CY1124681T1 - Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων - Google Patents

Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων

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Publication number
CY1124681T1
CY1124681T1 CY20211100936T CY211100936T CY1124681T1 CY 1124681 T1 CY1124681 T1 CY 1124681T1 CY 20211100936 T CY20211100936 T CY 20211100936T CY 211100936 T CY211100936 T CY 211100936T CY 1124681 T1 CY1124681 T1 CY 1124681T1
Authority
CY
Cyprus
Prior art keywords
vegf
ang
ophular
treatment
bispecific antibodies
Prior art date
Application number
CY20211100936T
Other languages
English (en)
Inventor
Harald Duerr
Frank Herting
Christian Klein
Joerg Thomas Regula
Matthias Rueth
Kay-Gunnar Stubenrauch
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48783248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124681(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of CY1124681T1 publication Critical patent/CY1124681T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Η παρούσα εφεύρεση σχετίζεται με διειδικό αντίσωμα έναντι ανθρώπινου αγγειακού ενδοθηλιακού αυξητικού παράγοντα (VEGF/VEGF-A) και έναντι ανθρώπινης αγγειοποιητίνης-2 (ANG-2) υποτάξης ανθρώπινης IgG1 ή IgG4 με μεταλλάξεις 1253Α, Η310Α και Η435Α, με μεθόδους για την παραγωγή τους, φαρμακευτικές συνθέσεις που περιέχουν τα εν λόγω αντισώματα και με χρήσεις αυτών.
CY20211100936T 2012-07-13 2021-11-01 Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων CY1124681T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12176299 2012-07-13
PCT/EP2013/064672 WO2014009465A1 (en) 2012-07-13 2013-07-11 Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
EP13736565.6A EP2872534B1 (en) 2012-07-13 2013-07-11 Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases

Publications (1)

Publication Number Publication Date
CY1124681T1 true CY1124681T1 (el) 2022-07-22

Family

ID=48783248

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100936T CY1124681T1 (el) 2012-07-13 2021-11-01 Διειδικα αντισωματα anti-vegf/anti-ang-2 και η χρηση τους στην αγωγη οφθαλμικων αγγειακων νοσων

Country Status (40)

Country Link
US (4) US9695233B2 (el)
EP (2) EP2872534B1 (el)
JP (5) JP6154900B2 (el)
KR (1) KR101774121B1 (el)
CN (1) CN104428315B (el)
AR (2) AR092027A1 (el)
AU (1) AU2013288641B2 (el)
CA (1) CA2874554C (el)
CL (2) CL2015000061A1 (el)
CO (1) CO7151542A2 (el)
CR (1) CR20140542A (el)
CY (1) CY1124681T1 (el)
DK (2) DK2872534T3 (el)
EA (1) EA032192B1 (el)
ES (2) ES2896493T3 (el)
FI (1) FIC20230011I1 (el)
FR (1) FR23C1010I2 (el)
HK (1) HK1206365A1 (el)
HR (2) HRP20211641T1 (el)
HU (2) HUE056217T2 (el)
IL (1) IL236292B (el)
IN (1) IN2014DN11157A (el)
LT (3) LT2872534T (el)
MA (1) MA37794B1 (el)
MX (1) MX361337B (el)
MY (1) MY183712A (el)
NL (1) NL301218I2 (el)
NO (1) NO2023009I1 (el)
NZ (1) NZ702201A (el)
PE (1) PE20150361A1 (el)
PH (1) PH12014502713B1 (el)
PL (2) PL3495387T3 (el)
PT (1) PT2872534T (el)
RS (2) RS62509B1 (el)
SG (1) SG11201408538PA (el)
SI (2) SI3495387T1 (el)
TW (1) TWI506036B (el)
UA (1) UA120029C2 (el)
WO (1) WO2014009465A1 (el)
ZA (1) ZA201408969B (el)

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