RU95108553A - Способ получения нуклеозидных аналогов с использованием бициклических промежуточных продуктов - Google Patents
Способ получения нуклеозидных аналогов с использованием бициклических промежуточных продуктовInfo
- Publication number
- RU95108553A RU95108553A RU95108553/04A RU95108553A RU95108553A RU 95108553 A RU95108553 A RU 95108553A RU 95108553/04 A RU95108553/04 A RU 95108553/04A RU 95108553 A RU95108553 A RU 95108553A RU 95108553 A RU95108553 A RU 95108553A
- Authority
- RU
- Russia
- Prior art keywords
- nucleoside analogues
- bicyclic intermediate
- intermediate products
- preparation
- preparation nucleoside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Изобретение относится к процессу производства в основном чистых цис-нуклеозидных аналогов при помощи нового бициклического промежуточного продукта ф-лы, приведенной в описании.
Claims (1)
- Изобретение относится к процессу производства в основном чистых цис-нуклеозидных аналогов при помощи нового бициклического промежуточного продукта ф-лы, приведенной в описании.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939311709A GB9311709D0 (en) | 1993-06-07 | 1993-06-07 | Stereoselective synthesis of nucleoside analogues using bicycle intermediate |
GB9311709.1 | 1993-06-07 | ||
PCT/CA1994/000311 WO1994029301A1 (en) | 1993-06-07 | 1994-06-07 | Stereoselective synthesis of nucleoside analogues using bicyclic intermediate |
Publications (2)
Publication Number | Publication Date |
---|---|
RU95108553A true RU95108553A (ru) | 1996-11-20 |
RU2139870C1 RU2139870C1 (ru) | 1999-10-20 |
Family
ID=10736757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU95108553A RU2139870C1 (ru) | 1993-06-07 | 1994-06-07 | Способ получения цис-нуклеозидных аналогов, их солей и сложных эфиров |
Country Status (22)
Country | Link |
---|---|
US (1) | US5763606A (ru) |
EP (1) | EP0654031B1 (ru) |
JP (1) | JP3110461B2 (ru) |
KR (1) | KR100304072B1 (ru) |
CN (1) | CN1046720C (ru) |
AT (1) | ATE188215T1 (ru) |
AU (1) | AU668829B2 (ru) |
BR (1) | BR9405423A (ru) |
CA (1) | CA2141029C (ru) |
DE (1) | DE69422374T2 (ru) |
DK (1) | DK0654031T3 (ru) |
ES (1) | ES2139744T3 (ru) |
FI (1) | FI112078B (ru) |
GB (1) | GB9311709D0 (ru) |
HK (1) | HK1008673A1 (ru) |
HU (1) | HU219199B (ru) |
NO (1) | NO303449B1 (ru) |
NZ (1) | NZ267379A (ru) |
OA (1) | OA10349A (ru) |
PL (1) | PL180870B1 (ru) |
RU (1) | RU2139870C1 (ru) |
WO (1) | WO1994029301A1 (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6175008B1 (en) | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
CA2203262A1 (en) * | 1994-10-22 | 1996-05-02 | Byeong Seon Jeong | Nucleoside derivatives and process for preparing thereof |
CA2714085C (en) | 1998-08-12 | 2013-02-05 | Emory University | Method of manufacture of 1,3-oxathiolane nucleosides |
US6979561B1 (en) * | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
CA2308559C (en) | 2000-05-16 | 2005-07-26 | Brantford Chemicals Inc. | 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues |
AU2002335489B2 (en) | 2001-03-01 | 2008-06-05 | Abbott Laboratories | Polymorphic and other crystalline forms of cis-FTC |
US20040224916A1 (en) | 2003-01-14 | 2004-11-11 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
KR101157468B1 (ko) * | 2004-02-03 | 2012-07-06 | 에모리 유니버시티 | 1,3-디옥솔란 뉴클레오시드 제조방법 |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
GB9009861D0 (en) * | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
WO1992010496A1 (en) * | 1990-12-05 | 1992-06-25 | University Of Georgia Research Foundation, Inc. | ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES |
ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
GB9116601D0 (en) * | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
US5332814A (en) * | 1991-11-12 | 1994-07-26 | Ciba-Geigy Corporation | Process for the preparation of carbacyclic nucleosides, and intermediates |
-
1993
- 1993-06-07 GB GB939311709A patent/GB9311709D0/en active Pending
- 1993-11-19 OA OA60438A patent/OA10349A/en unknown
-
1994
- 1994-06-07 JP JP07501139A patent/JP3110461B2/ja not_active Expired - Fee Related
- 1994-06-07 RU RU95108553A patent/RU2139870C1/ru not_active IP Right Cessation
- 1994-06-07 CN CN94190356A patent/CN1046720C/zh not_active Expired - Fee Related
- 1994-06-07 BR BR9405423A patent/BR9405423A/pt not_active Application Discontinuation
- 1994-06-07 DE DE69422374T patent/DE69422374T2/de not_active Expired - Fee Related
- 1994-06-07 HU HU9500364A patent/HU219199B/hu not_active IP Right Cessation
- 1994-06-07 US US08/379,644 patent/US5763606A/en not_active Expired - Fee Related
- 1994-06-07 DK DK94918252T patent/DK0654031T3/da active
- 1994-06-07 AU AU69667/94A patent/AU668829B2/en not_active Ceased
- 1994-06-07 KR KR1019950700453A patent/KR100304072B1/ko not_active IP Right Cessation
- 1994-06-07 ES ES94918252T patent/ES2139744T3/es not_active Expired - Lifetime
- 1994-06-07 WO PCT/CA1994/000311 patent/WO1994029301A1/en active IP Right Grant
- 1994-06-07 CA CA002141029A patent/CA2141029C/en not_active Expired - Fee Related
- 1994-06-07 PL PL94307350A patent/PL180870B1/pl not_active IP Right Cessation
- 1994-06-07 EP EP94918252A patent/EP0654031B1/en not_active Expired - Lifetime
- 1994-06-07 AT AT94918252T patent/ATE188215T1/de not_active IP Right Cessation
- 1994-06-07 NZ NZ267379A patent/NZ267379A/en not_active IP Right Cessation
-
1995
- 1995-02-06 NO NO950432A patent/NO303449B1/no unknown
- 1995-02-07 FI FI950535A patent/FI112078B/fi active
-
1998
- 1998-07-02 HK HK98108821A patent/HK1008673A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2141029A1 (en) | 1994-12-22 |
HU9500364D0 (en) | 1995-05-29 |
ATE188215T1 (de) | 2000-01-15 |
FI950535A0 (fi) | 1995-02-07 |
EP0654031B1 (en) | 1999-12-29 |
JPH08505643A (ja) | 1996-06-18 |
AU6966794A (en) | 1995-01-03 |
RU2139870C1 (ru) | 1999-10-20 |
GB9311709D0 (en) | 1993-07-21 |
HK1008673A1 (en) | 1999-05-14 |
OA10349A (en) | 2001-10-18 |
AU668829B2 (en) | 1996-05-16 |
HU219199B (en) | 2001-03-28 |
CN1110479A (zh) | 1995-10-18 |
BR9405423A (pt) | 1999-05-25 |
DE69422374D1 (de) | 2000-02-03 |
KR100304072B1 (ko) | 2001-11-22 |
DK0654031T3 (da) | 2000-06-13 |
HUT73630A (en) | 1996-08-28 |
FI112078B (fi) | 2003-10-31 |
ES2139744T3 (es) | 2000-02-16 |
EP0654031A1 (en) | 1995-05-24 |
US5763606A (en) | 1998-06-09 |
CA2141029C (en) | 2000-07-25 |
NO950432D0 (no) | 1995-02-06 |
NZ267379A (en) | 1997-04-24 |
PL180870B1 (pl) | 2001-04-30 |
NO950432L (no) | 1995-03-13 |
DE69422374T2 (de) | 2000-06-29 |
FI950535A (fi) | 1995-02-07 |
PL307350A1 (en) | 1995-05-15 |
NO303449B1 (no) | 1998-07-13 |
CN1046720C (zh) | 1999-11-24 |
JP3110461B2 (ja) | 2000-11-20 |
WO1994029301A1 (en) | 1994-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD4A | Correction of name of patent owner | ||
PD4A | Correction of name of patent owner | ||
MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20090608 |