EA200200688A1 - Антагонисты фактора, высвобождающего кортикотропин - Google Patents
Антагонисты фактора, высвобождающего кортикотропинInfo
- Publication number
- EA200200688A1 EA200200688A1 EA200200688A EA200200688A EA200200688A1 EA 200200688 A1 EA200200688 A1 EA 200200688A1 EA 200200688 A EA200200688 A EA 200200688A EA 200200688 A EA200200688 A EA 200200688A EA 200200688 A1 EA200200688 A1 EA 200200688A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antagonists
- factor
- disorders
- corticotropin
- releases
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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Abstract
Описываются антагонисты фактора, высвобождающего кортикотропин (CRF), имеющие формулы (I), (II) или (III), где пунктирные линии, А, В, Y, Z, R, R, R, R, Rи Rимеют значения, указанные в описании заявки, и способы их получения. Указанные соединения и их фармацевтически приемлемые соли полезны для лечения расстройств, в том числе расстройств ЦНС и расстройств, связанных со стрессом.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17661100P | 2000-01-18 | 2000-01-18 | |
PCT/IB2001/000004 WO2001053263A1 (en) | 2000-01-18 | 2001-01-05 | Corticotropin releasing factor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200200688A1 true EA200200688A1 (ru) | 2003-02-27 |
Family
ID=22645084
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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EA200300834A EA200300834A1 (ru) | 2000-01-18 | 2001-01-05 | Антагонисты фактора, высвобождающего кортикотропин |
EA200200688A EA200200688A1 (ru) | 2000-01-18 | 2001-01-05 | Антагонисты фактора, высвобождающего кортикотропин |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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EA200300834A EA200300834A1 (ru) | 2000-01-18 | 2001-01-05 | Антагонисты фактора, высвобождающего кортикотропин |
Country Status (36)
Country | Link |
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US (1) | US6833378B2 (ru) |
EP (1) | EP1263732A1 (ru) |
JP (1) | JP2003520272A (ru) |
KR (1) | KR20020063934A (ru) |
CN (1) | CN1395566A (ru) |
AP (1) | AP2002002583A0 (ru) |
AR (1) | AR027221A1 (ru) |
AU (1) | AU779995B2 (ru) |
BG (1) | BG106853A (ru) |
BR (1) | BR0107662A (ru) |
CA (1) | CA2397633A1 (ru) |
CO (1) | CO5271658A1 (ru) |
CR (1) | CR6698A (ru) |
CZ (1) | CZ20022390A3 (ru) |
EA (2) | EA200300834A1 (ru) |
EE (1) | EE200200400A (ru) |
GT (1) | GT200100007A (ru) |
HN (1) | HN2001000006A (ru) |
HR (1) | HRP20020599A2 (ru) |
HU (1) | HUP0204272A3 (ru) |
IL (1) | IL150632A0 (ru) |
IS (1) | IS6445A (ru) |
MA (1) | MA26864A1 (ru) |
MX (1) | MXPA02007047A (ru) |
NO (1) | NO20023424L (ru) |
OA (1) | OA12157A (ru) |
PA (1) | PA8510001A1 (ru) |
PE (1) | PE20011166A1 (ru) |
PL (1) | PL357589A1 (ru) |
SK (1) | SK10062002A3 (ru) |
SV (1) | SV2002000289A (ru) |
TN (1) | TNSN01008A1 (ru) |
UY (1) | UY26544A1 (ru) |
WO (1) | WO2001053263A1 (ru) |
YU (1) | YU54402A (ru) |
ZA (1) | ZA200205660B (ru) |
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JP4185154B2 (ja) | 2004-04-30 | 2008-11-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 中枢神経系障害治療用の置換モルホリン化合物 |
WO2005113511A1 (en) | 2004-05-12 | 2005-12-01 | Bristol-Myers Squibb Company | Urea antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
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US8153791B2 (en) | 2005-12-21 | 2012-04-10 | Janssen Pharmaceutica N.V. | Substituted pyrimidinyl oxime kinase inhibitors |
WO2007109783A2 (en) * | 2006-03-23 | 2007-09-27 | Janssen Pharmaceutica, N.V. | Substituted pyrimidine kinase inhibitors |
PT2076508E (pt) | 2006-10-18 | 2011-03-07 | Pfizer Prod Inc | Compostos de ureia de éter biarílico |
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- 2001-01-05 EA EA200200688A patent/EA200200688A1/ru unknown
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