ES2149880T3 - Sintesis de peptidos ciclicos. - Google Patents

Sintesis de peptidos ciclicos.

Info

Publication number
ES2149880T3
ES2149880T3 ES94920615T ES94920615T ES2149880T3 ES 2149880 T3 ES2149880 T3 ES 2149880T3 ES 94920615 T ES94920615 T ES 94920615T ES 94920615 T ES94920615 T ES 94920615T ES 2149880 T3 ES2149880 T3 ES 2149880T3
Authority
ES
Spain
Prior art keywords
synthesis
cyclic peptides
oxytocin
vasopressin
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94920615T
Other languages
English (en)
Inventor
Lars Henrik Harald Andersson
Jan-Ake Skoldback
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Original Assignee
Ferring BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring BV filed Critical Ferring BV
Application granted granted Critical
Publication of ES2149880T3 publication Critical patent/ES2149880T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN PROCESO PARA LA PREPARACION Y PURIFICACION DE PEPTIDOS CICLICOS QUE TIENEN MITADES DE DISULFURO EN UNA OPERACION DE PROCESAMIENTO UNICA QUE SIMPLIFICA LA SINTESIS Y REDUCE LOS COSTES DE PRODUCCION, PRODUCE ALTOS RENDIMIENTOS DE PEPTIDO PURO OBTENIDO MEDIANTE EL AISLAMIENTO DEL COMPUESTO CICLICO DESEADO A TRAVES DE CROMATOGRAFIA DE INTERCAMBIO DE ION DIRECTA COMO UNA PARTE INTEGRAL DEL PROCESO UNICO. EL PROCESO MEJORADO ES PARTICULARMENTE UTIL PARA LA PREPARACION DE VASOPRESINA Y OXITOCINA Y SUS CORRESPONDIENTES DERIVADOS Y ANALOGOS.
ES94920615T 1993-06-29 1994-06-22 Sintesis de peptidos ciclicos. Expired - Lifetime ES2149880T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8484993A 1993-06-29 1993-06-29

Publications (1)

Publication Number Publication Date
ES2149880T3 true ES2149880T3 (es) 2000-11-16

Family

ID=22187613

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94920615T Expired - Lifetime ES2149880T3 (es) 1993-06-29 1994-06-22 Sintesis de peptidos ciclicos.

Country Status (9)

Country Link
US (3) US5596078A (es)
EP (1) EP0710243B1 (es)
AT (1) ATE193892T1 (es)
DE (1) DE69424940T2 (es)
DK (1) DK0710243T3 (es)
ES (1) ES2149880T3 (es)
GR (1) GR3034405T3 (es)
PT (1) PT710243E (es)
WO (1) WO1995001368A1 (es)

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EP0710243B1 (en) * 1993-06-29 2000-06-14 Ferring B.V. Synthesis of cyclic peptides
US5674850A (en) * 1993-12-23 1997-10-07 Ferring Ab High purity desmopressin produced in large single batches
US5922680A (en) * 1996-10-23 1999-07-13 Ferring, B.V. Stabilized composition for oral administration of peptides
EP0896001A1 (en) * 1997-08-08 1999-02-10 Daicel Chemical Industries, Ltd. Method for preparing oxytocin antagoniste derivatives, intermediates for the preparation of oxytocin antagonist derivatives and method for preparing the intermediates
EP1080103A4 (en) * 1998-05-21 2003-07-02 Isis Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR NON-PARENTERAL ADMINISTRATION OF OLIGONUCLEOTIDES
JP4712975B2 (ja) 1999-01-12 2011-06-29 ケンブリッジ エンタープライズ リミティド 炎症反応を阻害又は増強するための組成物及び方法
US7566765B2 (en) * 2000-03-06 2009-07-28 Rigel Pharmaceuticals, Inc. Heterocyclic compounds containing a nine-membered carbon-nitrogen ring
US20040132706A1 (en) * 2001-10-05 2004-07-08 Daniela Salvemini Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP2322194A2 (en) * 2003-11-10 2011-05-18 Reprise Biopharmaceutics, LLC Pharmaceutical compositions including low dosages of desmopressin
ES2260563T3 (es) * 2003-11-13 2006-11-01 Ferring B.V. Paquete de blister y forma farmaceutica solida para ello.
US7729761B2 (en) 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
DK1709065T3 (da) * 2004-10-04 2010-08-23 Novetide Ltd Modion-bytningsfremgangsmåde til peptider
US20060116316A1 (en) * 2004-10-14 2006-06-01 Kinsella Todd M Heterocyclic inhibitors of IRES-mediated translation and methods of use thereof
SE528446C2 (sv) * 2006-03-02 2006-11-14 Ferring Int Ct Sa Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
JP5451613B2 (ja) 2007-08-06 2014-03-26 アラーガン、インコーポレイテッド デスモプレシン薬物送達のための方法及びデバイス
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
CN101372504B (zh) * 2007-08-22 2011-05-18 深圳翰宇药业股份有限公司 一种纯化去氨加压素的方法
LT2712622T (lt) * 2008-05-21 2016-09-26 Ferring B.V. Burnoje disperguojamas desmopresinas, skirtas nikturijos netrikdomo miego pirminio periodo pailginimui
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
WO2010119450A2 (en) 2009-04-06 2010-10-21 Matrix Laboratories Ltd An improved process for the preparation of desmopressin or its pharmaceutically acceptable salts
JP6073678B2 (ja) 2009-06-18 2017-02-01 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 安全なデスモプレシン投与
CA2822026C (en) 2009-12-17 2018-06-12 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
CN102127146B (zh) * 2010-12-24 2013-04-24 深圳翰宇药业股份有限公司 一种制备醋酸阿托西班的方法
CA2860226C (en) 2011-12-22 2022-10-18 Randolph S. Watnick Saposin-a derived peptides and uses thereof
EP2850095B1 (en) 2012-05-17 2019-10-09 RA Pharmaceuticals, Inc. Peptide and peptidomimetic inhibitors
CN118028464A (zh) 2013-03-14 2024-05-14 儿童医学中心公司 Cd36鉴定癌症对象以用于治疗的用途
WO2015148801A1 (en) 2014-03-26 2015-10-01 Children's Medical Center Corporation Cyclic prosaposin peptides and uses thereof
EP3973994A1 (en) 2014-06-12 2022-03-30 RA Pharmaceuticals, Inc. Modulation of complement activity
CN104761619A (zh) * 2015-01-06 2015-07-08 苏州天马医药集团天吉生物制药有限公司 醋酸去氨加压素的固相制备工艺
ES2900998T3 (es) 2015-01-28 2022-03-21 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento
EP3373947B1 (en) 2015-11-09 2022-03-02 Trustees Of Tufts College Compounds and methods for treating pain
WO2017098627A1 (ja) * 2015-12-10 2017-06-15 株式会社メニコン ペプチド組成物
CN108697759B (zh) 2015-12-16 2022-08-02 Ra制药公司 补体活性的调节剂
WO2018029676A1 (en) * 2016-08-09 2018-02-15 Omnix Medical Ltd. A combination of antimicrobial peptides and antibiotic drugs for treating diseases
BR112019011053A2 (pt) 2016-12-07 2019-10-15 Ra Pharmaceuticals Inc moduladores da atividade do complemento
WO2020212477A1 (en) * 2019-04-16 2020-10-22 Bachem Holding Ag Manufacture of disulfide bonded peptides
CN109929010B (zh) * 2019-05-06 2021-05-14 上海上药第一生化药业有限公司 一种加压素的精制方法
WO2022026463A1 (en) * 2020-07-27 2022-02-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Oxytocin analogues and methods for using the same

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
CH495957A (de) * 1966-09-15 1970-09-15 Ceskoslovenska Akademie Ved Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids
US4271068A (en) * 1968-05-10 1981-06-02 Ciba-Geigy Corporation Process for the manufacture of cystine-containing peptides
CH517705A (de) * 1969-12-16 1972-01-15 Ciba Geigy Ag Verfahren zur Herstellung von Cystin-haltigen Peptiden
US3929758A (en) * 1974-09-12 1975-12-30 Armour Pharma Cyclization of cysteine-containing peptides
US4033940A (en) * 1975-11-12 1977-07-05 Armour Pharmaceutical Company Cyclization of peptides
US4093610A (en) * 1977-01-31 1978-06-06 American Home Products Corporation Process for producing triglycyl-lysine vasopressin and intermediates therefor
US4216141A (en) * 1978-07-19 1980-08-05 The Salk Institute For Biological Studies Method for cyclization of peptides
DE2923787A1 (de) * 1979-06-12 1980-12-18 Max Planck Gesellschaft Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
IE56021B1 (en) * 1982-10-13 1991-03-27 Akzo Nv Peptides
SE8306367L (sv) * 1983-11-18 1985-05-19 Ferring Ab Antidiuretiskt verkande farmaceutiskt preparat
US4717715A (en) * 1986-06-23 1988-01-05 Smithkline Beckman Corporation ARG7 -ARG8 -vasopressin antagonists
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
DE3726324A1 (de) * 1987-08-07 1989-02-16 Hoechst Ag Cyclopeptide als resorptionsfoerderer bei applikation auf die schleimhaeute
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
SE502644C2 (sv) * 1990-02-27 1995-11-27 Ferring Ab Vasoaktiva vasotocinderivat
SE9002384D0 (sv) * 1990-07-09 1990-07-09 Ferring Ab Derivat av baklobshormoner
US5674850A (en) * 1993-12-23 1997-10-07 Ferring Ab High purity desmopressin produced in large single batches
CZ282456B6 (cs) * 1993-06-29 1997-07-16 Ferring B. V. Kompozice pro nasální podání desmopressinu
EP0710243B1 (en) * 1993-06-29 2000-06-14 Ferring B.V. Synthesis of cyclic peptides
US5500413A (en) * 1993-06-29 1996-03-19 Ferring Ab Process for manufacture of 1-deamino-8-D-arginine vasopressin
US5482931A (en) * 1993-06-29 1996-01-09 Ferring Ab Stabilized pharmaceutical peptide compositions

Also Published As

Publication number Publication date
WO1995001368A1 (en) 1995-01-12
DE69424940D1 (de) 2000-07-20
EP0710243B1 (en) 2000-06-14
PT710243E (pt) 2000-11-30
DK0710243T3 (da) 2000-10-16
US5990273A (en) 1999-11-23
EP0710243A1 (en) 1996-05-08
US5726287A (en) 1998-03-10
ATE193892T1 (de) 2000-06-15
US5596078A (en) 1997-01-21
GR3034405T3 (en) 2000-12-29
DE69424940T2 (de) 2000-12-28

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