AU2013288641B2 - Bispecific anti-VEGF/anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases - Google Patents

Bispecific anti-VEGF/anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases Download PDF

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Publication number
AU2013288641B2
AU2013288641B2 AU2013288641A AU2013288641A AU2013288641B2 AU 2013288641 B2 AU2013288641 B2 AU 2013288641B2 AU 2013288641 A AU2013288641 A AU 2013288641A AU 2013288641 A AU2013288641 A AU 2013288641A AU 2013288641 B2 AU2013288641 B2 AU 2013288641B2
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seq
antibody
vegf
bispecific
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AU2013288641A1 (en
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Harald Duerr
Frank Herting
Christian Klein
Joerg Thomas Regula
Matthias Rueth
Kay-Gunnar Stubenrauch
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Roche Glycart AG
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Roche Glycart AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
AU2013288641A 2012-07-13 2013-07-11 Bispecific anti-VEGF/anti-ANG-2 antibodies and their use in the treatment of ocular vascular diseases Active 2037-08-08 AU2013288641B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12176299.1 2012-07-13
EP12176299 2012-07-13
PCT/EP2013/064672 WO2014009465A1 (en) 2012-07-13 2013-07-11 Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases

Publications (2)

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AU2013288641A1 AU2013288641A1 (en) 2014-12-11
AU2013288641B2 true AU2013288641B2 (en) 2017-07-06

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AR (2) AR092027A1 (enExample)
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CA (1) CA2874554C (enExample)
CL (2) CL2015000061A1 (enExample)
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CR (1) CR20140542A (enExample)
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EA (1) EA032192B1 (enExample)
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FI (1) FIC20230011I1 (enExample)
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HR (2) HRP20211641T1 (enExample)
HU (2) HUE056217T2 (enExample)
IL (1) IL236292B (enExample)
IN (1) IN2014DN11157A (enExample)
LT (3) LT3495387T (enExample)
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MA (1) MA37794B1 (enExample)
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UA (1) UA120029C2 (enExample)
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NO2023009I1 (no) 2023-02-14
CO7151542A2 (es) 2014-12-29
CA2874554C (en) 2019-12-03
SI2872534T1 (sl) 2018-11-30
CY1124681T1 (el) 2022-07-22
JP6154900B2 (ja) 2017-06-28
HUE056217T2 (hu) 2022-02-28
MA37794B1 (fr) 2017-07-31
PL3495387T3 (pl) 2022-01-10
CN104428315A (zh) 2015-03-18
FIC20230011I1 (fi) 2023-02-13
TWI506036B (zh) 2015-11-01
SMT202100621T1 (it) 2022-01-10
HRP20181595T1 (hr) 2018-12-14
US20210095013A1 (en) 2021-04-01
MX361337B (es) 2018-12-04
ES2690312T3 (es) 2018-11-20
CR20140542A (es) 2015-02-12
HUS2300008I1 (hu) 2023-02-28
FR23C1010I1 (fr) 2023-04-14
MX2014015518A (es) 2015-06-23
JP7280859B2 (ja) 2023-05-24
EP2872534B1 (en) 2018-08-08
US10683345B2 (en) 2020-06-16
AR092027A1 (es) 2015-03-18
EA201500132A1 (ru) 2015-08-31
FR23C1010I2 (fr) 2024-04-05
CL2015000061A1 (es) 2015-05-08
JP2020062036A (ja) 2020-04-23
NL301218I2 (nl) 2023-04-04
NL301218I1 (enExample) 2023-02-15
JP2015527064A (ja) 2015-09-17
HRP20211641T1 (hr) 2022-02-04
ZA201408969B (en) 2019-04-24
LTC2872534I2 (enExample) 2024-10-25
CA2874554A1 (en) 2014-01-16
LT3495387T (lt) 2021-11-25
AR124240A2 (es) 2023-03-01
LTPA2023507I1 (enExample) 2023-03-10
MA37794A1 (fr) 2016-03-31
AU2013288641A1 (en) 2014-12-11
JP2017140038A (ja) 2017-08-17
US20170260265A1 (en) 2017-09-14
HK1206365A1 (en) 2016-01-08
CY2023005I2 (el) 2023-06-09
EP3495387B1 (en) 2021-09-01
DK2872534T3 (en) 2018-10-22
US20230212277A1 (en) 2023-07-06
RS62509B1 (sr) 2021-11-30
LT2872534T (lt) 2018-10-25
KR20150023688A (ko) 2015-03-05
LUC00300I2 (enExample) 2025-09-22
CL2017002146A1 (es) 2018-04-13
PH12014502713A1 (en) 2015-02-02
ES2896493T3 (es) 2022-02-24
SI3495387T1 (sl) 2021-12-31
US9695233B2 (en) 2017-07-04

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