TW202140557A - 使用cd123嵌合抗原受體治療癌症 - Google Patents

使用cd123嵌合抗原受體治療癌症 Download PDF

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TW202140557A
TW202140557A TW110102298A TW110102298A TW202140557A TW 202140557 A TW202140557 A TW 202140557A TW 110102298 A TW110102298 A TW 110102298A TW 110102298 A TW110102298 A TW 110102298A TW 202140557 A TW202140557 A TW 202140557A
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seq
amino acid
acid sequence
car
cells
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TW110102298A
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珍妮佛 布洛格登
莎兒 奇爾
大衛 葛萊斯
薩德 肯德雷恩
安卓斯 羅伊
瓊安 曼尼克
麥克 C 米隆
里昂 墨菲
大衛 波特
瑪寇 魯拉
王永強
期隆 吳
張繼全
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瑞士商諾華公司
賓夕法尼亞大學董事會
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2319/00Fusion polypeptide
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    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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TW110102298A 2014-08-19 2015-08-19 使用cd123嵌合抗原受體治療癌症 TW202140557A (zh)

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Application Number Priority Date Filing Date Title
CN2014084696 2014-08-19
WOPCT/CN2014/084696 2014-08-19
CN2014090508 2014-11-06
WOPCT/CN2014/090508 2014-11-06

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