
1994-03-29 |
1994-05-18 |
Electrosols Ltd |
Dispensing device
|
GB9410658D0
(en)
*
|
1994-05-27 |
1994-07-13 |
Electrosols Ltd |
Dispensing device
|
EP0952841A4
(fr)
|
1994-08-05 |
2000-11-02 |
Molecular Structural Biotechno |
Complexes biomoleculaires diriges
|
US6103271A
(en)
*
|
1994-12-02 |
2000-08-15 |
The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration |
Microencapsulation and electrostatic processing method
|
US5732400A
(en)
*
|
1995-01-04 |
1998-03-24 |
Citibank N.A. |
System and method for a risk-based purchase of goods
|
US6861053B1
(en)
*
|
1999-08-11 |
2005-03-01 |
Cedars-Sinai Medical Center |
Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
|
EP0833664A1
(fr)
|
1995-06-12 |
1998-04-08 |
G.D. SEARLE & CO. |
Traitement d'inflammations par une combinaison d'un inhibiteur de la cyclooxygenase-2 et d'un antagoniste du recepteur de leukotriene b 4?
|
US6118045A
(en)
|
1995-08-02 |
2000-09-12 |
Pharming B.V. |
Lysosomal proteins produced in the milk of transgenic animals
|
WO1997010353A1
(fr)
*
|
1995-09-14 |
1997-03-20 |
Virginia Tech Intellectual Property, Inc. |
Production d'enzymes lysosomiales par des systemes d'expression vegetaux
|
US5873523A
(en)
*
|
1996-02-29 |
1999-02-23 |
Yale University |
Electrospray employing corona-assisted cone-jet mode
|
WO1997037645A1
(fr)
*
|
1996-04-10 |
1997-10-16 |
The Regents Of The University Of California |
Correction des defaillances genetiques a l'aide de chaperons chimiques
|
US6270954B1
(en)
*
|
1996-04-10 |
2001-08-07 |
The Regents Of The University Of California |
Correction of genetic defects using chemical chaperones
|
ES2458292T3
(es)
|
1996-09-13 |
2014-04-30 |
Shire Human Genetic Therapies, Inc. |
Producción de alfa-galactosidasa A humana
|
CA2275889C
(fr)
|
1996-12-30 |
2008-03-18 |
Battelle Memorial Institute |
Preparation et methode de traitement de neoplasmes par inhalation
|
DE69838644T2
(de)
|
1997-06-23 |
2009-05-14 |
The University Of Saskatchewan |
Verfahren zur herstellung eines rekombinanten rinderadenovirus-vektors
|
US5858130A
(en)
*
|
1997-06-25 |
1999-01-12 |
Bethlehem Steel Corporation |
Composition and method for producing an alloy steel and a product therefrom for structural applications
|
JP4664450B2
(ja)
*
|
1997-06-30 |
2011-04-06 |
アンステイテユ・ギユスタブ・ルシー |
多細胞化真核生物細胞に核酸を導入する改良法およびその組合せ
|
US6233600B1
(en)
*
|
1997-07-15 |
2001-05-15 |
Eroom Technology, Inc. |
Method and system for providing a networked collaborative work environment
|
US5904646A
(en)
*
|
1997-09-08 |
1999-05-18 |
Jarvik; Robert |
Infection resistant power cable system for medically implanted electric motors
|
US6223177B1
(en)
*
|
1997-10-22 |
2001-04-24 |
Involv International Corporation |
Network based groupware system
|
WO1999020110A1
(fr)
|
1997-10-22 |
1999-04-29 |
Merck & Co., Inc. |
Therapie d'association permettant de reduire les risques lies aux maladies cardio-vasculaires et cerebro-vasculaires
|
CA2305768A1
(fr)
|
1997-10-29 |
2000-02-24 |
Genzyme Corporation |
Compositions et procedes pour traiter les maladies lysosomiales
|
US6136804A
(en)
|
1998-03-13 |
2000-10-24 |
Merck & Co., Inc. |
Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
|
US6274597B1
(en)
*
|
1998-06-01 |
2001-08-14 |
Mount Sinai School Of Medicine Of New York University |
Method of enhancing lysosomal α-Galactosidase A
|
US6442528B1
(en)
*
|
1998-06-05 |
2002-08-27 |
I2 Technologies Us, Inc. |
Exemplar workflow used in the design and deployment of a workflow for multi-enterprise collaboration
|
CN1243543C
(zh)
*
|
1998-07-20 |
2006-03-01 |
派普泰克有限公司 |
生物植入物配方
|
US20030166132A1
(en)
*
|
1998-08-26 |
2003-09-04 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US6336105B1
(en)
*
|
1998-11-16 |
2002-01-01 |
Trade Access Inc. |
System and method for representing data and providing electronic non-repudiation in a negotiations system
|
US6141653A
(en)
*
|
1998-11-16 |
2000-10-31 |
Tradeaccess Inc |
System for interative, multivariate negotiations over a network
|
WO2000034451A1
(fr)
*
|
1998-12-07 |
2000-06-15 |
Pharming Intellectual Property B.V. |
Traitement de la maladie de pompe
|
US6564246B1
(en)
*
|
1999-02-02 |
2003-05-13 |
International Business Machines Corporation |
Shared and independent views of shared workspace for real-time collaboration
|
JP2002543165A
(ja)
*
|
1999-05-03 |
2002-12-17 |
バテル・メモリアル・インスティテュート |
エーロゾル化および吸入のための組成物
|
US6567784B2
(en)
*
|
1999-06-03 |
2003-05-20 |
Ework Exchange, Inc. |
Method and apparatus for matching projects and workers
|
US7033780B1
(en)
|
1999-06-14 |
2006-04-25 |
Millennium Pharmaceuticals, Inc. |
Nucleic acids corresponding to TANGO 294 a gene encoding a lipase—like protein
|
US6374292B1
(en)
*
|
1999-07-20 |
2002-04-16 |
Sun Microsystems, Inc. |
Access control system for an ISP hosted shared email server
|
US7927587B2
(en)
*
|
1999-08-05 |
2011-04-19 |
Regents Of The University Of Minnesota |
MAPC administration for the treatment of lysosomal storage disorders
|
US6415270B1
(en)
*
|
1999-09-03 |
2002-07-02 |
Omnihub, Inc. |
Multiple auction coordination method and system
|
US6642038B1
(en)
|
1999-09-14 |
2003-11-04 |
Genzyme Glycobiology Research Institute, Inc. |
GlcNAc phosphotransferase of the lysosomal targeting pathway
|
WO2001056596A1
(fr)
|
2000-02-04 |
2001-08-09 |
Children's Hospital Research Foundation |
Utilisation de lipase acide lysosomiale pour traiter l'atherosclerose et des maladies associees
|
JP2003523388A
(ja)
|
2000-02-23 |
2003-08-05 |
アルテオン インコーポレーテッド |
チアゾリウム化合物及びタンパク質老化に関連する障害の治療
|
AU2001269923A1
(en)
*
|
2000-06-19 |
2002-01-02 |
Genzyme Corporation |
Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
|
US20040038365A1
(en)
*
|
2000-10-31 |
2004-02-26 |
Yonghong Xiao |
Regulation of human lysosomal acid lipase
|
US20030064437A1
(en)
*
|
2000-11-15 |
2003-04-03 |
Nick Wan |
Expression system for recombinant proteins
|
US20020193303A1
(en)
*
|
2001-01-25 |
2002-12-19 |
Millennium Pharmaceuticals, Inc. |
58860, a human cholesteryl ester hydrolase and uses therefor
|
WO2003002150A1
(fr)
|
2001-06-28 |
2003-01-09 |
Wyeth |
Composition et procede permettant de reduire des interactions nefastes entre des derives de phenothiazine et du plasma
|
WO2003002153A1
(fr)
*
|
2001-06-28 |
2003-01-09 |
Wyeth |
Composition et procede permettant de reduire des interactions nefastes entre des derives de phenothiazine et du plasma au moyen de cyclodextrines
|
US6800472B2
(en)
|
2001-12-21 |
2004-10-05 |
Genzyme Glycobiology Research Institute, Inc. |
Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase
|
US20050181474A1
(en)
*
|
2002-01-30 |
2005-08-18 |
Frank J. Giordano |
Transport peptides and uses therefor
|
EP1495328B1
(fr)
*
|
2002-04-16 |
2014-06-18 |
Vlaams Interuniversitair Instituut voor Biotechnologie vzw. |
Marqueur de la cirrhose du foie
|
CA2499188A1
(fr)
*
|
2002-09-27 |
2004-04-08 |
Cold Spring Harbor Laboratory |
Interference arn basee sur les cellules, et procedes et compositions s'y rapportant
|
CN1972709A
(zh)
|
2004-06-21 |
2007-05-30 |
阿姆斯特丹大学医学院 |
非酒精性脂肪性肝炎的治疗方法
|
BRPI0514409A
(pt)
|
2004-08-19 |
2008-06-10 |
Biogen Idec Inc |
redobra de proteìnas da famìlia de fator de crescimento transformante beta
|
US20070270367A1
(en)
|
2005-05-18 |
2007-11-22 |
University Of Kentucky Research Foundation |
Rybozyme-catalyzed insertion of targeted sequences into RNA
|
US20090297496A1
(en)
|
2005-09-08 |
2009-12-03 |
Childrens Hospital Medical Center |
Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
|
PL377180A1
(pl)
*
|
2005-09-21 |
2007-04-02 |
Instytut Farmaceutyczny |
Zastosowanie izoflawonów i ich pochodnych w leczeniu mukopolisacharydoz
|
US8748567B2
(en)
|
2006-05-22 |
2014-06-10 |
Children's Medical Center Corporation |
Method for delivery across the blood brain barrier
|
WO2007137303A2
(fr)
|
2006-05-24 |
2007-11-29 |
Myelin Repair Foundation, Inc. |
Perméabilité de la barrière hémato-encéphalique
|
US8143265B2
(en)
*
|
2007-04-16 |
2012-03-27 |
Meharry Medical College |
Method of treating atherosclerosis
|
WO2008131431A2
(fr)
*
|
2007-04-23 |
2008-10-30 |
St. Louis University |
Modulation de l'expression des protéines de la barrière hémato-encéphalique
|
AU2008256644B2
(en)
|
2007-05-24 |
2014-07-03 |
The United States Government As Represented By The Department Of Veterans Affairs |
Intranuclear protein transduction through a nucleoside salvage pathway
|
AU2008255565B2
(en)
*
|
2007-05-31 |
2013-10-24 |
Paradigm Biopharmaceuticals Ltd |
Sulphated xylans for treatment or prophylaxis of respiratory diseases
|
AU2008273094B2
(en)
*
|
2007-07-12 |
2013-05-09 |
Prosensa Technologies B.V. |
Molecules for targeting compounds to various selected organs, tissues or tumor cells
|
US20100291060A1
(en)
|
2007-08-29 |
2010-11-18 |
Shire Human Genetic Therapies, Inc |
Subcutaneous administration of alpha-galactosidase a
|
US8142265B2
(en)
*
|
2008-04-10 |
2012-03-27 |
Greg Carter |
Motorized air vent
|
FR2937322B1
(fr)
|
2008-10-22 |
2013-02-22 |
Vect Horus |
Derives peptidiques et leur utilisation comme vecteurs de molecules sous forme de conjugues
|
US8232073B2
(en)
*
|
2009-01-02 |
2012-07-31 |
Zacharon Pharmaceuticals, Inc. |
Quantification of non-reducing end glycan residual compounds
|
US8183003B2
(en)
*
|
2009-01-02 |
2012-05-22 |
Zacharon Pharmaceuticals, Inc. |
Polymer end group detection
|
WO2011049737A1
(fr)
*
|
2009-10-19 |
2011-04-28 |
Amicus Therapeutics, Inc. |
Nouvelles compositions pour prévenir et/ou traiter des troubles du stockage lysosomique
|
KR101077618B1
(ko)
|
2009-11-13 |
2011-10-27 |
경북대학교 산학협력단 |
뇌혈관 장벽을 통과하여 퇴행성 뇌신경 질환 부위의 세포사멸을 표적하는 펩타이드 및 이의 용도
|
US9095541B2
(en)
|
2009-11-24 |
2015-08-04 |
Arch Cancer Therapeutics, Inc. |
Brain tumor targeting peptides and methods
|
EP2561069B1
(fr)
|
2010-04-23 |
2017-03-08 |
Alexion Pharmaceuticals, Inc. |
Enzyme des maladies lysosomales
|
BR112013005673B1
(pt)
*
|
2010-09-09 |
2020-12-15 |
Alexion Pharmaceuticals, Inc |
Uso de lipase ácida lisossomal (lal) humana recombinante no tratamento da deficiência de lipase ácida lisossomal
|
WO2012112677A2
(fr)
|
2011-02-15 |
2012-08-23 |
Children's Hospital Medical Center |
Procédés de traitement d'un déficit en lipase acide lysosomale
|
US8865881B2
(en)
|
2011-02-22 |
2014-10-21 |
California Institute Of Technology |
Delivery of proteins using adeno-associated virus (AAV) vectors
|
WO2012159052A2
(fr)
|
2011-05-18 |
2012-11-22 |
Children's Hospital Medical Center |
Administration ciblée de protéines à travers la barrière hémato-encéphalique
|
US9155784B2
(en)
|
2011-06-20 |
2015-10-13 |
Icahn School Of Medicine At Mount Sinai |
Anti-TNF-α therapy for the mucopolysaccharidoses and other lysosomal disorders
|
WO2012177639A2
(fr)
|
2011-06-22 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Biotraitement et bioproduction à l'aide de lignées de cellules aviaires
|
MX351565B
(es)
|
2011-08-03 |
2017-10-19 |
Phoenix Tissue Repair Inc |
Colageno 7 y metodos relacionados.
|