KR102616429B1 - 암 치료에 사용하기 위한 항-cd123 키메라 항원 수용체 (car) - Google Patents

암 치료에 사용하기 위한 항-cd123 키메라 항원 수용체 (car) Download PDF

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KR102616429B1
KR102616429B1 KR1020177007130A KR20177007130A KR102616429B1 KR 102616429 B1 KR102616429 B1 KR 102616429B1 KR 1020177007130 A KR1020177007130 A KR 1020177007130A KR 20177007130 A KR20177007130 A KR 20177007130A KR 102616429 B1 KR102616429 B1 KR 102616429B1
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seq
amino acid
acid sequence
cells
cell
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KR20170039307A (ko
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제니퍼 브로그돈
사르 길
데이비드 글래스
사드 켄더리안
안드레아스 뢰브
조안 마닉
마이클 밀론
레온 머피
데이비드 엘. 포터
마르코 루엘라
용치앙 왕
치롱 우
지콴 장
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노파르티스 아게
더 트러스티스 오브 더 유니버시티 오브 펜실바니아
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K39/44—Antibodies bound to carriers
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
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KR1020177007130A 2014-08-19 2015-08-19 암 치료에 사용하기 위한 항-cd123 키메라 항원 수용체 (car) Active KR102616429B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2014/084696 2014-08-19
CN2014084696 2014-08-19
CN2014090508 2014-11-06
CNPCT/CN2014/090508 2014-11-06
PCT/US2015/045898 WO2016028896A1 (en) 2014-08-19 2015-08-19 Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment

Publications (2)

Publication Number Publication Date
KR20170039307A KR20170039307A (ko) 2017-04-10
KR102616429B1 true KR102616429B1 (ko) 2023-12-26

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KR1020177007130A Active KR102616429B1 (ko) 2014-08-19 2015-08-19 암 치료에 사용하기 위한 항-cd123 키메라 항원 수용체 (car)

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US (4) US9815901B2 (enExample)
EP (2) EP3183268B1 (enExample)
JP (2) JP7084138B2 (enExample)
KR (1) KR102616429B1 (enExample)
CN (2) CN107108744B (enExample)
AU (2) AU2015305531B2 (enExample)
CA (1) CA2958553A1 (enExample)
CO (1) CO2017001573A2 (enExample)
DK (1) DK3183268T3 (enExample)
ES (1) ES2791248T3 (enExample)
HU (1) HUE049218T2 (enExample)
IL (2) IL250362B (enExample)
LT (1) LT3183268T (enExample)
MX (1) MX2017002205A (enExample)
MY (1) MY189028A (enExample)
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PT (1) PT3183268T (enExample)
RU (2) RU2724999C2 (enExample)
SG (1) SG11201700770PA (enExample)
TW (2) TW202140557A (enExample)
WO (1) WO2016028896A1 (enExample)

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