JP2020507611A - 原発性胆汁性胆管炎の治療のための化合物および方法 - Google Patents

原発性胆汁性胆管炎の治療のための化合物および方法 Download PDF

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JP2020507611A
JP2020507611A JP2019544629A JP2019544629A JP2020507611A JP 2020507611 A JP2020507611 A JP 2020507611A JP 2019544629 A JP2019544629 A JP 2019544629A JP 2019544629 A JP2019544629 A JP 2019544629A JP 2020507611 A JP2020507611 A JP 2020507611A
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compound
individual
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solvate
hydrate
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JP2020507611A5 (OSRAM
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シェリル ジェラルディーン ラッセン，
シェリル ジェラルディーン ラッセン，
ロバート マーク ジョンズ，
ロバート マーク ジョンズ，
チュエ リウ，
チュエ リウ，
ロナルド ジェイ． クリストファー，
ロナルド ジェイ． クリストファー，
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アリーナ ファーマシューティカルズ， インコーポレイテッド
アリーナ ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019544629A 2017-02-16 2018-02-16 原発性胆汁性胆管炎の治療のための化合物および方法 Pending JP2020507611A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762459916P 2017-02-16 2017-02-16
US62/459,916 2017-02-16
US201762502129P 2017-05-05 2017-05-05
US62/502,129 2017-05-05
US201762506906P 2017-05-16 2017-05-16
US62/506,906 2017-05-16
PCT/US2018/000091 WO2018151873A1 (en) 2017-02-16 2018-02-16 Compounds and methods for treatment of primary biliary cholangitis

Publications (2)

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JP2020507611A true JP2020507611A (ja) 2020-03-12
JP2020507611A5 JP2020507611A5 (OSRAM) 2021-03-25

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US (2) US11534424B2 (OSRAM)
EP (1) EP3582772A1 (OSRAM)
JP (1) JP2020507611A (OSRAM)
KR (1) KR20190116416A (OSRAM)
CN (1) CN110520124A (OSRAM)
AU (1) AU2018220521A1 (OSRAM)
CA (1) CA3053418A1 (OSRAM)
MA (1) MA47504A (OSRAM)
MX (1) MX2019009841A (OSRAM)
WO (1) WO2018151873A1 (OSRAM)

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PL3242666T3 (pl) 2015-01-06 2025-02-17 Arena Pharmaceuticals, Inc. Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
DK3310760T3 (da) * 2015-06-22 2022-10-24 Arena Pharm Inc Krystallinsk L-argininsalt af (R)-2-(7-(4-cyclopentyl-3-(trifluormethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3- yl)eddikesyre til anvendelse ved S1P1-receptor-associerede lidelser
CN110520124A (zh) 2017-02-16 2019-11-29 艾尼纳制药公司 用于治疗原发性胆汁性胆管炎的化合物和方法
US11478448B2 (en) 2017-02-16 2022-10-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
BR112020024762A2 (pt) * 2018-06-06 2021-03-23 Arena Pharmaceuticals, Inc. métodos de tratamento de condições relacionadas ao receptor s1p1
WO2020072824A1 (en) * 2018-10-03 2020-04-09 Arena Pharmaceuticals, Inc. Methods for the treatment of scleroderma
CN118649163A (zh) * 2018-11-30 2024-09-17 艾尼纳制药公司 治疗与s1p1受体有关的病况的方法
AU2021205465A1 (en) * 2020-01-06 2022-07-14 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CN114980876A (zh) * 2020-02-10 2022-08-30 基恩菲特公司 用艾拉菲诺治疗原发性胆汁性胆管炎
WO2025177319A2 (en) * 2024-02-22 2025-08-28 Msn Laboratories Private Limited, R&D Center Solid state forms of L-Arginine, (3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopent[b]indole-3-acetate and processes for preparation thereof

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JPH11199477A (ja) * 1997-10-24 1999-07-27 Pharma Nord Uk Ltd 肝臓疾患のための医薬処方
WO2016209809A1 (en) * 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(compound1) for use in sipi receptor-associated disorders

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