GB2086390B - 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application - Google Patents
1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic applicationInfo
- Publication number
- GB2086390B GB2086390B GB8132559A GB8132559A GB2086390B GB 2086390 B GB2086390 B GB 2086390B GB 8132559 A GB8132559 A GB 8132559A GB 8132559 A GB8132559 A GB 8132559A GB 2086390 B GB2086390 B GB 2086390B
- Authority
- GB
- United Kingdom
- Prior art keywords
- azaalkanoylindoline
- carboxy
- compounds
- carboxylic acids
- pharmaceutical preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20376980A | 1980-11-03 | 1980-11-03 | |
US23991881A | 1981-03-03 | 1981-03-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2086390A GB2086390A (en) | 1982-05-12 |
GB2086390B true GB2086390B (en) | 1984-06-06 |
Family
ID=26898886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8132559A Expired GB2086390B (en) | 1980-11-03 | 1981-10-29 | 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0051301A1 (en) |
AU (1) | AU7702281A (en) |
CA (1) | CA1172258A (en) |
DD (1) | DD201888A5 (en) |
DK (1) | DK483681A (en) |
ES (3) | ES506784A0 (en) |
FI (1) | FI813422L (en) |
GB (1) | GB2086390B (en) |
GR (1) | GR74689B (en) |
HU (1) | HU185324B (en) |
IL (1) | IL64185A0 (en) |
NO (1) | NO813694L (en) |
PT (1) | PT73916B (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN156096B (en) * | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
DE3226768A1 (en) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | DERIVATIVES OF CIS, ENDO-2-AZABICYCLO- (3.3.0) -OCTAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF |
IE55867B1 (en) * | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
EP0170775B2 (en) * | 1981-12-29 | 1994-10-12 | Hoechst Aktiengesellschaft | Derivatives of bicyclic amino acids, processes for their preparation, agents containing them and their use as well as bicyclic amino acids as intermediates and process for their preparation |
DE3210496A1 (en) * | 1982-03-23 | 1983-10-06 | Hoechst Ag | NEW DERIVATIVES OF BICYCLIC AMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF, AND NEW BICYCLIC AMINO ACIDS AS INTERMEDIATE STAGES AND METHOD FOR THE PRODUCTION THEREOF |
US4520205A (en) * | 1982-06-28 | 1985-05-28 | American Home Products Corporation | Chemical resolution of (+)-2,3-dihydroindole-2-carboxylic acid |
US5175306A (en) * | 1983-01-31 | 1992-12-29 | Hoechst Aktiengesellschaft | Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters |
FR2546886B2 (en) * | 1983-06-06 | 1986-05-16 | Adir | DERIVATIVES OF ISOINDOLEDICARBOXYLIC ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE3324263A1 (en) * | 1983-07-06 | 1985-01-17 | Hoechst Ag, 6230 Frankfurt | DERIVATIVES OF 2-AZABICYCLO (3.1.0) HEXAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THEIR SUBSTANCES AND THE USE THEREOF, AND 2-AZABICYCLO (3.1.0) HEXANE DERIVATIVES AS INTERMEDIATE PRODUCTS AND PROCESS PRODUCTS |
DE3333455A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
DE3333454A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
DE3413710A1 (en) * | 1984-04-12 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | METHOD FOR TREATING HEART INSUFFICIENCY |
US5684016A (en) * | 1984-04-12 | 1997-11-04 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency |
DE3431541A1 (en) * | 1984-08-28 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | CIS, ENDO-2-AZABICYCLOALKAN-3-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION |
US5231080A (en) * | 1985-10-15 | 1993-07-27 | Hoechst Aktiengesellschaft | Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
DE3633496A1 (en) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS WITH CALCIUMANTAGONISTS AND THEIR USE IN MEDICINAL PRODUCTS |
DE3639879A1 (en) * | 1986-11-21 | 1988-06-01 | Hoechst Ag | METHOD FOR PRODUCING MONO, BI AND TRICYCLIC AMINO ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD, AND A METHOD FOR PRODUCING THE SAME |
DE3722007A1 (en) * | 1987-07-03 | 1989-01-12 | Hoechst Ag | METHOD FOR PRODUCING BICYCLIC AMINOCARBONIC ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD AND THE USE THEREOF |
TW197945B (en) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
EP0706525A1 (en) * | 1993-06-30 | 1996-04-17 | Novartis AG | Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4303583A (en) * | 1979-08-13 | 1981-12-01 | American Home Products Corporation | 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones |
IE52663B1 (en) * | 1980-04-02 | 1988-01-20 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
-
1981
- 1981-10-29 GB GB8132559A patent/GB2086390B/en not_active Expired
- 1981-10-30 EP EP81109378A patent/EP0051301A1/en not_active Withdrawn
- 1981-10-30 FI FI813422A patent/FI813422L/en not_active Application Discontinuation
- 1981-10-30 CA CA000389117A patent/CA1172258A/en not_active Expired
- 1981-11-02 ES ES506784A patent/ES506784A0/en active Granted
- 1981-11-02 GR GR66399A patent/GR74689B/el unknown
- 1981-11-02 NO NO813694A patent/NO813694L/en unknown
- 1981-11-02 IL IL64185A patent/IL64185A0/en unknown
- 1981-11-02 PT PT73916A patent/PT73916B/en unknown
- 1981-11-02 DK DK483681A patent/DK483681A/en not_active Application Discontinuation
- 1981-11-02 HU HU813251A patent/HU185324B/en unknown
- 1981-11-02 AU AU77022/81A patent/AU7702281A/en not_active Abandoned
- 1981-11-03 DD DD81234586A patent/DD201888A5/en unknown
-
1982
- 1982-10-15 ES ES516556A patent/ES8401026A1/en not_active Expired
- 1982-10-15 ES ES516555A patent/ES8401025A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0051301A1 (en) | 1982-05-12 |
ES516556A0 (en) | 1983-12-01 |
CA1172258A (en) | 1984-08-07 |
NO813694L (en) | 1982-05-04 |
ES516555A0 (en) | 1983-12-01 |
FI813422L (en) | 1982-05-04 |
DK483681A (en) | 1982-05-04 |
GB2086390A (en) | 1982-05-12 |
HU185324B (en) | 1985-01-28 |
PT73916B (en) | 1983-11-30 |
ES8303329A1 (en) | 1983-02-01 |
ES8401026A1 (en) | 1983-12-01 |
AU7702281A (en) | 1982-05-13 |
ES8401025A1 (en) | 1983-12-01 |
GR74689B (en) | 1984-07-03 |
DD201888A5 (en) | 1983-08-17 |
PT73916A (en) | 1981-12-01 |
IL64185A0 (en) | 1982-02-28 |
ES506784A0 (en) | 1983-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |