NL300287I2 - Beta-amino tetrahydroimidazo(1,2-A)pyrazines en tetrehydrotriazolo(4,3-A)pyrazines als dipeptidyl peptidaseremmers voor de behandeling of preventie van diabetes - Google Patents

Beta-amino tetrahydroimidazo(1,2-A)pyrazines en tetrehydrotriazolo(4,3-A)pyrazines als dipeptidyl peptidaseremmers voor de behandeling of preventie van diabetes

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Publication number
NL300287I2
NL300287I2 NL300287C NL300287C NL300287I2 NL 300287 I2 NL300287 I2 NL 300287I2 NL 300287 C NL300287 C NL 300287C NL 300287 C NL300287 C NL 300287C NL 300287 I2 NL300287 I2 NL 300287I2
Authority
NL
Netherlands
Prior art keywords
pyrazines
diabetes
prevention
dipeptidyl peptidase
treatment
Prior art date
Application number
NL300287C
Other languages
English (en)
Dutch (nl)
Other versions
NL300287I1 (nl
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300287(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NL300287I1 publication Critical patent/NL300287I1/nl
Publication of NL300287I2 publication Critical patent/NL300287I2/nl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/28—Antiandrogens
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
NL300287C 2001-07-06 2007-08-16 Beta-amino tetrahydroimidazo(1,2-A)pyrazines en tetrehydrotriazolo(4,3-A)pyrazines als dipeptidyl peptidaseremmers voor de behandeling of preventie van diabetes NL300287I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (2)

Publication Number Publication Date
NL300287I1 NL300287I1 (nl) 2007-10-01
NL300287I2 true NL300287I2 (nl) 2009-04-01

Family

ID=23172273

Family Applications (2)

Application Number Title Priority Date Filing Date
NL300287C NL300287I2 (nl) 2001-07-06 2007-08-16 Beta-amino tetrahydroimidazo(1,2-A)pyrazines en tetrehydrotriazolo(4,3-A)pyrazines als dipeptidyl peptidaseremmers voor de behandeling of preventie van diabetes
NL300357C NL300357I2 (nl) 2001-07-06 2008-08-15 Beta-amino tetrahydroimidazo (1,2-A)pyrazines en

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL300357C NL300357I2 (nl) 2001-07-06 2008-08-15 Beta-amino tetrahydroimidazo (1,2-A)pyrazines en

Country Status (45)

Country Link
US (9) US7125873B2 (h)
EP (4) EP2292232B1 (h)
JP (1) JP3762407B2 (h)
KR (1) KR100606871B1 (h)
CN (2) CN1861077A (h)
AR (1) AR036114A1 (h)
AT (2) ATE321048T1 (h)
AU (1) AU2002320303B2 (h)
BE (1) BE2007C047I2 (h)
BG (1) BG108493A (h)
BR (1) BRPI0210866B8 (h)
CA (1) CA2450740C (h)
CR (1) CR7235A (h)
CY (3) CY2007019I2 (h)
DE (4) DE122007000056I1 (h)
DK (2) DK1625847T3 (h)
DO (1) DOP2002000438A (h)
EA (2) EA012701B1 (h)
EC (1) ECSP044935A (h)
ES (2) ES2344846T3 (h)
FR (2) FR07C0041I2 (h)
GE (2) GEP20063734B (h)
HR (1) HRP20031098B1 (h)
HU (2) HU225695B1 (h)
IL (3) IL159109A0 (h)
IS (2) IS2218B (h)
JO (1) JO2230B1 (h)
LT (1) LTC1412357I2 (h)
LU (2) LUC91360I2 (h)
MA (1) MA27053A1 (h)
ME (1) ME00439B (h)
MX (1) MXPA04000018A (h)
MY (1) MY127961A (h)
NL (2) NL300287I2 (h)
NO (4) NO321999B1 (h)
NZ (1) NZ529833A (h)
PE (1) PE20030654A1 (h)
PL (1) PL196278B6 (h)
PT (2) PT1625847E (h)
RS (1) RS50737B (h)
SI (1) SI1412357T1 (h)
TW (1) TWI226331B (h)
UA (1) UA74912C2 (h)
WO (1) WO2003004498A1 (h)
ZA (1) ZA200309294B (h)

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