RO85072B - Procedeu pentru prepararea n-(1-carboxi-3-fenilpropil)-l-alanil-l-prolinei - Google Patents

Procedeu pentru prepararea n-(1-carboxi-3-fenilpropil)-l-alanil-l-prolinei

Info

Publication number
RO85072B
RO85072B RO108579A RO10857979A RO85072B RO 85072 B RO85072 B RO 85072B RO 108579 A RO108579 A RO 108579A RO 10857979 A RO10857979 A RO 10857979A RO 85072 B RO85072 B RO 85072B
Authority
RO
Romania
Prior art keywords
alanyl
phenylpropyl
proline
carboxy
preparation
Prior art date
Application number
RO108579A
Other languages
English (en)
Other versions
RO85072A (ro
Inventor
A. Arthur Patchett
E. Elbert Harris
J. Mathew Wyvratt
W. Edward Tristram
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25513965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO85072(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of RO85072A publication Critical patent/RO85072A/ro
Publication of RO85072B publication Critical patent/RO85072B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea N-(1-carboxi-3-fenilpropil)-L-alanil-L-protinei cu formula I: (vezi formula) printr-un amestec apos de L-alanil-Lprolina cu formula si acid 4-fenil-2-oxobutiric, corectarea pH-ul amestecului la 7,5 cu hidroxid de sodiu, tratarea amestecului cu cianorohidrat de sodiu si produs rezultat se absoarbe pe o rasina schimbatoare de ioni puternic acid, se elueaza apoasa de piridina 2%, obtinîndu-se un produs brut diasterometric care se purifica prin filtrare prin gel, si, daca se doreste, se separa cu 2 izomeri pe cale cromatografica.
RO108579A 1978-12-11 1979-12-08 Procedeu pentru prepararea n-(1-carboxi-3-fenilpropil)-l-alanil-l-prolinei RO85072B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96824978A 1978-12-11 1978-12-11

Publications (2)

Publication Number Publication Date
RO85072A RO85072A (ro) 1984-08-17
RO85072B true RO85072B (ro) 1984-09-30

Family

ID=25513965

Family Applications (4)

Application Number Title Priority Date Filing Date
RO7999486A RO80264A (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unui derivat de alanilprolina
RO108578A RO85071B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unui derivat de alanilprolina
RO108580A RO85073B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unor derivati de aminoacizi
RO108579A RO85072B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea n-(1-carboxi-3-fenilpropil)-l-alanil-l-prolinei

Family Applications Before (3)

Application Number Title Priority Date Filing Date
RO7999486A RO80264A (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unui derivat de alanilprolina
RO108578A RO85071B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unui derivat de alanilprolina
RO108580A RO85073B (ro) 1978-12-11 1979-12-08 Procedeu pentru prepararea unor derivati de aminoacizi

Country Status (33)

Country Link
US (2) US4374829A (ro)
EP (1) EP0012401B1 (ro)
JP (3) JPS5581845A (ro)
KR (3) KR850000847B1 (ro)
AR (1) AR231971A1 (ro)
AU (1) AU530380B2 (ro)
BG (6) BG39467A3 (ro)
CA (4) CA1302005C (ro)
CS (1) CS237311B2 (ro)
DD (1) DD148770A5 (ro)
DE (2) DE2966767D1 (ro)
DK (1) DK165455C (ro)
EG (1) EG14182A (ro)
ES (2) ES8101540A1 (ro)
FI (1) FI68405C (ro)
GR (1) GR72251B (ro)
HK (1) HK27487A (ro)
HU (1) HU182902B (ro)
IE (1) IE48922B1 (ro)
IL (1) IL58849A (ro)
LU (1) LU90173I2 (ro)
MA (1) MA18664A1 (ro)
NL (4) NL930006I2 (ro)
NO (3) NO151622C (ro)
NZ (1) NZ192312A (ro)
PH (1) PH24268A (ro)
PL (2) PL131140B1 (ro)
PT (1) PT70542A (ro)
RO (4) RO80264A (ro)
SU (1) SU1287756A3 (ro)
YU (3) YU42655B (ro)
ZA (1) ZA796688B (ro)
ZW (1) ZW24479A1 (ro)

Families Citing this family (399)

* Cited by examiner, † Cited by third party
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