JP7084138B2 - 癌処置に使用するための抗ｃｄ１２３キメラ抗原受容体（ｃａｒ） - Google Patents

癌処置に使用するための抗ｃｄ１２３キメラ抗原受容体（ｃａｒ） Download PDF

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JP7084138B2
JP7084138B2 JP2017509621A JP2017509621A JP7084138B2 JP 7084138 B2 JP7084138 B2 JP 7084138B2 JP 2017509621 A JP2017509621 A JP 2017509621A JP 2017509621 A JP2017509621 A JP 2017509621A JP 7084138 B2 JP7084138 B2 JP 7084138B2
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amino acid
acid sequence
cells
car
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JP2017530694A5 (enExample
JP2017530694A (ja
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ジェニファー・ブログドン
サール・ギル
デイビッド・グラス
サード・ケンデリアン
アンドレアス・レーヴ
ジョアン・マニック
マイケル・ミローン
レオン・マーフィー
デイビッド・エル・ポーター
マルコ・ルエラ
ワン・ヨンチアン
チーロン・ウー
ジャン・ジーチュエン
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ノバルティス アーゲー
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K39/44—Antibodies bound to carriers
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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JP2017509621A 2014-08-19 2015-08-19 癌処置に使用するための抗ｃｄ１２３キメラ抗原受容体（ｃａｒ） Active JP7084138B2 (ja)

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JP2021121574A JP2021184715A (ja) 2014-08-19 2021-07-26 癌処置に使用するための抗ｃｄ１２３キメラ抗原受容体（ｃａｒ）

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CN2014084696 2014-08-19
CNPCT/CN2014/084696 2014-08-19
CNPCT/CN2014/090508 2014-11-06
CN2014090508 2014-11-06
PCT/US2015/045898 WO2016028896A1 (en) 2014-08-19 2015-08-19 Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment

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JP2021121574A Division JP2021184715A (ja) 2014-08-19 2021-07-26 癌処置に使用するための抗ｃｄ１２３キメラ抗原受容体（ｃａｒ）

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JP2017530694A JP2017530694A (ja) 2017-10-19
JP2017530694A5 JP2017530694A5 (enExample) 2018-09-27
JPWO2016028896A5 JPWO2016028896A5 (enExample) 2022-02-25
JP7084138B2 true JP7084138B2 (ja) 2022-06-14

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JP2021121574A Pending JP2021184715A (ja) 2014-08-19 2021-07-26 癌処置に使用するための抗ｃｄ１２３キメラ抗原受容体（ｃａｒ）

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US (4) US9815901B2 (enExample)
EP (2) EP3712171A1 (enExample)
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KR (1) KR102616429B1 (enExample)
CN (2) CN112410363A (enExample)
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