JPS6438050A - Novel production process - Google Patents

Novel production process

Info

Publication number
JPS6438050A
JPS6438050A JP62194134A JP19413487A JPS6438050A JP S6438050 A JPS6438050 A JP S6438050A JP 62194134 A JP62194134 A JP 62194134A JP 19413487 A JP19413487 A JP 19413487A JP S6438050 A JPS6438050 A JP S6438050A
Authority
JP
Japan
Prior art keywords
amino
peptide
protecting group
group
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62194134A
Other languages
Japanese (ja)
Other versions
JPH0794418B2 (en
Inventor
Takumi Tanaka
Takeji Masaki
Masami Soejima
Susumu Tsunasawa
Fumio Sakiyama
Haruhiko Sugiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Wako Pure Chemical Corp
Original Assignee
Wako Pure Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wako Pure Chemical Industries Ltd filed Critical Wako Pure Chemical Industries Ltd
Priority to JP62194134A priority Critical patent/JPH0794418B2/en
Publication of JPS6438050A publication Critical patent/JPS6438050A/en
Publication of JPH0794418B2 publication Critical patent/JPH0794418B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE:To obtain the titled compound useful as a lysine-specific enzyme inhibitor, etc. in high yield and purity at a low cost, by reacting a lysinal derivative with an amino acid or peptide and removing acetal group and amino- protecting group from the resultant acetal compound. CONSTITUTION:The objective lysinal peptide derivative of formula II (A is amino acid residue or peptide residue) can be produced by (1) reacting a compound of formula I (R<1> is amino-protecting group or H; R<2> is amino-protecting group; R<3> and R<4> are 1-4C alkyl or together form a ring) with an amino acid (e.g. valine or leucine) or a peptide to introduce an amino acid or peptide group to the alpha-amino group and (2) removing the amino-protecting group and aldehyde- protecting group with dilute hydrochloric acid or acetic acid, etc., at the same time or by separate means. The side-reaction product can be easily separated by this process.
JP62194134A 1987-08-03 1987-08-03 New manufacturing method Expired - Lifetime JPH0794418B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62194134A JPH0794418B2 (en) 1987-08-03 1987-08-03 New manufacturing method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62194134A JPH0794418B2 (en) 1987-08-03 1987-08-03 New manufacturing method

Publications (2)

Publication Number Publication Date
JPS6438050A true JPS6438050A (en) 1989-02-08
JPH0794418B2 JPH0794418B2 (en) 1995-10-11

Family

ID=16319473

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62194134A Expired - Lifetime JPH0794418B2 (en) 1987-08-03 1987-08-03 New manufacturing method

Country Status (1)

Country Link
JP (1) JPH0794418B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014696A2 (en) * 1991-02-22 1992-09-03 The Du Pont Merck Pharmaceutical Company SUBSTITUTED α-AMINOALDEHYDES AND DERIVATIVES
EP0519748A2 (en) * 1991-06-21 1992-12-23 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
EP0520336A2 (en) * 1991-06-19 1992-12-30 FUJIREBIO Inc. Aldehyde derivatives and their use as calpain inhibitors

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014696A2 (en) * 1991-02-22 1992-09-03 The Du Pont Merck Pharmaceutical Company SUBSTITUTED α-AMINOALDEHYDES AND DERIVATIVES
EP0520336A2 (en) * 1991-06-19 1992-12-30 FUJIREBIO Inc. Aldehyde derivatives and their use as calpain inhibitors
EP0519748A2 (en) * 1991-06-21 1992-12-23 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
EP0519748A3 (en) * 1991-06-21 1993-05-05 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1b converting enzyme

Also Published As

Publication number Publication date
JPH0794418B2 (en) 1995-10-11

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