ATE80380T1 - Diastereoselektives verfahren zur herstellung von zwischenprodukten verwendbar zur peptidderivatensynthese. - Google Patents

Diastereoselektives verfahren zur herstellung von zwischenprodukten verwendbar zur peptidderivatensynthese.

Info

Publication number
ATE80380T1
ATE80380T1 AT89107141T AT89107141T ATE80380T1 AT E80380 T1 ATE80380 T1 AT E80380T1 AT 89107141 T AT89107141 T AT 89107141T AT 89107141 T AT89107141 T AT 89107141T AT E80380 T1 ATE80380 T1 AT E80380T1
Authority
AT
Austria
Prior art keywords
preparation
intermediate products
peptide derivative
derivative synthesis
diastereoselective process
Prior art date
Application number
AT89107141T
Other languages
English (en)
Inventor
Franco Pellacini
Dario Chiarino
Angelo Carenzi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Application granted granted Critical
Publication of ATE80380T1 publication Critical patent/ATE80380T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT89107141T 1988-05-11 1989-04-20 Diastereoselektives verfahren zur herstellung von zwischenprodukten verwendbar zur peptidderivatensynthese. ATE80380T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20542/88A IT1217567B (it) 1988-05-11 1988-05-11 Processo diastereoselettivo per la preparazione di intermedi utili per la sintesi di derivati peptidici
EP89107141A EP0341462B1 (de) 1988-05-11 1989-04-20 Diastereoselektives Verfahren zur Herstellung von Zwischenprodukten verwendbar zur Peptidderivatensynthese

Publications (1)

Publication Number Publication Date
ATE80380T1 true ATE80380T1 (de) 1992-09-15

Family

ID=11168517

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89107141T ATE80380T1 (de) 1988-05-11 1989-04-20 Diastereoselektives verfahren zur herstellung von zwischenprodukten verwendbar zur peptidderivatensynthese.

Country Status (8)

Country Link
US (1) US5157143A (de)
EP (1) EP0341462B1 (de)
JP (1) JP2860559B2 (de)
AT (1) ATE80380T1 (de)
DE (1) DE68902771T2 (de)
ES (1) ES2052801T3 (de)
GR (1) GR3006432T3 (de)
IT (1) IT1217567B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648511A (en) * 1990-11-19 1997-07-15 G.D. Searle & Co. Method for making intermediates useful in the synthesis of retroviral protease inhibitors
US6743929B1 (en) 1992-08-25 2004-06-01 G. D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
ATE284863T1 (de) * 1996-02-08 2005-01-15 Nippon Kayaku Kk Verfahren zur erzeugung optisch aktiver cyanohydrine
JP2001048850A (ja) 1999-05-28 2001-02-20 Kanegafuchi Chem Ind Co Ltd ノルスタチン誘導体の製造法
JP2002047256A (ja) * 2000-07-26 2002-02-12 Kanegafuchi Chem Ind Co Ltd α−アミノ−α´，α´，α´−トリハロケトン誘導体、α−アミノ−α´，α´，α´−トリハロアルコ−ル誘導体、及び、α−ヒドロキシ−β−アミノカルボン酸誘導体の製造法
WO2007029587A1 (ja) 2005-09-05 2007-03-15 Dainippon Sumitomo Pharma Co., Ltd. βセクレターゼ阻害剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936902B2 (ja) * 1977-06-22 1984-09-06 財団法人微生物化学研究会 （２ｓ，３ｒ）−３−アミノ−２−ヒドロキシ−４−ｐ−ヒドロキシフエニルブタノイル−（ｓ）−ロイシンおよびその製造法
NL188162C (nl) * 1978-11-25 1992-04-16 Nippon Kayaku Kk Werkwijze voor het bereiden van een bestatinederivaat.
JPS6033439B2 (ja) * 1980-03-07 1985-08-02 財団法人相模中央化学研究所 ジペプチドの製造方法

Also Published As

Publication number Publication date
EP0341462B1 (de) 1992-09-09
DE68902771D1 (de) 1992-10-15
US5157143A (en) 1992-10-20
DE68902771T2 (de) 1993-01-07
EP0341462A1 (de) 1989-11-15
ES2052801T3 (es) 1994-07-16
IT1217567B (it) 1990-03-30
GR3006432T3 (de) 1993-06-21
JP2860559B2 (ja) 1999-02-24
JPH0228144A (ja) 1990-01-30
IT8820542A0 (it) 1988-05-11

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