CY2023005I1 - Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων - Google Patents

Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων

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Publication number
CY2023005I1
CY2023005I1 CY2023005C CY2023005C CY2023005I1 CY 2023005 I1 CY2023005 I1 CY 2023005I1 CY 2023005 C CY2023005 C CY 2023005C CY 2023005 C CY2023005 C CY 2023005C CY 2023005 I1 CY2023005 I1 CY 2023005I1
Authority
CY
Cyprus
Prior art keywords
ophular
ang
vegf
treatment
bispecific antibodies
Prior art date
Application number
CY2023005C
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English (en)
Other versions
CY2023005I2 (el
Original Assignee
F. Hoffmann-La Roche Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48783248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2023005(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CY2023005I1 publication Critical patent/CY2023005I1/el
Publication of CY2023005I2 publication Critical patent/CY2023005I2/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
CY2023005C 2012-07-13 2023-02-13 Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων CY2023005I2 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12176299 2012-07-13
PCT/EP2013/064672 WO2014009465A1 (en) 2012-07-13 2013-07-11 Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
EP13736565.6A EP2872534B1 (en) 2012-07-13 2013-07-11 Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases

Publications (2)

Publication Number Publication Date
CY2023005I1 true CY2023005I1 (el) 2023-06-09
CY2023005I2 CY2023005I2 (el) 2023-06-09

Family

ID=48783248

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20211100936T CY1124681T1 (el) 2012-07-13 2021-11-01 Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων
CY2023005C CY2023005I2 (el) 2012-07-13 2023-02-13 Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων

Family Applications Before (1)

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CY20211100936T CY1124681T1 (el) 2012-07-13 2021-11-01 Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων

Country Status (41)

Country Link
US (4) US9695233B2 (el)
EP (2) EP3495387B1 (el)
JP (5) JP6154900B2 (el)
KR (1) KR101774121B1 (el)
CN (1) CN104428315B (el)
AR (2) AR092027A1 (el)
AU (1) AU2013288641B2 (el)
CA (1) CA2874554C (el)
CL (2) CL2015000061A1 (el)
CO (1) CO7151542A2 (el)
CR (1) CR20140542A (el)
CY (2) CY1124681T1 (el)
DK (2) DK2872534T3 (el)
EA (1) EA032192B1 (el)
ES (2) ES2690312T3 (el)
FI (1) FIC20230011I1 (el)
FR (1) FR23C1010I2 (el)
HR (2) HRP20181595T1 (el)
HU (2) HUE056217T2 (el)
IL (1) IL236292B (el)
IN (1) IN2014DN11157A (el)
LT (3) LT2872534T (el)
LU (1) LUC00300I2 (el)
MA (1) MA37794B1 (el)
MX (1) MX361337B (el)
MY (1) MY183712A (el)
NL (1) NL301218I2 (el)
NO (1) NO2023009I1 (el)
NZ (1) NZ702201A (el)
PE (1) PE20150361A1 (el)
PH (1) PH12014502713B1 (el)
PL (2) PL2872534T3 (el)
PT (1) PT2872534T (el)
RS (2) RS57704B1 (el)
SG (1) SG11201408538PA (el)
SI (2) SI2872534T1 (el)
SM (1) SMT202100621T1 (el)
TW (1) TWI506036B (el)
UA (1) UA120029C2 (el)
WO (1) WO2014009465A1 (el)
ZA (1) ZA201408969B (el)

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EP2872534A1 (en) 2015-05-20
LUC00300I2 (el) 2025-09-22
CN104428315A (zh) 2015-03-18
SG11201408538PA (en) 2015-02-27
KR20150023688A (ko) 2015-03-05
US20210095013A1 (en) 2021-04-01
MA37794B1 (fr) 2017-07-31
JP6462750B2 (ja) 2019-01-30
CO7151542A2 (es) 2014-12-29
UA120029C2 (uk) 2019-09-25
PE20150361A1 (es) 2015-03-14
SMT202100621T1 (it) 2022-01-10
IN2014DN11157A (el) 2015-10-02
DK2872534T3 (en) 2018-10-22
LTC2872534I2 (el) 2024-10-25
HRP20181595T1 (hr) 2018-12-14
JP2021036888A (ja) 2021-03-11
PL2872534T3 (pl) 2018-12-31
JP6796184B2 (ja) 2020-12-02
NZ702201A (en) 2018-01-26
AR124240A2 (es) 2023-03-01
FR23C1010I1 (fr) 2023-04-14
DK3495387T3 (da) 2021-11-08
WO2014009465A1 (en) 2014-01-16
AU2013288641B2 (en) 2017-07-06
CN104428315B (zh) 2017-09-29
CY2023005I2 (el) 2023-06-09
FR23C1010I2 (fr) 2024-04-05
JP2019062905A (ja) 2019-04-25
RS57704B1 (sr) 2018-12-31
HUE056217T2 (hu) 2022-02-28
EP3495387A1 (en) 2019-06-12
US20230212277A1 (en) 2023-07-06
TWI506036B (zh) 2015-11-01
JP2017140038A (ja) 2017-08-17
US20170260265A1 (en) 2017-09-14
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EA201500132A1 (ru) 2015-08-31
US10683345B2 (en) 2020-06-16

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