IL64185A0 - 1-carboxy-azaalkanoylindoline-2-carboxylic acids and ester and amide derivatives thereof,their manufacture and pharmaceutical compositions containing them - Google Patents
1-carboxy-azaalkanoylindoline-2-carboxylic acids and ester and amide derivatives thereof,their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL64185A0 IL64185A0 IL64185A IL6418581A IL64185A0 IL 64185 A0 IL64185 A0 IL 64185A0 IL 64185 A IL64185 A IL 64185A IL 6418581 A IL6418581 A IL 6418581A IL 64185 A0 IL64185 A0 IL 64185A0
- Authority
- IL
- Israel
- Prior art keywords
- azaalkanoylindoline
- carboxy
- ester
- manufacture
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20376980A | 1980-11-03 | 1980-11-03 | |
US23991881A | 1981-03-03 | 1981-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL64185A0 true IL64185A0 (en) | 1982-02-28 |
Family
ID=26898886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL64185A IL64185A0 (en) | 1980-11-03 | 1981-11-02 | 1-carboxy-azaalkanoylindoline-2-carboxylic acids and ester and amide derivatives thereof,their manufacture and pharmaceutical compositions containing them |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0051301A1 (en) |
AU (1) | AU7702281A (en) |
CA (1) | CA1172258A (en) |
DD (1) | DD201888A5 (en) |
DK (1) | DK483681A (en) |
ES (3) | ES506784A0 (en) |
FI (1) | FI813422L (en) |
GB (1) | GB2086390B (en) |
GR (1) | GR74689B (en) |
HU (1) | HU185324B (en) |
IL (1) | IL64185A0 (en) |
NO (1) | NO813694L (en) |
PT (1) | PT73916B (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN156096B (en) * | 1981-03-19 | 1985-05-11 | Usv Pharma Corp | |
DE3226768A1 (en) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | DERIVATIVES OF CIS, ENDO-2-AZABICYCLO- (3.3.0) -OCTAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF |
GR78413B (en) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
EP0170775B2 (en) * | 1981-12-29 | 1994-10-12 | Hoechst Aktiengesellschaft | Derivatives of bicyclic amino acids, processes for their preparation, agents containing them and their use as well as bicyclic amino acids as intermediates and process for their preparation |
DE3210496A1 (en) * | 1982-03-23 | 1983-10-06 | Hoechst Ag | NEW DERIVATIVES OF BICYCLIC AMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF, AND NEW BICYCLIC AMINO ACIDS AS INTERMEDIATE STAGES AND METHOD FOR THE PRODUCTION THEREOF |
US4520205A (en) * | 1982-06-28 | 1985-05-28 | American Home Products Corporation | Chemical resolution of (+)-2,3-dihydroindole-2-carboxylic acid |
US5175306A (en) * | 1983-01-31 | 1992-12-29 | Hoechst Aktiengesellschaft | Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters |
FR2546886B2 (en) * | 1983-06-06 | 1986-05-16 | Adir | DERIVATIVES OF ISOINDOLEDICARBOXYLIC ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE3324263A1 (en) * | 1983-07-06 | 1985-01-17 | Hoechst Ag, 6230 Frankfurt | DERIVATIVES OF 2-AZABICYCLO (3.1.0) HEXAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THEIR SUBSTANCES AND THE USE THEREOF, AND 2-AZABICYCLO (3.1.0) HEXANE DERIVATIVES AS INTERMEDIATE PRODUCTS AND PROCESS PRODUCTS |
DE3333454A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
DE3333455A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
US5684016A (en) * | 1984-04-12 | 1997-11-04 | Hoechst Aktiengesellschaft | Method of treating cardiac insufficiency |
DE3413710A1 (en) * | 1984-04-12 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | METHOD FOR TREATING HEART INSUFFICIENCY |
DE3431541A1 (en) * | 1984-08-28 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | CIS, ENDO-2-AZABICYCLOALKAN-3-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION |
US5231080A (en) * | 1985-10-15 | 1993-07-27 | Hoechst Aktiengesellschaft | Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease |
US5231084A (en) * | 1986-03-27 | 1993-07-27 | Hoechst Aktiengesellschaft | Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons |
DE3633496A1 (en) * | 1986-10-02 | 1988-04-14 | Hoechst Ag | COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS WITH CALCIUMANTAGONISTS AND THEIR USE IN MEDICINAL PRODUCTS |
DE3639879A1 (en) * | 1986-11-21 | 1988-06-01 | Hoechst Ag | METHOD FOR PRODUCING MONO, BI AND TRICYCLIC AMINO ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD, AND A METHOD FOR PRODUCING THE SAME |
DE3722007A1 (en) * | 1987-07-03 | 1989-01-12 | Hoechst Ag | METHOD FOR PRODUCING BICYCLIC AMINOCARBONIC ACIDS, INTERMEDIATE PRODUCTS OF THIS METHOD AND THE USE THEREOF |
TW197945B (en) * | 1990-11-27 | 1993-01-11 | Hoechst Ag | |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
WO1995001353A1 (en) * | 1993-06-30 | 1995-01-12 | Ciba-Geigy Ag | Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4303583A (en) * | 1979-08-13 | 1981-12-01 | American Home Products Corporation | 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones |
IE52663B1 (en) * | 1980-04-02 | 1988-01-20 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
-
1981
- 1981-10-29 GB GB8132559A patent/GB2086390B/en not_active Expired
- 1981-10-30 EP EP81109378A patent/EP0051301A1/en not_active Withdrawn
- 1981-10-30 CA CA000389117A patent/CA1172258A/en not_active Expired
- 1981-10-30 FI FI813422A patent/FI813422L/en not_active Application Discontinuation
- 1981-11-02 PT PT73916A patent/PT73916B/en unknown
- 1981-11-02 ES ES506784A patent/ES506784A0/en active Granted
- 1981-11-02 GR GR66399A patent/GR74689B/el unknown
- 1981-11-02 NO NO813694A patent/NO813694L/en unknown
- 1981-11-02 AU AU77022/81A patent/AU7702281A/en not_active Abandoned
- 1981-11-02 DK DK483681A patent/DK483681A/en not_active Application Discontinuation
- 1981-11-02 IL IL64185A patent/IL64185A0/en unknown
- 1981-11-02 HU HU813251A patent/HU185324B/en unknown
- 1981-11-03 DD DD81234586A patent/DD201888A5/en unknown
-
1982
- 1982-10-15 ES ES516556A patent/ES516556A0/en active Granted
- 1982-10-15 ES ES516555A patent/ES516555A0/en active Granted
Also Published As
Publication number | Publication date |
---|---|
ES8303329A1 (en) | 1983-02-01 |
ES8401026A1 (en) | 1983-12-01 |
GB2086390A (en) | 1982-05-12 |
ES8401025A1 (en) | 1983-12-01 |
FI813422L (en) | 1982-05-04 |
AU7702281A (en) | 1982-05-13 |
GB2086390B (en) | 1984-06-06 |
HU185324B (en) | 1985-01-28 |
DK483681A (en) | 1982-05-04 |
PT73916B (en) | 1983-11-30 |
EP0051301A1 (en) | 1982-05-12 |
DD201888A5 (en) | 1983-08-17 |
GR74689B (en) | 1984-07-03 |
CA1172258A (en) | 1984-08-07 |
ES506784A0 (en) | 1983-02-01 |
NO813694L (en) | 1982-05-04 |
PT73916A (en) | 1981-12-01 |
ES516555A0 (en) | 1983-12-01 |
ES516556A0 (en) | 1983-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL64185A0 (en) | 1-carboxy-azaalkanoylindoline-2-carboxylic acids and ester and amide derivatives thereof,their manufacture and pharmaceutical compositions containing them | |
IL74882A0 (en) | Naphthyridine-,quinoline-and benzoxazine-carboxylic acids and derivatives thereof,their manufacture and pharmaceutical compositions containing them | |
SG6885G (en) | 2-hydroxy-5-phenylazobenzoic acid derivatives and pharmaceutical compositions containing them | |
IL59628A (en) | 4-amino-3-quinolinecarboxylic acids and salts and esters thereof and pharmaceutical compositions containing them | |
IL67103A0 (en) | Ester and amide derivatives of 13,14-didehydroprostaglandins,their preparation and pharmaceutical compositions containing them | |
IL64075A0 (en) | Substituted azabicyclooctane-carboxylic acids,their preparation and pharmaceutical compositions containing them | |
GB2053909B (en) | Pyrrolidinylalkycarboxylic acid amide derivatives their preparation and pharmaceutical compositions containing them | |
IL68804A (en) | 2-azetidinone-1-sulfonic acids,their manufacture and pharmaceutical compositions containing them | |
GB2086912B (en) | Enkephalin derivatives production thereof and pharmaceutical compositions | |
IL61210A (en) | 3-benzoyl-2-nitrophenylacetic acids and metal salts,amides and esters thereof and pharmaceutical compositions containing them | |
JPS562960A (en) | Pyrrolidinylalkylcarboxylic acid amide derivative* its manufacture and medicinal composition | |
NZ194784A (en) | 7 -aminothiadizolylacetylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions | |
IL79181A0 (en) | 3-(substituted)propenylaminothiazolylcephalosporanic acids and esters thereof,their preparation and pharmaceutical compositions containing them | |
IL60700A0 (en) | 25-halocholest-5-ene-2 ,22-diols and esters thereof and pharmaceutical compositions containing them | |
GB2056856B (en) | Pharmaceutical compositions comprising aminobenzoic acid derivatives | |
NZ194241A (en) | 7b-aminothiadiazolylacetamido-3-cephem-4 carboxylic acid derivatives and pharmaceutical compositions | |
JPS5721354A (en) | Esters of carnitine alkoxy-acyl derivatives, manufacture and medicinal composition as effective component thereof | |
IL61675A0 (en) | N-substituted -amino acids and derivatives thereof,their preparation and pharmaceutical compositions containing them | |
IL62326A0 (en) | 7 beta-amido-3-cephem-4-carboxylic acid derivatives,their manufacture and pharmaceutical compositions containing them | |
NZ194122A (en) | Acylaminobenzoic acid derivatives and pharmaceutical compositions | |
IL55006A (en) | Oxaminic acids and salts and esters thereof,their production and pharmaceutical compositions containing them | |
IL60444A0 (en) | 2-amino-3-(alkylthiobenzoyl)-phenylacetic acids and pharmaceutical compositions containing them | |
IL53549A0 (en) | 1-aziridine-carboxylic acid ester derivatives process for their preparation and pharmaceutical compositions containing the same | |
IL62826A (en) | Fluoromethylated pyrosine methyl ester,its salts and pharmaceutical compositions comprising them | |
DE3067008D1 (en) | 1-azaxanthone-3-carboxylic acids, their preparation and pharmaceutical compositions containing them |