DE69424940D1 - Synthese zyklischer peptide - Google Patents

Synthese zyklischer peptide

Info

Publication number
DE69424940D1
DE69424940D1 DE69424940T DE69424940T DE69424940D1 DE 69424940 D1 DE69424940 D1 DE 69424940D1 DE 69424940 T DE69424940 T DE 69424940T DE 69424940 T DE69424940 T DE 69424940T DE 69424940 D1 DE69424940 D1 DE 69424940D1
Authority
DE
Germany
Prior art keywords
cyclic peptide
synthesis
synthesis cyclic
oxytocin
vasopressin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69424940T
Other languages
English (en)
Other versions
DE69424940T2 (de
Inventor
Lars Henrik Harald Andersson
Jan-Ake Skoeldbaeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Original Assignee
Ferring BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring BV filed Critical Ferring BV
Publication of DE69424940D1 publication Critical patent/DE69424940D1/de
Application granted granted Critical
Publication of DE69424940T2 publication Critical patent/DE69424940T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69424940T 1993-06-29 1994-06-22 Synthese zyklischer peptide Expired - Lifetime DE69424940T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8484993A 1993-06-29 1993-06-29
PCT/SE1994/000620 WO1995001368A1 (en) 1993-06-29 1994-06-22 Improved synthesis of cyclic peptides

Publications (2)

Publication Number Publication Date
DE69424940D1 true DE69424940D1 (de) 2000-07-20
DE69424940T2 DE69424940T2 (de) 2000-12-28

Family

ID=22187613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69424940T Expired - Lifetime DE69424940T2 (de) 1993-06-29 1994-06-22 Synthese zyklischer peptide

Country Status (9)

Country Link
US (3) US5596078A (de)
EP (1) EP0710243B1 (de)
AT (1) ATE193892T1 (de)
DE (1) DE69424940T2 (de)
DK (1) DK0710243T3 (de)
ES (1) ES2149880T3 (de)
GR (1) GR3034405T3 (de)
PT (1) PT710243E (de)
WO (1) WO1995001368A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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US5674850A (en) * 1993-12-23 1997-10-07 Ferring Ab High purity desmopressin produced in large single batches
PT710243E (pt) * 1993-06-29 2000-11-30 Ferring Bv Sintese melhorada de peptidos ciclicos.
US5922680A (en) * 1996-10-23 1999-07-13 Ferring, B.V. Stabilized composition for oral administration of peptides
EP0896001A1 (de) * 1997-08-08 1999-02-10 Daicel Chemical Industries, Ltd. Verfahren zur Herstellung von Oxytocin-Antagonist-Derivaten, Zwischenprodukte zur Herstellung von Oxytocin-Antagonist-Derivaten und Verfahren zur Herstellung der Zwischenprodukte
EP1469009A2 (de) * 1998-05-21 2004-10-20 Isis Parmaceuticals, Inc. Zusammensetzungen und Verfahren für nicht-parenterale Verabreichung von Oligonukleotiden
EP2386565A3 (de) 1999-01-12 2013-11-20 Cambridge Enterprise Ltd. Verbindungen und Verfahren zur Hemmung oder Verstärkung einer Entzündungsreaktion
US7566765B2 (en) * 2000-03-06 2009-07-28 Rigel Pharmaceuticals, Inc. Heterocyclic compounds containing a nine-membered carbon-nitrogen ring
US20040132706A1 (en) * 2001-10-05 2004-07-08 Daniela Salvemini Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
CN1878563A (zh) * 2003-11-10 2006-12-13 西摩·H·费恩 包含低剂量去氨加压素的药物组合物
ES2260563T3 (es) * 2003-11-13 2006-11-01 Ferring B.V. Paquete de blister y forma farmaceutica solida para ello.
US7729761B2 (en) 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
EP2163558A3 (de) * 2004-10-04 2010-10-27 Novetide, Ltd. Gegenionenaustauschverfahren für Peptide
EP1810028A2 (de) * 2004-10-14 2007-07-25 Rigel Pharmaceuticals, Inc. Heterocyklische inhibitoren von ires-vermittelter translation und verwendungverfahren damit
SE528446C2 (sv) * 2006-03-02 2006-11-14 Ferring Int Ct Sa Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
WO2011084685A2 (en) 2009-12-17 2011-07-14 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
US7960336B2 (en) * 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
CA2695634C (en) 2007-08-06 2018-01-23 Serenity Pharmaceuticals Corporation Methods and devices for desmopressin drug delivery
US8563527B2 (en) 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
CN101372504B (zh) * 2007-08-22 2011-05-18 深圳翰宇药业股份有限公司 一种纯化去氨加压素的方法
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
DK3225250T3 (da) * 2008-05-21 2019-11-04 Ferring Bv Orodispersibel desmopressin til forlængelse af den indledende søvnperiode, som ikke forstyrres af nykturi
EP2417150A2 (de) 2009-04-06 2012-02-15 Matrix Laboratories Ltd Verbessertes verfahren zur herstellung von desmopressin oder pharmazeutisch unbedenklichen salzen davon
DK3679941T3 (da) 2009-06-18 2022-11-14 Serenity Pharmaceuticals Llc Sikker indgivelse af desmopressin
CN102127146B (zh) * 2010-12-24 2013-04-24 深圳翰宇药业股份有限公司 一种制备醋酸阿托西班的方法
US10736935B2 (en) 2011-12-22 2020-08-11 Children's Medical Center Corporation Saposin-A derived peptides and uses thereof
EP2850095B1 (de) 2012-05-17 2019-10-09 RA Pharmaceuticals, Inc. Peptid- und peptidomimetische inhibitoren
EP2971166B1 (de) 2013-03-14 2021-05-19 Children's Medical Center Corporation Psap peptide zur behandlung von cd36-exprimierenden krebs
EP3122369B1 (de) 2014-03-26 2022-08-31 Children's Medical Center Corporation Cyclische prosaposinpeptide und verwendungen davon
EP3628680B1 (de) 2014-06-12 2021-09-08 RA Pharmaceuticals, Inc. Modulation der komplementaktivität
CN104761619A (zh) * 2015-01-06 2015-07-08 苏州天马医药集团天吉生物制药有限公司 醋酸去氨加压素的固相制备工艺
RS62630B9 (sr) 2015-01-28 2022-04-29 Ra Pharmaceuticals Inc Modulatori aktivnosti komplementa
US10899796B2 (en) 2015-11-09 2021-01-26 Tufts Medical Center Compounds and methods for treating pain
EP3388089B1 (de) * 2015-12-10 2022-05-18 Menicon Co., Ltd. Peptidzusammensetzung
EP3389692B1 (de) 2015-12-16 2020-03-04 RA Pharmaceuticals, Inc. Modulatoren der komplementaktivität
US10745452B2 (en) 2016-08-09 2020-08-18 Omnix Medical Ltd. Combination of antimicrobial peptides and antibiotic drugs for treating diseases
BR112019011053A2 (pt) 2016-12-07 2019-10-15 Ra Pharmaceuticals Inc moduladores da atividade do complemento
CN114026107A (zh) * 2019-04-16 2022-02-08 巴克姆股份公司 二硫键肽的生产
CN109929010B (zh) * 2019-05-06 2021-05-14 上海上药第一生化药业有限公司 一种加压素的精制方法
WO2022026463A1 (en) * 2020-07-27 2022-02-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Oxytocin analogues and methods for using the same

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH495957A (de) * 1966-09-15 1970-09-15 Ceskoslovenska Akademie Ved Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids
US4271068A (en) * 1968-05-10 1981-06-02 Ciba-Geigy Corporation Process for the manufacture of cystine-containing peptides
CH517705A (de) * 1969-12-16 1972-01-15 Ciba Geigy Ag Verfahren zur Herstellung von Cystin-haltigen Peptiden
US3929758A (en) * 1974-09-12 1975-12-30 Armour Pharma Cyclization of cysteine-containing peptides
US4033940A (en) * 1975-11-12 1977-07-05 Armour Pharmaceutical Company Cyclization of peptides
US4093610A (en) * 1977-01-31 1978-06-06 American Home Products Corporation Process for producing triglycyl-lysine vasopressin and intermediates therefor
US4216141A (en) * 1978-07-19 1980-08-05 The Salk Institute For Biological Studies Method for cyclization of peptides
DE2923787A1 (de) * 1979-06-12 1980-12-18 Max Planck Gesellschaft Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
IE56021B1 (en) * 1982-10-13 1991-03-27 Akzo Nv Peptides
SE8306367L (sv) * 1983-11-18 1985-05-19 Ferring Ab Antidiuretiskt verkande farmaceutiskt preparat
US4717715A (en) * 1986-06-23 1988-01-05 Smithkline Beckman Corporation ARG7 -ARG8 -vasopressin antagonists
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
DE3726324A1 (de) * 1987-08-07 1989-02-16 Hoechst Ag Cyclopeptide als resorptionsfoerderer bei applikation auf die schleimhaeute
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
SE502644C2 (sv) * 1990-02-27 1995-11-27 Ferring Ab Vasoaktiva vasotocinderivat
SE9002384D0 (sv) * 1990-07-09 1990-07-09 Ferring Ab Derivat av baklobshormoner
US5500413A (en) * 1993-06-29 1996-03-19 Ferring Ab Process for manufacture of 1-deamino-8-D-arginine vasopressin
US5482931A (en) * 1993-06-29 1996-01-09 Ferring Ab Stabilized pharmaceutical peptide compositions
JPH09502425A (ja) * 1993-06-29 1997-03-11 フエリング ビー ヴイ デスモプレッシン鼻腔投与用組成
US5674850A (en) * 1993-12-23 1997-10-07 Ferring Ab High purity desmopressin produced in large single batches
PT710243E (pt) * 1993-06-29 2000-11-30 Ferring Bv Sintese melhorada de peptidos ciclicos.

Also Published As

Publication number Publication date
DK0710243T3 (da) 2000-10-16
ES2149880T3 (es) 2000-11-16
GR3034405T3 (en) 2000-12-29
ATE193892T1 (de) 2000-06-15
EP0710243A1 (de) 1996-05-08
EP0710243B1 (de) 2000-06-14
WO1995001368A1 (en) 1995-01-12
US5990273A (en) 1999-11-23
US5596078A (en) 1997-01-21
DE69424940T2 (de) 2000-12-28
US5726287A (en) 1998-03-10
PT710243E (pt) 2000-11-30

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