EA199700434A1 - Циклическое соединение, способ его получения и способ получения смеси диастереомеров - Google Patents

Циклическое соединение, способ его получения и способ получения смеси диастереомеров

Info

Publication number
EA199700434A1
EA199700434A1 EA199700434A EA199700434A EA199700434A1 EA 199700434 A1 EA199700434 A1 EA 199700434A1 EA 199700434 A EA199700434 A EA 199700434A EA 199700434 A EA199700434 A EA 199700434A EA 199700434 A1 EA199700434 A1 EA 199700434A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diastereomers
preparing
mixture
preparation
cyclic compound
Prior art date
Application number
EA199700434A
Other languages
English (en)
Other versions
EA000867B1 (ru
Inventor
Тосифуми Акиба
Тутому Ебата
Татсуру Саито
Садахиро Симизу
Кеиити Хираи
Наоки Охта
Тосиаки Тодзо
Original Assignee
Дайити Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайити Фармасьютикал Ко., Лтд. filed Critical Дайити Фармасьютикал Ко., Лтд.
Publication of EA199700434A1 publication Critical patent/EA199700434A1/ru
Publication of EA000867B1 publication Critical patent/EA000867B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к соединению, представленному формулой (I), в которой n является целым числом от 2 до 5, Rпредставляет атом водорода или заместитель, изображаемый приведенной ниже формулой (I), в которой каждый из R, Rи Rпредставляет фенильную, фенилметильную или нафтильную группу, которая может быть замещена по меньшей мере одним заместителем, выбираемым из группы, состоящей из алкильной группы с 1-4 атомами углерода, алкоксильной группы с 1-4 атомами углерода, атома галогена и нитрогруппы, атом водорода или алкильную группу с 1-4 атомами углерода; и представляет атом водорода или алкильную группу с 1-4 атомами углерода, при условии, что исключается соединение, в котором n равен 2, Rявляется атомом водорода и Rпредставляет собой этильную группу, и к соединению, изображаемому приведенной ниже формулой (II), полезному в качестве антибактериального средства, которое получают с помощью соединения формулы (I), а также к новому способу синтеза с целью недорогого, с малым числом стадий и промышленно выгодного получения такого соединения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700434A 1995-05-26 1996-05-23 Циклическое соединение, способ его получения и способ получения смеси диастереомеров EA000867B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12775695 1995-05-26
JP30791395 1995-11-27
PCT/JP1996/001373 WO1996037470A1 (fr) 1995-05-26 1996-05-23 Procedes de preparation de composes cycliques

Publications (2)

Publication Number Publication Date
EA199700434A1 true EA199700434A1 (ru) 1998-06-25
EA000867B1 EA000867B1 (ru) 2000-06-26

Family

ID=26463637

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700434A EA000867B1 (ru) 1995-05-26 1996-05-23 Циклическое соединение, способ его получения и способ получения смеси диастереомеров

Country Status (15)

Country Link
US (3) US5856518A (ru)
EP (2) EP0829473B1 (ru)
KR (1) KR100399512B1 (ru)
CN (2) CN1190421C (ru)
AT (1) ATE221876T1 (ru)
AU (1) AU5778996A (ru)
CA (1) CA2221946C (ru)
DE (1) DE69622862T2 (ru)
DK (1) DK0829473T3 (ru)
EA (1) EA000867B1 (ru)
ES (1) ES2181886T3 (ru)
NO (2) NO316070B1 (ru)
PT (1) PT829473E (ru)
TW (1) TW453986B (ru)
WO (1) WO1996037470A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
US6197974B1 (en) * 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines
US6191306B1 (en) * 1999-08-03 2001-02-20 Eastman Chemical Company Process for the preparation of cyclopropylglycine
KR100895421B1 (ko) 2000-08-08 2009-05-07 다이이찌 세이야꾸 가부시기가이샤 쌍환 화합물의 제조방법 및 이의 중간체
CN1184221C (zh) * 2001-08-08 2005-01-12 中国医学科学院医药生物技术研究所 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法
JP2003171354A (ja) 2001-12-06 2003-06-20 Daicel Chem Ind Ltd 光学活性アミン化合物又はその塩の製造方法
EP1882685A4 (en) * 2005-05-20 2010-10-27 Daiichi Sankyo Co Ltd METHOD FOR PRODUCING AN ASYMMETRIC TETRASUBSTITUTED CARBON CONTAINING COMPOUND
CN103012198A (zh) * 2011-09-21 2013-04-03 中国药科大学 光学活性环状化合物的制备方法
KR200469128Y1 (ko) * 2013-05-16 2013-09-25 김진란 첨가물의 수납부가 형성된 속뚜껑
CN103435523B (zh) * 2013-08-13 2015-12-23 苏州楚凯药业有限公司 (1r，2s)-2-氟-环丙胺对甲苯磺酸盐的制备方法
CN109956896B (zh) * 2017-12-14 2021-03-12 中国医药集团总公司四川抗菌素工业研究所 一种螺[环丙烷-1,3-吲哚啉]骨架物及其晶体和其制备方法与用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557220A1 (de) * 1975-12-19 1977-06-23 Goedecke Ag N-substituierte spirolactame
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
JP2964420B2 (ja) * 1990-10-12 1999-10-18 第一製薬株式会社 アザスピロヘプタン誘導体の塩
JP3021109B2 (ja) * 1991-05-17 2000-03-15 第一製薬株式会社 アミノ化合物の製法
JP3045574B2 (ja) * 1991-05-17 2000-05-29 第一製薬株式会社 アミノ化合物の製造法
JP3432880B2 (ja) * 1994-02-09 2003-08-04 第一製薬株式会社 光学活性アザスピロ化合物の製法
JPH07233146A (ja) * 1994-02-23 1995-09-05 Dai Ichi Seiyaku Co Ltd ラセミ化法
JP3366723B2 (ja) * 1994-04-18 2003-01-14 第一製薬株式会社 脱保護法
JP3523921B2 (ja) * 1994-12-09 2004-04-26 第一製薬株式会社 アザスピロ誘導体およびその製造法

Also Published As

Publication number Publication date
WO1996037470A1 (fr) 1996-11-28
ES2181886T3 (es) 2003-03-01
EP0829473B1 (en) 2002-08-07
CA2221946A1 (en) 1996-11-28
DE69622862D1 (de) 2002-09-12
TW453986B (en) 2001-09-11
CN1080259C (zh) 2002-03-06
NO975391L (no) 1998-01-26
EP0829473A4 (en) 1998-10-07
US6218548B1 (en) 2001-04-17
ATE221876T1 (de) 2002-08-15
US5856518A (en) 1999-01-05
NO316070B1 (no) 2003-12-08
EP1148047A3 (en) 2004-10-06
KR19990022000A (ko) 1999-03-25
KR100399512B1 (ko) 2004-03-30
CN1190421C (zh) 2005-02-23
US6013806A (en) 2000-01-11
NO324846B1 (no) 2007-12-17
DE69622862T2 (de) 2003-03-27
AU5778996A (en) 1996-12-11
EA000867B1 (ru) 2000-06-26
CN1191529A (zh) 1998-08-26
CA2221946C (en) 2005-03-15
NO20031884D0 (no) 2003-04-25
NO975391D0 (no) 1997-11-24
EP1148047A2 (en) 2001-10-24
EP0829473A1 (en) 1998-03-18
DK0829473T3 (da) 2002-12-02
CN1326930A (zh) 2001-12-19
PT829473E (pt) 2002-11-29
NO20031884L (no) 1998-01-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU