BR112014001283A2 - métodos de tratamento de doenças cardiovasculares e prevenção da eficácia da terapia de exercício - Google Patents

métodos de tratamento de doenças cardiovasculares e prevenção da eficácia da terapia de exercício

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Publication number
BR112014001283A2
BR112014001283A2 BR112014001283A BR112014001283A BR112014001283A2 BR 112014001283 A2 BR112014001283 A2 BR 112014001283A2 BR 112014001283 A BR112014001283 A BR 112014001283A BR 112014001283 A BR112014001283 A BR 112014001283A BR 112014001283 A2 BR112014001283 A2 BR 112014001283A2
Authority
BR
Brazil
Prior art keywords
cardiovascular disease
subject
exercise therapy
individual
therapy
Prior art date
Application number
BR112014001283A
Other languages
English (en)
Inventor
V Snider James
W Gerwien Robert
Original Assignee
Critical Care Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Critical Care Diagnostics Inc filed Critical Critical Care Diagnostics Inc
Publication of BR112014001283A2 publication Critical patent/BR112014001283A2/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

abstract methods of treating a subject having a cardiovascular disease, selecting a therapy for a subject having a cardiovascular disease, identifying a subject having a cardiovascular disease that will benefit or not benefit from exercise therapy, determining whether a subject having a cardiovascular disease should begin, continue, not begin, discontinue, or avoid exercise therapy, determining whether a subject having a cardiovascular disease should continue, discontinue, or avoid exercise therapy, reducing the risk of an adverse outcome (e.g., death) in a subject having a cardiovascular disease, and predicting the efficacy of exercise therapy in a subject having a cardiovascular disease. these methods include determining a level of soluble st2 in a subject. ----------------------------------------------------------------------------- tradução do resumo resumo patente de invenção: "métodos de tratamento de doenças cardiovasculares e prevenção da eficácia da terapia de exercício". a presente invenção refere-se aos métodos de tratamento de um indivíduo que tem uma doença cardiovascular, a seleção de uma terapia para um paciente portador de uma doença cardiovascular, a identificação de um indivíduo com uma doença cardiovascular que irá beneficiar ou não beneficiar da terapia de exercício, determinar se um indivíduo com uma doença cardiovascular deve começar, continuar, não começar, interromper ou evitar a terapia de exercícios, determinar se um indivíduo que tem uma doença cardiovascular deve continuar, interromper ou evitar a terapia de exercício, reduzindo o risco de um resultado adverso (por exemplo, morte) em um indi-víduo que tem uma doença cardiovascular, e predizer a eficácia da terapia de exercício em um indivíduo com uma doença cardiovascular. estes métodos incluem a determinação de um nível de st2 solúvel em um indivíduo.
BR112014001283A 2011-07-18 2012-07-18 métodos de tratamento de doenças cardiovasculares e prevenção da eficácia da terapia de exercício BR112014001283A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161508923P 2011-07-18 2011-07-18
US201161509359P 2011-07-19 2011-07-19
PCT/US2012/047238 WO2013012945A1 (en) 2011-07-18 2012-07-18 Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy

Publications (1)

Publication Number Publication Date
BR112014001283A2 true BR112014001283A2 (pt) 2017-02-21

Family

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Family Applications (1)

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BR112014001283A BR112014001283A2 (pt) 2011-07-18 2012-07-18 métodos de tratamento de doenças cardiovasculares e prevenção da eficácia da terapia de exercício

Country Status (13)

Country Link
US (5) US8748110B2 (pt)
EP (2) EP2734222B1 (pt)
JP (2) JP6134316B2 (pt)
CN (2) CN103796669B (pt)
AU (2) AU2012284039B2 (pt)
BR (1) BR112014001283A2 (pt)
CA (1) CA2842072A1 (pt)
DK (1) DK2734222T3 (pt)
ES (1) ES2611403T3 (pt)
HK (1) HK1198125A1 (pt)
MX (1) MX351428B (pt)
PL (1) PL2734222T3 (pt)
WO (1) WO2013012945A1 (pt)

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Also Published As

Publication number Publication date
AU2012284039B2 (en) 2017-03-30
EP3173093A1 (en) 2017-05-31
US20130071404A1 (en) 2013-03-21
US8748110B2 (en) 2014-06-10
CA2842072A1 (en) 2013-01-24
EP2734222B1 (en) 2016-10-19
AU2012284039A1 (en) 2014-02-06
US20190049444A1 (en) 2019-02-14
US20170122942A1 (en) 2017-05-04
MX351428B (es) 2017-10-13
CN103796669A (zh) 2014-05-14
CN106908604A (zh) 2017-06-30
CN103796669B (zh) 2016-11-09
AU2017204261B2 (en) 2018-09-06
JP6134316B2 (ja) 2017-05-24
AU2017204261A1 (en) 2017-07-13
US10928393B2 (en) 2021-02-23
CN106908604B (zh) 2019-01-29
EP3173093B1 (en) 2018-12-05
PL2734222T3 (pl) 2017-03-31
WO2013012945A1 (en) 2013-01-24
JP2017194469A (ja) 2017-10-26
JP2014529059A (ja) 2014-10-30
DK2734222T3 (en) 2017-01-30
JP6416974B2 (ja) 2018-10-31
MX2014000715A (es) 2014-02-20
EP2734222A4 (en) 2015-04-15
US20140286944A1 (en) 2014-09-25
EP2734222A1 (en) 2014-05-28
US20210164976A1 (en) 2021-06-03
ES2611403T3 (es) 2017-05-08
HK1198125A1 (en) 2015-03-13
US9551708B2 (en) 2017-01-24

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