ES8604609A1 - Procedimiento para la obtencion de la 1-(n-(1(r,s)-(etoxi- carbonil)-3-fenilpropil)-l-alanil)-l-prolina - Google Patents

Procedimiento para la obtencion de la 1-(n-(1(r,s)-(etoxi- carbonil)-3-fenilpropil)-l-alanil)-l-prolina

Info

Publication number
ES8604609A1
ES8604609A1 ES544781A ES544781A ES8604609A1 ES 8604609 A1 ES8604609 A1 ES 8604609A1 ES 544781 A ES544781 A ES 544781A ES 544781 A ES544781 A ES 544781A ES 8604609 A1 ES8604609 A1 ES 8604609A1
Authority
ES
Spain
Prior art keywords
proline
alanyl
phenylpropyl
ethoxycarbonyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544781A
Other languages
English (en)
Other versions
ES544781A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES544781A priority Critical patent/ES8604609A1/es
Priority to DE19853542735 priority patent/DE3542735A1/de
Publication of ES544781A0 publication Critical patent/ES544781A0/es
Publication of ES8604609A1 publication Critical patent/ES8604609A1/es
Priority to MX3003A priority patent/MX162827B/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LA 1-(N-(1(R,S)-(ETOXICARBONIL)-3-FENILPROPIL)-L-ALANIL)-L-PROLINA. CONSISTE EN PARTIR DEL 4-FENIL-2-OXOBUTIRATO DE ETILO Y HACERLO REACCIONAR CON LA L-ALANINA EN PRESENCIA DE UN AGENTE REDUCTOR COMO EL CIANOBOROHIDRURO DE SODIO O EL HIDROGENO EN PRESENCIA DE UN CATALIZADOR Y BAJO LA ACCION DE UN AGENTE DESECANTE, EN EL SENO DE UN DISOLVENTE POLAR, PARA OBTENER LA N-(1(R,S)-(ETOXICARBONIL)-3-FENILPROPIL)-L-ALANINA DE FORMULA (II) QUE POSTERIORMENTE SE HACE REACCIONAR CON LA N-HIDROXISUCCINIMIDA, EN PRESENCIA DE UN AGENTE CONDENSANTE Y EN UN DISOLVENTE POLAR PARA OBTENER LA N-(1(R,S)-(ETOXICARBONIL)-3-FENILPROPIL)-L-ALANINA DE FORMULA (III) QUE FINALMENTE SE HACE REACCIONAR CON LA L-PROLINA EN PRESENCIA DE UNA BASE Y EN UN DISOLVENTE POLAR PARA OBTENER EL PRODUCTO DESEADO DE FORMULA (I).
ES544781A 1985-07-02 1985-07-02 Procedimiento para la obtencion de la 1-(n-(1(r,s)-(etoxi- carbonil)-3-fenilpropil)-l-alanil)-l-prolina Expired ES8604609A1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES544781A ES8604609A1 (es) 1985-07-02 1985-07-02 Procedimiento para la obtencion de la 1-(n-(1(r,s)-(etoxi- carbonil)-3-fenilpropil)-l-alanil)-l-prolina
DE19853542735 DE3542735A1 (de) 1985-07-02 1985-12-03 Verfahren zur herstellung von 1-(n-(1(r,s)-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-prolin
MX3003A MX162827B (es) 1985-07-02 1986-07-02 Procedimiento para la obtencion de la 1-(n-(1(r,s)-(etoxicarbonil)-3-fenilpropil)-l-alanil)-l-prolina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES544781A ES8604609A1 (es) 1985-07-02 1985-07-02 Procedimiento para la obtencion de la 1-(n-(1(r,s)-(etoxi- carbonil)-3-fenilpropil)-l-alanil)-l-prolina

Publications (2)

Publication Number Publication Date
ES544781A0 ES544781A0 (es) 1986-02-01
ES8604609A1 true ES8604609A1 (es) 1986-02-01

Family

ID=8489450

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544781A Expired ES8604609A1 (es) 1985-07-02 1985-07-02 Procedimiento para la obtencion de la 1-(n-(1(r,s)-(etoxi- carbonil)-3-fenilpropil)-l-alanil)-l-prolina

Country Status (3)

Country Link
DE (1) DE3542735A1 (es)
ES (1) ES8604609A1 (es)
MX (1) MX162827B (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES544781A0 (es) 1986-02-01
DE3542735A1 (de) 1987-01-08
MX162827B (es) 1991-06-28

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Legal Events

Date Code Title Description
PC1A Transfer granted
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20051018