RU95108553A - Способ получения нуклеозидных аналогов с использованием бициклических промежуточных продуктов - Google Patents

Способ получения нуклеозидных аналогов с использованием бициклических промежуточных продуктов

Info

Publication number
RU95108553A
RU95108553A RU95108553/04A RU95108553A RU95108553A RU 95108553 A RU95108553 A RU 95108553A RU 95108553/04 A RU95108553/04 A RU 95108553/04A RU 95108553 A RU95108553 A RU 95108553A RU 95108553 A RU95108553 A RU 95108553A
Authority
RU
Russia
Prior art keywords
nucleoside analogues
bicyclic intermediate
intermediate products
preparation
preparation nucleoside
Prior art date
Application number
RU95108553/04A
Other languages
English (en)
Other versions
RU2139870C1 (ru
Inventor
С.Мансур Тарек
Ca]
Иванс Коллин
Джин Хаолун
М.Сиддику Арсхад
Х.Л.Тсе Аллан
Cn]
In]
Gb]
Original Assignee
Биокем Фарма Инк. (CA)
Биокем Фарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Биокем Фарма Инк. (CA), Биокем Фарма Инк. filed Critical Биокем Фарма Инк. (CA)
Publication of RU95108553A publication Critical patent/RU95108553A/ru
Application granted granted Critical
Publication of RU2139870C1 publication Critical patent/RU2139870C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к процессу производства в основном чистых цис-нуклеозидных аналогов при помощи нового бициклического промежуточного продукта ф-лы, приведенной в описании.

Claims (1)

  1. Изобретение относится к процессу производства в основном чистых цис-нуклеозидных аналогов при помощи нового бициклического промежуточного продукта ф-лы, приведенной в описании.
RU95108553A 1993-06-07 1994-06-07 Способ получения цис-нуклеозидных аналогов, их солей и сложных эфиров RU2139870C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939311709A GB9311709D0 (en) 1993-06-07 1993-06-07 Stereoselective synthesis of nucleoside analogues using bicycle intermediate
GB9311709.1 1993-06-07
PCT/CA1994/000311 WO1994029301A1 (en) 1993-06-07 1994-06-07 Stereoselective synthesis of nucleoside analogues using bicyclic intermediate

Publications (2)

Publication Number Publication Date
RU95108553A true RU95108553A (ru) 1996-11-20
RU2139870C1 RU2139870C1 (ru) 1999-10-20

Family

ID=10736757

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95108553A RU2139870C1 (ru) 1993-06-07 1994-06-07 Способ получения цис-нуклеозидных аналогов, их солей и сложных эфиров

Country Status (22)

Country Link
US (1) US5763606A (ru)
EP (1) EP0654031B1 (ru)
JP (1) JP3110461B2 (ru)
KR (1) KR100304072B1 (ru)
CN (1) CN1046720C (ru)
AT (1) ATE188215T1 (ru)
AU (1) AU668829B2 (ru)
BR (1) BR9405423A (ru)
CA (1) CA2141029C (ru)
DE (1) DE69422374T2 (ru)
DK (1) DK0654031T3 (ru)
ES (1) ES2139744T3 (ru)
FI (1) FI112078B (ru)
GB (1) GB9311709D0 (ru)
HK (1) HK1008673A1 (ru)
HU (1) HU219199B (ru)
NO (1) NO303449B1 (ru)
NZ (1) NZ267379A (ru)
OA (1) OA10349A (ru)
PL (1) PL180870B1 (ru)
RU (1) RU2139870C1 (ru)
WO (1) WO1994029301A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6175008B1 (en) 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
CA2203262A1 (en) * 1994-10-22 1996-05-02 Byeong Seon Jeong Nucleoside derivatives and process for preparing thereof
CA2714085C (en) 1998-08-12 2013-02-05 Emory University Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2308559C (en) 2000-05-16 2005-07-26 Brantford Chemicals Inc. 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
AU2002335489B2 (en) 2001-03-01 2008-06-05 Abbott Laboratories Polymorphic and other crystalline forms of cis-FTC
US20040224916A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
KR101157468B1 (ko) * 2004-02-03 2012-07-06 에모리 유니버시티 1,3-디옥솔란 뉴클레오시드 제조방법
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
WO1992010496A1 (en) * 1990-12-05 1992-06-25 University Of Georgia Research Foundation, Inc. ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates

Also Published As

Publication number Publication date
CA2141029A1 (en) 1994-12-22
HU9500364D0 (en) 1995-05-29
ATE188215T1 (de) 2000-01-15
FI950535A0 (fi) 1995-02-07
EP0654031B1 (en) 1999-12-29
JPH08505643A (ja) 1996-06-18
AU6966794A (en) 1995-01-03
RU2139870C1 (ru) 1999-10-20
GB9311709D0 (en) 1993-07-21
HK1008673A1 (en) 1999-05-14
OA10349A (en) 2001-10-18
AU668829B2 (en) 1996-05-16
HU219199B (en) 2001-03-28
CN1110479A (zh) 1995-10-18
BR9405423A (pt) 1999-05-25
DE69422374D1 (de) 2000-02-03
KR100304072B1 (ko) 2001-11-22
DK0654031T3 (da) 2000-06-13
HUT73630A (en) 1996-08-28
FI112078B (fi) 2003-10-31
ES2139744T3 (es) 2000-02-16
EP0654031A1 (en) 1995-05-24
US5763606A (en) 1998-06-09
CA2141029C (en) 2000-07-25
NO950432D0 (no) 1995-02-06
NZ267379A (en) 1997-04-24
PL180870B1 (pl) 2001-04-30
NO950432L (no) 1995-03-13
DE69422374T2 (de) 2000-06-29
FI950535A (fi) 1995-02-07
PL307350A1 (en) 1995-05-15
NO303449B1 (no) 1998-07-13
CN1046720C (zh) 1999-11-24
JP3110461B2 (ja) 2000-11-20
WO1994029301A1 (en) 1994-12-22

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Legal Events

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PD4A Correction of name of patent owner
PD4A Correction of name of patent owner
MM4A The patent is invalid due to non-payment of fees

Effective date: 20090608