JP3878849B2 - インダゾール及びプロテインキナーゼ阻害のためのその使用 - Google Patents

インダゾール及びプロテインキナーゼ阻害のためのその使用 Download PDF

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JP3878849B2
JP3878849B2 JP2001507809A JP2001507809A JP3878849B2 JP 3878849 B2 JP3878849 B2 JP 3878849B2 JP 2001507809 A JP2001507809 A JP 2001507809A JP 2001507809 A JP2001507809 A JP 2001507809A JP 3878849 B2 JP3878849 B2 JP 3878849B2
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indazole
calc
mmol
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JP2003503481A (ja
JP2003503481A5 (OSRAM
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ロバート・スティーブン・カニア
スティーブン・リー・ベンダー
アレン・ジェイ・ボーチャート
ジョン・エフ・ブラガンツァ
ステファン・ジェームズ・クリップス
イェ・ファ
マイケル・デイビッド・ジョンソン
テオドーア・オットー・ジョンソン・ジュニア
ヒープ・テ・ルー
シンシア・ルイーズ・パルマー
ジークフリード・ハインツ・ライッヒ
アンナ・マリア・テンプチーク−ラッセル
ミン・テン
クリスティーン・トーマス
マイケル・デイビッド・バーニー
マイケル・ブレナン・ウォレス
マイケル・レイモンド・コリンズ
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アグロン ファ−マシュ−テイカルズ インコ−ポレイテッド
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001507809A 1999-07-02 2000-06-30 インダゾール及びプロテインキナーゼ阻害のためのその使用 Expired - Lifetime JP3878849B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14213099P 1999-07-02 1999-07-02
US60/142,130 1999-07-02
PCT/US2000/018263 WO2001002369A2 (en) 1999-07-02 2000-06-30 Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use

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JP2006232927A Division JP3969669B2 (ja) 1999-07-02 2006-08-30 インダゾール及びプロテインキナーゼ阻害のためのその使用

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JP2003503481A JP2003503481A (ja) 2003-01-28
JP2003503481A5 JP2003503481A5 (OSRAM) 2006-05-18
JP3878849B2 true JP3878849B2 (ja) 2007-02-07

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JP2006232927A Expired - Lifetime JP3969669B2 (ja) 1999-07-02 2006-08-30 インダゾール及びプロテインキナーゼ阻害のためのその使用

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EP (2) EP1614683B1 (OSRAM)
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KR (1) KR100529639B1 (OSRAM)
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SK288365B6 (sk) 1999-02-10 2016-07-01 Astrazeneca Ab Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
CN100379734C (zh) 1999-12-24 2008-04-09 阿文蒂斯药物有限公司 氮杂吲哚类化合物
WO2001057034A1 (en) 2000-02-07 2001-08-09 Bristol-Myers Squibb Co. 3-aminopyrazole inhibitors of cyclin dependent kinases
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