KR100816572B1 - 항-vegf 항체 및 이를 포함하는 약제학적 조성물 - Google Patents
항-vegf 항체 및 이를 포함하는 약제학적 조성물 Download PDFInfo
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- KR100816572B1 KR100816572B1 KR1020017013746A KR20017013746A KR100816572B1 KR 100816572 B1 KR100816572 B1 KR 100816572B1 KR 1020017013746 A KR1020017013746 A KR 1020017013746A KR 20017013746 A KR20017013746 A KR 20017013746A KR 100816572 B1 KR100816572 B1 KR 100816572B1
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- vegf
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Applications Claiming Priority (3)
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| US13143299P | 1999-04-28 | 1999-04-28 | |
| US60/131,432 | 1999-04-28 | ||
| PCT/US2000/011367 WO2000064946A2 (en) | 1999-04-28 | 2000-04-28 | Compositions and methods for cancer treatment by selectively inhibiting vegf |
Publications (2)
| Publication Number | Publication Date |
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| KR20020019905A KR20020019905A (ko) | 2002-03-13 |
| KR100816572B1 true KR100816572B1 (ko) | 2008-03-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017013746A Expired - Fee Related KR100816572B1 (ko) | 1999-04-28 | 2000-04-28 | 항-vegf 항체 및 이를 포함하는 약제학적 조성물 |
Country Status (17)
| Country | Link |
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| EP (2) | EP1179541B1 (enExample) |
| JP (2) | JP4926320B2 (enExample) |
| KR (1) | KR100816572B1 (enExample) |
| CN (2) | CN1308347C (enExample) |
| AT (1) | ATE269357T1 (enExample) |
| AU (1) | AU763954B2 (enExample) |
| BR (1) | BR0010017A (enExample) |
| CA (1) | CA2372053C (enExample) |
| DE (1) | DE60011612T2 (enExample) |
| ES (1) | ES2223705T3 (enExample) |
| HK (1) | HK1045700B (enExample) |
| IL (1) | IL145941A (enExample) |
| MX (1) | MXPA01010891A (enExample) |
| NZ (1) | NZ514918A (enExample) |
| WO (1) | WO2000064946A2 (enExample) |
| ZA (2) | ZA200108612B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101093717B1 (ko) | 2008-11-26 | 2011-12-19 | 한국생명공학연구원 | Vegf―특이적인 인간항체 |
Families Citing this family (534)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5367057A (en) * | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
| US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
| US6448077B1 (en) * | 1994-02-10 | 2002-09-10 | Imclone Systems, Inc. | Chimeric and humanized monoclonal antibodies specific to VEGF receptors |
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| EP1060242A4 (en) * | 1998-01-23 | 2003-09-17 | Imclone Systems Inc | Purified populations of stem cells |
| WO2000018885A1 (en) * | 1998-09-29 | 2000-04-06 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
| US6537520B1 (en) * | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
| DE69941187D1 (de) * | 1998-06-01 | 2009-09-10 | Agensys Inc | Serpentintransmembranantigene exprimiert in menschlichem krebs und deren verwendungen |
| US6962702B2 (en) | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| KR20010081089A (ko) * | 1998-12-21 | 2001-08-25 | 에드워드 에이. 맥더모 2세, 로이드 제이. 오울드 | 절단된 vegf-d에 대한 항체 및 그것의 이용 |
| IT1312077B1 (it) * | 1999-04-15 | 2002-04-04 | Univ Degli Studi Milano | Polipeptidi ad attivita' antiangiogenica. |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| MXPA01010891A (es) * | 1999-04-28 | 2002-11-07 | Univ Texas | Composiciones y metodos para el tratamiento contra el cancer mediante la inhibicion selectiva del factor de crecimiento endotelial vascular (vegf). |
| US20030021792A1 (en) * | 2001-06-08 | 2003-01-30 | Roben Paul W. | Tissue-specific endothelial membrane proteins |
| US6924359B1 (en) * | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| CA2386457A1 (en) * | 1999-10-06 | 2001-04-12 | Basf Aktiengesellschaft | Inhibitors of the endothelin signalling pathway and .alpha.v.beta.3 integrin receptor antagonists for combination therapy |
| US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
| EP1997513B1 (en) * | 2000-02-10 | 2012-04-11 | Massachusetts Eye & Ear Infirmary | Combinations and compositions for use in PDT in treating ocular conditions involving unwanted choriodal neovascularisation |
| AU4243201A (en) * | 2000-02-24 | 2001-09-03 | Eidgenoess Tech Hochschule | Antibody specific for the ed-b domain of fibronectin, conjugates comprising saidantibody, and their use for the detection and treatment of angiogenesis |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
| US20050019826A1 (en) | 2000-03-31 | 2005-01-27 | Roselyne Tournaire | Peptides blocking vascular endothelial growth factor(vegf)-mediated angiogenesis, polynucleotides encoding said pepetides and methods of use thereof |
| US7355019B2 (en) * | 2000-06-06 | 2008-04-08 | Sibtech, Inc. | Cysteine-containing peptide tag for site-specific conjugation of proteins |
| US7288390B2 (en) * | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| US7163681B2 (en) * | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| FR2813606B1 (fr) * | 2000-09-01 | 2004-04-30 | Inst Nat Sante Rech Med | Proteine bard1 tronquee, et ses applications diagnostiques et therapeutiques |
| IL154696A (en) * | 2000-09-05 | 2008-11-03 | Biosight Ltd | Peptide conjugated anti-cancer prodrugs |
| US8314060B2 (en) * | 2000-09-05 | 2012-11-20 | Biosight Ltd. | Peptide conjugated anti-cancer prodrugs |
| CA2421783A1 (en) * | 2000-09-07 | 2002-03-14 | Schering Aktiengesellschaft | Receptor in the edb fibronectin domain |
| US20020091082A1 (en) * | 2000-09-13 | 2002-07-11 | Aiello Lloyd P. | Methods of modulating symptoms of hypertension |
| EP1506962B1 (en) * | 2000-10-20 | 2008-07-02 | Eisai R&D Management Co., Ltd. | Nitrogen-containing aromatic heterocycles |
| US7273722B2 (en) * | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
| US20050209310A1 (en) * | 2000-12-22 | 2005-09-22 | Chaplin David J | Methods for modulating tumor growth and metastasis |
| US7037906B1 (en) * | 2000-12-22 | 2006-05-02 | Oxigene, Inc. | Methods for modulating tumor growth and metastasis |
| WO2002096948A2 (en) * | 2001-01-29 | 2002-12-05 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
| KR20030091978A (ko) * | 2001-01-29 | 2003-12-03 | 아이덱 파마슈티칼즈 코포레이션 | 변형된 항체 및 사용 방법 |
| US20030077826A1 (en) * | 2001-02-02 | 2003-04-24 | Lena Edelman | Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC) |
| US7601825B2 (en) * | 2001-03-05 | 2009-10-13 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer |
| US6924358B2 (en) | 2001-03-05 | 2005-08-02 | Agensys, Inc. | 121P1F1: a tissue specific protein highly expressed in various cancers |
| EP2295074A1 (en) * | 2001-03-07 | 2011-03-16 | Mannkind Corporation | Anti-neovasculature preparations for treating cancer |
| AU2002252444A1 (en) * | 2001-03-23 | 2002-10-08 | Board Of Regents, The University Of Texas System | Methods for inhibition of angiogenesis, tumor growth and metastasis by fully human anti-il8 and anti-muc18 in diverse types of tumors |
| WO2002079254A1 (en) * | 2001-03-29 | 2002-10-10 | Janoff Edward N | Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae |
| US7638598B2 (en) * | 2001-04-06 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | ErbB interface peptidomimetics and methods of use thereof |
| US20030191073A1 (en) * | 2001-11-07 | 2003-10-09 | Challita-Eid Pia M. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
| WO2002083850A2 (en) * | 2001-04-13 | 2002-10-24 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
| KR20030093316A (ko) | 2001-04-13 | 2003-12-06 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 혈관 내피 성장 인자 2 |
| US6884869B2 (en) * | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| EP1401875A4 (en) * | 2001-05-04 | 2005-01-26 | Univ Utah Res Found | HYALURONIC ACID-CONTAINING BIOKON JUGATES: TARGETED DELIVERY OF ANTIBODIES TO CANCER CELLS |
| US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
| US7361341B2 (en) * | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
| US20090226429A1 (en) * | 2001-05-25 | 2009-09-10 | Human Genome Sciences, Inc. | Antibodies That Immunospecifically Bind to TRAIL Receptors |
| US20030007974A1 (en) * | 2001-05-30 | 2003-01-09 | Nanus David M. | Endopeptidase/anti-PSMA antibody fusion proteins for treatment of cancer |
| IL158969A0 (en) * | 2001-06-01 | 2004-05-12 | Cornell Res Foundation Inc | Modified antibodies to prostate-specific membrane antigen and uses thereof |
| US7514078B2 (en) * | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
| US7666414B2 (en) * | 2001-06-01 | 2010-02-23 | Cornell Research Foundation, Inc. | Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen |
| WO2002102973A2 (en) | 2001-06-20 | 2002-12-27 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| US20040247597A1 (en) * | 2001-06-20 | 2004-12-09 | Peter Carmeliet | Method of treating atherosclerosis and other inflammatory diseases |
| EP1399484B1 (en) * | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
| US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| US20060073141A1 (en) * | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| EP1416960A4 (en) * | 2001-07-13 | 2006-02-22 | Imclone Systems Inc | ANTIBODIES AGAINST VEGFR-1 TO TREAT BREAST CANCER |
| AU2002326531A1 (en) * | 2001-08-03 | 2003-02-17 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies to activated erbb family members and methods of use thereof |
| ATE378056T1 (de) * | 2001-08-10 | 2007-11-15 | Imclone Systems Inc | Medizinische verwendung von stammzellen, die vegfr-1 exprimieren |
| AU2002336446B2 (en) * | 2001-09-06 | 2008-03-06 | Agensys, Inc. | Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer |
| US7494646B2 (en) * | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
| US7192586B2 (en) * | 2001-09-20 | 2007-03-20 | Cornell Research Foundation, Inc. | Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate specific membrane antigen |
| US20030129193A1 (en) * | 2001-09-27 | 2003-07-10 | Board Of Regents, The University Of Texas System And Peregrine Pharmaceuticals, Inc. | Combined methods for tumor vasculature coaguligand treatment |
| JP2005507659A (ja) * | 2001-10-15 | 2005-03-24 | イミューノメディクス、インコーポレイテッド | 直接ターゲッティング結合タンパク質 |
| JP4200100B2 (ja) * | 2001-11-07 | 2008-12-24 | アジェンシス,インコーポレイテッド | 癌の処置および検出において有用な161p2f10bと称される、核酸および対応タンパク質 |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| EP1453546A2 (en) * | 2001-12-04 | 2004-09-08 | Nanospectra Biosciences, Inc. | Treatment of angiogenesis disorders using targeted nanoparticles |
| WO2003057006A2 (en) * | 2001-12-28 | 2003-07-17 | Abgenix, Inc. | Use of antibodies against the muc18 antigen |
| US20030194421A1 (en) * | 2001-12-28 | 2003-10-16 | Angiotech Pharmaceuticals, Inc. | Treatment of uveitis |
| JP2005516965A (ja) * | 2001-12-28 | 2005-06-09 | アブジェニックス・インコーポレーテッド | 抗muc18抗体を使用する方法 |
| KR100623128B1 (ko) * | 2002-01-02 | 2006-09-14 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
| EP2239274A1 (en) * | 2002-01-03 | 2010-10-13 | Bayer Schering Pharma AG | New methods for diagnosis and treatment of tumours |
| JP4242590B2 (ja) * | 2002-01-11 | 2009-03-25 | 俊一 塩澤 | 慢性関節リウマチの疾患感受性遺伝子、及びその利用 |
| EP2075256A2 (en) | 2002-01-14 | 2009-07-01 | William Herman | Multispecific binding molecules |
| US20080193445A1 (en) * | 2002-01-18 | 2008-08-14 | Liliane Goetsch | Novel anti-IGF-IR antibodies and uses thereof |
| US20080063639A1 (en) * | 2002-01-18 | 2008-03-13 | Pierre Fabre Medicament | Method for the treatment of psoriasis comprising novel anti-IGF-IR antibodies |
| US7241444B2 (en) * | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
| IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| EP1469860A4 (en) * | 2002-01-24 | 2005-09-07 | Yissum Res Dev Co | ANTICANCER COMBINATION AND USE THEREOF |
| WO2003062404A1 (en) * | 2002-01-25 | 2003-07-31 | Gamida-Cell Ltd. | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
| US20050042632A1 (en) * | 2002-02-13 | 2005-02-24 | Sirna Therapeutics, Inc. | Antibodies having specificity for nucleic acids |
| US6992176B2 (en) * | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| US7071311B2 (en) * | 2002-02-13 | 2006-07-04 | Sirna Therapeutics, Inc. | Antibodies having specificity for 2′-C-allyl nucleic acids |
| AU2003216341A1 (en) * | 2002-02-20 | 2003-09-09 | Dyax Corporation | Mhc-peptide complex binding ligands |
| US8435529B2 (en) | 2002-06-14 | 2013-05-07 | Immunomedics, Inc. | Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy |
| US8491896B2 (en) * | 2002-06-14 | 2013-07-23 | Immunomedics, Inc. | Anti-pancreatic cancer antibodies |
| JP2005526506A (ja) * | 2002-03-04 | 2005-09-08 | イムクローン システムズ インコーポレイティド | Kdrに特異的なヒト抗体及びその利用 |
| SG108837A1 (en) * | 2002-03-11 | 2005-02-28 | Pi Eta Consulting Co Pte Ltd | An enterprise knowledge and information acquisition, management and communications system with intelligent user interfaces |
| US20050124794A1 (en) * | 2002-03-15 | 2005-06-09 | Mccrae Keith | Cell surface tropomyosin as a target of angiogenesis inhibition |
| WO2004004667A2 (en) * | 2002-03-15 | 2004-01-15 | The Regents Of The University Of California | Method of immunotherapy |
| RU2209634C1 (ru) * | 2002-04-29 | 2003-08-10 | Иткес Александр Веньяминович | Набор эстроген-рецептор для обнаружения рецепторов к эстрогенам в биопсийных гистологических препаратах (варианты) |
| US20070178065A1 (en) * | 2002-05-03 | 2007-08-02 | Lattime Edmund C | Neutralizing factors as vaccine adjuvants |
| US20050169883A1 (en) * | 2002-05-06 | 2005-08-04 | Prestwich Glenn D. | Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents |
| NZ548796A (en) * | 2002-05-15 | 2008-01-31 | Janssen Pharmaceutica Nv | N-substituted trycyclic 3-aminopyrazoles as PDFG receptor inhibitors |
| EP1513543B1 (en) | 2002-05-23 | 2010-10-06 | The Trustees of The University of Pennsylvania | Fas peptide mimetics and uses thereof |
| ATE461713T1 (de) * | 2002-05-29 | 2010-04-15 | Immunomedics Inc | Zusammensetzungen für die radioimmuntherapie von gehirn-tumoren |
| JP4511108B2 (ja) * | 2002-05-31 | 2010-07-28 | オンコリクス インコーポレイテッド | ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 |
| US20040022726A1 (en) * | 2002-06-03 | 2004-02-05 | Goldenberg David M. | Methods and compositions for intravesical therapy of bladder cancer |
| US9599619B2 (en) | 2002-06-14 | 2017-03-21 | Immunomedics, Inc. | Anti-pancreatic cancer antibodies |
| JP5110768B2 (ja) * | 2002-06-14 | 2012-12-26 | イミューノメディクス、インコーポレイテッド | モノクローナル抗体pam4ならびに膵臓癌の診断および治療のためのその使用 |
| US8574854B2 (en) | 2002-06-14 | 2013-11-05 | Immunomedics, Inc. | Anti-mucin antibodies for early detection and treatment of pancreatic cancer |
| US8821868B2 (en) | 2002-06-14 | 2014-09-02 | Immunomedics, Inc. | Anti-pancreatic cancer antibodies |
| CN1675245B (zh) * | 2002-06-14 | 2011-01-12 | 免疫医疗公司 | 人源化单克隆抗体hPAM4 |
| DE60305919T2 (de) * | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | Dual-specifische liganden mit erhöhter halbwertszeit |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| PT2269656E (pt) | 2002-07-15 | 2014-12-02 | Univ Texas | Anticorpos selecionados e peptídeos de duramicina que se ligam a fosfolipídios aniônicos e aminofosfolipídios e seus usos no tratamento de infecções virais e câncer |
| EP2256108B1 (en) | 2002-07-18 | 2016-03-23 | Janssen Pharmaceutica NV | Substituted triazine kinase inhibitors |
| NZ520321A (en) * | 2002-07-19 | 2005-03-24 | Auckland Uniservices Ltd | Use of an agent adapted to inhibit HIF in use together with an antiangiogenic agent for treating tumours in a non- human animal |
| JP4741838B2 (ja) | 2002-07-31 | 2011-08-10 | シアトル ジェネティクス,インコーポレーテッド | 癌、自己免疫疾患または感染症を治療するための薬物結合体およびその使用 |
| US20040077684A1 (en) * | 2002-08-16 | 2004-04-22 | Bart De Corte | Piperidinyl compounds that selectively bind integrins |
| US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
| US7226755B1 (en) * | 2002-09-25 | 2007-06-05 | The Procter & Gamble Company | HPTPbeta as a target in treatment of angiogenesis mediated disorders |
| US7507568B2 (en) * | 2002-09-25 | 2009-03-24 | The Proctor & Gamble Company | Three dimensional coordinates of HPTPbeta |
| AU2003276084B2 (en) * | 2002-10-10 | 2009-07-09 | Merck Patent Gmbh | Bispecific anti-Erb-B antibodies and their use in tumor therapy |
| US9701754B1 (en) | 2002-10-23 | 2017-07-11 | City Of Hope | Covalent disulfide-linked diabodies and uses thereof |
| PT1572748E (pt) * | 2002-12-17 | 2010-09-28 | Merck Patent Gmbh | Anticorpo humanizado (h14.18) do anticorpo 14.18 de rato que se liga ao gd2 e a sua fusão com a il-2 |
| EP1578801A2 (en) * | 2002-12-27 | 2005-09-28 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| US20050026826A1 (en) * | 2003-01-17 | 2005-02-03 | Margarethe Hoenig | Feline proinsulin, insulin and constituent peptides |
| US20060039858A1 (en) * | 2003-02-11 | 2006-02-23 | Ekaterina Dadachova | Radiolabeled antibodies and peptides for treatment of tumors |
| US7402385B2 (en) * | 2003-02-11 | 2008-07-22 | Albert Einstein College Of Medicine Of Yeshiva University | Radiolabeled antibodies for treatment of tumors |
| DK1594542T3 (da) * | 2003-02-20 | 2010-10-11 | Seattle Genetics Inc | Anti-CD70 antistof-lægemiddelkonjugater og deres anvendelse ved behandling af cancer |
| US20080025989A1 (en) | 2003-02-20 | 2008-01-31 | Seattle Genetics, Inc. | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| US7759468B1 (en) * | 2003-03-05 | 2010-07-20 | University Of Kentucky Research Foundation | Bioactive peptide-based probes |
| US20060104968A1 (en) * | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| CA2530166A1 (en) * | 2003-03-07 | 2004-09-23 | Randolph D. Glickman | Antibody-targeted photodynamic therapy |
| JPWO2004080462A1 (ja) * | 2003-03-10 | 2006-06-08 | エーザイ株式会社 | c−Kitキナーゼ阻害剤 |
| DK1608685T3 (da) * | 2003-03-28 | 2007-06-11 | Regeneron Pharma | VEGF antagonister til behandlingen af diabetes |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| JP4703567B2 (ja) * | 2003-05-23 | 2011-06-15 | ジェネンテック, インコーポレイテッド | 膠細胞起源の腫瘍の診断と治療のための組成物と方法 |
| US7605235B2 (en) * | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
| RS20150135A1 (sr) * | 2003-05-30 | 2015-08-31 | Genentech Inc. | Tretman sa anti-vegf antitelima |
| US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
| US20050008649A1 (en) * | 2003-06-02 | 2005-01-13 | University Of Miami | Chimeric molecules and methods of use |
| WO2005000223A2 (en) * | 2003-06-04 | 2005-01-06 | Children's Medical Center Corporation | Method of treating retinopathies and disorders associated with blood vessel loss |
| US7178491B2 (en) * | 2003-06-05 | 2007-02-20 | Caterpillar Inc | Control system and method for engine valve actuator |
| US9005613B2 (en) | 2003-06-16 | 2015-04-14 | Immunomedics, Inc. | Anti-mucin antibodies for early detection and treatment of pancreatic cancer |
| WO2004112825A2 (en) | 2003-06-17 | 2004-12-29 | Mannkind Corporation | Combinations of tumor-associated antigens for the treatment of various types of cancers |
| DE602004015454D1 (de) | 2003-06-25 | 2008-09-11 | Peregrine Pharmaceuticals Inc | Verfahren und vorrichtung zur kontinuierlichen radioaktiven markierung von proteinen im grossen massstab |
| EP3037105B1 (en) * | 2003-06-27 | 2021-03-17 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
| CN1930187B (zh) * | 2003-06-27 | 2015-08-19 | 艾默根佛蒙特有限公司 | 针对表皮生长因子受体的缺失突变体的抗体及其使用 |
| US7825085B2 (en) * | 2003-06-30 | 2010-11-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Fragments of NKp44 and NKp46 for targeting viral-infected and tumor cells |
| KR20060079180A (ko) | 2003-07-02 | 2006-07-05 | 노보 노르디스크 에이/에스 | Nk 세포 활성을 조절하기 위한 조성물 및 방법 |
| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| AR046510A1 (es) * | 2003-07-25 | 2005-12-14 | Regeneron Pharma | Composicion de un antagonista de vegf y un agente anti-proliferativo |
| WO2005086612A2 (en) * | 2003-07-29 | 2005-09-22 | Immunomedics, Inc. | Fluorinated carbohydrate conjugates |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| AP2012006644A0 (en) * | 2003-08-01 | 2012-12-31 | Genentech Inc | Anti-VEGF antibodies |
| AU2012201667B2 (en) * | 2003-08-01 | 2014-11-27 | Genentech, Inc. | Anti-VEGF antibodies |
| US7758859B2 (en) | 2003-08-01 | 2010-07-20 | Genentech, Inc. | Anti-VEGF antibodies |
| US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| WO2005044853A2 (en) * | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
| WO2005016369A1 (en) * | 2003-08-06 | 2005-02-24 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist in combination with radiation therapy |
| WO2005014618A2 (en) * | 2003-08-08 | 2005-02-17 | Immunomedics, Inc. | Bispecific antibodies for inducing apoptosis of tumor and diseased cells |
| US7547518B2 (en) | 2003-08-19 | 2009-06-16 | Becton, Dickinson And Company | Method of screening endothelial cells for angiogenic capability |
| EP2281885A1 (en) | 2003-08-27 | 2011-02-09 | Ophthotech Corporation | Combination therapy for the treatment of ocular neovascular disorders |
| US20050095627A1 (en) * | 2003-09-03 | 2005-05-05 | The Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| CN104998273A (zh) | 2003-11-06 | 2015-10-28 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| JP4303726B2 (ja) * | 2003-11-11 | 2009-07-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウレア誘導体およびその製造方法 |
| WO2005047319A2 (en) * | 2003-11-12 | 2005-05-26 | The University Of Georgia Research Foundation, Inc. | Dna sequence and expressed recombinant glycoproteins related to feline thyrotropin |
| EP1691836B1 (en) * | 2003-11-13 | 2012-02-22 | Sutter West Bay Hospitals | Anti-pecam therapy for metastasis suppression |
| CN1914179A (zh) * | 2003-11-13 | 2007-02-14 | 詹森药业有限公司 | 用于生物分子靶标识别的固定的n-取代的三环3-氨基吡唑类 |
| US20080220049A1 (en) * | 2003-12-05 | 2008-09-11 | Adnexus, A Bristol-Myers Squibb R&D Company | Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins |
| BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
| US7799327B2 (en) * | 2003-12-24 | 2010-09-21 | Henry John Smith | Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment |
| WO2005069906A2 (en) * | 2004-01-16 | 2005-08-04 | Yale University | Methods and compositions relating to vascular endothelial growth factor and th2 mediated inflammatory diseases |
| US7939634B2 (en) * | 2004-01-27 | 2011-05-10 | Compugen Ltd. | Polynucleotides encoding polypeptides and methods using same |
| US20110020273A1 (en) * | 2005-04-06 | 2011-01-27 | Ibc Pharmaceuticals, Inc. | Bispecific Immunocytokine Dock-and-Lock (DNL) Complexes and Therapeutic Use Thereof |
| EP1722762A2 (en) * | 2004-03-02 | 2006-11-22 | Massachusetts Institute of Technology | Nanocell drug delivery system |
| WO2005084329A2 (en) * | 2004-03-02 | 2005-09-15 | Ludwig Institute For Cancer Research | Method for inhibiting tumor formation and growth |
| WO2005094882A1 (en) * | 2004-03-03 | 2005-10-13 | Millennium Pharmaceuticals, Inc. | Modified antibodies to prostate-specific membrane antigen and uses thereof |
| JP2007527539A (ja) * | 2004-03-05 | 2007-09-27 | ザ スクリプス リサーチ インスティテュート | ハイスループットグリカンマイクロアレイ |
| WO2005087808A2 (en) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Growth factor binding constructs materials and methods |
| CN1930188B (zh) * | 2004-03-10 | 2012-01-11 | 克赖顿大学 | 雌激素受体和使用方法 |
| AU2012265582B2 (en) * | 2004-03-26 | 2015-04-16 | Ophthotech Corporation | Combination therapy for the treatment of ocular neovascular disorders |
| JP2008505853A (ja) | 2004-04-13 | 2008-02-28 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体 |
| NZ550816A (en) | 2004-04-22 | 2009-12-24 | Agensys Inc | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
| US20060182783A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
| CN1304427C (zh) * | 2004-06-08 | 2007-03-14 | 成都康弘生物科技有限公司 | 抑制血管新生的融合蛋白质及其用途 |
| US20060159689A1 (en) * | 2004-06-17 | 2006-07-20 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
| US20060008468A1 (en) * | 2004-06-17 | 2006-01-12 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
| US8029766B2 (en) * | 2004-06-18 | 2011-10-04 | Elmaleh David R | Intravascular imaging device and uses thereof |
| US20060008415A1 (en) * | 2004-06-25 | 2006-01-12 | Protein Design Labs, Inc. | Stable liquid and lyophilized formulation of proteins |
| WO2006003179A2 (en) | 2004-07-01 | 2006-01-12 | Novo Nordisk A/S | Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use |
| AU2005259835B2 (en) * | 2004-07-02 | 2011-07-07 | The Walter And Eliza Hall Institute Of Medical Research | Alpha-helical mimetics |
| CA2575675A1 (en) | 2004-07-30 | 2006-03-09 | Adeza Biomedical Corporation | Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin |
| CN1997386B (zh) * | 2004-07-30 | 2012-05-30 | 瑞泽恩制药公司 | 通过阻断vegf介导的活性来治疗i型糖尿病的方法 |
| DK2412728T3 (en) | 2004-08-03 | 2015-04-07 | Innate Pharma | Therapeutic compositions for cancer, that target 4Ig-B7-H3 |
| US20070003943A1 (en) * | 2004-08-09 | 2007-01-04 | Northwestern University | Tumor angiogenesis inhibitor alpha 1-antitrypsin |
| CN1316249C (zh) * | 2004-08-25 | 2007-05-16 | 北京健平九星生物医药科技有限公司 | 一种酶联检测试剂盒及制备方法 |
| DK1784181T3 (da) * | 2004-08-31 | 2013-09-02 | Newsouth Innovations Pty Ltd | VEGF-hæmning |
| RU2007108716A (ru) * | 2004-09-10 | 2008-10-20 | Вайет (Us) | Гуманизированные антитела к антигену 5т4 и конъюгаты гуманизированного антитела к антигену 5т4 с калихеамицином |
| US8772269B2 (en) * | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| EP2364699A1 (en) | 2004-09-13 | 2011-09-14 | Eisai R&D Management Co., Ltd. | Joint use of sulfonamide based compound with angiogenesis inhibitor |
| EP1799812A4 (en) * | 2004-09-16 | 2009-09-09 | Gamida Cell Ltd | EX VIVO CULTIVATION METHODS OF STEM CELLS AND PRECURSOR BY CO-CULTURE WITH MESENCHYMAL CELLS |
| US8969379B2 (en) * | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| EP1799200A1 (en) * | 2004-10-04 | 2007-06-27 | Cellgate, Inc. | Polyamine analogs as therapeutic agents for ocular diseases |
| EP1812033A4 (en) * | 2004-10-06 | 2009-11-11 | Tiltan Pharma Ltd | METHOD AND COMPOSITION FOR REINFORCE ANTI-ANGIOGENESIS THERAPY |
| US8337838B2 (en) * | 2004-10-15 | 2012-12-25 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| US7641903B2 (en) * | 2004-10-15 | 2010-01-05 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| JP5222559B2 (ja) * | 2004-10-15 | 2013-06-26 | シアトル ジェネティックス, インコーポレイテッド | 癌および免疫障害の処置および予防のための抗cd70抗体ならびにその使用 |
| SG156668A1 (en) * | 2004-10-19 | 2009-11-26 | Amgen Inc | Angiopoietin-2 specific binding agents |
| NZ590132A (en) * | 2004-10-21 | 2012-03-30 | Genentech Inc | Dosage regime for treating intraocular neovascular diseases with VEGF |
| ES2325344B1 (es) * | 2004-11-02 | 2010-06-09 | Univ Madrid Autonoma | Inhibidores de angiogenesis multifuncionales y multivalentes. |
| US7595149B1 (en) | 2004-11-08 | 2009-09-29 | University Of Kentucky Research Foundation | Methods for cancer detection |
| WO2006055809A2 (en) | 2004-11-18 | 2006-05-26 | Imclone Systems Incorporated | Antibodies against vascular endothelial growth factor receptor-1 |
| WO2006068758A2 (en) * | 2004-11-19 | 2006-06-29 | The Scripps Research Institute | Detection, prevention and treatment of breast cancer |
| RU2007126970A (ru) * | 2004-12-17 | 2009-01-27 | Джинентех, Инк. (US) | Антиагиогенная терапия аутоиммунного заболевания у пациентов, предшествующее лечение которых не дало результата |
| US20080267971A1 (en) * | 2004-12-21 | 2008-10-30 | Green Larry L | Antibodies Directed to Angiopoietin-2 and Uses Thereof |
| SI2727583T1 (sl) | 2004-12-22 | 2022-01-31 | Nitto Denko Corporation | Nosilec učinkovine in komplet nosilca učinkovine za zaviranje fibroze |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| MX2007007935A (es) | 2004-12-28 | 2007-12-06 | Innate Pharma Sa | Anticuerpos monoclonales contra nkg2a. |
| AU2005321904B2 (en) * | 2004-12-29 | 2012-07-12 | Mannkind Corporation | Methods to elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic or therapeutic purposes |
| JP2008526760A (ja) | 2004-12-29 | 2008-07-24 | マンカインド コーポレイション | 種々の腫瘍関連抗原を含む組成物の抗癌ワクチンとしての使用 |
| JP5154949B2 (ja) | 2005-01-06 | 2013-02-27 | ノヴォ ノルディスク アー/エス | ウイルス感染を治療するための組成物および方法 |
| EP1836225B1 (en) | 2005-01-06 | 2011-11-02 | Novo Nordisk A/S | Kir-binding agents and methods of use thereof |
| US20090196850A1 (en) | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
| US20080248030A1 (en) * | 2005-02-02 | 2008-10-09 | Children's Medical Center Corporation | Method of Treating Angiogenic Diseases |
| US20080213399A1 (en) | 2005-02-03 | 2008-09-04 | Topotarget Uk Limited | Combination Therapies Using Hdac Inhibitors |
| WO2006082515A2 (en) | 2005-02-07 | 2006-08-10 | Glycart Biotechnology Ag | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
| US20060188508A1 (en) * | 2005-02-17 | 2006-08-24 | Cohen Stanley N | Methods and compositions for modulating angiogenesis |
| US20060210645A1 (en) * | 2005-03-02 | 2006-09-21 | Du Mee Charles P | Pharmaceutically acceptable carrier for ophthalmic compositions |
| CA2598452A1 (en) * | 2005-03-11 | 2006-09-21 | Regeneron Pharmaceuticals, Inc. | Treating anemia by inhibition of vegf |
| ES2633574T3 (es) | 2005-03-25 | 2017-09-22 | Regeneron Pharmaceuticals, Inc. | Formulaciones de antagonistas de VEGF |
| US8350009B2 (en) * | 2005-03-31 | 2013-01-08 | Agensys, Inc. | Antibodies and related molecules that bind to 161P2F10B proteins |
| AU2006230563B8 (en) * | 2005-03-31 | 2010-06-17 | Agensys, Inc. | Antibodies and related molecules that bind to 161P2F10B proteins |
| US20060222595A1 (en) * | 2005-03-31 | 2006-10-05 | Priyabrata Mukherjee | Nanoparticles for therapeutic and diagnostic applications |
| EP1712241A1 (en) * | 2005-04-15 | 2006-10-18 | Centre National De La Recherche Scientifique (Cnrs) | Composition for treating cancer adapted for intra-tumoral administration and uses thereof |
| CA2605507C (en) | 2005-04-19 | 2016-06-28 | Seattle Genetics, Inc. | Humanized anti-cd70 binding agents and uses thereof |
| CA2606598C (en) * | 2005-05-13 | 2014-12-23 | Topotarget Uk Limited | Pharmaceutical formulations of hdac inhibitors |
| US7767710B2 (en) | 2005-05-25 | 2010-08-03 | Calosyn Pharma, Inc. | Method for treating osteoarthritis |
| US20060269579A1 (en) * | 2005-05-25 | 2006-11-30 | Musculoskeletal Research Llc | Compositions for treating osteoarthritis |
| US7541367B2 (en) * | 2005-05-31 | 2009-06-02 | Janssen Pharmaceutica, N.V. | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders |
| US20060281768A1 (en) * | 2005-06-10 | 2006-12-14 | Gaul Michael D | Thienopyrimidine and thienopyridine kinase modulators |
| US20060281788A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| US8071768B2 (en) * | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
| US7825244B2 (en) * | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
| US7999088B2 (en) | 2005-06-17 | 2011-08-16 | Mannkind Corporation | Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
| EP1748050A1 (en) * | 2005-07-28 | 2007-01-31 | Rijksuniversiteit Groningen | Targeting-enhanced activation of galectins |
| JP5066446B2 (ja) * | 2005-08-01 | 2012-11-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を予測する方法 |
| WO2007015578A1 (ja) | 2005-08-02 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を検定する方法 |
| ES2363758T3 (es) | 2005-08-15 | 2011-08-16 | Vegenics Pty Ltd | Vegf y pdgf modificados con propiedades angiogénicas mejoradas. |
| KR100990590B1 (ko) * | 2005-09-01 | 2010-10-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 붕해성이 개선된 의약 조성물의 제조 방법 |
| ES2543341T3 (es) * | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| GB0519398D0 (en) * | 2005-09-23 | 2005-11-02 | Antisoma Plc | Biological materials and uses thereof |
| US20070071756A1 (en) * | 2005-09-26 | 2007-03-29 | Peyman Gholam A | Delivery of an agent to ameliorate inflammation |
| NZ566395A (en) * | 2005-09-26 | 2012-03-30 | Medarex Inc | Human monoclonal antibodies to CD70 |
| US9447185B2 (en) | 2005-10-14 | 2016-09-20 | Innate Pharma, S.A. | Compositions and methods for treating proliferative disorders |
| CN101340909B (zh) | 2005-10-18 | 2012-01-11 | 詹森药业有限公司 | 抑制flt3激酶的方法 |
| CN101534865A (zh) * | 2005-10-19 | 2009-09-16 | Ibc药品公司 | 生物活性装配体的制备方法及其用途 |
| US8765164B2 (en) * | 2005-10-21 | 2014-07-01 | Kenneth W. Carpenter | Poly(ester urea) polymers and methods of use |
| US20090291437A1 (en) * | 2005-11-02 | 2009-11-26 | O'brien Sean | Methods for targeting quadruplex sequences |
| US20090053236A1 (en) * | 2005-11-07 | 2009-02-26 | Eisai R & D Management Co., Ltd. | USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR |
| US20110125203A1 (en) * | 2009-03-20 | 2011-05-26 | ElectroCore, LLC. | Magnetic Stimulation Devices and Methods of Therapy |
| US7747324B2 (en) * | 2005-11-10 | 2010-06-29 | Electrocore Llc | Electrical stimulation treatment of bronchial constriction |
| CA2627923C (en) | 2005-11-10 | 2016-01-12 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer |
| US8041428B2 (en) | 2006-02-10 | 2011-10-18 | Electrocore Llc | Electrical stimulation treatment of hypotension |
| US9037247B2 (en) | 2005-11-10 | 2015-05-19 | ElectroCore, LLC | Non-invasive treatment of bronchial constriction |
| US8812112B2 (en) * | 2005-11-10 | 2014-08-19 | ElectroCore, LLC | Electrical treatment of bronchial constriction |
| WO2007061127A1 (ja) * | 2005-11-22 | 2007-05-31 | Eisai R & D Management Co., Ltd. | 多発性骨髄腫に対する抗腫瘍剤 |
| US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
| AU2006321364B2 (en) * | 2005-12-01 | 2011-11-10 | Domantis Limited | Noncompetitive domain antibody formats that bind Interleukin 1 Receptor type 1 |
| JP5489465B2 (ja) † | 2005-12-16 | 2014-05-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Dll4アンタゴニストによって腫瘍増殖を阻害する治療方法 |
| ME02736B (me) * | 2005-12-21 | 2017-10-20 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| EP1978985A2 (en) * | 2005-12-23 | 2008-10-15 | Board Of Regents Of The University Of Texas System | Anti-hyperproliferative therapies targeting hdgf |
| WO2007079437A2 (en) * | 2006-01-03 | 2007-07-12 | Kereos, Inc. | Combination antitumor therapies |
| EP1977405A2 (en) * | 2006-01-23 | 2008-10-08 | Ad Group | Systems and methods for distributing emergency messages |
| US20070175313A1 (en) * | 2006-01-31 | 2007-08-02 | Kevin Vandervliet | MP3 player holder assembly |
| WO2007092062A1 (en) * | 2006-02-10 | 2007-08-16 | Electrocore, Inc. | Methods and apparatus for treating anaphylaxis using electrical modulation |
| WO2007094828A2 (en) * | 2006-02-10 | 2007-08-23 | Electrocore, Inc. | Electrical stimulation treatment of hypotension |
| WO2007101202A1 (en) * | 2006-02-27 | 2007-09-07 | Research Development Foundation | Cell-targeted ikb and methods for the use thereof |
| CA2646329C (en) * | 2006-03-20 | 2018-07-03 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| TW200812615A (en) * | 2006-03-22 | 2008-03-16 | Hoffmann La Roche | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
| TWI390034B (zh) | 2006-04-06 | 2013-03-21 | Kyowa Hakko Kirin Co Ltd | Novel anti-CD98 antibody |
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint Pharmaceuticals, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US20100241188A1 (en) * | 2009-03-20 | 2010-09-23 | Electrocore, Inc. | Percutaneous Electrical Treatment Of Tissue |
| EP2016070B1 (en) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| NZ572200A (en) | 2006-04-20 | 2011-09-30 | Janssen Pharmaceutica Nv | Method of inhibiting c-kit kinase |
| US7414050B2 (en) | 2006-04-20 | 2008-08-19 | Janssen Pharmaceutica, N.V. | Inhibitors of c-fms kinase |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| US20070253960A1 (en) * | 2006-04-28 | 2007-11-01 | Josee Roy | Pharmaceutical removal of vascular extensions from a degenerating disc |
| US20070258976A1 (en) * | 2006-05-04 | 2007-11-08 | Ward Keith W | Combination Therapy for Diseases Involving Angiogenesis |
| EP2012826B1 (en) * | 2006-05-04 | 2016-04-13 | Fovea Pharmaceuticals | Combination comprising a vegf inhibitor and a serine protease for treating neovascular diseases |
| US20070265170A1 (en) * | 2006-05-15 | 2007-11-15 | Ola Blixt | Detection, prevention and treatment of ovarian cancer |
| CA2652442C (en) * | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| AU2007254167B2 (en) * | 2006-05-19 | 2012-11-15 | Technion Research And Development Foundation Ltd. | Fusion proteins, uses thereof and processes for producing same |
| US20100196336A1 (en) | 2006-05-23 | 2010-08-05 | Dongsu Park | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
| EP2046384A4 (en) * | 2006-06-15 | 2009-12-02 | Fibron Ltd | ANTIBODIES BLOCKING FIBROBLAST GROWTH FACTOR RECEPTOR ACTIVATION AND METHODS OF USING THE SAME |
| JP2009539999A (ja) * | 2006-06-15 | 2009-11-19 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 第2の薬剤との組み合わせにおいてリンホトキシンベータ受容体結合分子を使用する複合療法 |
| PT2944306T (pt) | 2006-06-16 | 2021-02-15 | Regeneron Pharma | Formulações antagonistas de vegf adequadas para administração intravitreal |
| EP2044097A4 (en) * | 2006-06-23 | 2010-10-06 | Quintessence Biosciences Inc | Modified ribonucleases |
| US7589212B2 (en) * | 2006-06-27 | 2009-09-15 | Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US8846685B2 (en) | 2006-06-27 | 2014-09-30 | Aerpio Therapeutics Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7795444B2 (en) | 2006-06-27 | 2010-09-14 | Warner Chilcott Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| EP2044939A1 (en) * | 2006-06-29 | 2009-04-08 | Eisai R&D Management Co., Ltd. | Therapeutic agent for liver fibrosis |
| US20100021379A1 (en) * | 2006-06-29 | 2010-01-28 | The Regents Of The University Of California | Chemical Antibodies for Immunotherapy and Imaging |
| US8298801B2 (en) | 2006-07-17 | 2012-10-30 | Quintessence Biosciences, Inc. | Methods and compositions for the treatment of cancer |
| CA2659353C (en) * | 2006-07-28 | 2014-07-15 | Sanofi-Aventis | Composition and method for treatment of tumors |
| AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| EP2065372B1 (en) * | 2006-08-28 | 2012-11-28 | Eisai R&D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
| US20080070855A1 (en) * | 2006-09-20 | 2008-03-20 | James Pitzer Gills | Treatment with anti-VEGF agents to prevent postoperative inflammation and angiogenesis in normal and diseased eyes |
| SI2066694T1 (sl) * | 2006-09-29 | 2016-02-29 | Oncomed Pharmaceuticals, Inc. | Sestavki in postopki za diagnosticiranje in zdravljenje raka |
| AU2007311092A1 (en) * | 2006-10-17 | 2008-04-24 | Dyax Corp. | Sequential combination therapy |
| CN101589059A (zh) | 2006-10-20 | 2009-11-25 | 株式会社未来创药研究所 | 包含抗hb-egf抗体作为活性成分的药物组合物 |
| EP3040347A3 (en) * | 2006-10-20 | 2016-09-21 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient |
| US8975374B2 (en) * | 2006-10-20 | 2015-03-10 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient |
| MX2009004532A (es) * | 2006-10-27 | 2009-09-04 | Lpath Inc | Composiciones y metodos para unir esfingosina-1-fosfato. |
| MX2009003938A (es) | 2006-10-27 | 2009-04-24 | Genentech Inc | Anticuerpos e inmunoconjugados y sus usos. |
| WO2008055072A2 (en) * | 2006-10-27 | 2008-05-08 | Lpath, Inc. | Compositions and methods for treating ocular diseases and conditions |
| EP2083830A1 (en) | 2006-11-17 | 2009-08-05 | Innate Pharma | Improved methods of using phosphoantigen for the treatment of cancer |
| US20080254482A1 (en) * | 2006-11-22 | 2008-10-16 | Invitrogen Corporation | Autoimmune disease biomarkers |
| CA2670471A1 (en) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir |
| NZ578354A (en) * | 2006-12-14 | 2012-01-12 | Medarex Inc | Antibody-partner molecule conjugates that bind cd70 and uses thereof |
| BRPI0720552A2 (pt) * | 2006-12-19 | 2014-01-07 | Genentech Inc | Antagonistas específicos de vegf para terapia adjuvante e neoadjuvante e o tratamento de tumores em estágio precoce |
| WO2008074853A1 (en) * | 2006-12-21 | 2008-06-26 | Novartis Ag | Ophthalmic rebamipide solution |
| JP5618172B2 (ja) * | 2007-01-05 | 2014-11-05 | 国立大学法人東京大学 | 抗prg−3抗体を用いる癌の診断および治療 |
| WO2008089070A2 (en) * | 2007-01-12 | 2008-07-24 | Dyax Corp. | Combination therapy for the treatment of cancer |
| US8962655B2 (en) * | 2007-01-29 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Composition for treatment of undifferentiated gastric cancer |
| US7816390B2 (en) * | 2007-01-31 | 2010-10-19 | Janssen Pharmaceutica Nv | N-substituted tricyclic 3-aminopyrazoles as anti-mitotic tubulin polymerization inhibitors |
| EP2125895B1 (en) | 2007-02-02 | 2015-04-08 | Vegenics Pty Ltd | Vegf receptor antagonists for treating organ transplant alloimmunity and arteriosclerosis |
| WO2008097497A2 (en) | 2007-02-02 | 2008-08-14 | Adnexus, A Bristol-Myers Squibb R & D Company | Vegf pathway blockade |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| US20080286337A1 (en) * | 2007-05-15 | 2008-11-20 | Boston Foundation For Sight | Method of treating a disease in an eye using a scleral lens |
| AU2008259513B2 (en) * | 2007-06-06 | 2014-07-24 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
| KR100883430B1 (ko) | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
| PE20090368A1 (es) * | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
| US8097422B2 (en) | 2007-06-20 | 2012-01-17 | Salk Institute For Biological Studies | Kir channel modulators |
| US20090047689A1 (en) * | 2007-06-20 | 2009-02-19 | John Kolman | Autoantigen biomarkers for early diagnosis of lung adenocarcinoma |
| EP2170894A1 (en) * | 2007-06-21 | 2010-04-07 | Janssen Pharmaceutica N.V. | Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline |
| US8334239B2 (en) | 2007-07-10 | 2012-12-18 | The Board Of Regents Of The University Of Texas System | High affinity VEGF-receptor antagonists |
| RS53595B1 (sr) | 2007-07-16 | 2015-02-27 | Genentech, Inc. | Anti-cd79b antitela i imunokonjugati i metode upotrebe |
| ES2528922T3 (es) | 2007-07-16 | 2015-02-13 | Genentech, Inc. | Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso |
| US20100285000A1 (en) * | 2007-08-20 | 2010-11-11 | Bristol-Myers Squibb Company | Use of vegfr-2 inhibitors for treating metastatic cancer |
| JP6035009B2 (ja) | 2007-08-22 | 2016-11-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| CA2698343C (en) | 2007-09-04 | 2018-06-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| WO2009036368A2 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| CA2700173C (en) * | 2007-09-25 | 2016-10-11 | Topotarget Uk Limited | Methods of synthesis of certain hydroxamic acid compounds |
| WO2009042854A1 (en) * | 2007-09-26 | 2009-04-02 | Musculoskeletal Research Llc | Ion-channel regulator compositions and methods of using same |
| US20100291113A1 (en) * | 2007-10-03 | 2010-11-18 | Cornell University | Treatment of Proliferative Disorders Using Antibodies to PSMA |
| JP2010540681A (ja) * | 2007-10-08 | 2010-12-24 | クインテッセンス バイオサイエンシズ,インコーポレーテッド | リボヌクレアーゼに基づく治療のための組成物及び方法 |
| JO3240B1 (ar) * | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| US8361465B2 (en) * | 2007-10-26 | 2013-01-29 | Lpath, Inc. | Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents |
| US20090170770A1 (en) * | 2007-11-06 | 2009-07-02 | Ali Hafezi-Moghadam | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor |
| US20110003890A1 (en) * | 2007-11-08 | 2011-01-06 | Jason Joel Schwartz | Use of angiogenesis antagonists in conditions of abnormal venous proliferation |
| JP5809415B2 (ja) * | 2007-11-09 | 2015-11-10 | ペレグリン ファーマシューティカルズ,インコーポレーテッド | 抗vegf抗体の組成物および方法 |
| AU2013205269B2 (en) * | 2007-11-09 | 2016-05-19 | Affitech Research As | Anti-VEGF antibody compositions and methods |
| CN101848895B (zh) | 2007-11-09 | 2013-10-23 | 卫材R&D管理有限公司 | 血管新生抑制物质和抗肿瘤性铂络合物的组合使用 |
| ES2369717T3 (es) * | 2007-11-30 | 2011-12-05 | F. Hoffmann-La Roche Ag | Estabilización de conjugados que comprenden una molécula conectora de tiourea. |
| TWI580694B (zh) * | 2007-11-30 | 2017-05-01 | 建南德克公司 | 抗-vegf抗體 |
| US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
| EP2240156A2 (en) * | 2007-12-28 | 2010-10-20 | BioInvent International AB | Antibody-containing formulation for the use for treating cardiovascular diseases associated with atherosclerosis |
| CA2713137C (en) * | 2008-01-25 | 2017-10-24 | Hadasit Medical Research Services And Development Ltd. | Targeting of innate immune response to tumor site |
| BRPI0906576A2 (pt) * | 2008-01-29 | 2015-07-07 | Eisai R&D Man Co Ltd | Composição farmacêutica, kit, uso de um composto, e, agente terapêutico para câncer |
| IL287292B (en) | 2008-01-31 | 2022-09-01 | Genentech Inc | Cycteine engineering anti-cd79b antibodies and antibody-drug conjugates |
| JP2011517314A (ja) | 2008-02-14 | 2011-06-02 | ブリストル−マイヤーズ スクイブ カンパニー | Egfrに結合する操作されたタンパク質に基づく標的化された治療薬 |
| ES2536208T3 (es) * | 2008-03-07 | 2015-05-21 | Onxeo Dk, Branch Of Onxeo S.A., France | Métodos de tratamiento que emplean infusión continua prolongada de Belinostat |
| US8663643B2 (en) | 2008-03-18 | 2014-03-04 | Genentech, Inc. | Combinations of an anti-HER2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| CN103992405B (zh) * | 2008-03-26 | 2016-08-17 | 宜康公司 | 抗-vegf抗体 |
| AU2014202474B2 (en) * | 2008-03-26 | 2016-07-28 | Epitomics, Inc. | Anti-VEGF antibody |
| KR100998569B1 (ko) * | 2008-03-31 | 2010-12-07 | 한국원자력연구원 | 암 또는 전이암 진단 및 치료용 방사면역접합체,및 이를이용한 암 또는 전이암 억제제 개발 |
| EP2280731A1 (en) * | 2008-04-09 | 2011-02-09 | Technion Research and Development Foundation, Ltd. | Anti human immunodeficiency antibodies and uses thereof |
| CN102083615B (zh) * | 2008-04-10 | 2014-08-13 | 战略系统有限公司 | 用于三维模型打印的系统和方法 |
| WO2009133208A1 (en) | 2008-05-02 | 2009-11-05 | Novartis Ag | Improved fibronectin-based binding molecules and uses thereof |
| CA2723197C (en) | 2008-05-02 | 2017-09-19 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| ES2338400B1 (es) * | 2008-05-06 | 2011-09-14 | David Benet Ferrus | Conjunto de moleculas antiangiogenicas y su uso. |
| US8082730B2 (en) * | 2008-05-20 | 2011-12-27 | Caterpillar Inc. | Engine system having particulate reduction device and method |
| CN102099373A (zh) | 2008-05-22 | 2011-06-15 | 百时美施贵宝公司 | 基于纤连蛋白的多价支架结构域蛋白 |
| US20090298088A1 (en) * | 2008-05-30 | 2009-12-03 | Belyaev Alexander S | Cleavable catalytic binding and detection system |
| CN110372792A (zh) | 2008-06-25 | 2019-10-25 | 艾斯巴技术-诺华有限责任公司 | 抑制vegf的稳定和可溶的抗体 |
| US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
| CN102227443B (zh) | 2008-10-01 | 2014-05-14 | 昆特森斯生物科学公司 | 治疗性核糖核酸酶 |
| JP2012505228A (ja) * | 2008-10-07 | 2012-03-01 | レクサン ファーマシューティカルズ インコーポレイテッド | Hpma−ドセタキセルまたはゲムシタビンコンジュゲートおよびその使用 |
| US8871202B2 (en) | 2008-10-24 | 2014-10-28 | Lpath, Inc. | Prevention and treatment of pain using antibodies to sphingosine-1-phosphate |
| PL2842573T3 (pl) | 2008-11-07 | 2018-04-30 | Galaxy Biotech, Llc | Przeciwciała monoklonalne swoiste dla receptora 2 czynnika wzrostu fibroblastów |
| PA8849001A1 (es) | 2008-11-21 | 2010-06-28 | Lilly Co Eli | Anticuerpos de c-met |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| CN102227226B (zh) | 2008-12-12 | 2015-05-13 | 贝林格尔.英格海姆国际有限公司 | 抗igf抗体 |
| EP3543256A1 (en) * | 2009-01-12 | 2019-09-25 | Cytomx Therapeutics Inc. | Modified antibody compositions, methods of making and using thereof |
| GB0900555D0 (en) * | 2009-01-14 | 2009-02-11 | Topotarget As | New methods |
| WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
| WO2010091234A2 (en) | 2009-02-06 | 2010-08-12 | The General Hospital Corporation | Methods of treating vascular lesions |
| EP3903829B1 (en) | 2009-02-13 | 2023-05-03 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| US10517969B2 (en) * | 2009-02-17 | 2019-12-31 | Cornell University | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| EP2398494A4 (en) | 2009-02-23 | 2015-10-28 | Cytomx Therapeutics Inc | Proproteins and their methods of use |
| KR101224468B1 (ko) * | 2009-05-20 | 2013-01-23 | 주식회사 파멥신 | 신규한 형태의 이중표적항체 및 그 용도 |
| US20120135064A1 (en) * | 2009-05-27 | 2012-05-31 | Northeastern University | Conjugated nanodelivery vehicles |
| GB0909906D0 (en) | 2009-06-09 | 2009-07-22 | Affitech As | Antibodies |
| CN105412094A (zh) | 2009-07-06 | 2016-03-23 | 爱尔皮奥治疗有限公司 | 用于防止癌细胞转移的化合物、组合物和方法 |
| US8883832B2 (en) | 2009-07-06 | 2014-11-11 | Aerpio Therapeutics Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| US8956600B2 (en) * | 2009-08-10 | 2015-02-17 | Taiwan Liposome Co. Ltd. | Ophthalmic drug delivery system containing phospholipid and cholesterol |
| CN102002104A (zh) | 2009-08-28 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种抗vegf的单克隆抗体及含有该抗体的药物组合物 |
| US8178307B2 (en) * | 2009-09-02 | 2012-05-15 | National Tsing Hua University | Methods and compositions for detection of lethal cell and uses thereof |
| WO2011028642A1 (en) | 2009-09-04 | 2011-03-10 | University Of Louisville Research Foundation, Inc. | Genetic determinants of prostate cancer risk |
| EP2293071A1 (en) * | 2009-09-07 | 2011-03-09 | Universität Zu Köln | Biomarker for colorectal cancer |
| EP2478110B1 (en) | 2009-09-16 | 2016-01-06 | Immunomedics, Inc. | Class i anti-cea antibodies and uses thereof |
| JP5749273B2 (ja) | 2009-10-13 | 2015-07-15 | レクサン ファーマシューティカルズ インコーポレイテッド | 抗がん剤送達のためのポリマー系 |
| TR201818814T4 (tr) | 2009-10-16 | 2019-01-21 | Oncomed Pharm Inc | Dll4 antagonist antikorlarının ve anti-hipertansif ajanların terapötik kombinasyonu ve kullanımı. |
| HRP20191129T1 (hr) | 2009-11-24 | 2019-09-20 | Alethia Biotherapeutics Inc. | Anti-klusterinska protutijela i ulomci koji vežu antigen i njihova uporaba za smanjivanje volumena tumora |
| ES2978177T3 (es) | 2009-12-02 | 2024-09-06 | Immunomedics Inc | Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer |
| EP2506876B1 (en) | 2009-12-02 | 2016-10-12 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| EP2526421B1 (en) * | 2010-01-22 | 2018-11-21 | Immunomedics, Inc. | Detection of early-stage pancreatic adenocarcinoma |
| ES2668645T3 (es) | 2010-02-08 | 2018-05-21 | Agensys, Inc. | Conjugados de fármaco y anticuerpo (ADC) que se unen a proteínas 161P2F10B |
| GB201002238D0 (en) | 2010-02-10 | 2010-03-31 | Affitech As | Antibodies |
| RU2615143C2 (ru) | 2010-03-24 | 2017-04-04 | Адвирна | Самодоставляющие PHKi соединения уменьшенного размера |
| CN106074591B (zh) | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | 眼部症候中的rna干扰 |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| US20130108646A1 (en) | 2010-05-04 | 2013-05-02 | Medimmune, Llc | Optimized degenerative muscle disease diagnostics and treatments |
| EP2576615B1 (en) | 2010-05-26 | 2016-03-30 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
| ES2573515T3 (es) | 2010-06-25 | 2016-06-08 | Eisai R&D Management Co., Ltd. | Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados |
| BR112013000341A2 (pt) * | 2010-07-07 | 2017-09-26 | Tubitak | estruturas de anticorpos recombinantes ligando-se e bloqueando o crescimento da atividade vascular endotelial de fator 2 (vegfr-2/kdr) |
| CN101942022B (zh) * | 2010-07-29 | 2013-07-24 | 华东理工大学 | 抗人表皮生长因子受体单链抗体-铁蛋白重链亚基蛋白、构建方法及其用途 |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| US8722044B2 (en) | 2011-03-15 | 2014-05-13 | Janssen Biotech, Inc. | Human tissue factor antibody and uses thereof |
| EP2697394A4 (en) | 2011-04-12 | 2015-01-14 | Electronic Biosciences Inc | CHEMICALLY MODIFIED NANOPORA DEVICES AT A SPECIFIC SITE |
| MX2013009931A (es) | 2011-04-18 | 2013-10-01 | Eisai R&D Man Co Ltd | Agentes terapeuticos contra tumores. |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| CA2831572C (en) | 2011-05-02 | 2019-11-26 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
| EP2714937B1 (en) | 2011-06-03 | 2018-11-14 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| EP2540828A1 (en) | 2011-06-30 | 2013-01-02 | Gene Signal International SA | Composition comprising inhibitors of IRS-1 and of VEGF |
| CN108159426A (zh) | 2011-06-30 | 2018-06-15 | 基因信号国际公司 | 含有irs-1抑制剂和vegf抑制剂的组合物 |
| US9682144B2 (en) | 2011-06-30 | 2017-06-20 | Gene Signal International, Sa | Composition comprising inhibitors of IRS-1 and of VEGF |
| US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
| PT3485903T (pt) | 2011-09-23 | 2023-02-17 | Mereo Biopharma 5 Inc | Agentes de ligação a vegf/dll4 e utilizações dos mesmos |
| US20130095065A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for Treating Vascular Leak Syndrome and Cancer |
| CN102492038B (zh) * | 2011-12-09 | 2014-05-28 | 中国人民解放军军事医学科学院基础医学研究所 | 抗人Tim-3的中和性单克隆抗体L3D及其用途 |
| SG11201403062YA (en) | 2011-12-13 | 2014-07-30 | Engeneic Molecular Delivery Pty Ltd | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
| WO2013121426A1 (en) | 2012-02-13 | 2013-08-22 | Gamida-Cell Ltd. | Culturing of mesenchymal stem cells |
| EA201491568A1 (ru) | 2012-02-22 | 2014-11-28 | Алетиа Байотерапьютикс Инк. | Совместное применение ингибитора кластерина и ингибитора egfr для лечения рака |
| EP2823311B1 (en) | 2012-03-06 | 2016-04-27 | Life Technologies Corporation | Biomarkers for systemic lupus erythematosus |
| CN104411332B (zh) | 2012-03-30 | 2018-11-23 | 索伦托治疗有限公司 | 与vegfr2结合的全人抗体 |
| EP2861998B1 (en) | 2012-06-18 | 2020-07-22 | Electronic Biosciences Inc. | Cell-free assay device and methods of use |
| US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
| US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
| JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
| US9303046B2 (en) | 2012-08-07 | 2016-04-05 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
| US9382329B2 (en) | 2012-08-14 | 2016-07-05 | Ibc Pharmaceuticals, Inc. | Disease therapy by inducing immune response to Trop-2 expressing cells |
| AU2013302696B9 (en) | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| CA2889638A1 (en) | 2012-10-31 | 2014-05-08 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a dll4 antagonist |
| JP6133431B2 (ja) | 2012-11-24 | 2017-05-24 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用 |
| DK2900277T3 (da) | 2012-12-13 | 2022-04-04 | Immunomedics Inc | Doser af immunokonjugater af antistoffer og sn-38 til forbedret effektivitet og reduceret toksicitet |
| MX2015004979A (es) | 2012-12-21 | 2015-07-17 | Eisai R&D Man Co Ltd | Forma amorfa de derivado de quinolina y metodo para su produccion. |
| WO2014110261A1 (en) | 2013-01-11 | 2014-07-17 | Massachusetts Eye And Ear Infirmary | Cyp450 lipid metabolites reduce inflammation and angiogenesis |
| MY170528A (en) | 2013-02-18 | 2019-08-09 | Vegenics Pty Ltd | Vegfr-3 ligand binding molecules and uses thereof |
| US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
| KR102049990B1 (ko) | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| US9452228B2 (en) | 2013-04-01 | 2016-09-27 | Immunomedics, Inc. | Antibodies reactive with an epitope located in the N-terminal region of MUC5AC comprising cysteine-rich subdomain 2 (Cys2) |
| WO2014182635A1 (en) | 2013-05-08 | 2014-11-13 | Baldwin Megan E | Biomarkers for age-related macular degeneration (amd) |
| NZ714049A (en) | 2013-05-14 | 2020-05-29 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| KR101541478B1 (ko) * | 2013-05-31 | 2015-08-05 | 동아쏘시오홀딩스 주식회사 | 항-vegf 항체 및 이를 포함하는 암 또는 신생혈관형성관련 질환의 예방, 진단 또는 치료용 약학 조성물 |
| EP3019243A4 (en) | 2013-07-12 | 2017-03-15 | Ophthotech Corporation | Methods for treating or preventing ophthalmological conditions |
| ME03476B (me) | 2013-08-01 | 2020-01-20 | Five Prime Therapeutics Inc | Nefukozilisana anti-fgfr2iiib antitijela |
| CN113151180A (zh) | 2013-12-02 | 2021-07-23 | 菲奥医药公司 | 癌症的免疫治疗 |
| US9914769B2 (en) * | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
| WO2015126548A1 (en) | 2014-02-21 | 2015-08-27 | Ibc Pharmaceuticals, Inc. | Disease therapy by inducing immune response to trop-2 expressing cells |
| CA2935748A1 (en) | 2014-02-25 | 2015-09-03 | Immunomedics, Inc. | Humanized rfb4 anti-cd22 antibody |
| US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| ES2913840T3 (es) | 2014-03-20 | 2022-06-06 | Bristol Myers Squibb Co | Dominios de tipo III de fibronectina de unión a seroalbúmina |
| WO2015164541A1 (en) * | 2014-04-22 | 2015-10-29 | Presage Biosciences, Inc. | Methods and devices for evaluating drug candidates |
| WO2015200260A1 (en) | 2014-06-24 | 2015-12-30 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| PT3170005T (pt) | 2014-07-18 | 2019-07-16 | Sanofi Sa | Método para a previsão do resultado de um tratamento com aflibercept de um paciente suspeito de sofrer de um cancro |
| CN113683564A (zh) | 2014-08-28 | 2021-11-23 | 卫材R&D管理有限公司 | 高纯度喹啉衍生物及其生产方法 |
| CA2958882A1 (en) * | 2014-09-02 | 2016-03-10 | Immunogen, Inc. | Methods for formulating antibody drug conjugate compositions |
| EP3689910A3 (en) | 2014-09-23 | 2020-12-02 | F. Hoffmann-La Roche AG | Method of using anti-cd79b immunoconjugates |
| JP6678941B2 (ja) | 2014-10-07 | 2020-04-15 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 抗体−薬物コンジュゲートのネオアジュバント使用 |
| ES2808153T3 (es) | 2014-10-31 | 2021-02-25 | Mereo Biopharma 5 Inc | Terapia de combinación para tratamiento de enfermedad |
| TWI695837B (zh) | 2014-12-04 | 2020-06-11 | 比利時商健生藥品公司 | 作為激酶調節劑之三唑並嗒 |
| ES2833530T3 (es) * | 2015-01-06 | 2021-06-15 | Zhuhai Essex Bio Pharmaceutical Co Ltd | Anticuerpo anti-VEGF |
| AR103477A1 (es) | 2015-01-28 | 2017-05-10 | Lilly Co Eli | Compuestos de vegfa / ang2 |
| LT3263106T (lt) | 2015-02-25 | 2024-01-10 | Eisai R&D Management Co., Ltd. | Chinolino darinių kartumo sumažinimo būdas |
| US9895313B2 (en) | 2015-03-03 | 2018-02-20 | Cureport, Inc. | Combination liposomal pharmaceutical formulations |
| CN107530291A (zh) | 2015-03-03 | 2018-01-02 | 奎尔波特股份有限公司 | 双重负载的脂质体药物制剂 |
| CA2978226C (en) | 2015-03-04 | 2025-02-18 | Eisai R&D Management Co., Ltd. | COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER |
| JP6746845B2 (ja) | 2015-04-22 | 2020-08-26 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 循環trop−2陽性癌細胞の単離、検出、診断及び/または特徴付け |
| AU2015242210A1 (en) | 2015-06-15 | 2017-12-07 | Hangzhou Dac Biotech Co., Ltd | Hydrophilic linkers for conjugation |
| CN107801379B (zh) | 2015-06-16 | 2021-05-25 | 卫材R&D管理有限公司 | 抗癌剂 |
| WO2016210108A1 (en) | 2015-06-25 | 2016-12-29 | Immunomedics, Inc. | Combining anti-hla-dr or anti-trop-2 antibodies with microtubule inhibitors, parp inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer |
| PL3316885T3 (pl) | 2015-07-01 | 2021-12-06 | Immunomedics, Inc. | Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a |
| JP6759326B2 (ja) | 2015-07-12 | 2020-09-23 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 細胞結合分子の共役のための架橋連結体 |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| CN108136012B (zh) | 2015-08-07 | 2022-10-04 | 伊麦吉纳博公司 | 靶向分子的抗原结合构建体 |
| RU2718048C2 (ru) | 2015-08-20 | 2020-03-30 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое терапевтическое средство |
| KR102725051B1 (ko) | 2015-09-23 | 2024-11-04 | 제넨테크, 인크. | 항-vegf 항체의 최적화된 변이체들 |
| JP6893504B2 (ja) | 2015-09-23 | 2021-06-23 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 速い解離速度を有する血清アルブミン結合フィブロネクチンタイプiiiドメイン |
| AU2016326609B2 (en) | 2015-09-23 | 2023-03-09 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| WO2017059397A1 (en) | 2015-10-01 | 2017-04-06 | Whitehead Institute For Biomedical Research | Labeling of antibodies |
| WO2017075585A1 (en) * | 2015-10-30 | 2017-05-04 | The Jackson Laboratory | Compositions and methods relating to tumor analysis |
| KR20250034528A (ko) | 2015-11-23 | 2025-03-11 | 파이브 프라임 테라퓨틱스, 인크. | 암 치료에서의 단독의, 또는 면역 자극제와 병용한, fgfr2 억제제 |
| CA3007276C (en) | 2015-12-03 | 2021-12-28 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitor to treat macular degeneration in a patient population |
| AU2016381964B2 (en) | 2015-12-30 | 2024-02-15 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| KR102293755B1 (ko) | 2016-01-06 | 2021-08-24 | 오더-메이드 메디컬 리서치 인코포레이티드 | 고친화성 항vegf 항체 |
| CN108779172B (zh) * | 2016-01-06 | 2022-02-08 | 定制药品研究株式会社 | 抑制vegf与nrp1结合的抗体 |
| CN114703244A (zh) * | 2016-05-10 | 2022-07-05 | 豪夫迈·罗氏有限公司 | 重组产生多肽期间减少三硫键的方法 |
| ES2985318T3 (es) * | 2016-05-30 | 2024-11-05 | Eiken Chemical | Anticuerpo monoclonal anti hemoglobina humana o kit de anticuerpos, partícula portadora insoluble en la que se inmoviliza el anticuerpo monoclonal anti hemoglobina humana, reactivo de medición y método de medición usando el mismo |
| WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| GB2551979A (en) | 2016-06-30 | 2018-01-10 | Rs Arastirma Egitim Danismanlik Llac Sanayi Ticaret Ltd | Cleavable polymer drug conjugates |
| CA3037461A1 (en) * | 2016-09-27 | 2018-04-05 | The University Of The Highlands And Islands | Antigen biomarkers |
| CN109789209A (zh) * | 2016-10-14 | 2019-05-21 | 诺华股份有限公司 | 使用csf-1r抑制剂治疗眼部疾病的方法 |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN110099682B (zh) | 2016-11-14 | 2023-03-31 | 杭州多禧生物科技有限公司 | 偶联连接体,含有此连接体的细胞结合分子-药物偶联物及其制备和应用 |
| GB2556055B (en) | 2016-11-16 | 2022-03-23 | Rs Arastirma Egitim Danismanlik Ilac Sanayi Ticaret Ltd Sti | Self-assembled diblock copolymers composed of pegmema and drug bearing polymeric segments |
| WO2018147275A1 (ja) | 2017-02-08 | 2018-08-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| AU2018247767B2 (en) | 2017-04-03 | 2025-01-30 | F. Hoffmann-La Roche Ag | Antibodies binding to STEAP-1 |
| JP7204132B2 (ja) * | 2017-05-02 | 2023-01-16 | 国立研究開発法人国立がん研究センター | プラスミンにより切断可能な抗不溶性フィブリン抗体と薬物とのコンジュゲート |
| PT3624837T (pt) | 2017-05-16 | 2025-10-01 | Five Prime Therapeutics Inc | Anticorpos anti-fgfr2 em combinação com agentes quimioterapêuticos no tratamento do cancro |
| RU2019134940A (ru) | 2017-05-16 | 2021-06-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Лечение гепатоцеллюлярной карциномы |
| US10543231B2 (en) | 2017-05-19 | 2020-01-28 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| US10894019B2 (en) | 2017-08-15 | 2021-01-19 | University Of South Carolina | Drug delivery system and method for targeting cancer stem cells |
| EP3731865A1 (en) | 2017-12-29 | 2020-11-04 | F. Hoffmann-La Roche AG | Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody |
| CN112203679A (zh) | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | Il-6抗体及其融合构建体和缀合物 |
| US20210009695A1 (en) * | 2018-03-19 | 2021-01-14 | Pharmabcine Inc. | Anti-vegfr-2 antibody |
| JP2021522308A (ja) | 2018-05-04 | 2021-08-30 | トゥリーズ | 上皮細胞及び骨髄細胞の両方を活性化するtlr3リガンド |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| CN113272323A (zh) * | 2018-12-21 | 2021-08-17 | 豪夫迈·罗氏有限公司 | 用于改善抗vegf抗体对vegf与vegf-r1的结合的抑制的方法 |
| US11672767B2 (en) | 2019-05-13 | 2023-06-13 | University Of South Carolina | Enzymatically cleavable self-assembled nanoparticles for morphogen delivery |
| EP4021894A1 (en) | 2019-08-30 | 2022-07-06 | University of Rochester | Septin inhibitors for treatment of cancers |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| TWI877278B (zh) | 2019-12-30 | 2025-03-21 | 美商思進公司 | 以非海藻糖苷化抗-cd70抗體治療癌症之方法 |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| US20250073349A1 (en) | 2021-05-10 | 2025-03-06 | Kawasaki Institute Of Industrial Promotion | Antibody having reduced binding affinity for antigen |
| JP2024541058A (ja) | 2021-11-03 | 2024-11-06 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ. | 抗体の特異的共役 |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456550A (en) | 1982-11-22 | 1984-06-26 | President And Fellows Of Harvard College | Vascular permeability factor |
| US4925922A (en) * | 1983-02-22 | 1990-05-15 | Xoma Corporation | Potentiation of cytotoxic conjugates |
| FR2566271B1 (fr) | 1984-06-20 | 1986-11-07 | Sanofi Sa | Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention |
| CA1289880C (en) | 1985-12-06 | 1991-10-01 | Jeffrey L. Winkelhake | Anti-human ovarian cancer immunotoxins and methods of use thereof |
| FR2601679B1 (fr) | 1986-07-15 | 1990-05-25 | Sanofi Sa | Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant |
| CA1338645C (en) | 1987-01-06 | 1996-10-15 | George R. Pettit | Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins" |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5008196A (en) | 1987-08-21 | 1991-04-16 | Monsanto Company | Stimulation of endothelial cell growth |
| US5036003A (en) | 1987-08-21 | 1991-07-30 | Monsanto Company | Antibodies to VPF |
| US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| US5024834A (en) | 1988-07-12 | 1991-06-18 | Cetus Corporation | Thioether linked immunotoxin conjugates |
| US6007817A (en) | 1988-10-11 | 1999-12-28 | University Of Southern California | Vasopermeability enhancing immunoconjugates |
| US5240848A (en) | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US4940726A (en) | 1989-04-26 | 1990-07-10 | Arizona Board Of Regents | Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2 |
| US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| US6020145A (en) * | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
| US5194596A (en) | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5165923A (en) | 1989-11-20 | 1992-11-24 | Imperial Cancer Research Technology | Methods and compositions for the treatment of hodgkin's disease |
| ATE221915T1 (de) | 1991-02-22 | 2002-08-15 | American Cyanamid Co | Identifizierung eines menschlichen rezeptor- tyrosinkinasegens |
| US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| US20020032313A1 (en) * | 1991-03-29 | 2002-03-14 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| US20030206899A1 (en) * | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| WO1993008210A1 (en) | 1991-10-18 | 1993-04-29 | Beth Israel Hospital Association | Vascular permeability factor targeted compounds |
| US6022541A (en) | 1991-10-18 | 2000-02-08 | Beth Israel Deaconess Medical Center | Immunological preparation for concurrent specific binding to spatially exposed regions of vascular permeability factor bound in-vivo to a tumor associated blood vessel |
| US5234955A (en) | 1991-12-20 | 1993-08-10 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US5660827A (en) | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| AU3737893A (en) * | 1992-03-05 | 1993-10-05 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
| US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US5281700A (en) | 1992-08-11 | 1994-01-25 | The Regents Of The University Of California | Method of recovering endothelial membrane from tissue and applications thereof |
| WO1994010202A1 (en) | 1992-10-28 | 1994-05-11 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| AU673865B2 (en) | 1992-10-29 | 1996-11-28 | Australian National University, The | Angiogenesis inhibitory antibodies |
| CN1701814A (zh) | 1992-11-13 | 2005-11-30 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
| US5643755A (en) | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
| US5879672A (en) | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
| US5840301A (en) | 1994-02-10 | 1998-11-24 | Imclone Systems Incorporated | Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors |
| GB9410533D0 (en) | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | In situ hybridisation and immuno-Chemical localisation of a growth factor |
| US5786344A (en) | 1994-07-05 | 1998-07-28 | Arch Development Corporation | Camptothecin drug combinations and methods with reduced side effects |
| JP4361133B2 (ja) | 1994-07-11 | 2009-11-11 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | 血管系の特異的凝固のための方法および組成物 |
| US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
| US5650490A (en) | 1994-10-07 | 1997-07-22 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 2 |
| US5561122A (en) | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| US5730977A (en) | 1995-08-21 | 1998-03-24 | Mitsui Toatsu Chemicals, Inc. | Anti-VEGF human monoclonal antibody |
| US6020473A (en) | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
| US5854205A (en) * | 1995-10-23 | 1998-12-29 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
| JPH09124697A (ja) | 1995-11-01 | 1997-05-13 | Toagosei Co Ltd | ペプチド及びモノクローナル抗体 |
| US5942385A (en) | 1996-03-21 | 1999-08-24 | Sugen, Inc. | Method for molecular diagnosis of tumor angiogenesis and metastasis |
| US5851797A (en) | 1996-06-19 | 1998-12-22 | Regeneron Pharmaceuticals, Inc. | Tie ligand-3, methods of making and uses thereof |
| US6008319A (en) | 1996-12-23 | 1999-12-28 | University Of Southern California | Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof |
| US6291667B1 (en) | 1997-01-31 | 2001-09-18 | Parkash S. Gill | Method and composition for treatment of kaposi's sarcoma |
| ES2361267T3 (es) | 1997-04-07 | 2011-06-15 | Genentech Inc. | Procedimiento para la produccion de anticuerpos humanizados mediante mutagénesis aleatoria. |
| ES2273415T3 (es) | 1997-04-07 | 2007-05-01 | Genentech, Inc. | Anticuerpos anti-vegf. |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| DE69832798T2 (de) * | 1997-06-03 | 2006-09-14 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Regulatorische sequenzen für die in-vivo-expression einer heterologen dns-sequenz in endothelzellen und ihre verwendungen. |
| US5972338A (en) | 1997-09-19 | 1999-10-26 | Genentech, Inc. | Tie ligands homologues |
| US6057435A (en) | 1997-09-19 | 2000-05-02 | Genentech, Inc. | Tie ligand homologues |
| US6030831A (en) | 1997-09-19 | 2000-02-29 | Genetech, Inc. | Tie ligand homologues |
| WO1999040118A1 (en) | 1998-02-04 | 1999-08-12 | Kyowa Hakko Kogyo Co., Ltd. | Antibodies against human vegf receptor kdr |
| WO2000034337A1 (en) | 1998-12-10 | 2000-06-15 | Tsukuba Research Laboratory, Toagosei Co., Ltd. | Humanized monoclonal antibodies against vascular endothelial cell growth factor |
| ATE300957T1 (de) | 1998-12-22 | 2005-08-15 | Genentech Inc | Antagonisten von vaskular-endothelialen zellwachstumsfaktoren und ihre anwendung |
| MXPA01010891A (es) | 1999-04-28 | 2002-11-07 | Univ Texas | Composiciones y metodos para el tratamiento contra el cancer mediante la inhibicion selectiva del factor de crecimiento endotelial vascular (vegf). |
| US6703020B1 (en) * | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| US7740841B1 (en) | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
| IL159894A0 (en) * | 2001-07-17 | 2004-06-20 | Res Dev Foundation | Therapeutic agents comprising pro-apoptotic proteins |
-
2000
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- 2000-04-28 AU AU48049/00A patent/AU763954B2/en not_active Ceased
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- 2000-04-28 BR BR0010017-0A patent/BR0010017A/pt not_active Application Discontinuation
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2001
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- 2001-11-30 US US09/998,831 patent/US6676941B2/en not_active Expired - Lifetime
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2003
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2010
- 2010-09-30 JP JP2010223006A patent/JP2011046720A/ja not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| Cancer Research, Vol. 58, No. 9, pp. 1952-1959 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101093717B1 (ko) | 2008-11-26 | 2011-12-19 | 한국생명공학연구원 | Vegf―특이적인 인간항체 |
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