KR101774121B1 - 이중특이적 항-vegf/항-ang-2 항체 및 안 혈관 질환의 치료에 있어서 이의 용도 - Google Patents

이중특이적 항-vegf/항-ang-2 항체 및 안 혈관 질환의 치료에 있어서 이의 용도 Download PDF

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KR101774121B1
KR101774121B1 KR1020157000528A KR20157000528A KR101774121B1 KR 101774121 B1 KR101774121 B1 KR 101774121B1 KR 1020157000528 A KR1020157000528 A KR 1020157000528A KR 20157000528 A KR20157000528 A KR 20157000528A KR 101774121 B1 KR101774121 B1 KR 101774121B1
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KR20150023688A (ko
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헤럴드 듀어
프랭크 헤르팅
크리스찬 클라인
외르크 레귤라
마티아스 뤼트
카이-군나르 스투벤라우흐
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로슈 글리카트 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Molecular Biology (AREA)
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  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Microbiology (AREA)
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KR1020157000528A 2012-07-13 2013-07-11 이중특이적 항-vegf/항-ang-2 항체 및 안 혈관 질환의 치료에 있어서 이의 용도 Active KR101774121B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12176299 2012-07-13
EP12176299.1 2012-07-13
PCT/EP2013/064672 WO2014009465A1 (en) 2012-07-13 2013-07-11 Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases

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KR20150023688A KR20150023688A (ko) 2015-03-05
KR101774121B1 true KR101774121B1 (ko) 2017-09-01

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US9695233B2 (en) 2017-07-04
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PL2872534T3 (pl) 2018-12-31
CL2017002146A1 (es) 2018-04-13
PH12014502713B1 (en) 2019-11-29
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CA2874554C (en) 2019-12-03
AR124240A2 (es) 2023-03-01
EP3495387B1 (en) 2021-09-01
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US20230212277A1 (en) 2023-07-06
PH12014502713A1 (en) 2015-02-02
JP2020062036A (ja) 2020-04-23
LT3495387T (lt) 2021-11-25
US20140017244A1 (en) 2014-01-16
CA2874554A1 (en) 2014-01-16
ES2896493T3 (es) 2022-02-24
KR20150023688A (ko) 2015-03-05
IN2014DN11157A (enExample) 2015-10-02
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JP2019062905A (ja) 2019-04-25
CO7151542A2 (es) 2014-12-29
PL3495387T3 (pl) 2022-01-10
ES2690312T3 (es) 2018-11-20
MA37794A1 (fr) 2016-03-31
EP2872534A1 (en) 2015-05-20
AU2013288641A1 (en) 2014-12-11
EP3495387A1 (en) 2019-06-12
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JP6154900B2 (ja) 2017-06-28
MY183712A (en) 2021-03-09
NL301218I1 (enExample) 2023-02-15
JP7280859B2 (ja) 2023-05-24
ZA201408969B (en) 2019-04-24
HRP20181595T1 (hr) 2018-12-14
RS57704B1 (sr) 2018-12-31
CN104428315A (zh) 2015-03-18
PE20150361A1 (es) 2015-03-14
US20210095013A1 (en) 2021-04-01
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HK1206365A1 (en) 2016-01-08
JP2021036888A (ja) 2021-03-11
CY1124681T1 (el) 2022-07-22
SI2872534T1 (sl) 2018-11-30
SG11201408538PA (en) 2015-02-27
SMT202100621T1 (it) 2022-01-10
CL2015000061A1 (es) 2015-05-08
US20170260265A1 (en) 2017-09-14
RS62509B1 (sr) 2021-11-30
NL301218I2 (nl) 2023-04-04
MX361337B (es) 2018-12-04
EA201500132A1 (ru) 2015-08-31
CY2023005I2 (el) 2023-06-09
DK3495387T3 (da) 2021-11-08
SI3495387T1 (sl) 2021-12-31
HRP20211641T1 (hr) 2022-02-04
IL236292B (en) 2020-06-30
MA37794B1 (fr) 2017-07-31
TW201406782A (zh) 2014-02-16
CN104428315B (zh) 2017-09-29

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