ES2181886T3 - Procedimientos de preparacion de compuestos ciclicos. - Google Patents

Procedimientos de preparacion de compuestos ciclicos.

Info

Publication number
ES2181886T3
ES2181886T3 ES96914415T ES96914415T ES2181886T3 ES 2181886 T3 ES2181886 T3 ES 2181886T3 ES 96914415 T ES96914415 T ES 96914415T ES 96914415 T ES96914415 T ES 96914415T ES 2181886 T3 ES2181886 T3 ES 2181886T3
Authority
ES
Spain
Prior art keywords
procedures
preparation
cycling
compounds
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96914415T
Other languages
English (en)
Inventor
Toshifumi Akiba
Tutomu Ebata
Tatsuru Saito
Sadahiro Shimizu
Keiichi Hirai
Naoki Ohta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2181886T3 publication Critical patent/ES2181886T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Mechanical Coupling Of Light Guides (AREA)

Abstract

ESTA INVENCION PROPORCIONA UN COMPUESTO REPRESENTADO POR LA SIGUIENTE FORMULA (I) [EN LA FORMULA, N ES UN ENTERO COMPRENDIDO ENTRE 2 Y 5; R SUP,1} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO DE SUSTITUCION REPRESENTADO POR LA SIGUIENTE FORMULA R SUP,1}, EN LA CUAL R SUP,A}, R SUP,B} Y R SUP,C} REPRESENTAN UN GRUPO FENIL, FENILMETIL O NAFTIL (QUE PUEDE ESTAR SUSTITUIDO POR AL MENOS UN GRUPO DE SUSTITUCION SELECCIONADO DENTRO DEL GRUPO FORMADO POR UN GRUPO ALQUIL DE 1 A 4 ATOMOS DE CARBONO, UN GRUPO ALCOXIL DE 1 A 4 ATOMOS DE CARBONO, UN ATOMO DE HALOGENO Y UN GRUPO NITRO), UN ATOMO DE HIDROGENO O UN GRUPO ALQUIL CON 1 A 4 ATOMOS DE CARBONO; Y R SUP,2} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUIL CON 1 A 4 ATOMOS DE CARBONO, CON LA SALVEDAD DE QUE SE EXCLUYE UN COMPUESTO EN EL CUAL N ES 2, R SUP,1} ES UN ATOMO DE HIDROGENO Y R SUP,2} ES UN GRUPO ETIL] Y UN COMPUESTO REPRESENTADO POR LA SIGUIENTE FORMULA (II) UTIL COMO AGENTE ANTIBACTERIANO QUE SE OBTIENE MEDIANTE EL COMPUESTO DE FORMULA(I); Y TAMBIEN PROPORCIONA UN NUEVO PROCESO DE SINTESIS PARA LA PRODUCCION ECONOMICA, EN POCAS FASES E INDUSTRIALMENTE VENTAJOSA DE ESTOS.
ES96914415T 1995-05-26 1996-05-23 Procedimientos de preparacion de compuestos ciclicos. Expired - Lifetime ES2181886T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12775695 1995-05-26
JP30791395 1995-11-27

Publications (1)

Publication Number Publication Date
ES2181886T3 true ES2181886T3 (es) 2003-03-01

Family

ID=26463637

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96914415T Expired - Lifetime ES2181886T3 (es) 1995-05-26 1996-05-23 Procedimientos de preparacion de compuestos ciclicos.

Country Status (15)

Country Link
US (3) US5856518A (es)
EP (2) EP1148047A3 (es)
KR (1) KR100399512B1 (es)
CN (2) CN1190421C (es)
AT (1) ATE221876T1 (es)
AU (1) AU5778996A (es)
CA (1) CA2221946C (es)
DE (1) DE69622862T2 (es)
DK (1) DK0829473T3 (es)
EA (1) EA000867B1 (es)
ES (1) ES2181886T3 (es)
NO (2) NO316070B1 (es)
PT (1) PT829473E (es)
TW (1) TW453986B (es)
WO (1) WO1996037470A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
US6197974B1 (en) * 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines
US6191306B1 (en) * 1999-08-03 2001-02-20 Eastman Chemical Company Process for the preparation of cyclopropylglycine
EP1310487B1 (en) 2000-08-08 2007-01-03 Daiichi Pharmaceutical Co., Ltd. Processes for preparation of bicyclic compounds and intermediates therefor
CN1184221C (zh) * 2001-08-08 2005-01-12 中国医学科学院医药生物技术研究所 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法
JP2003171354A (ja) 2001-12-06 2003-06-20 Daicel Chem Ind Ltd 光学活性アミン化合物又はその塩の製造方法
US7928232B2 (en) * 2005-05-20 2011-04-19 Daiichi Sankyo Company, Limited Method for producing asymmetric tetrasubstituted carbon atom-containing compound
CN103012198A (zh) * 2011-09-21 2013-04-03 中国药科大学 光学活性环状化合物的制备方法
KR200469128Y1 (ko) * 2013-05-16 2013-09-25 김진란 첨가물의 수납부가 형성된 속뚜껑
CN103435523B (zh) * 2013-08-13 2015-12-23 苏州楚凯药业有限公司 (1r，2s)-2-氟-环丙胺对甲苯磺酸盐的制备方法
CN109956896B (zh) * 2017-12-14 2021-03-12 中国医药集团总公司四川抗菌素工业研究所 一种螺[环丙烷-1,3-吲哚啉]骨架物及其晶体和其制备方法与用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557220A1 (de) * 1975-12-19 1977-06-23 Goedecke Ag N-substituierte spirolactame
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
JP2964420B2 (ja) * 1990-10-12 1999-10-18 第一製薬株式会社 アザスピロヘプタン誘導体の塩
JP3045574B2 (ja) * 1991-05-17 2000-05-29 第一製薬株式会社 アミノ化合物の製造法
JP3021109B2 (ja) * 1991-05-17 2000-03-15 第一製薬株式会社 アミノ化合物の製法
JP3432880B2 (ja) * 1994-02-09 2003-08-04 第一製薬株式会社 光学活性アザスピロ化合物の製法
JPH07233146A (ja) * 1994-02-23 1995-09-05 Dai Ichi Seiyaku Co Ltd ラセミ化法
JP3366723B2 (ja) * 1994-04-18 2003-01-14 第一製薬株式会社 脱保護法
JP3523921B2 (ja) * 1994-12-09 2004-04-26 第一製薬株式会社 アザスピロ誘導体およびその製造法

Also Published As

Publication number Publication date
NO975391L (no) 1998-01-26
US5856518A (en) 1999-01-05
US6218548B1 (en) 2001-04-17
NO324846B1 (no) 2007-12-17
CA2221946A1 (en) 1996-11-28
EP0829473B1 (en) 2002-08-07
AU5778996A (en) 1996-12-11
CN1191529A (zh) 1998-08-26
PT829473E (pt) 2002-11-29
CN1190421C (zh) 2005-02-23
ATE221876T1 (de) 2002-08-15
EP0829473A1 (en) 1998-03-18
CN1080259C (zh) 2002-03-06
KR19990022000A (ko) 1999-03-25
EP1148047A2 (en) 2001-10-24
TW453986B (en) 2001-09-11
NO975391D0 (no) 1997-11-24
DE69622862D1 (de) 2002-09-12
NO316070B1 (no) 2003-12-08
NO20031884L (no) 1998-01-26
DK0829473T3 (da) 2002-12-02
EA000867B1 (ru) 2000-06-26
EA199700434A1 (ru) 1998-06-25
DE69622862T2 (de) 2003-03-27
CN1326930A (zh) 2001-12-19
KR100399512B1 (ko) 2004-03-30
EP1148047A3 (en) 2004-10-06
NO20031884D0 (no) 2003-04-25
US6013806A (en) 2000-01-11
EP0829473A4 (en) 1998-10-07
CA2221946C (en) 2005-03-15
WO1996037470A1 (fr) 1996-11-28

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