JP2019077731A5 - - Google Patents
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- JP2019077731A5 JP2019077731A5 JP2019027222A JP2019027222A JP2019077731A5 JP 2019077731 A5 JP2019077731 A5 JP 2019077731A5 JP 2019027222 A JP2019027222 A JP 2019027222A JP 2019027222 A JP2019027222 A JP 2019027222A JP 2019077731 A5 JP2019077731 A5 JP 2019077731A5
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- 239000000203 mixture Substances 0.000 claims 14
- 239000000651 prodrug Substances 0.000 claims 10
- 229940002612 prodrugs Drugs 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims 4
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 201000008325 diseases of cellular proliferation Diseases 0.000 claims 4
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- 230000003213 activating Effects 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 200000000018 inflammatory disease Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
Claims (10)
- 被験体における新生物、自己免疫疾患、または炎症性疾患を処置するための、あるいは、被験体における血管新生を阻害するための、活性化可能なプロドラッグ組成物であって、
ここで、該活性化可能なプロドラッグ組成物は、TGRGPSWV(配列番号267)、SARGPSRW(配列番号268)、TARGPSFK(配列番号269)、TARGPSW(配列番号270)、LSGRSDNH(配列番号271)、GGWHTGRN(配列番号272)、HTGRSGAL(配列番号273)、PLTGRSGG(配列番号274)、LTGRSGA(配列番号275)、AARGPAIH(配列番号276)、RGPAFNPM(配列番号277)、SSRGPAYL(配列番号278)、RGPATPIM(配列番号279)およびRGPA(配列番号280)からなる群より選択されるアミノ酸配列を含む切断可能なポリペプチドを含み、
ここで、該アミノ酸配列は、ウロキナーゼ型プラスミノーゲン活性化因子(uPA)によって切断することができ、それによって、該活性化可能なプロドラッグ組成物を活性化する、活性化可能なプロドラッグ組成物。 - 被験体における新生物、自己免疫疾患、または炎症性疾患を処置するための医薬の製造における、あるいは、被験体における血管新生を阻害するための医薬の製造における、活性化可能なプロドラッグ組成物の使用であって、
ここで、該プロドラッグ組成物は、TGRGPSWV(配列番号267)、SARGPSRW(配列番号268)、TARGPSFK(配列番号269)、TARGPSW(配列番号270)、LSGRSDNH(配列番号271)、GGWHTGRN(配列番号272)、HTGRSGAL(配列番号273)、PLTGRSGG(配列番号274)、LTGRSGA(配列番号275)、AARGPAIH(配列番号276)、RGPAFNPM(配列番号277)、SSRGPAYL(配列番号278)、RGPATPIM(配列番号279)およびRGPA(配列番号280)からなる群より選択されるアミノ酸配列を含む切断可能なポリペプチドを含み、
ここで、該アミノ酸配列は、ウロキナーゼ型プラスミノーゲン活性化因子(uPA)によって切断することができ、それによって、該活性化可能なプロドラッグ組成物を活性化する、使用。 - 前記新生物が癌である、請求項2に記載の使用。
- 前記活性化可能なプロドラッグ組成物が、該活性化可能なプロドラッグ組成物と結合体化した薬剤を含む、請求項2または3に記載の使用。
- 前記薬剤が治療剤である、請求項4に記載の使用。
- 前記薬剤が抗腫瘍剤である、請求項4または5に記載の使用。
- 前記新生物が癌である、請求項1に記載の組成物。
- 前記活性化可能なプロドラッグ組成物が、該活性化可能なプロドラッグ組成物と結合体化した薬剤を含む、請求項1または7に記載の組成物。
- 前記薬剤が治療剤である、請求項8に記載の組成物。
- 前記薬剤が抗腫瘍剤である、請求項8または9に記載の組成物。
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14410509P | 2009-01-12 | 2009-01-12 | |
US14411009P | 2009-01-12 | 2009-01-12 | |
US61/144,110 | 2009-01-12 | ||
US61/144,105 | 2009-01-12 | ||
US24941609P | 2009-10-07 | 2009-10-07 | |
US24944109P | 2009-10-07 | 2009-10-07 | |
US61/249,416 | 2009-10-07 | ||
US61/249,441 | 2009-10-07 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017157121A Division JP6571730B2 (ja) | 2009-01-12 | 2017-08-16 | 改変した抗体組成物、それを作製および使用する方法 |
Related Child Applications (1)
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JP2020156514A Division JP7221259B2 (ja) | 2009-01-12 | 2020-09-17 | 改変した抗体組成物、それを作製および使用する方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019077731A JP2019077731A (ja) | 2019-05-23 |
JP2019077731A5 true JP2019077731A5 (ja) | 2020-03-05 |
JP6860601B2 JP6860601B2 (ja) | 2021-04-14 |
Family
ID=42317225
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
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JP2011545537A Active JP5851842B2 (ja) | 2009-01-12 | 2010-01-12 | 改変した抗体組成物、それを作製および使用する方法 |
JP2015146530A Active JP6271476B2 (ja) | 2009-01-12 | 2015-07-24 | 改変した抗体組成物、それを作製および使用する方法 |
JP2017157121A Active JP6571730B2 (ja) | 2009-01-12 | 2017-08-16 | 改変した抗体組成物、それを作製および使用する方法 |
JP2019027222A Active JP6860601B2 (ja) | 2009-01-12 | 2019-02-19 | 改変した抗体組成物、それを作製および使用する方法 |
JP2020156514A Active JP7221259B2 (ja) | 2009-01-12 | 2020-09-17 | 改変した抗体組成物、それを作製および使用する方法 |
Family Applications Before (3)
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JP2011545537A Active JP5851842B2 (ja) | 2009-01-12 | 2010-01-12 | 改変した抗体組成物、それを作製および使用する方法 |
JP2015146530A Active JP6271476B2 (ja) | 2009-01-12 | 2015-07-24 | 改変した抗体組成物、それを作製および使用する方法 |
JP2017157121A Active JP6571730B2 (ja) | 2009-01-12 | 2017-08-16 | 改変した抗体組成物、それを作製および使用する方法 |
Family Applications After (1)
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JP2020156514A Active JP7221259B2 (ja) | 2009-01-12 | 2020-09-17 | 改変した抗体組成物、それを作製および使用する方法 |
Country Status (9)
Country | Link |
---|---|
US (9) | US20100189651A1 (ja) |
EP (2) | EP2385955B1 (ja) |
JP (5) | JP5851842B2 (ja) |
CN (2) | CN102482347B (ja) |
AU (4) | AU2010203353B2 (ja) |
BR (1) | BRPI1006141B8 (ja) |
CA (1) | CA2749339A1 (ja) |
RU (1) | RU2636046C2 (ja) |
WO (1) | WO2010081173A2 (ja) |
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