|
US2729949A
(en)
*
|
1954-11-19 |
1956-01-10 |
Rca Corp |
Cumulative cooling system
|
|
US3773719A
(en)
|
1966-12-06 |
1973-11-20 |
Hoffmann La Roche |
2-aminoxy-2'-acyl-acetanilide
|
|
US4658019A
(en)
|
1979-04-26 |
1987-04-14 |
Ortho Pharmaceutical Corporation |
Complement-fixing monoclonal antibody to human T cells
|
|
JPS5912436B2
(ja)
|
1980-08-05 |
1984-03-23 |
ファナック株式会社 |
工業用ロボットの安全機構
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
EP0281604B1
(en)
|
1986-09-02 |
1993-03-31 |
Enzon Labs Inc. |
Single polypeptide chain binding molecules
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US6121424A
(en)
|
1991-11-25 |
2000-09-19 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
WO1991006319A1
(en)
|
1989-10-27 |
1991-05-16 |
Arch Development Corporation |
Methods and compositions for promoting immunopotentiation
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
WO1996033735A1
(en)
|
1995-04-27 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DK0585287T3
(da)
|
1990-07-10 |
2000-04-17 |
Cambridge Antibody Tech |
Fremgangsmåde til fremstilling af specifikke bindingsparelementer
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
US5474771A
(en)
|
1991-11-15 |
1995-12-12 |
The Trustees Of Columbia University In The City Of New York |
Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
|
|
PT1024191E
(pt)
|
1991-12-02 |
2008-12-22 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
|
CA2131151A1
(en)
|
1992-03-24 |
1994-09-30 |
Kevin S. Johnson |
Methods for producing members of specific binding pairs
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
ES2301158T3
(es)
|
1992-07-24 |
2008-06-16 |
Amgen Fremont Inc. |
Produccion de anticuerpos xenogenicos.
|
|
US5648267A
(en)
|
1992-11-13 |
1997-07-15 |
Idec Pharmaceuticals Corporation |
Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
|
|
JPH08509612A
(ja)
|
1993-04-26 |
1996-10-15 |
ジェンファーム インターナショナル インコーポレイテッド |
異種抗体を産生することができるトランスジェニック非ヒト動物
|
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
|
UA40577C2
(uk)
|
1993-08-02 |
2001-08-15 |
Мерк Патент Гмбх |
Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
|
|
WO1995015388A1
(en)
|
1993-12-03 |
1995-06-08 |
Medical Research Council |
Recombinant binding proteins and peptides
|
|
US5595756A
(en)
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
US5945311A
(en)
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
|
DE122009000068I2
(de)
|
1994-06-03 |
2011-06-16 |
Ascenion Gmbh |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
|
DE69535243T2
(de)
|
1994-07-13 |
2007-05-10 |
Chugai Seiyaku K.K. |
Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper
|
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6805869B2
(en)
|
1996-06-12 |
2004-10-19 |
Shanghai Cp Guojian Pharmaceutical Co., Ltd. |
Cellular vaccines and immunotherapeutics and methods for their preparation
|
|
DK0826695T3
(da)
*
|
1996-09-03 |
2002-04-15 |
Gsf Forschungszentrum Umwelt |
Tilintetgørelse af kontaminerende tumorceller i stamcelletransplantater med bispecifikke antistoffer
|
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
ATE299938T1
(de)
|
1997-05-02 |
2005-08-15 |
Genentech Inc |
Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
|
ATE375365T1
(de)
|
1998-04-02 |
2007-10-15 |
Genentech Inc |
Antikörper varianten und fragmente davon
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
WO1999061057A2
(en)
|
1998-05-23 |
1999-12-02 |
Tanox, Inc. |
Molecules targeting cd40 and tumor cells
|
|
AU5728999A
(en)
|
1998-07-28 |
2000-02-21 |
Micromet Ag |
Heterominibodies
|
|
US7029652B2
(en)
|
1998-09-16 |
2006-04-18 |
The Regents Of The University Of California |
Method of treating tumors
|
|
WO2000018806A1
(de)
*
|
1998-09-25 |
2000-04-06 |
Horst Lindhofer |
Bispezifische und trispezifische antikörper, die spezifisch mit induzierbaren oberflächenantigenen als operationelle zielstrukturen reagieren
|
|
US20030035798A1
(en)
|
2000-08-16 |
2003-02-20 |
Fang Fang |
Humanized antibodies
|
|
PL209392B1
(pl)
|
1999-01-15 |
2011-08-31 |
Genentech Inc |
Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
ES2233359T3
(es)
|
1999-03-11 |
2005-06-16 |
Micromet Ag |
Construcciones de anticuerpos dirigidos contra el ccr5 y su empleo en el tratamiento de enfermedades autoinmunologicas.
|
|
EP1729327B2
(en)
|
1999-05-13 |
2022-08-10 |
The Trustees Of Princeton University |
Use of a phosphorescent iridium compound as emissive molecule in an organic light emitting device
|
|
EP1325338A2
(en)
|
2000-04-03 |
2003-07-09 |
Oxford GlycoSciences (UK) Limited |
Diagnosis and treatment of alzheimer's disease
|
|
CA2409991A1
(en)
|
2000-05-24 |
2001-11-29 |
Imclone Systems Incorporated |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
|
DE10034607A1
(de)
|
2000-07-20 |
2002-02-07 |
Gundram Jung |
Multispezifisches Reagenz zur selektiven Stimulierung von Zelloberflächenrezeptoren
|
|
RU2252786C2
(ru)
|
2000-09-08 |
2005-05-27 |
Микромет Аг |
Конструкции антител и хемокинов и их применение при иммунологических нарушениях
|
|
US7083784B2
(en)
|
2000-12-12 |
2006-08-01 |
Medimmune, Inc. |
Molecules with extended half-lives, compositions and uses thereof
|
|
RU2179862C1
(ru)
|
2000-12-26 |
2002-02-27 |
Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" |
Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
|
|
CN1294148C
(zh)
|
2001-04-11 |
2007-01-10 |
中国科学院遗传与发育生物学研究所 |
环状单链三特异抗体
|
|
KR100953520B1
(ko)
|
2001-06-22 |
2010-04-21 |
츄가이 세이야꾸 가부시키가이샤 |
항글리피칸 3항체를 포함하는 항암제
|
|
CA2463879C
(en)
|
2001-10-25 |
2012-12-04 |
Genentech, Inc. |
Glycoprotein compositions
|
|
US20030190705A1
(en)
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
JP2006502091A
(ja)
|
2002-03-01 |
2006-01-19 |
イミューノメディクス、インコーポレイテッド |
クリアランス速度を高めるための二重特異性抗体点変異
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20030216551A1
(en)
|
2002-03-08 |
2003-11-20 |
Diabetogen Biosciences Inc. |
Fully human anti-CD3 monoclonal antibodies
|
|
WO2003107218A1
(ja)
|
2002-05-31 |
2003-12-24 |
セレスター・レキシコ・サイエンシズ株式会社 |
相互作用予測装置
|
|
US7750204B2
(en)
|
2002-06-05 |
2010-07-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing antibody
|
|
AU2003244817B2
(en)
*
|
2002-06-28 |
2010-08-26 |
Domantis Limited |
Antigen-binding immunoglobulin single variable domains and dual-specific constructs
|
|
WO2004022595A1
(ja)
|
2002-09-04 |
2004-03-18 |
Chugai Seiyaku Kabushiki Kaisha |
MRL/lprマウスを用いた抗体の作製
|
|
EP1553975B8
(en)
|
2002-09-27 |
2023-04-12 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
US20060235208A1
(en)
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
GB0224082D0
(en)
|
2002-10-16 |
2002-11-27 |
Celltech R&D Ltd |
Biological products
|
|
BRPI0315295C1
(pt)
|
2002-10-17 |
2021-05-25 |
Genmab As |
anticorpo monoclonal humano isolado, célula hospedeira procariótica, composição farmacêutica, molécula biespecífica, usos de um anticorpo, métodos in vitro de detectar a presença de antígeno de cd20 ou uma célula que expressa cd20 em uma amostra, kit, e, vetor de expressão
|
|
US20040253237A1
(en)
|
2002-12-05 |
2004-12-16 |
Ian Walters |
Methods of treatment of ulcerative colitis with anti-CD3 antibodies
|
|
CA2512729C
(en)
|
2003-01-09 |
2014-09-16 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant fc regions and methods of using same
|
|
US8337841B2
(en)
|
2003-01-21 |
2012-12-25 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of screening for antibody light chains
|
|
US7563869B2
(en)
|
2003-01-23 |
2009-07-21 |
Ono Pharmaceutical Co., Ltd. |
Substance specific to human PD-1
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
JP2004321100A
(ja)
|
2003-04-25 |
2004-11-18 |
Rikogaku Shinkokai |
IgGのFc領域を含むタンパク質の変異体
|
|
RU2337107C2
(ru)
|
2003-05-02 |
2008-10-27 |
Ксенкор, Инк. |
ОПТИМИЗИРОВАННЫЕ Fc-ВАРИАНТЫ, ИМЕЮЩИЕ ИЗМЕНЕННОЕ СВЯЗЫВАНИЕ С FcγR, И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
|
|
AR044388A1
(es)
|
2003-05-20 |
2005-09-07 |
Applied Molecular Evolution |
Moleculas de union a cd20
|
|
UA101945C2
(uk)
|
2003-05-30 |
2013-05-27 |
Дженентек, Инк. |
Лікування злоякісного новоутворення за допомогою бевацизумабу
|
|
WO2004106375A1
(en)
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
|
AU2004266159A1
(en)
|
2003-08-22 |
2005-03-03 |
Biogen Idec Ma Inc. |
Improved antibodies having altered effector function and methods for making the same
|
|
US7288638B2
(en)
|
2003-10-10 |
2007-10-30 |
Bristol-Myers Squibb Company |
Fully human antibodies against human 4-1BB
|
|
MXPA06004035A
(es)
|
2003-10-16 |
2006-08-31 |
Micromet Ag |
Aglutinantes cd3 de-inmunizados multi-especificos.
|
|
US9296820B2
(en)
|
2003-11-05 |
2016-03-29 |
Roche Glycart Ag |
Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
|
|
WO2005063815A2
(en)
|
2003-11-12 |
2005-07-14 |
Biogen Idec Ma Inc. |
Fcϝ receptor-binding polypeptide variants and methods related thereto
|
|
PL1691837T3
(pl)
|
2003-12-10 |
2012-11-30 |
Squibb & Sons Llc |
IP-10 przeciwciała i ich zastosowanie
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
KR20060132006A
(ko)
|
2004-03-23 |
2006-12-20 |
비오겐 아이덱 엠에이 아이엔씨. |
수용체 커플링제 및 이의 치료적 용도
|
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
|
CN1984931B
(zh)
*
|
2004-06-03 |
2012-11-28 |
诺维莫尼公司 |
抗-cd3抗体及其使用方法
|
|
CA2569509C
(en)
|
2004-06-03 |
2014-08-12 |
Novimmune S.A. |
Anti-cd3 antibodies and methods of use thereof
|
|
SI1674111T1
(sl)
|
2004-07-09 |
2011-02-28 |
Chugai Pharmaceutical Co Ltd |
Protitelo proti glipikanu 3
|
|
EP2471813B1
(en)
|
2004-07-15 |
2014-12-31 |
Xencor, Inc. |
Optimized Fc variants
|
|
AU2005274905B2
(en)
|
2004-08-04 |
2010-12-23 |
Mentrik Biotech, Llc |
Variant Fc regions
|
|
WO2006028936A2
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
|
RU2437893C2
(ru)
|
2004-12-09 |
2011-12-27 |
Мерк Патент Гмбх |
Варианты il-7 со сниженной иммуногенностью
|
|
WO2006065208A1
(en)
|
2004-12-14 |
2006-06-22 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
FR2879204B1
(fr)
|
2004-12-15 |
2007-02-16 |
Lab Francais Du Fractionnement |
Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b.
|
|
US8728828B2
(en)
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
EP1858925A2
(en)
|
2005-01-12 |
2007-11-28 |
Xencor, Inc. |
Antibodies and fc fusion proteins with altered immunogenicity
|
|
AU2006232287B2
(en)
|
2005-03-31 |
2011-10-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing polypeptides by regulating polypeptide association
|
|
WO2006105338A2
(en)
|
2005-03-31 |
2006-10-05 |
Xencor, Inc. |
Fc VARIANTS WITH OPTIMIZED PROPERTIES
|
|
PT1876236E
(pt)
|
2005-04-08 |
2014-10-22 |
Chugai Pharmaceutical Co Ltd |
Anticorpos para substituição da função do factor de coagulação sanguínea viii
|
|
CN101193910A
(zh)
|
2005-04-15 |
2008-06-04 |
健泰科生物技术公司 |
HGFβ链变体
|
|
WO2006132352A1
(ja)
|
2005-06-10 |
2006-12-14 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2を含有する医薬組成物
|
|
CA2611726C
(en)
|
2005-06-10 |
2017-07-11 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical compositions containing sc(fv)2
|
|
KR20080025174A
(ko)
|
2005-06-23 |
2008-03-19 |
메디뮨 인코포레이티드 |
응집 및 단편화 프로파일이 최적화된 항체 제제
|
|
CN101627054A
(zh)
|
2005-07-11 |
2010-01-13 |
马克罗基因公司 |
用人源化抗cd16a抗体治疗自身免疫疾病的方法
|
|
CN101309703A
(zh)
*
|
2005-09-12 |
2008-11-19 |
诺维莫尼公司 |
抗cd3抗体组合物
|
|
WO2007041635A2
(en)
|
2005-10-03 |
2007-04-12 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
|
WO2007053659A2
(en)
|
2005-11-01 |
2007-05-10 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Method of screening for hepatocellular carcinoma
|
|
JP2009514537A
(ja)
*
|
2005-11-03 |
2009-04-09 |
ジェネンテック・インコーポレーテッド |
治療的抗her2抗体融合ポリペプチド
|
|
EP1820513A1
(en)
|
2006-02-15 |
2007-08-22 |
Trion Pharma Gmbh |
Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
|
|
TW200745163A
(en)
|
2006-02-17 |
2007-12-16 |
Syntonix Pharmaceuticals Inc |
Peptides that block the binding of IgG to FcRn
|
|
PT1999154E
(pt)
|
2006-03-24 |
2013-01-24 |
Merck Patent Gmbh |
Domínios proteicos heterodiméricos modificados
|
|
EP2009101B1
(en)
|
2006-03-31 |
2017-10-25 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
|
CN104761637B
(zh)
|
2006-03-31 |
2021-10-15 |
中外制药株式会社 |
调控抗体血液动力学的方法
|
|
EP2433650A3
(en)
|
2006-06-06 |
2012-12-19 |
Tolerrx Inc. |
Administration of anti-CD3 antibodies in the treatment of autoimmune diseases
|
|
GB0611116D0
(en)
|
2006-06-06 |
2006-07-19 |
Oxford Genome Sciences Uk Ltd |
Proteins
|
|
JP2009541275A
(ja)
|
2006-06-22 |
2009-11-26 |
ノボ・ノルデイスク・エー/エス |
二重特異性抗体の生産
|
|
WO2008010991A2
(en)
|
2006-07-17 |
2008-01-24 |
Quintessence Biosciences, Inc. |
Methods and compositions for the treatment of cancer
|
|
PL2383297T3
(pl)
*
|
2006-08-14 |
2013-06-28 |
Xencor Inc |
Zoptymalizowane przeciwciała ukierunkowane na CD19
|
|
GB0620894D0
(en)
|
2006-10-20 |
2006-11-29 |
Univ Southampton |
Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
|
|
CA2673470A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Macrogenics, Inc. |
Methods for the treatment of lada and other adult-onset autoimmune diabetes using immunosuppressive monoclonal antibodies with reduced toxicity
|
|
US8398956B2
(en)
|
2007-01-11 |
2013-03-19 |
Immunomedics, Inc. |
In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
|
|
US20110236374A1
(en)
|
2007-01-24 |
2011-09-29 |
Kyowa Hakko Kirin Co., Ltd. |
Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2
|
|
CN101679974B
(zh)
|
2007-03-27 |
2015-09-30 |
航道生物技术有限责任公司 |
包含抗体替代轻链序列的构建体和文库
|
|
ES2593484T3
(es)
|
2007-03-29 |
2016-12-09 |
Genmab A/S |
Anticuerpos biespecíficos y métodos de producción de los mismos
|
|
RS53008B2
(sr)
|
2007-04-03 |
2022-12-30 |
Amgen Res Munich Gmbh |
Interspecijski specifičan cd3-epsilon vezujući domen
|
|
RU2769948C2
(ru)
|
2007-04-03 |
2022-04-11 |
Эмджен Рисерч (Мьюник) Гмбх |
CD3-Эпсилон-связывающий домен с межвидовой специфичностью
|
|
EP2144931A2
(en)
|
2007-04-04 |
2010-01-20 |
The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services |
Monoclonal antibodies against dengue and other viruses with deletion in fc region
|
|
ES2540854T3
(es)
|
2007-06-29 |
2015-07-14 |
Merck Sharp & Dohme Corp. |
Usos de antagonistas MDL-1
|
|
ME02345B
(me)
|
2007-07-17 |
2016-08-31 |
Squibb & Sons Llc |
MONOKLONSKA ANTlTELA PROTIV GLIPIKANA-3
|
|
ES2595638T3
(es)
|
2007-09-26 |
2017-01-02 |
Chugai Seiyaku Kabushiki Kaisha |
Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR
|
|
KR101680906B1
(ko)
*
|
2007-09-26 |
2016-11-30 |
추가이 세이야쿠 가부시키가이샤 |
항체 정상영역 개변체
|
|
US8497355B2
(en)
|
2007-09-28 |
2013-07-30 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-glypican-3 antibody having improved kinetics in plasma
|
|
JO3076B1
(ar)
*
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
EP2203180B1
(en)
*
|
2007-10-22 |
2012-11-21 |
Merck Serono S.A. |
Single ifn-beta fused to a mutated igg fc fragment
|
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
JP6157046B2
(ja)
|
2008-01-07 |
2017-07-05 |
アムジェン インコーポレイテッド |
静電的ステアリング(electrostaticsteering)効果を用いた抗体Fcヘテロ二量体分子を作製するための方法
|
|
EP2241578B1
(en)
|
2008-01-11 |
2016-04-20 |
The University of Tokyo |
Anti-cldn6 antibody
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
|
EP2238170B1
(en)
|
2008-01-31 |
2016-11-23 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity
|
|
WO2009100140A1
(en)
|
2008-02-04 |
2009-08-13 |
Medarex, Inc. |
Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof
|
|
EP2604279A1
(en)
*
|
2008-03-27 |
2013-06-19 |
ZymoGenetics, Inc. |
Compositions and methods for inhibiting PDGFRBETA and VEGF-A
|
|
MX2010011145A
(es)
|
2008-04-11 |
2011-04-11 |
Merrimack Pharmaceuticals Inc |
Enlazadores de la albumina de suero humana y conjugados de la misma.
|
|
WO2009129538A2
(en)
|
2008-04-18 |
2009-10-22 |
Xencor, Inc. |
Human equivalent monoclonal antibodies engineered from nonhuman variable regions
|
|
SG190572A1
(en)
*
|
2008-04-29 |
2013-06-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
|
CN102149825B
(zh)
*
|
2008-07-08 |
2015-07-22 |
Abbvie公司 |
前列腺素e2双重可变结构域免疫球蛋白及其用途
|
|
DE102008032385B4
(de)
*
|
2008-07-09 |
2018-03-29 |
Audi Ag |
Hochdruckeinspritzanordnung für eine direkteinspritzende Brennkraftmaschine
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
WO2010028797A1
(en)
|
2008-09-10 |
2010-03-18 |
F. Hoffmann-La Roche Ag |
Multivalent antibodies
|
|
CN102164960A
(zh)
*
|
2008-09-26 |
2011-08-24 |
罗氏格黎卡特股份公司 |
双特异性抗-egfr/抗-igf-1r抗体
|
|
EP2370467B1
(en)
|
2008-10-01 |
2016-09-07 |
Amgen Research (Munich) GmbH |
Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody
|
|
US20110293619A1
(en)
|
2008-10-01 |
2011-12-01 |
Micromet Ag |
CROSS-SPECIES-SPECIFIC PSMAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY
|
|
EP2337795A2
(en)
|
2008-10-01 |
2011-06-29 |
Dako Denmark A/S |
Mhc multimers in cancer vaccines and immune monitoring
|
|
AU2009303318B2
(en)
|
2008-10-10 |
2016-06-30 |
Aptevo Research And Development Llc |
TCR complex immunotherapeutics
|
|
WO2010059315A1
(en)
|
2008-11-18 |
2010-05-27 |
Merrimack Pharmaceuticals, Inc. |
Human serum albumin linkers and conjugates thereof
|
|
DE202008016028U1
(de)
|
2008-12-04 |
2010-04-15 |
Melitta Haushaltsprodukte Gmbh & Co. Kg |
Behälter zur Aufbewahrung von Gegenständen
|
|
RU2011127198A
(ru)
*
|
2008-12-04 |
2013-01-10 |
Эбботт Лэборетриз |
Иммуноглобулины с двойными вариабельными доменами и их применение
|
|
UA109633C2
(uk)
*
|
2008-12-09 |
2015-09-25 |
|
Антитіло людини проти тканинного фактора
|
|
DK2786762T3
(da)
*
|
2008-12-19 |
2019-05-06 |
Macrogenics Inc |
Kovalente diabodies og anvendelser deraf
|
|
WO2010075249A2
(en)
|
2008-12-22 |
2010-07-01 |
Genentech, Inc. |
A method for treating rheumatoid arthritis with b-cell antagonists
|
|
EP2389386A4
(en)
|
2009-01-12 |
2013-11-06 |
Ge Healthcare Bio Sciences Ab |
affinity chromatography
|
|
JP2012515556A
(ja)
|
2009-01-23 |
2012-07-12 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
低下したエフェクタ機能を有する安定化Fcポリペプチドおよび使用方法
|
|
ES3000111T3
(en)
|
2009-02-13 |
2025-02-27 |
Immunomedics Inc |
Intermediates for preparing conjugates with an intracellularly-cleavable linkage
|
|
TWI541021B
(zh)
|
2009-03-05 |
2016-07-11 |
艾伯維有限公司 |
Il-17結合蛋白
|
|
JP5717624B2
(ja)
|
2009-03-19 |
2015-05-13 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
MA33208B1
(fr)
|
2009-03-25 |
2012-04-02 |
Genentech Inc |
Anticorps anti-fgfr3 et procédés d'utilisation de ceux-ci
|
|
RU2587621C2
(ru)
|
2009-04-01 |
2016-06-20 |
Дженентек, Инк. |
АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
|
WO2010129304A2
(en)
|
2009-04-27 |
2010-11-11 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
KR20120024763A
(ko)
|
2009-05-15 |
2012-03-14 |
추가이 세이야쿠 가부시키가이샤 |
항axl 항체
|
|
JP5375323B2
(ja)
|
2009-05-15 |
2013-12-25 |
株式会社ニコン |
移動体装置、露光装置、及び移動体制御方法
|
|
PE20120540A1
(es)
|
2009-05-27 |
2012-05-09 |
Hoffmann La Roche |
Anticuerpos triespecificos o tetraespecificos
|
|
MY192182A
(en)
|
2009-06-26 |
2022-08-04 |
Regeneron Pharma |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
BR112012004546A8
(pt)
|
2009-08-29 |
2017-12-05 |
Abbott Lab |
Terapêutica por proteínas ligantes dll4-ligantes
|
|
CA2773515C
(en)
|
2009-09-29 |
2015-04-28 |
Roche Glycart Ag |
Bispecific death receptor agonistic antibodies
|
|
CA2778334A1
(en)
|
2009-10-20 |
2011-04-28 |
Charlotte Mckee |
Anti-cd3 antibody dosing in autoimmune disease
|
|
DK3305813T3
(da)
|
2009-11-11 |
2020-04-20 |
Astellas Pharma Inc |
Antistoffer, der er specifikke for claudin 6 (cldn6)
|
|
US10053513B2
(en)
|
2009-11-30 |
2018-08-21 |
Janssen Biotech, Inc. |
Antibody Fc mutants with ablated effector functions
|
|
US8961967B2
(en)
|
2009-11-30 |
2015-02-24 |
Janssen Biotech, Inc. |
Antibody Fc mutants with ablated effector functions
|
|
CA2785414C
(en)
|
2009-12-25 |
2019-01-22 |
Tomoyuki Igawa |
Polypeptide modification method for purifying polypeptide multimers
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
WO2011108714A1
(ja)
|
2010-03-04 |
2011-09-09 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
US9162161B2
(en)
|
2010-03-31 |
2015-10-20 |
Jsr Corporation |
Filler for affinity chromatography
|
|
TWI653333B
(zh)
|
2010-04-01 |
2019-03-11 |
安進研究(慕尼黑)有限責任公司 |
跨物種專一性之PSMAxCD3雙專一性單鏈抗體
|
|
HRP20241208T1
(hr)
|
2010-04-20 |
2024-11-22 |
Genmab A/S |
Heterodimerni proteini koji sadrže fc fragment protutijela i postupci za njihovu proizvodnju
|
|
KR101860963B1
(ko)
|
2010-04-23 |
2018-05-24 |
제넨테크, 인크. |
이종다량체 단백질의 생산
|
|
US9527926B2
(en)
|
2010-05-14 |
2016-12-27 |
Rinat Neuroscience Corp. |
Heterodimeric proteins and methods for producing and purifying them
|
|
EP2576621B1
(en)
|
2010-05-27 |
2019-04-10 |
Genmab A/S |
Monoclonal antibodies against her2
|
|
EP2404936A1
(en)
|
2010-07-06 |
2012-01-11 |
Ganymed Pharmaceuticals AG |
Cancer therapy using CLDN6 target-directed antibodies in vivo
|
|
ES2758994T3
(es)
|
2010-11-05 |
2020-05-07 |
Zymeworks Inc |
Diseño anticuerpo heterodimérico estable con mutaciones en el dominio Fc
|
|
TWI452136B
(zh)
*
|
2010-11-17 |
2014-09-11 |
中外製藥股份有限公司 |
A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation
|
|
PT3434767T
(pt)
|
2010-11-30 |
2026-01-23 |
Chugai Pharmaceutical Co Ltd |
Agente terapêutico indutor de citotoxicidade
|
|
UY33826A
(es)
*
|
2010-12-22 |
2012-07-31 |
Abbott Lab |
Proteínas de unión con dominios trivariables y sus usos
|
|
ES2617983T3
(es)
|
2011-01-10 |
2017-06-20 |
Ct Atlantic Ltd. |
Terapia de combinación que incluye anticuerpos de unión a antígenos asociados a tumores
|
|
EP2673297A2
(en)
|
2011-02-11 |
2013-12-18 |
Zyngenia, Inc. |
Monovalent and multivalent multispecific complexes and uses thereof
|
|
MX352889B
(es)
|
2011-02-25 |
2017-12-13 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo de fc especifico para fcyriib.
|
|
BR112013023918A2
(pt)
|
2011-03-25 |
2016-12-13 |
Glenmark Pharmaceuticals Sa |
imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para produzir uma imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para construir uma interface proteína-proteína de um domínio de uma proteína de múltiplos domínios e uso de um domínio doador de um primeiro e de um segundo membro de uma super-família de imunoglobulina de ocorrência natural
|
|
AU2012233313C1
(en)
|
2011-03-30 |
2017-08-03 |
Chugai Seiyaku Kabushiki Kaisha |
Method for altering plasma retention and immunogenicity of antigen-binding molecule
|
|
DK2699598T3
(en)
|
2011-04-19 |
2019-04-23 |
Pfizer |
COMBINATIONS OF ANTI-4-1BB ANTIBODIES AND ADCC-INducing ANTIBODIES FOR TREATMENT OF CANCER
|
|
ES2989943T3
(es)
|
2011-05-13 |
2024-11-28 |
Astellas Pharma Inc |
Anticuerpos para el tratamiento de un cáncer que expresa la Claudina 6
|
|
EP2537864B1
(en)
|
2011-06-24 |
2019-08-07 |
Laboratoire Français du Fractionnement et des Biotechnologies |
Fc variants with reduced effector functions
|
|
CN103796681B
(zh)
|
2011-06-30 |
2018-07-20 |
建新公司 |
T细胞活化的抑制剂
|
|
US8790651B2
(en)
*
|
2011-07-21 |
2014-07-29 |
Zoetis Llc |
Interleukin-31 monoclonal antibody
|
|
EP2748202B1
(en)
|
2011-08-23 |
2018-07-04 |
Roche Glycart AG |
Bispecific antigen binding molecules
|
|
NO2748201T3
(https=)
|
2011-08-23 |
2018-05-12 |
|
|
|
CN109134658B
(zh)
*
|
2011-10-31 |
2022-10-14 |
中外制药株式会社 |
控制了重链与轻链的缔合的抗原结合分子
|
|
WO2013070468A1
(en)
|
2011-11-08 |
2013-05-16 |
The Trustees Of The University Of Pennsylvania |
Glypican-3-specific antibody and uses thereof
|
|
ES2716823T3
(es)
|
2011-11-17 |
2019-06-17 |
Jung Gundram |
Anticuerpos biespecíficos para uso médico
|
|
HUE033245T2
(hu)
|
2011-12-19 |
2017-11-28 |
Synimmune Gmbh |
Bispecifikus ellenanyag molekula
|
|
US9049708B2
(en)
|
2012-02-03 |
2015-06-02 |
Interdigital Patent Holdings, Inc. |
Method and apparatus for coexistence among wireless transmit/receive units (WTRUs) operating in the same spectrum
|
|
EP3517548A1
(en)
|
2012-03-13 |
2019-07-31 |
NovImmune S.A. |
Readily isolated bispecific antibodies with native immunoglobulin format
|
|
EP2832856A4
(en)
*
|
2012-03-29 |
2016-01-27 |
Chugai Pharmaceutical Co Ltd |
ANTI-LAMP5 ANTIBODIES AND USE THEREOF
|
|
JP6509724B2
(ja)
|
2012-04-20 |
2019-05-08 |
アプティーボ リサーチ アンド デベロップメント エルエルシー |
Cd3結合ポリペプチド
|
|
US20140154270A1
(en)
|
2012-05-21 |
2014-06-05 |
Chen Wang |
Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
|
|
SG11201407972RA
(en)
|
2012-06-01 |
2015-01-29 |
Us Health |
High-affinity monoclonal antibodies to glypican-3 and use thereof
|
|
CN104736174B
(zh)
|
2012-07-06 |
2019-06-14 |
根马布私人有限公司 |
具有三重突变的二聚体蛋白质
|
|
CN104379169A
(zh)
|
2012-08-14 |
2015-02-25 |
Ibc药品公司 |
用于治疗疾病的t-细胞重定向双特异性抗体
|
|
WO2014038686A1
(ja)
|
2012-09-10 |
2014-03-13 |
株式会社カネカ |
吸着体
|
|
JOP20200236A1
(ar)
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
HUE042040T2
(hu)
|
2012-09-27 |
2019-06-28 |
Merus Nv |
Bispecifikus IGG antitestek mint T-sejt kapcsolók
|
|
WO2014075697A1
(en)
|
2012-11-13 |
2014-05-22 |
Biontech Ag |
Agents for treatment of claudin expressing cancer diseases
|
|
JP6499079B2
(ja)
|
2012-11-13 |
2019-04-10 |
バイオエヌテック アーゲーBioNTech AG |
クローディンを発現するガン疾患を処置するための剤
|
|
CN103833852A
(zh)
|
2012-11-23 |
2014-06-04 |
上海市肿瘤研究所 |
针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体
|
|
EP3508215A3
(en)
|
2012-12-03 |
2019-10-02 |
Bristol-Myers Squibb Company |
Enhancing anti-cancer activity of immunomodulatory fc fusion proteins
|
|
WO2014116846A2
(en)
|
2013-01-23 |
2014-07-31 |
Abbvie, Inc. |
Methods and compositions for modulating an immune response
|
|
WO2014138306A1
(en)
|
2013-03-05 |
2014-09-12 |
Baylor College Of Medicine |
Engager cells for immunotherapy
|
|
EP2970486B1
(en)
|
2013-03-15 |
2018-05-16 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
US20140302037A1
(en)
|
2013-03-15 |
2014-10-09 |
Amgen Inc. |
BISPECIFIC-Fc MOLECULES
|
|
US20140377253A1
(en)
|
2013-03-15 |
2014-12-25 |
Abbvie Biotherapeutics Inc. |
Fc variants
|
|
WO2014165818A2
(en)
|
2013-04-05 |
2014-10-09 |
T Cell Therapeutics, Inc. |
Compositions and methods for preventing and treating prostate cancer
|
|
ME03675B
(me)
|
2013-07-05 |
2020-10-20 |
Genmab As |
Humanizovana ili himerna anтi-cd3 antiтela
|
|
HK1224331A1
(zh)
|
2013-07-17 |
2017-08-18 |
Foundation Medicine, Inc. |
治疗尿路上皮癌的方法
|
|
ES2881306T3
(es)
|
2013-09-27 |
2021-11-29 |
Chugai Pharmaceutical Co Ltd |
Método para la producción de heteromultímeros de polipéptidos
|
|
MX2016003617A
(es)
|
2013-09-30 |
2016-07-21 |
Chugai Pharmaceutical Co Ltd |
Metodo para producir molecula de enlace al antigeno usando fago auxiliar modificado.
|
|
JP2016538275A
(ja)
|
2013-11-04 |
2016-12-08 |
グレンマーク ファーマシューティカルズ, エセ.アー. |
T細胞再標的化ヘテロ二量体免疫グロブリン(hetero−dimeric immunoglobulin)の製造
|
|
RU2016122041A
(ru)
|
2013-11-06 |
2017-12-11 |
ЭББВИ СТЕМСЕНТРКС ЭлЭлСи |
Новые анти-клаудин антитела и способы их применения
|
|
IL263466B2
(en)
|
2013-12-17 |
2023-10-01 |
Genentech Inc |
Anti-CD3 antibodies and methods of using them
|
|
CA2936244A1
(en)
|
2014-01-21 |
2015-07-30 |
Medimmune, Llc |
Compositions and methods for modulating and redirecting immune responses
|
|
CA2939711C
(en)
|
2014-02-21 |
2020-09-29 |
Cellectis |
Method for in situ inhibition of regulatory t cells
|
|
EP3699195A3
(en)
|
2014-03-28 |
2020-11-04 |
Xencor, Inc. |
Bispecific antibodies that bind to cd38 and cd3
|
|
AU2015244814B2
(en)
|
2014-04-07 |
2020-12-24 |
Chugai Seiyaku Kabushiki Kaisha |
Immunoactivating antigen-binding molecule
|
|
CN106714831A
(zh)
|
2014-04-21 |
2017-05-24 |
艾伯维施特姆森特克斯有限责任公司 |
新的抗‑rnf43抗体和使用方法
|
|
MX2016014434A
(es)
|
2014-05-13 |
2017-02-23 |
Chugai Pharmaceutical Co Ltd |
Molecula de union a antigeno redirigida a celulas t para celulas que tienen funcion de inmunosupresion.
|
|
KR20160002132A
(ko)
|
2014-06-30 |
2016-01-07 |
삼성전자주식회사 |
음장 효과를 제공하기 위한 전자 장치 및 방법
|
|
AR101262A1
(es)
|
2014-07-26 |
2016-12-07 |
Regeneron Pharma |
Plataforma de purificación para anticuerpos biespecíficos
|
|
CN105444789A
(zh)
|
2014-08-25 |
2016-03-30 |
同方威视技术股份有限公司 |
一种光纤光栅解调仪及其温度控制方法
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
JP6630036B2
(ja)
|
2014-09-30 |
2020-01-15 |
Jsr株式会社 |
標的物の精製方法、及び、ミックスモード用担体
|
|
WO2016105503A1
(en)
|
2014-12-24 |
2016-06-30 |
Genentech, Inc. |
Therapeutic, diagnostic and prognostic methods for cancer of the bladder
|
|
US10544220B2
(en)
*
|
2015-01-08 |
2020-01-28 |
Genmab A/S |
Bispecific antibodies against CD3 and CD20
|
|
EP3288981A1
(en)
|
2015-05-01 |
2018-03-07 |
Genentech, Inc. |
Masked anti-cd3 antibodies and methods of use
|
|
WO2016194992A1
(ja)
|
2015-06-05 |
2016-12-08 |
中外製薬株式会社 |
免疫活性化剤の併用
|
|
JP6837436B2
(ja)
|
2015-07-10 |
2021-03-03 |
中外製薬株式会社 |
内因性cd3遺伝子をヒトcd3遺伝子に置換した非ヒト動物
|
|
CA3000884A1
(en)
|
2015-10-05 |
2017-04-13 |
Metafora Biosystems |
Receptor-binding domains ligands for the detection, diagnosis and treatment of pancreatic cancer
|
|
WO2017086419A1
(ja)
|
2015-11-18 |
2017-05-26 |
中外製薬株式会社 |
液性免疫応答の増強方法
|
|
WO2017086367A1
(ja)
|
2015-11-18 |
2017-05-26 |
中外製薬株式会社 |
免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子を用いた併用療法
|
|
AU2016381992B2
(en)
|
2015-12-28 |
2024-01-04 |
Chugai Seiyaku Kabushiki Kaisha |
Method for promoting efficiency of purification of Fc region-containing polypeptide
|
|
IL313507A
(en)
|
2016-02-03 |
2024-08-01 |
Amgen Res Munich Gmbh |
Constructs of bispecific antibodies to BCMA and CD3 that bind to T cells, preparations containing the same and uses thereof
|
|
US11072666B2
(en)
|
2016-03-14 |
2021-07-27 |
Chugai Seiyaku Kabushiki Kaisha |
Cell injury inducing therapeutic drug for use in cancer therapy
|
|
CN109475627B
(zh)
|
2016-05-26 |
2023-01-06 |
齐鲁普吉湾生物治疗公司 |
抗体混合物
|
|
EP3489262A4
(en)
|
2016-07-19 |
2020-07-08 |
Ibentrus, Inc. |
BISPECIFIC PROTEINS AND PROCESSES FOR THEIR PREPARATION
|
|
WO2018054484A1
(en)
|
2016-09-23 |
2018-03-29 |
Biontech Ag |
Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
|
|
JP7784795B2
(ja)
|
2016-11-15 |
2025-12-12 |
ジェネンテック, インコーポレイテッド |
抗cd20/抗cd3二重特異性抗体による処置のための投与
|
|
KR102692708B1
(ko)
*
|
2016-12-20 |
2024-08-07 |
에프. 호프만-라 로슈 아게 |
항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법
|
|
SG11201909160WA
(en)
|
2017-04-11 |
2019-10-30 |
Inhibrx Inc |
Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
|
|
WO2018203567A1
(en)
|
2017-05-02 |
2018-11-08 |
Chugai Seiyaku Kabushiki Kaisha |
Cytotoxicity-inducing therapeutic agent
|
|
KR20200014379A
(ko)
|
2017-06-05 |
2020-02-10 |
얀센 바이오테크 인코포레이티드 |
비대칭 ch2-ch3 영역 돌연변이를 갖는 조작된 다중특이성 항체 및 다른 다량체 단백질
|
|
PE20210005A1
(es)
*
|
2017-09-29 |
2021-01-05 |
Chugai Pharmaceutical Co Ltd |
Molecula de union al antigeno multiespecifica que tiene actividad de sustitucion de la funcion de cofactor del factor viii de coagulacion de sangre (fviii) y formulacion farmaceutica que contiene tal molecula como ingrediente activo
|
|
JP7314146B2
(ja)
*
|
2017-12-28 |
2023-07-25 |
中外製薬株式会社 |
細胞傷害誘導治療剤
|
|
US20210054076A1
(en)
|
2018-01-05 |
2021-02-25 |
Chugai Seiyaku Kabushiki Kaisha |
Cytotoxicity-inducing therapeutic agent
|
|
JP7337079B2
(ja)
*
|
2018-02-15 |
2023-09-01 |
マクロジェニクス,インコーポレーテッド |
変異型cd3結合ドメイン、及び疾患の治療のための併用療法におけるその使用
|
|
UA130542C2
(uk)
|
2018-05-16 |
2026-03-18 |
Янссен Байотек, Інк. |
Антитіло до cd38 та терапевтичний засіб, який перенаправляє т-клітини, для лікування множинної мієломи у суб'єкта
|
|
TWI869346B
(zh)
*
|
2018-05-30 |
2025-01-11 |
瑞士商諾華公司 |
Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法
|
|
WO2020095866A1
(en)
|
2018-11-05 |
2020-05-14 |
Chugai Seiyaku Kabushiki Kaisha |
Her2 s310f specific antigen-binding molecules
|
|
EP3897851A2
(en)
|
2018-12-17 |
2021-10-27 |
Revitope Limited |
Twin immune cell engager
|
|
WO2020153467A1
(ja)
|
2019-01-24 |
2020-07-30 |
中外製薬株式会社 |
新規がん抗原及びそれらの抗原に対する抗体
|
|
WO2020250915A1
(ja)
|
2019-06-10 |
2020-12-17 |
中外製薬株式会社 |
サイトカイン阻害剤と組み合わせて使用するための抗t細胞抗原結合分子
|
|
MX2022000111A
(es)
|
2019-07-10 |
2022-02-10 |
Chugai Pharmaceutical Co Ltd |
Moleculas de union a claudina-6 y usos de las mismas.
|
|
WO2021010326A1
(ja)
|
2019-07-12 |
2021-01-21 |
中外製薬株式会社 |
抗変異型fgfr3抗体およびその使用
|
|
CN114502590A
(zh)
*
|
2019-09-18 |
2022-05-13 |
诺华股份有限公司 |
Entpd2抗体、组合疗法、以及使用这些抗体和组合疗法的方法
|
|
TW202204410A
(zh)
*
|
2020-03-31 |
2022-02-01 |
日商中外製藥股份有限公司 |
免疫活化多特異性抗原結合分子及其用途
|
|
MX2022015764A
(es)
|
2020-06-19 |
2023-01-19 |
Chugai Pharmaceutical Co Ltd |
Molecula de union al antigeno anti-celulas t para usarse en combinacion con un inhibidor de angiogenesis.
|