IL58849A
(en)
*
|
1978-12-11 |
1983-03-31 |
Merck & Co Inc |
Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
|
US4595675A
(en)
*
|
1979-09-19 |
1986-06-17 |
Hoechst Aktiengesellschaft |
Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
|
US4616031A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4616029A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydromdole-2-carboxylic acids as antihypertensives
|
FR2503155A2
(fr)
*
|
1980-10-02 |
1982-10-08 |
Science Union & Cie |
Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
|
US4508729A
(en)
*
|
1979-12-07 |
1985-04-02 |
Adir |
Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
|
US4644008A
(en)
*
|
1979-12-07 |
1987-02-17 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4616030A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
JPS5683483A
(en)
*
|
1979-12-13 |
1981-07-08 |
Santen Pharmaceut Co Ltd |
Thiazolidine compound
|
US4350704A
(en)
*
|
1980-10-06 |
1982-09-21 |
Warner-Lambert Company |
Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
|
IE52663B1
(en)
*
|
1980-04-02 |
1988-01-20 |
Warner Lambert Co |
Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
|
FR2480747A1
(fr)
*
|
1980-04-17 |
1981-10-23 |
Roques Bernard |
Derives d'acides amines et leur application therapeutique
|
GR74635B
(el)
*
|
1980-08-18 |
1984-06-29 |
Merck & Co Inc |
|
PT73522B
(en)
*
|
1980-08-18 |
1983-07-14 |
Merck & Co Inc |
Process for preparing substituted caprylolactam derivatives as antihypertensives
|
IL63540A0
(en)
*
|
1980-08-18 |
1981-11-30 |
Merck & Co Inc |
Substituted enantholactam derivatives as antihypertensives
|
GR75019B
(el)
*
|
1980-09-17 |
1984-07-12 |
Univ Miami |
|
US4344949A
(en)
*
|
1980-10-03 |
1982-08-17 |
Warner-Lambert Company |
Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
|
GR75775B
(el)
*
|
1980-10-06 |
1984-08-02 |
Merck & Co Inc |
|
DE19575012I2
(de)
*
|
1980-10-23 |
2002-01-24 |
Schering Corp |
Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
|
ZA817261B
(en)
*
|
1980-10-23 |
1982-09-29 |
Schering Corp |
Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
|
US4296110A
(en)
*
|
1980-10-28 |
1981-10-20 |
E. I. Du Pont De Nemours And Company |
Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
|
AU543804B2
(en)
*
|
1980-10-31 |
1985-05-02 |
Takeda Chemical Industries Ltd. |
Amides having bicyclic substituents on nitrogen
|
GB2086390B
(en)
*
|
1980-11-03 |
1984-06-06 |
Ciba Geigy Ag |
1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
|
US4462943A
(en)
*
|
1980-11-24 |
1984-07-31 |
E. R. Squibb & Sons, Inc. |
Carboxyalkyl amino acid derivatives of various substituted prolines
|
CY1406A
(en)
*
|
1980-12-18 |
1988-04-22 |
Schering Corp |
Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
|
US4906615A
(en)
*
|
1980-12-18 |
1990-03-06 |
Schering Corporation |
Substituted dipeptides as inhibitors of enkephalinases
|
IE53315B1
(en)
*
|
1980-12-18 |
1988-10-12 |
Schering Corp |
Substituted dipeptides,processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
|
EP0057998B1
(en)
*
|
1981-01-23 |
1984-08-08 |
Takeda Chemical Industries, Ltd. |
Alicyclic compounds, their production and use
|
US4532342A
(en)
*
|
1981-02-20 |
1985-07-30 |
Warner-Lambert Company |
N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
|
EP0059966B1
(en)
*
|
1981-03-09 |
1986-08-13 |
Merck & Co. Inc. |
Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives
|
US4512979A
(en)
|
1981-03-23 |
1985-04-23 |
Merck & Co., Inc. |
Dipeptides containing thialysine and related amino acids as antihypertensives
|
US4820729A
(en)
*
|
1981-03-30 |
1989-04-11 |
Rorer Pharmaceutical Corporation |
N-substituted-amido-amino acids
|
AU556932B2
(en)
*
|
1981-03-30 |
1986-11-27 |
Usv Pharmaceutical Corp. |
Dipetide with heterocyclic groiup
|
US4510322A
(en)
*
|
1981-07-13 |
1985-04-09 |
Merck & Co., Inc. |
Indacrinone having enhanced uricosuric
|
US4454291A
(en)
*
|
1981-07-20 |
1984-06-12 |
American Home Products Corporation |
N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
|
US4454292A
(en)
*
|
1981-07-20 |
1984-06-12 |
American Home Products Corporation |
N-[2-Substituted-1-oxoalkyl]-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
|
CS226907B1
(en)
*
|
1981-08-07 |
1984-04-16 |
Kasafirek Evzen |
Alkylamides of carboxyalkanoylpeptides
|
US4766110A
(en)
*
|
1981-08-21 |
1988-08-23 |
Ryan James W |
Novel complex amido and imido derivatives of carboxyalkyl peptides
|
ZA826022B
(en)
*
|
1981-08-21 |
1983-08-31 |
Univ Miami |
Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
|
DE3226768A1
(de)
*
|
1981-11-05 |
1983-05-26 |
Hoechst Ag, 6230 Frankfurt |
Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
|
US4410520A
(en)
*
|
1981-11-09 |
1983-10-18 |
Ciba-Geigy Corporation |
3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
|
EP0079522B1
(en)
*
|
1981-11-09 |
1986-05-07 |
Merck & Co. Inc. |
N-carboxymethyl(amidino)lysyl-proline antihypertensive agents
|
EP0079521A1
(en)
*
|
1981-11-09 |
1983-05-25 |
Merck & Co. Inc. |
Process for preparation of carboxyalkyldipeptide derivatives
|
EP0081094A1
(en)
*
|
1981-11-12 |
1983-06-15 |
Merck & Co. Inc. |
Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
|
EP0080822A1
(en)
*
|
1981-11-27 |
1983-06-08 |
Beecham Group Plc |
Anti-hypertensive prolinol-based peptides
|
US4503043A
(en)
*
|
1981-12-07 |
1985-03-05 |
Warner-Lambert Company |
Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
|
GR78413B
(el)
*
|
1981-12-29 |
1984-09-27 |
Hoechst Ag |
|
JPS58126851A
(ja)
*
|
1982-01-11 |
1983-07-28 |
メルク エンド カムパニー インコーポレーテッド |
抗高血圧剤として有用なアミノアシル含有ジペプチド誘導体
|
EP0083923B1
(en)
*
|
1982-01-11 |
1988-10-19 |
Merck & Co. Inc. |
Aminoacyl-containing dipeptide derivatives useful as antihypertensives
|
US4555502A
(en)
*
|
1982-09-30 |
1985-11-26 |
Merck & Co., Inc. |
Aminoacyl-containing dipeptide derivatives useful as antihypertensives
|
IE54551B1
(en)
*
|
1982-01-22 |
1989-11-22 |
Ici Plc |
Amide derivatives
|
US4665087A
(en)
*
|
1982-02-22 |
1987-05-12 |
Ciba-Geigy Corporation |
1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
|
DE3360065D1
(en)
*
|
1982-03-08 |
1985-03-28 |
Schering Corp |
Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
|
US4410807A
(en)
*
|
1982-03-26 |
1983-10-18 |
Kay Industries, Inc. |
Regulating device for polyphase electrical circuits
|
DE3211397A1
(de)
*
|
1982-03-27 |
1983-11-10 |
Hoechst Ag, 6230 Frankfurt |
Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
|
DE3211676A1
(de)
*
|
1982-03-30 |
1983-10-06 |
Hoechst Ag |
Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
|
JPS58188847A
(ja)
*
|
1982-04-26 |
1983-11-04 |
Takeda Chem Ind Ltd |
ペプチド誘導体
|
US4681886A
(en)
*
|
1982-04-30 |
1987-07-21 |
E. R. Squibb & Sons, Inc. |
Substituted 4-phenoxy or 4-phenylthio prolines
|
US4555503A
(en)
*
|
1982-05-05 |
1985-11-26 |
Merck & Co., Inc. |
N2 -(Substituted)carboxymethyl-N6 -(substituted)-lysyl-and αε-aminoalkyl)glycyl amino acid antihypertensive agents
|
US4483850A
(en)
*
|
1982-05-10 |
1984-11-20 |
Merck & Co., Inc. |
N-Terminal substituted oligopeptide converting enzyme inhibitors
|
ZA833214B
(en)
*
|
1982-05-12 |
1983-12-28 |
Hoffmann La Roche |
Bicyclic compounds
|
GB2128984B
(en)
*
|
1982-05-12 |
1985-05-22 |
Hoffmann La Roche |
Diaza-bicyclic compounds
|
ZA832844B
(en)
*
|
1982-05-18 |
1984-03-28 |
Smithkline Beckman Corp |
Oligopeptide prodrugs
|
JPS6058233B2
(ja)
*
|
1982-05-24 |
1985-12-19 |
田辺製薬株式会社 |
2−オキソイミダゾリジン誘導体及びその製法
|
US4442030A
(en)
*
|
1982-06-07 |
1984-04-10 |
Merck & Co., Inc. |
Process for preparing carboxyalkyl dipeptides
|
EP0103077B1
(en)
*
|
1982-06-17 |
1988-05-18 |
Schering Corporation |
Substituted dipeptides, methods for their production, pharmaceutical compositions containing them, method for making such pharmaceutical compositions
|
US4442089A
(en)
*
|
1982-07-06 |
1984-04-10 |
E. R. Squibb & Sons, Inc. |
Method for treating glaucoma with topical or systemic ACE inhibitor compositions
|
US4736066A
(en)
*
|
1982-07-19 |
1988-04-05 |
E. R. Squibb & Sons, Inc. |
Intermediate for substituted peptide compounds
|
US4473575A
(en)
*
|
1982-07-19 |
1984-09-25 |
Ciba-Geigy Corporation |
3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
|
AU1643283A
(en)
*
|
1982-07-19 |
1984-01-26 |
E.R. Squibb & Sons, Inc. |
Substituted peptides
|
AU560285B2
(en)
*
|
1982-07-19 |
1987-04-02 |
Imperial Chemical Industries Plc |
Heterocyclyl carbonyl sulphonamides
|
US4470973A
(en)
*
|
1982-07-19 |
1984-09-11 |
E. R. Squibb & Sons, Inc. |
Substituted peptide compounds
|
US4661515A
(en)
*
|
1982-07-21 |
1987-04-28 |
Usv Pharmaceutical Corporation |
Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
|
US4742067A
(en)
*
|
1982-07-22 |
1988-05-03 |
E. R. Squibb & Sons, Inc. |
Acylalkylaminocarbonyl substituted amino and imino acid compounds
|
US4621092A
(en)
*
|
1982-07-22 |
1986-11-04 |
E. R. Squibb & Sons, Inc. |
Substituted proline compounds, composition and method of use
|
US4487716A
(en)
*
|
1982-08-23 |
1984-12-11 |
American Home Products Corporation |
N-(1-Carboxy-3-phenylpropyl)-dipeptides
|
US4439364A
(en)
*
|
1982-09-01 |
1984-03-27 |
E. I. Du Pont De Nemours & Company |
Process for preparing antihypertensive 1-substituted cyclic lactam-2-carboxylic acids and their derivatives
|
US4866173A
(en)
*
|
1982-09-22 |
1989-09-12 |
Rorer Pharmaceutical Corporation |
Therapeutic substituted semicarbazides
|
US4500713A
(en)
*
|
1982-09-23 |
1985-02-19 |
Usv Pharmaceutical Corporation |
Therapeutic dipeptides
|
US4634716A
(en)
*
|
1982-09-30 |
1987-01-06 |
Merck & Co., Inc. |
Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
|
US4499079A
(en)
*
|
1982-11-18 |
1985-02-12 |
E. R. Squibb & Sons, Inc. |
Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
|
US4642315A
(en)
*
|
1982-11-18 |
1987-02-10 |
E. R. Squibb & Sons, Inc. |
Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
|
US4587234A
(en)
*
|
1982-11-18 |
1986-05-06 |
E. R. Squibb & Sons, Inc. |
Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
|
US4482544A
(en)
*
|
1982-11-29 |
1984-11-13 |
Usv Pharmaceutical Corporation |
Compounds for treating hypertension
|
US4456595A
(en)
*
|
1982-12-06 |
1984-06-26 |
E. R. Squibb & Sons, Inc. |
Carboxy and substituted carboxy aroly peptides
|
US4826812A
(en)
*
|
1982-12-27 |
1989-05-02 |
Schering Corporation |
Antiglaucoma agent
|
DE3300774A1
(de)
*
|
1983-01-12 |
1984-07-12 |
Hoechst Ag, 6230 Frankfurt |
Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
|
US4496541A
(en)
*
|
1983-01-12 |
1985-01-29 |
Usv Pharmaceutical Corporation |
Compounds for treating hypertension
|
DE3302125A1
(de)
*
|
1983-01-22 |
1984-07-26 |
Boehringer Ingelheim KG, 6507 Ingelheim |
Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
|
EP0115091A1
(en)
*
|
1983-01-27 |
1984-08-08 |
ENI-Ente Nazionale Idrocarburi |
N-carboxyacyl derivatives of cyclic amino acids, useful as antihypertensives
|
US4659711A
(en)
*
|
1983-01-31 |
1987-04-21 |
Usv Pharmaceutical Corporation |
1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for treating hypertension
|
US5175306A
(en)
*
|
1983-01-31 |
1992-12-29 |
Hoechst Aktiengesellschaft |
Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
|
US4711884A
(en)
*
|
1983-02-28 |
1987-12-08 |
E. R. Squibb & Sons, Inc. |
Thiazine and thiazepine containing compounds
|
US4596791A
(en)
*
|
1983-03-16 |
1986-06-24 |
Usv Pharmaceutical Corp. |
Compounds for treating hypertension
|
US4666906A
(en)
*
|
1983-03-16 |
1987-05-19 |
Usv Pharmaceutical Corporation |
Compounds for treating hypertension
|
US4481191A
(en)
*
|
1983-03-30 |
1984-11-06 |
The Regents Of The University Of California |
Method for controlling blood pressure
|
GB8311286D0
(en)
*
|
1983-04-26 |
1983-06-02 |
Searle & Co |
Carboxyalkyl peptide derivatives
|
US4585758A
(en)
*
|
1983-05-20 |
1986-04-29 |
Usv Pharmaceutical Corp. |
Angiotensin-converting enzyme inhibitors
|
EP0127124A3
(en)
*
|
1983-05-23 |
1987-04-08 |
Usv Pharmaceutical Corporation |
Compounds for treating hypertension
|
US4574079A
(en)
*
|
1983-05-27 |
1986-03-04 |
Gavras Haralambos P |
Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites
|
US4783444A
(en)
*
|
1984-09-17 |
1988-11-08 |
Schering Corporation |
Antiglaucoma compositions and methods
|
US4840772A
(en)
*
|
1983-06-02 |
1989-06-20 |
Schering Corporation |
Antiglaucoma compositions and methods
|
US4584285A
(en)
*
|
1983-06-02 |
1986-04-22 |
Schering Corporation |
Antihypertensive agents
|
US4472384A
(en)
*
|
1983-06-15 |
1984-09-18 |
Merck & Co., Inc. |
Antihypertensive composition
|
US4514391A
(en)
*
|
1983-07-21 |
1985-04-30 |
E. R. Squibb & Sons, Inc. |
Hydroxy substituted peptide compounds
|
DE3333454A1
(de)
*
|
1983-09-16 |
1985-04-11 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
|
DE3333455A1
(de)
*
|
1983-09-16 |
1985-04-11 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur herstellung n-alkylierter dipeptide und deren estern
|
EP0137746A3
(en)
*
|
1983-09-22 |
1986-01-08 |
FISONS plc |
Nitrogen substituted angiotensin converting enzyme inhibitors
|
US4642355A
(en)
*
|
1984-02-24 |
1987-02-10 |
Otsuka Pharmaceutical Factory, Inc. |
Proline derivatives
|
EP0181342B1
(en)
*
|
1984-03-01 |
1992-10-28 |
ERK, Vernon |
Method of treating hypertension in vertebrates
|
CA1254699A
(en)
*
|
1984-03-12 |
1989-05-23 |
Jasjit S. Bindra |
Renin inhibitors containing statine or derivatives thereof
|
US4536501A
(en)
*
|
1984-03-30 |
1985-08-20 |
E. R. Squibb & Sons, Inc. |
Substituted 4-phenoxy or 4-phenylthio prolines
|
DE3413710A1
(de)
*
|
1984-04-12 |
1985-10-24 |
Hoechst Ag, 6230 Frankfurt |
Verfahren zur behandlung der herzinsuffizienz
|
EP0159396B1
(en)
|
1984-04-12 |
1990-06-27 |
G.D. Searle & Co. |
Carboxyalkyl peptide derivatives
|
US4568666A
(en)
*
|
1984-10-18 |
1986-02-04 |
G. D. Searle & Co. |
Carboxylalkyl peptide derivatives
|
US5684016A
(en)
*
|
1984-04-12 |
1997-11-04 |
Hoechst Aktiengesellschaft |
Method of treating cardiac insufficiency
|
US4558150A
(en)
*
|
1984-04-19 |
1985-12-10 |
E. R. Squibb & Sons, Inc. |
Intermediates for preparing amino thiol dipeptides
|
US4500518A
(en)
*
|
1984-04-19 |
1985-02-19 |
E. R. Squibb & Sons, Inc. |
Amino thiol dipeptides
|
AU569789B2
(en)
*
|
1984-05-03 |
1988-02-18 |
Brigham And Women's Hospital |
A.c.e. inhibitors to treat renal diseases
|
US4558037A
(en)
*
|
1984-06-04 |
1985-12-10 |
Merck & Co., Inc. |
Cardiovascular composition
|
EP0168769A3
(en)
*
|
1984-07-16 |
1989-02-08 |
Merck & Co. Inc. |
Process for preparing carboxyalkyl dipeptides
|
US4801721A
(en)
*
|
1984-08-16 |
1989-01-31 |
Ryan James W |
Stereospecific synthesis of carboxyalkyl peptides
|
USH642H
(en)
|
1984-08-20 |
1989-06-06 |
E. R. Squibb & Sons, Inc. |
Substituted urido amino and imino acids and esters
|
US4626545A
(en)
*
|
1984-08-27 |
1986-12-02 |
Merck & Co., Inc. |
Amino acid derivatives as enzyme inhibitors
|
DE3431541A1
(de)
*
|
1984-08-28 |
1986-03-06 |
Hoechst Ag, 6230 Frankfurt |
Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
|
GB8422165D0
(en)
*
|
1984-09-01 |
1984-10-03 |
Wellcome Found |
Compounds
|
US4746676A
(en)
*
|
1984-09-12 |
1988-05-24 |
Rorer Pharmaceutical Corporation |
Carboxyalkyl dipeptide compounds
|
IT1176983B
(it)
*
|
1984-10-16 |
1987-08-26 |
Zambon Spa |
Dipeptidi ad attivita' farmacologica
|
DE3437917A1
(de)
*
|
1984-10-17 |
1986-04-17 |
Bayer Ag, 5090 Leverkusen |
Kombination von dihydropyridinen mit ace-hemmern sowie ihre verwendung in arzneimitteln
|
FR2575163B1
(fr)
*
|
1984-12-20 |
1987-03-20 |
Sanofi Sa |
Tri- et tetrapeptides reduits inhibiteurs de la secretion gastrique, procede d'obtention et compositions pharmaceutiques les contenant
|
CS250699B2
(en)
*
|
1984-12-21 |
1987-05-14 |
Pfizer |
Method of octahydro-6-azaindole's depetidic derivatives production
|
EP0187037A3
(en)
*
|
1984-12-21 |
1988-03-23 |
Takeda Chemical Industries, Ltd. |
Piperidine derivatives, their production and use
|
US4762821A
(en)
*
|
1985-03-22 |
1988-08-09 |
Syntex (U.S.A.) Inc. |
N',N"-dialkylguanidino dipeptides
|
CN86101850A
(zh)
*
|
1985-03-22 |
1987-02-04 |
森得克斯(美国)有限公司 |
N,n′-二烷基胍基二肽的制造方法与用途
|
EP0201741B1
(en)
*
|
1985-04-16 |
1991-07-31 |
Suntory Limited |
Dipeptide derivatives, processes for preparing them, pharmaceutical composition and use
|
ES8604609A1
(es)
*
|
1985-07-02 |
1986-02-01 |
Uriach & Cia Sa J |
Procedimiento para la obtencion de la 1-(n-(1(r,s)-(etoxi- carbonil)-3-fenilpropil)-l-alanil)-l-prolina
|
ATE72431T1
(de)
|
1985-08-31 |
1992-02-15 |
Fisons Plc |
5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren.
|
DE3532036A1
(de)
*
|
1985-09-09 |
1987-03-26 |
Hoechst Ag |
Pharmazeutische zubereitung zur behandlung des bluthochdrucks
|
US5256687A
(en)
*
|
1985-09-09 |
1993-10-26 |
Hoechst Aktiengesellschaft |
Pharmaceutical composition for the treatment of high blood pressure
|
US5231080A
(en)
*
|
1985-10-15 |
1993-07-27 |
Hoechst Aktiengesellschaft |
Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
|
US4886813A
(en)
*
|
1985-11-13 |
1989-12-12 |
Otsuka Pharmaceutical Factory, Inc. |
Proline derivatives
|
JPH0653757B2
(ja)
*
|
1985-12-06 |
1994-07-20 |
味の素株式会社 |
プロリン誘導体の芳香族スルホン酸塩
|
JPH0662671B2
(ja)
*
|
1986-01-17 |
1994-08-17 |
株式会社大塚製薬工場 |
プロリン誘導体
|
US4771037A
(en)
*
|
1986-01-21 |
1988-09-13 |
Ici Americas Inc. |
N-carboxyalkyl compounds
|
PT84379B
(en)
*
|
1986-02-28 |
1989-01-24 |
Wellcome Found |
New compounds
|
HUT46045A
(en)
*
|
1986-02-28 |
1988-09-28 |
Wellcome Found |
Process for producing new compounds and pharmaceutics comprising same
|
US5231084A
(en)
*
|
1986-03-27 |
1993-07-27 |
Hoechst Aktiengesellschaft |
Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
|
ATE90076T1
(de)
|
1986-03-27 |
1993-06-15 |
Merck Frosst Canada Inc |
Tetrahydrocarbazole ester.
|
US4738850A
(en)
*
|
1986-05-27 |
1988-04-19 |
E. R. Squibb & Sons, Inc. |
Controlled release formulation and method
|
EP0254032A3
(en)
*
|
1986-06-20 |
1990-09-05 |
Schering Corporation |
Neutral metalloendopeptidase inhibitors in the treatment of hypertension
|
EP0566157A1
(en)
|
1986-06-20 |
1993-10-20 |
Schering Corporation |
Neutral metalloendopeptidase inhibitors in the treatment of hypertension
|
US4749688A
(en)
*
|
1986-06-20 |
1988-06-07 |
Schering Corporation |
Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
|
AT395012B
(de)
*
|
1986-06-27 |
1992-08-25 |
Richter Gedeon Vegyeszet |
Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen
|
DE3627613A1
(de)
*
|
1986-08-14 |
1988-02-18 |
Merck Patent Gmbh |
Pharmazeutische zubereitung
|
ATE70048T1
(de)
*
|
1986-09-10 |
1991-12-15 |
Syntex Inc |
Selektive amidinierung von diaminen.
|
US5948939A
(en)
*
|
1986-09-10 |
1999-09-07 |
Syntex (U.S.A.) Inc. |
Selective amidination of diamines
|
DE3633496A1
(de)
*
|
1986-10-02 |
1988-04-14 |
Hoechst Ag |
Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
|
DE3639879A1
(de)
*
|
1986-11-21 |
1988-06-01 |
Hoechst Ag |
Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
|
CA1313724C
(en)
*
|
1987-02-19 |
1993-02-16 |
Shizuo Saito |
Aminoacid derivatives as antihypertensives
|
JPH075633B2
(ja)
*
|
1987-02-19 |
1995-01-25 |
アサヒビール株式会社 |
アミノ酸誘導体その製造方法及び血圧降下剤
|
US4837354A
(en)
*
|
1987-02-26 |
1989-06-06 |
Merrell Dow Pharmaceuticals Inc. |
Process for making and isolating (R)-2-hydroxy-4-phenylbutyric acid and esters
|
US5262436A
(en)
*
|
1987-03-27 |
1993-11-16 |
Schering Corporation |
Acylamino acid antihypertensives in the treatment of congestive heart failure
|
JPH0657707B2
(ja)
*
|
1987-05-25 |
1994-08-03 |
吉富製薬株式会社 |
ピペリジン化合物
|
CA1337400C
(en)
*
|
1987-06-08 |
1995-10-24 |
Norma G. Delaney |
Inhibitors of neutral endopeptidase
|
DE3722007A1
(de)
*
|
1987-07-03 |
1989-01-12 |
Hoechst Ag |
Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
|
FR2619813B1
(fr)
*
|
1987-08-28 |
1991-05-03 |
Adir |
Nouveaux derives de l'acide aza - 2 bicyclooctane carboxylique - 3, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
|
USH734H
(en)
|
1988-03-07 |
1990-02-06 |
E. R. Squibb & Sons, Inc. |
Method for inhibiting onset of or treating migraine headaches employing an ACE inhibitor
|
DE3739690A1
(de)
*
|
1987-11-24 |
1989-06-08 |
Hoechst Ag |
Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen
|
US5110927A
(en)
*
|
1987-12-31 |
1992-05-05 |
The United States Of America As Represented By The Department Of Health And Human Services |
Prazosin analog with increased selectivity and duration of action
|
DE3803225A1
(de)
*
|
1988-02-04 |
1989-08-17 |
Hoechst Ag |
Aminosaeureamide mit psychotroper wirkung, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
|
US5136044A
(en)
*
|
1988-04-04 |
1992-08-04 |
Kanegafuchi Kagaku Kogyo Kabushiki Kaisha |
N2 -carboxy-3-phenylpropyl)-l-lysine derivative and process of producing lysinolpril using the compound
|
IL90189A0
(en)
*
|
1988-06-01 |
1989-12-15 |
Squibb & Sons Inc |
Pharmaceutical compositions containing a benzazepine-type calcium channel blocker
|
GB8827308D0
(en)
*
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
GB8827305D0
(en)
*
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
SE506179C2
(sv)
*
|
1989-01-23 |
1997-11-17 |
Ciba Geigy Ag |
Farmaceutisk lågkomposition av benazepril och ett tiaziddiuretikum
|
ZA902661B
(en)
*
|
1989-04-10 |
1991-01-30 |
Schering Corp |
Mercapto-acyl amino acids
|
DE3915236A1
(de)
*
|
1989-05-10 |
1990-11-15 |
Merck Patent Gmbh |
Pharmazeutische zubereitung
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
US5110799A
(en)
*
|
1989-07-28 |
1992-05-05 |
Merck & Co., Inc. |
Antiherpetic agents
|
DE3926606A1
(de)
*
|
1989-08-11 |
1991-02-14 |
Hoechst Ag |
Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
|
GB8919251D0
(en)
*
|
1989-08-24 |
1989-10-04 |
British Bio Technology |
Compounds
|
US5212165A
(en)
*
|
1989-10-23 |
1993-05-18 |
E. R. Squibb & Sons, Inc. |
Method for rehabilitating the vasorelaxant action of the coronary arteries impaired through atherosclerosis or hypercholesterolemia employing an ace inhibitor
|
JPH075530B2
(ja)
*
|
1989-11-21 |
1995-01-25 |
シェリング・コーポレーション |
カルボキシアルキルカルボニルアミノ酸エンドペプチダーゼ阻害剤
|
US5407960A
(en)
*
|
1989-12-22 |
1995-04-18 |
Schering Corporation |
Mercaptocycloacyl aminoacid endopeptidase inhibitors
|
US5075302A
(en)
*
|
1990-03-09 |
1991-12-24 |
Schering Corporation |
Mercaptoacyl aminolactam endopeptidase inhibitors
|
HU227346B1
(en)
|
1990-05-11 |
2011-04-28 |
Pfizer |
Process for producing synergetic pharmaceutical composition
|
US5821232A
(en)
*
|
1990-05-11 |
1998-10-13 |
Pfizer Inc. |
Synergistic therapeutic compositions and methods
|
US5166143A
(en)
*
|
1990-05-31 |
1992-11-24 |
E. R. Squibb & Sons, Inc. |
Method for preventing onset of restenosis after angioplasty employing an ace inhibitor
|
US6300362B1
(en)
|
1990-07-25 |
2001-10-09 |
Novartis Ag (Formerly Sandoz Ltd.) |
Stabilized pharmaceutical compositions comprising acid donors
|
US5173506A
(en)
*
|
1990-08-16 |
1992-12-22 |
Schering Corporation |
N-(mercaptoalkyl)ureas and carbamates
|
TW197945B
(el)
*
|
1990-11-27 |
1993-01-11 |
Hoechst Ag |
|
EP0490379A3
(de)
*
|
1990-12-13 |
1992-06-24 |
BERLIN-CHEMIE Aktiengesellschaft |
Diaminosäurederivate und pharmazeutische Zusammensetzungen
|
US5124152A
(en)
*
|
1991-01-07 |
1992-06-23 |
Fisons Corporation |
Parenteral formulation of metolazone
|
GB9102635D0
(en)
*
|
1991-02-07 |
1991-03-27 |
British Bio Technology |
Compounds
|
US5530161A
(en)
*
|
1991-07-08 |
1996-06-25 |
British Bio-Technology Limited |
Hydroxamic acid based collagenase inhibitors
|
US5977160A
(en)
*
|
1992-04-10 |
1999-11-02 |
Brigham And Women's Hospital, Inc. |
Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
|
US5972990A
(en)
*
|
1992-04-10 |
1999-10-26 |
Brigham And Women's Hospital, Inc. |
Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
|
US5552397A
(en)
*
|
1992-05-18 |
1996-09-03 |
E. R. Squibb & Sons, Inc. |
Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
|
US5646276A
(en)
*
|
1992-05-13 |
1997-07-08 |
Bristol-Myers Squibb Co. |
Diazepine containing dual action inhibitors
|
US5504080A
(en)
*
|
1992-10-28 |
1996-04-02 |
Bristol-Myers Squibb Co. |
Benzo-fused lactams
|
US5589499A
(en)
*
|
1992-11-25 |
1996-12-31 |
Weth; Gosbert |
Dopaminergic agents for the treatment of cerebral and peripheral blood flow disorders
|
US5455353A
(en)
*
|
1993-03-24 |
1995-10-03 |
Hoffmann-La Roche Inc. |
4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
|
US5508272A
(en)
*
|
1993-06-15 |
1996-04-16 |
Bristol-Myers Squibb Company |
Compounds containing a fused bicycle ring and processes therefor
|
DE59409631D1
(de)
*
|
1993-07-15 |
2001-02-15 |
Hoffmann La Roche |
Pharmazeutische Kombination, die einen Hemmer des Renin-Angiotensin-Systems und einen Endothelin-Antagonisten enthält
|
US5362727A
(en)
*
|
1993-07-26 |
1994-11-08 |
Bristol-Myers Squibb |
Substituted azepino[2,1-a]isoquinoline compounds
|
US5525723A
(en)
*
|
1993-11-18 |
1996-06-11 |
Bristol-Myers Squibb Co. |
Compounds containing a fused multiple ring lactam
|
AU696868B2
(en)
*
|
1994-03-29 |
1998-09-17 |
Merck & Co., Inc. |
Treatment of atherosclerosis with angiotensin II receptor blocking imidazoles
|
AU2394795A
(en)
*
|
1994-04-28 |
1995-11-29 |
Du Pont Merck Pharmaceutical Company, The |
Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
|
US5616775A
(en)
*
|
1994-05-05 |
1997-04-01 |
Bristol-Myers Squibb Co. |
Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
|
AU2942495A
(en)
*
|
1994-07-13 |
1996-02-16 |
Lek Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. |
Process for the preparation of compounds having ace inhibitory action as well as novel compounds useful as starting materials or intermediates in said process
|
CA2128199C
(en)
*
|
1994-07-15 |
1997-02-04 |
Bernard Charles Sherman |
Stable solid pharmaceutical compositions containing enalapril maleate
|
US5601801A
(en)
*
|
1994-08-02 |
1997-02-11 |
Merck Frosst Canada, Inc. |
Radiolabelled angiotensin converting enzyme inhibitors
|
CN1065860C
(zh)
*
|
1994-08-27 |
2001-05-16 |
王隶书 |
提取盐酸甜菜碱工艺
|
DE4431530C2
(de)
*
|
1994-09-03 |
2002-01-31 |
Degussa |
Verfahren zur Herstellung von 2-[3(S)-Amino-2(R)-hydroxy-4-phenylbutyl]-N-tert.butyl-decahydro-(4aS,8aS)-isochinolin-3(S)-carboxamid
|
US5587375A
(en)
*
|
1995-02-17 |
1996-12-24 |
Bristol-Myers Squibb Company |
Azepinone compounds useful in the inhibition of ACE and NEP
|
WO1996032468A2
(en)
|
1995-04-11 |
1996-10-17 |
Merck & Co., Inc. |
Bioprocess for production of dipeptide based compounds
|
US5877313A
(en)
*
|
1995-05-17 |
1999-03-02 |
Bristol-Myers Squibb |
Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
|
US5650408A
(en)
*
|
1995-06-07 |
1997-07-22 |
Karanewsky; Donald S. |
Thiazolo benzazepine containing dual action inhibitors
|
US5635504A
(en)
*
|
1995-06-07 |
1997-06-03 |
Bristol-Myers Squibb Co. |
Diazepine containing dual action inhibitors
|
US20020042377A1
(en)
*
|
1995-06-07 |
2002-04-11 |
Steiner Joseph P. |
Rotamase enzyme activity inhibitors
|
US5859031A
(en)
|
1995-06-07 |
1999-01-12 |
Gpi Nil Holdings, Inc. |
Small molecule inhibitors of rotamase enzyme activity
|
US7056935B2
(en)
|
1995-06-07 |
2006-06-06 |
Gpi Nil Holdings, Inc. |
Rotamase enzyme activity inhibitors
|
CN1053437C
(zh)
*
|
1995-07-19 |
2000-06-14 |
五洲药厂 |
赖诺普利合成方法
|
US5573780A
(en)
*
|
1995-08-04 |
1996-11-12 |
Apotex Usa Inc. |
Stable solid formulation of enalapril salt and process for preparation thereof
|
US5550127A
(en)
*
|
1995-09-07 |
1996-08-27 |
Pantano; James A. |
Method of treatment for eiph in racing stock
|
EP0863764A4
(en)
*
|
1995-09-15 |
1999-04-07 |
Merck & Co Inc |
METHOD FOR THE ANALYSIS OF ISOMERS OF ENALAPRIL AND ENALAPRILATE
|
US5670655A
(en)
*
|
1995-09-15 |
1997-09-23 |
Merck & Co. Inc. |
Method for analyzing isomers of enalapril and enalaprilat
|
US5801197A
(en)
*
|
1995-10-31 |
1998-09-01 |
Gpi Nil Holdings, Inc. |
Rotamase enzyme activity inhibitors
|
EP0910375B1
(en)
*
|
1996-06-24 |
2002-05-02 |
Merck & Co., Inc. |
A composition of enalapril and losartan
|
CA2182258C
(en)
*
|
1996-07-29 |
2001-04-17 |
K.S. Keshava Murthy |
Sodium enalapril complex and the use thereof to make sodium enalapril
|
US6218424B1
(en)
|
1996-09-25 |
2001-04-17 |
Gpi Nil Holdings, Inc. |
Heterocyclic ketone and thioester compounds and uses
|
US5786378A
(en)
*
|
1996-09-25 |
1998-07-28 |
Gpi Nil Holdings, Inc. |
Heterocyclic thioesters
|
US5801187A
(en)
|
1996-09-25 |
1998-09-01 |
Gpi-Nil Holdings, Inc. |
Heterocyclic esters and amides
|
US6187784B1
(en)
|
1998-06-03 |
2001-02-13 |
Gpi Nil Holdings, Inc. |
Pipecolic acid derivative hair growth compositions and uses
|
US6271244B1
(en)
|
1998-06-03 |
2001-08-07 |
Gpi Nil Holdings, Inc. |
N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
|
US6187796B1
(en)
|
1998-06-03 |
2001-02-13 |
Gpi Nil Holdings, Inc. |
Sulfone hair growth compositions and uses
|
US20010049381A1
(en)
|
1997-06-04 |
2001-12-06 |
Gpl Nil Holdings, Inc., |
Pyrrolidine derivative hair growth compositions and uses
|
US5945441A
(en)
|
1997-06-04 |
1999-08-31 |
Gpi Nil Holdings, Inc. |
Pyrrolidine carboxylate hair revitalizing agents
|
US6274602B1
(en)
|
1998-06-03 |
2001-08-14 |
Gpi Nil Holdings, Inc. |
Heterocyclic thioester and ketone hair growth compositions and uses
|
US6548642B1
(en)
*
|
1997-07-21 |
2003-04-15 |
Ohio University |
Synthetic genes for plant gums
|
US7378506B2
(en)
*
|
1997-07-21 |
2008-05-27 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
US6570062B1
(en)
*
|
1997-07-21 |
2003-05-27 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
US6639050B1
(en)
|
1997-07-21 |
2003-10-28 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
IN184759B
(el)
|
1997-07-22 |
2000-09-23 |
Kaneka Corp |
|
IT1299341B1
(it)
*
|
1998-02-09 |
2000-03-16 |
Pfc Italiana Srl |
Processo per la produzione di alcossicarbonildipeptidi intermedi nella sintesi del lisinopril.
|
US6296871B1
(en)
|
1998-04-12 |
2001-10-02 |
Ranbaxy Laboratories Limited |
Stable solid pharmaceutical compositions containing enalapril maleate
|
JP2002516904A
(ja)
|
1998-06-03 |
2002-06-11 |
ジーピーアイ ニル ホールディングス インコーポレイテッド |
N−複素環式カルボン酸またはカルボン酸等配電子体のn−結合スルホンアミド
|
US6429215B1
(en)
|
1998-06-03 |
2002-08-06 |
Gpi Nil Holdings, Inc. |
N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
|
US6331537B1
(en)
|
1998-06-03 |
2001-12-18 |
Gpi Nil Holdings, Inc. |
Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
|
US6172087B1
(en)
|
1998-06-03 |
2001-01-09 |
Gpi Nil Holding, Inc. |
N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
|
CA2334204A1
(en)
|
1998-06-03 |
1999-12-09 |
Gpi Nil Holdings, Inc. |
Heterocyclic ester and amide hair growth compositions and uses
|
KR20010052557A
(ko)
*
|
1998-06-05 |
2001-06-25 |
로즈 암스트롱, 크리스틴 에이. 트러트웨인 |
산화마그네슘을 사용한, ace 억제제 함유 조성물의안정화
|
JP4405675B2
(ja)
*
|
1998-07-21 |
2010-01-27 |
株式会社カネカ |
N−(1(s)−エトキシカルボニル−3−フェニルプロピル)−l−アラニル−l−プロリンのマレイン酸塩の晶出方法
|
US6395758B1
(en)
|
1998-08-14 |
2002-05-28 |
Gpi Nil Holdings, Inc. |
Small molecule carbamates or ureas for vision and memory disorders
|
US6339101B1
(en)
|
1998-08-14 |
2002-01-15 |
Gpi Nil Holdings, Inc. |
N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
|
US6399648B1
(en)
|
1998-08-14 |
2002-06-04 |
Gpi Nil Holdings, Inc. |
N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
|
US7338976B1
(en)
|
1998-08-14 |
2008-03-04 |
Gpi Nil Holdings, Inc. |
Heterocyclic esters or amides for vision and memory disorders
|
US6337340B1
(en)
|
1998-08-14 |
2002-01-08 |
Gpi Nil Holdings, Inc. |
Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
|
US6376517B1
(en)
|
1998-08-14 |
2002-04-23 |
Gpi Nil Holdings, Inc. |
Pipecolic acid derivatives for vision and memory disorders
|
US6333340B1
(en)
|
1998-08-14 |
2001-12-25 |
Gpi Nil Holdings, Inc. |
Small molecule sulfonamides for vision and memory disorders
|
US6218423B1
(en)
|
1998-08-14 |
2001-04-17 |
Gpi Nil Holdings, Inc. |
Pyrrolidine derivatives for vision and memory disorders
|
US6335348B1
(en)
|
1998-08-14 |
2002-01-01 |
Gpi Nil Holdings, Inc. |
Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
|
US6384056B1
(en)
|
1998-08-14 |
2002-05-07 |
Gpi Nil Holdings, Inc. |
Heterocyclic thioesters or ketones for vision and memory disorders
|
US6506788B1
(en)
|
1998-08-14 |
2003-01-14 |
Gpi Nil Holdings, Inc. |
N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
|
US6191144B1
(en)
|
1998-08-17 |
2001-02-20 |
Warner-Lambert Company |
Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis
|
US6462072B1
(en)
|
1998-09-21 |
2002-10-08 |
Gpi Nil Holdings, Inc. |
Cyclic ester or amide derivatives
|
CN1324234A
(zh)
*
|
1998-09-25 |
2001-11-28 |
格利科克斯有限公司 |
果糖胺氧化酶,拮抗剂和抑制剂
|
EP1115842A4
(en)
*
|
1998-09-25 |
2002-08-21 |
Glycox Corp Ltd |
DETERMINATION OF FRUCTOSAMINE OXIDASE: METHODS AND SUBSTANCES
|
NZ333206A
(en)
|
1998-12-08 |
2000-07-28 |
Bernard Charles Sherman |
Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
|
US6048874A
(en)
*
|
1999-01-26 |
2000-04-11 |
Medeva Pharmaceuticals Manufacturing, Inc. |
Parenteral metolazone formulations
|
US6555139B2
(en)
|
1999-06-28 |
2003-04-29 |
Wockhardt Europe Limited |
Preparation of micron-size pharmaceutical particles by microfluidization
|
EP1216037A2
(en)
*
|
1999-09-21 |
2002-06-26 |
Emory University |
Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
|
US20030113330A1
(en)
*
|
1999-11-08 |
2003-06-19 |
Uhal Bruce D. |
Methods for treating pulmonary fibrosis
|
US6569456B2
(en)
|
2000-01-13 |
2003-05-27 |
Osmotica Corp. |
Osmotic device containing diltiazem and an ACE inhibitor or diuretic
|
BR0108077A
(pt)
*
|
2000-02-04 |
2002-10-22 |
Children S Hospital Res Founda |
Processo para reduzir placas ateroscleróticas em um mamìfero, método para tratamento da aterosclerose em um mamìfero, composição, métodos para prover proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo ou mistura deles, para células de um mamìfero tendo deficiência na proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo , para prover lipase de ácido lisossomal biologicamente ativa para células de um mamìfero tendo deficiência de lipase de ácido lisossomal biologicamente ativa, para prover lipase de ácido lisossoal biologicamente ativa para células de um mamìfero com aterosclerose, para tratamento da doença de wolman em um mamìfero, para tratamento de doença de armazenagem de colesteril éster em um mamìfero, e, para tratamento da aterosclerose em um mamìfero
|
US6635277B2
(en)
|
2000-04-12 |
2003-10-21 |
Wockhardt Limited |
Composition for pulsatile delivery of diltiazem and process of manufacture
|
ES2375268T3
(es)
|
2000-12-14 |
2012-02-28 |
The Brigham And Women's Hospital, Inc. |
Marcadores inflamatorios para la detección y prevención de diabetes mellitus.
|
US6627760B1
(en)
|
2001-06-25 |
2003-09-30 |
Astrazeneca Ab |
Amorphous compound
|
US6462174B1
(en)
|
2001-06-25 |
2002-10-08 |
Astrazeneca Ab |
Amorphous compound
|
US6458769B1
(en)
|
2001-06-25 |
2002-10-01 |
Astrazeneca Ab |
Amorphous compound
|
AU2002348276A1
(en)
*
|
2001-11-16 |
2003-06-10 |
Bristol-Myers Squibb Company |
Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
|
SI21101A
(sl)
*
|
2001-11-26 |
2003-06-30 |
LEK farmacevtska dru�ba d.d. |
Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo
|
US20030215526A1
(en)
*
|
2002-03-08 |
2003-11-20 |
Scott Stofik |
Stable formulations of angiotensin converting enzyme (ACE) inhibitors
|
WO2003077901A1
(en)
*
|
2002-03-08 |
2003-09-25 |
Protemix Corporation Limited |
Preventing and/or treating cardiovascular disease and/or associated heart failure
|
EP3072978B1
(en)
|
2002-05-09 |
2018-07-11 |
The Brigham and Women's Hospital, Inc. |
1l1rl-1 as a cardiovascular disease marker
|
DE60213880T2
(de)
*
|
2002-06-19 |
2007-01-18 |
Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. |
Verfahren zur herstellung von lisinopril
|
CN1681495B
(zh)
|
2002-08-19 |
2010-05-12 |
辉瑞产品公司 |
用于治疗过度增生性疾病的组合物
|
JP2006503014A
(ja)
|
2002-08-20 |
2006-01-26 |
プロテミックス コーポレイション リミティド |
剤形及び関連する治療法
|
CA2498757A1
(en)
*
|
2002-09-11 |
2004-03-25 |
Toaeiyo Ltd. |
Proline ester and preparation containing the same for percutaneous administration
|
US20040110241A1
(en)
*
|
2002-12-06 |
2004-06-10 |
Segal Mark S. |
Materials and methods for monitoring vascular endothelial function
|
US20070218139A1
(en)
*
|
2002-12-20 |
2007-09-20 |
Smith Thomas J |
High Pressure Compaction For Pharmaceutical Formulations
|
CL2004000366A1
(es)
*
|
2003-02-26 |
2005-01-07 |
Pharmacia Corp Sa Organizada B |
USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
|
CL2004000544A1
(es)
*
|
2003-03-18 |
2005-01-28 |
Pharmacia Corp Sa Organizada B |
Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati
|
US20060252120A1
(en)
*
|
2003-05-09 |
2006-11-09 |
Kieliszewski Marcia J |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
KR20110117731A
(ko)
|
2003-05-30 |
2011-10-27 |
랜박시 래보러터리스 리미티드 |
치환된 피롤 유도체와 hmg―co 억제제로서의 이의 용도
|
US7459474B2
(en)
*
|
2003-06-11 |
2008-12-02 |
Bristol-Myers Squibb Company |
Modulators of the glucocorticoid receptor and method
|
US20040265238A1
(en)
*
|
2003-06-27 |
2004-12-30 |
Imtiaz Chaudry |
Inhalable formulations for treating pulmonary hypertension and methods of using same
|
WO2005009446A1
(en)
*
|
2003-07-17 |
2005-02-03 |
Cotherix, Inc. |
Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
|
US20060089374A1
(en)
*
|
2003-07-17 |
2006-04-27 |
Glenn Cornett |
Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
|
US20050037063A1
(en)
*
|
2003-07-21 |
2005-02-17 |
Bolton Anthony E. |
Combined therapies
|
AU2004315596B2
(en)
|
2003-08-29 |
2011-11-24 |
President And Fellows Of Harvard College |
Inhibitors of cellular necrosis
|
US7371759B2
(en)
*
|
2003-09-25 |
2008-05-13 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
US20050153885A1
(en)
*
|
2003-10-08 |
2005-07-14 |
Yun Anthony J. |
Treatment of conditions through modulation of the autonomic nervous system
|
US7420059B2
(en)
*
|
2003-11-20 |
2008-09-02 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
ATE546734T1
(de)
|
2003-12-05 |
2012-03-15 |
Cleveland Clinic Foundation |
Risikomarker für eine herzkreislaufkrankheit
|
AU2004298393A1
(en)
*
|
2003-12-19 |
2005-06-30 |
Protemix Corporation Limited |
Copper antagonist compounds
|
NZ548513A
(en)
*
|
2004-01-14 |
2010-05-28 |
Univ Ohio |
Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
|
EP1751177A4
(en)
*
|
2004-04-19 |
2008-07-16 |
Univ Ohio |
NETWORKABLE GLYCOPROTEINS AND METHOD FOR THEIR PRODUCTION
|
US7803838B2
(en)
*
|
2004-06-04 |
2010-09-28 |
Forest Laboratories Holdings Limited |
Compositions comprising nebivolol
|
ES2449066T3
(es)
|
2004-07-19 |
2014-03-18 |
Philera New Zealand Limited |
Síntesis de trietilentetraminas
|
US9164104B2
(en)
|
2004-10-06 |
2015-10-20 |
The Brigham And Women's Hospital, Inc. |
Relevance of achieved levels of markers of systemic inflammation following treatment
|
JP2008528626A
(ja)
*
|
2005-01-31 |
2008-07-31 |
マイラン ラボラトリーズ インク. |
ヒドロキシル化されたネビボロールを含む薬学的組成物
|
EP1899365B1
(en)
*
|
2005-05-27 |
2012-09-12 |
University of Cape Town |
Angiotensin i-converting enzyme (ace) inhibitors
|
EP1982711A1
(en)
|
2005-05-31 |
2008-10-22 |
Mylan Laboratories, Inc |
Compositions comprsing nebivolol
|
US20080242834A1
(en)
*
|
2005-07-08 |
2008-10-02 |
Ohio University |
Methods of Predicting Hyp-Glycosylation Sites For Proteins Expressed and Secreted in Plant Cells, and Related Methods and Products
|
US20090297496A1
(en)
*
|
2005-09-08 |
2009-12-03 |
Childrens Hospital Medical Center |
Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
|
US8119358B2
(en)
|
2005-10-11 |
2012-02-21 |
Tethys Bioscience, Inc. |
Diabetes-related biomarkers and methods of use thereof
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
AU2006313430B2
(en)
|
2005-11-08 |
2012-09-06 |
Ranbaxy Laboratories Limited |
Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
US7592461B2
(en)
|
2005-12-21 |
2009-09-22 |
Bristol-Myers Squibb Company |
Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
|
WO2007097951A2
(en)
*
|
2006-02-17 |
2007-08-30 |
Nitromed, Inc. |
Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
|
CA2646598C
(en)
*
|
2006-03-21 |
2014-08-19 |
Amylin Pharmaceuticals, Inc. |
Peptide-peptidase inhibitor conjugates and methods of using same
|
US20070238770A1
(en)
*
|
2006-04-05 |
2007-10-11 |
Bristol-Myers Squibb Company |
Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
|
US20080057590A1
(en)
|
2006-06-07 |
2008-03-06 |
Mickey Urdea |
Markers associated with arteriovascular events and methods of use thereof
|
WO2008057862A2
(en)
|
2006-11-01 |
2008-05-15 |
Bristol-Myers Squibb Company |
MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
|
EP2099767A1
(en)
|
2006-11-01 |
2009-09-16 |
Brystol-Myers Squibb Company |
Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof
|
JP5498168B2
(ja)
|
2006-12-01 |
2014-05-21 |
ブリストル−マイヤーズ スクイブ カンパニー |
アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体
|
WO2008131224A2
(en)
|
2007-04-18 |
2008-10-30 |
Tethys Bioscience, Inc. |
Diabetes-related biomarkers and methods of use thereof
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
MX354786B
(es)
|
2007-06-04 |
2018-03-21 |
Synergy Pharmaceuticals Inc |
Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
|
EP2195034A2
(en)
*
|
2007-09-27 |
2010-06-16 |
Amylin Pharmaceuticals, Inc. |
Peptide-peptidase inhibitor conjugates and methods of making and using same
|
EP2211906A2
(en)
*
|
2007-11-07 |
2010-08-04 |
Janssen Pharmaceutica, N.V. |
Combination therapy comprising angiotensin converting enzyme inhibitors and vasopressin receptor antagonists
|
US7828840B2
(en)
*
|
2007-11-15 |
2010-11-09 |
Med Institute, Inc. |
Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
|
CA2726917C
(en)
|
2008-06-04 |
2018-06-26 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
GB2460915B
(en)
|
2008-06-16 |
2011-05-25 |
Biovascular Inc |
Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
|
WO2010009319A2
(en)
|
2008-07-16 |
2010-01-21 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
SI23149A
(sl)
|
2009-09-21 |
2011-03-31 |
Silverstone Pharma |
Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
|
US8119817B2
(en)
*
|
2009-09-29 |
2012-02-21 |
Degussa-Huels Ag |
Process for separating the diastereomers of RSS-and SSS-N- α [1-carboxy-3-phenylpropyl] lysylproline
|
EP2531163A1
(en)
|
2010-02-01 |
2012-12-12 |
The Hospital For Sick Children |
Remote ischemic conditioning for treatment and preventon of restenosis
|
CA2795053A1
(en)
|
2010-03-31 |
2011-10-06 |
The Hospital For Sick Children |
Use of remote ischemic conditioning to improve outcome after myocardial infarction
|
US9393025B2
(en)
|
2010-04-08 |
2016-07-19 |
The Hospital For Sick Children |
Use of remote ischemic conditioning for traumatic injury
|
WO2011161223A2
(en)
|
2010-06-23 |
2011-12-29 |
Krka, Tovarna Zdravil, D.D., Novo Mesto |
Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
AR084290A1
(es)
|
2010-12-15 |
2013-05-08 |
Theravance Inc |
Inhibidores de neprilisina, metodos para su preparacion e intermediarios utilizados en los mismos, composiciones farmaceuticas que los comprenden y su uso en la fabricacion de medicamentos para tratar enfermedades mediadas por la inhibicion de nep
|
CA2817368C
(en)
|
2010-12-15 |
2019-12-31 |
Theravance, Inc. |
Neprilysin inhibitors
|
SI2654729T1
(sl)
|
2010-12-24 |
2016-08-31 |
Krka, D.D., Novo Mesto |
Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino
|
ES2582640T3
(es)
|
2011-02-17 |
2016-09-14 |
Theravance Biopharma R&D Ip, Llc |
Derivados aminobutíricos sustituidos como inhibidores de neprilisina
|
US8449890B2
(en)
|
2011-02-17 |
2013-05-28 |
Theravance, Inc. |
Neprilysin inhibitors
|
CN103748070B
(zh)
|
2011-05-31 |
2015-06-24 |
施万生物制药研发Ip有限责任公司 |
脑啡肽酶抑制剂
|
ES2699773T3
(es)
|
2011-05-31 |
2019-02-12 |
Theravance Biopharma R&D Ip Llc |
Inhibidores de neprilisina
|
CA2835216A1
(en)
|
2011-05-31 |
2012-12-06 |
Theravance, Inc. |
Neprilysin inhibitors
|
WO2013012945A1
(en)
|
2011-07-18 |
2013-01-24 |
Critical Care Diagnostics, Inc. |
Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy
|
CN103906508A
(zh)
|
2011-08-26 |
2014-07-02 |
沃克哈特有限公司 |
治疗心血管疾病的方法
|
TWI560172B
(en)
|
2011-11-02 |
2016-12-01 |
Theravance Biopharma R&D Ip Llc |
Neprilysin inhibitors
|
EP2855458B1
(en)
|
2012-05-11 |
2018-08-08 |
Reset Therapeutics, Inc. |
Carbazole-containing sulfonamides as cryptochrome modulators
|
CN104350052B
(zh)
|
2012-05-31 |
2017-05-31 |
施万生物制药研发Ip有限责任公司 |
一氧化氮供体脑啡肽酶抑制剂
|
PT2864292T
(pt)
|
2012-06-08 |
2017-07-10 |
Theravance Biopharma R&D Ip Llc |
Inibidores de neprisilina
|
US8871792B2
(en)
|
2012-06-08 |
2014-10-28 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
ES2786506T3
(es)
|
2012-08-01 |
2020-10-13 |
Zahra Tavakoli |
Composiciones congeladas fluidas que comprenden un agente terapéutico
|
US9126956B2
(en)
|
2012-08-08 |
2015-09-08 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
US8568747B1
(en)
|
2012-10-05 |
2013-10-29 |
Silvergate Pharmaceuticals, Inc. |
Enalapril compositions
|
CA2902456A1
(en)
|
2013-03-05 |
2014-09-12 |
Theravance Biopharma R&D Ip, Llc |
Neprilysin inhibitors
|
WO2014151200A2
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
EP2968276A4
(en)
|
2013-03-15 |
2017-02-15 |
President and Fellows of Harvard College |
Hybrid necroptosis inhibitors
|
EP2970384A1
(en)
|
2013-03-15 |
2016-01-20 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
EP2976062B1
(en)
|
2013-03-21 |
2021-11-03 |
Eupraxia Pharmaceuticals USA LLC |
Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
|
EP2986599A1
(en)
|
2013-04-17 |
2016-02-24 |
Pfizer Inc. |
N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
|
JP6606491B2
(ja)
|
2013-06-05 |
2019-11-13 |
シナジー ファーマシューティカルズ インコーポレイテッド |
グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法
|
WO2015027021A1
(en)
|
2013-08-22 |
2015-02-26 |
Bristol-Myers Squibb Company |
Imide and acylurea derivatives as modulators of the glucocorticoid receptor
|
MX2016009760A
(es)
|
2014-01-30 |
2016-11-08 |
Theravance Biopharma R&D Ip Llc |
Inhibidores de neprilisina.
|
RU2016135057A
(ru)
|
2014-01-30 |
2018-03-12 |
ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи |
Производные 5-бифенил-4-гетероарилкарбониламинопентановой кислоты в качестве ингибиторов неприлизина
|
TWI690521B
(zh)
|
2014-04-07 |
2020-04-11 |
美商同步製藥公司 |
作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
|
US20170165315A1
(en)
|
2014-07-31 |
2017-06-15 |
Pharmathen S.A. |
Orodispersible film composition comprising enalapril for the treatment of hypertension in a pediatric population
|
WO2016055901A1
(en)
|
2014-10-08 |
2016-04-14 |
Pfizer Inc. |
Substituted amide compounds
|
MY187899A
(en)
|
2015-02-11 |
2021-10-27 |
Theravance Biopharma R&D Ip Llc |
(2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor
|
HUE052732T2
(hu)
|
2015-02-19 |
2021-05-28 |
Theravance Biopharma R&D Ip Llc |
(2R,4R)-5-(5'-klór-2'-fluorbifenil-4-il)-2-hidroxi-4-[(5-metiloxazol-2-karbonil)amino]pentánsav
|
CN108289857A
(zh)
|
2015-10-27 |
2018-07-17 |
优普顺药物公司 |
局部麻醉药的持续释放制剂
|
US9463183B1
(en)
|
2015-10-30 |
2016-10-11 |
Silvergate Pharmaceuticals, Inc. |
Lisinopril formulations
|
CA3015505C
(en)
|
2016-03-08 |
2024-03-05 |
Theravance Biopharma R&D Ip, Llc |
Crystalline (2s,4r)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof
|
US9669008B1
(en)
|
2016-03-18 |
2017-06-06 |
Silvergate Pharmaceuticals, Inc. |
Enalapril formulations
|
WO2018097999A1
(en)
*
|
2016-11-23 |
2018-05-31 |
The Regents Of The University Of California |
Compositions and methods for modulating protease activity
|
CA3080193A1
(en)
*
|
2017-10-26 |
2019-05-02 |
Southern Research Institute |
Dipeptide analogs as tgf-beta inhibitors
|
CN109734775A
(zh)
*
|
2018-12-31 |
2019-05-10 |
辰欣药业股份有限公司 |
一种马来酸依那普利的精制方法
|
BR112021013807A2
(pt)
|
2019-01-18 |
2021-11-30 |
Astrazeneca Ab |
Inibidores de pcsk9 e seus métodos de uso
|
US20240124520A1
(en)
*
|
2019-10-16 |
2024-04-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
N-acylated histidine dipeptides as anticancer agents
|
GB2595203A
(en)
|
2020-03-03 |
2021-11-24 |
Alkaloid Ad Skopje |
Formulation
|