ATE193892T1 - Synthese zyklischer peptide - Google Patents

Synthese zyklischer peptide

Info

Publication number
ATE193892T1
ATE193892T1 AT94920615T AT94920615T ATE193892T1 AT E193892 T1 ATE193892 T1 AT E193892T1 AT 94920615 T AT94920615 T AT 94920615T AT 94920615 T AT94920615 T AT 94920615T AT E193892 T1 ATE193892 T1 AT E193892T1
Authority
AT
Austria
Prior art keywords
synthesis
cyclic peptides
oxytocin
vasopressin
analogs
Prior art date
Application number
AT94920615T
Other languages
English (en)
Inventor
Lars Henrik Harald Andersson
Jan-Ake Skoeldbaeck
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Application granted granted Critical
Publication of ATE193892T1 publication Critical patent/ATE193892T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94920615T 1993-06-29 1994-06-22 Synthese zyklischer peptide ATE193892T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8484993A 1993-06-29 1993-06-29
PCT/SE1994/000620 WO1995001368A1 (en) 1993-06-29 1994-06-22 Improved synthesis of cyclic peptides

Publications (1)

Publication Number Publication Date
ATE193892T1 true ATE193892T1 (de) 2000-06-15

Family

ID=22187613

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94920615T ATE193892T1 (de) 1993-06-29 1994-06-22 Synthese zyklischer peptide

Country Status (9)

Country Link
US (3) US5596078A (de)
EP (1) EP0710243B1 (de)
AT (1) ATE193892T1 (de)
DE (1) DE69424940T2 (de)
DK (1) DK0710243T3 (de)
ES (1) ES2149880T3 (de)
GR (1) GR3034405T3 (de)
PT (1) PT710243E (de)
WO (1) WO1995001368A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674850A (en) * 1993-12-23 1997-10-07 Ferring Ab High purity desmopressin produced in large single batches
DE69424940T2 (de) * 1993-06-29 2000-12-28 Ferring B.V., Hoofdorp Synthese zyklischer peptide
US5922680A (en) * 1996-10-23 1999-07-13 Ferring, B.V. Stabilized composition for oral administration of peptides
EP0896001A1 (de) * 1997-08-08 1999-02-10 Daicel Chemical Industries, Ltd. Verfahren zur Herstellung von Oxytocin-Antagonist-Derivaten, Zwischenprodukte zur Herstellung von Oxytocin-Antagonist-Derivaten und Verfahren zur Herstellung der Zwischenprodukte
CA2329130A1 (en) * 1998-05-21 1999-11-25 Isis Pharmaceuticals Inc. Compositions and methods for non-parenteral delivery of oligonucleotides
AU2610000A (en) 1999-01-12 2000-08-01 Cambridge University Technical Services Limited Compounds and methods to inhibit or augment an inflammatory response
US7566765B2 (en) * 2000-03-06 2009-07-28 Rigel Pharmaceuticals, Inc. Heterocyclic compounds containing a nine-membered carbon-nitrogen ring
US20040132706A1 (en) * 2001-10-05 2004-07-08 Daniela Salvemini Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP2322197A2 (de) * 2003-11-10 2011-05-18 Reprise Biopharmaceutics, LLC Pharmazeutische Zusammensetzungen mit niedrigen Dosen von Desmopressin
DE60305043T2 (de) * 2003-11-13 2006-11-30 Ferring B.V. Blisterverpackung und feste Dosierungsform enthaltend Desmopressin
US7729761B2 (en) 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
CA2582083A1 (en) * 2004-10-04 2006-04-20 Novetide, Ltd. A counterion exchange process for peptides
US20060116316A1 (en) * 2004-10-14 2006-06-01 Kinsella Todd M Heterocyclic inhibitors of IRES-mediated translation and methods of use thereof
SE0600482L (sv) * 2006-03-02 2006-11-14 Ferring Int Ct Sa Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
CA2988753A1 (en) 2007-08-06 2009-02-12 Serenity Pharmaceuticals, Llc Methods and devices for desmopressin drug delivery
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
CN101372504B (zh) * 2007-08-22 2011-05-18 深圳翰宇药业股份有限公司 一种纯化去氨加压素的方法
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
ES2462465T5 (es) * 2008-05-21 2018-02-28 Ferring B.V. Desmopresina bucodispersable para aumentar el periodo inicial del sueño no alterado por nocturia
US20120094910A1 (en) 2009-04-06 2012-04-19 Ananda Kuppanna Improved process for the preparation of desmopressin or its pharmaceutically acceptable salts
MX343193B (es) 2009-06-18 2016-10-26 Allergan Inc Administracion segura de desmopresina.
EP2513137B1 (de) 2009-12-17 2018-02-28 Children's Medical Center Corporation Aus saposin-a gewonnene peptide und verwendungen davon
CN102127146B (zh) * 2010-12-24 2013-04-24 深圳翰宇药业股份有限公司 一种制备醋酸阿托西班的方法
ES2974506T3 (es) 2011-12-22 2024-06-27 Childrens Medical Center Péptidos derivados de saposina-A y usos de los mismos
WO2013172954A1 (en) 2012-05-17 2013-11-21 Ra Pharmaceuticals, Inc Peptide and peptidomimetic inhibitors
EP3919070B1 (de) 2013-03-14 2024-10-16 Children's Medical Center Corporation Verwendung von cd36 zur identifizierung von krebspatienten zur behandlung mit einem psap peptid
JP6727129B2 (ja) 2014-03-26 2020-07-22 ザ チルドレンズ メディカル センター コーポレーション 環状プロサポシンペプチドおよびその使用
BR122023024819A2 (pt) 2014-06-12 2023-12-26 Ra Pharmaceuticals, Inc. Uso de um polipeptídeo para inibir a clivagem de c5 em um sistema celular
CN104761619A (zh) * 2015-01-06 2015-07-08 苏州天马医药集团天吉生物制药有限公司 醋酸去氨加压素的固相制备工艺
US9937222B2 (en) 2015-01-28 2018-04-10 Ra Pharmaceuticals, Inc. Modulators of complement activity
CA3004933A1 (en) 2015-11-09 2017-05-18 Trustees Of Tufts College Bam8-22 peptide compounds and methods for treating pain
RU2740185C2 (ru) * 2015-12-10 2021-01-12 Меникон Ко., Лтд. Пептидная композиция
CN108697759B (zh) 2015-12-16 2022-08-02 Ra制药公司 补体活性的调节剂
WO2018029676A1 (en) * 2016-08-09 2018-02-15 Omnix Medical Ltd. A combination of antimicrobial peptides and antibiotic drugs for treating diseases
EP3551210A1 (de) 2016-12-07 2019-10-16 RA Pharmaceuticals, Inc. Modulatoren der komplementaktivität
JP2022529774A (ja) * 2019-04-16 2022-06-24 バッヘン・ホールディング・アクチエンゲゼルシャフト ジスルフィド結合ペプチドの製造
CN109929010B (zh) * 2019-05-06 2021-05-14 上海上药第一生化药业有限公司 一种加压素的精制方法
US20230265124A1 (en) * 2020-07-27 2023-08-24 Az. Bd. of Reg. on Behalf of the Univ. of Arizona Oxytocin analogues and methods for using the same

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH495957A (de) * 1966-09-15 1970-09-15 Ceskoslovenska Akademie Ved Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids
US4271068A (en) * 1968-05-10 1981-06-02 Ciba-Geigy Corporation Process for the manufacture of cystine-containing peptides
CH517705A (de) * 1969-12-16 1972-01-15 Ciba Geigy Ag Verfahren zur Herstellung von Cystin-haltigen Peptiden
US3929758A (en) * 1974-09-12 1975-12-30 Armour Pharma Cyclization of cysteine-containing peptides
US4033940A (en) * 1975-11-12 1977-07-05 Armour Pharmaceutical Company Cyclization of peptides
US4093610A (en) * 1977-01-31 1978-06-06 American Home Products Corporation Process for producing triglycyl-lysine vasopressin and intermediates therefor
US4216141A (en) * 1978-07-19 1980-08-05 The Salk Institute For Biological Studies Method for cyclization of peptides
DE2923787A1 (de) * 1979-06-12 1980-12-18 Max Planck Gesellschaft Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
IE56021B1 (en) * 1982-10-13 1991-03-27 Akzo Nv Peptides
SE8306367L (sv) * 1983-11-18 1985-05-19 Ferring Ab Antidiuretiskt verkande farmaceutiskt preparat
US4717715A (en) * 1986-06-23 1988-01-05 Smithkline Beckman Corporation ARG7 -ARG8 -vasopressin antagonists
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
DE3726324A1 (de) * 1987-08-07 1989-02-16 Hoechst Ag Cyclopeptide als resorptionsfoerderer bei applikation auf die schleimhaeute
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
SE502644C2 (sv) * 1990-02-27 1995-11-27 Ferring Ab Vasoaktiva vasotocinderivat
SE9002384D0 (sv) * 1990-07-09 1990-07-09 Ferring Ab Derivat av baklobshormoner
US5500413A (en) * 1993-06-29 1996-03-19 Ferring Ab Process for manufacture of 1-deamino-8-D-arginine vasopressin
US5482931A (en) * 1993-06-29 1996-01-09 Ferring Ab Stabilized pharmaceutical peptide compositions
PT708657E (pt) * 1993-06-29 2001-11-30 Ferring Bv Composicoes para administracao nasal de desmopressina
DE69424940T2 (de) * 1993-06-29 2000-12-28 Ferring B.V., Hoofdorp Synthese zyklischer peptide
US5674850A (en) * 1993-12-23 1997-10-07 Ferring Ab High purity desmopressin produced in large single batches

Also Published As

Publication number Publication date
DK0710243T3 (da) 2000-10-16
WO1995001368A1 (en) 1995-01-12
US5596078A (en) 1997-01-21
US5726287A (en) 1998-03-10
US5990273A (en) 1999-11-23
DE69424940T2 (de) 2000-12-28
EP0710243A1 (de) 1996-05-08
GR3034405T3 (en) 2000-12-29
PT710243E (pt) 2000-11-30
EP0710243B1 (de) 2000-06-14
DE69424940D1 (de) 2000-07-20
ES2149880T3 (es) 2000-11-16

Similar Documents

Publication Publication Date Title
ATE193892T1 (de) Synthese zyklischer peptide
ZA911153B (en) Process for the preparation of oxetanones
SE9903291D0 (sv) New process
MY116862A (en) New processes for preparing pesticidal intermediates
US4868307A (en) Derivatives of bicyclic aminocarboxylic acids
Kiyooka et al. Photochemical intramolecular cyclization reactions of acylgermanes
Alcaraz et al. Enantioselective synthesis of (+)-(1R, 2S)-allocoronamic acid
PH30922A (en) Process for cyclic amino acid anticonvulsant compound.
MY104452A (en) Processes for the preparation of morniflumate and analogous compounds.
BG105426A (bg) Метод за пречистване на амониев сулфат
EP0426762B1 (de) Verfahren zur herstellung von dipeptiden mit c-terminalen nicht-proteinogenen aminosäuren
EP0147472A4 (de) 4-chlor-4-methyl-5-methylen-1,3-dioxolan-2-on.
RB et al. Facile synthesis of β-amino disulfides, cystines, and their direct incorporation into peptides
GB1571835A (en) Aminocyclols
Andersson et al. Synthesis of cyclic peptides
DK0383645T3 (da) Fremgangsmåde til fremstilling af antihæmofilifaktor (FVIIIc) med meget høj renhed
SE9800865D0 (sv) New Process
Shiba et al. Synthesis of alanyl-1-aminoethanesulfonic acid
JPS6438050A (en) Novel production process
SU586165A1 (ru) Способ получени окситоцина и дезаминоокситоцина
Nabeta et al. The reaction products of epoxydon with thiols, ethylmercaptan and cysteamine
Ferreira et al. High yield synthesis of heterocyclic alanine derivatives
EP0804215A4 (de) Anhand einer vorlage aufgebautes synthetisches protein
PL377635A1 (pl) Sposób wytwarzania bicyklicznych związków peptydowych
ES2019500A6 (es) Nuevo procedimiento para la preparacion de antraciclinonas y sus 5-iminoderivados.

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee