JP2012176978A5 - - Google Patents
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- JP2012176978A5 JP2012176978A5 JP2012128849A JP2012128849A JP2012176978A5 JP 2012176978 A5 JP2012176978 A5 JP 2012176978A5 JP 2012128849 A JP2012128849 A JP 2012128849A JP 2012128849 A JP2012128849 A JP 2012128849A JP 2012176978 A5 JP2012176978 A5 JP 2012176978A5
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- pharmaceutically acceptable
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Claims (15)
- δPKCアイソザイムによって調節される疾患状態について処置するための薬学的組成物であって、治療有効量の、(a)配列番号27、配列番号28、配列番号29および配列番号30、ならびに(b)(a)におけるアミノ酸配列における保存的アミノ酸置換を有し、かつ、δPKCアイソザイムによって調節される疾患状態の処置の活性を有するペプチドからなる群より選択されるペプチドを含み、該処置を必要とする哺乳動物へと投与するために処方されたものである、薬学的組成物。
- 前記ペプチドが、配列番号26のN末端の2アミノ酸を含まない、請求項1に記載の薬学的組成物。
- 前記ペプチドが、キャリアペプチドに結合体化されている、請求項1または2に記載の薬学的組成物。
- 前記ペプチドが、ポリ−Arg、Tat、またはDrosophila Antennapediaホメオドメインから選択されるキャリアペプチドにCys−Cys結合している、請求項3に記載の薬学的組成物。
- 前記ペプチドが、配列番号27、配列番号28、配列番号29および配列番号30からなる群から選択される、請求項1に記載の薬学的組成物。
- (a)配列番号27、配列番号28、配列番号29および配列番号30、ならびに(b)(a)におけるアミノ酸配列における保存的アミノ酸置換を有し、かつ、δPKCアイソザイムによって調節される疾患状態の処置の活性を有するペプチドからなる群より選択されるδPKC V5ペプチド。
- 前記ペプチドが、配列番号26のN末端の2アミノ酸を含まない、請求項6に記載のペプチド。
- 前記ペプチドが、キャリアペプチドに結合体化されている、請求項6に記載のペプチド。
- 前記ペプチドが、ポリ−Arg、Tat、またはDrosophila Antennapediaホメオドメインから選択されるキャリアペプチドにCys−Cys結合している、請求項8に記載のペプチド。
- 配列番号27、配列番号28、配列番号29および配列番号30からなる群から選択される、請求項6に記載のペプチド。
- 薬学的処方物であって、薬学的に受容可能な賦形剤および請求項6に記載のペプチドを含む、処方物。
- 薬学的処方物であって、薬学的に受容可能な賦形剤および請求項8に記載のペプチド/キャリア結合体を含む、処方物。
- 薬学的処方物であって、薬学的に受容可能な賦形剤および請求項9に記載のペプチド/キャリア結合体を含む、処方物。
- 薬学的処方物であって、薬学的に受容可能な賦形剤および請求項10に記載のペプチドを含む、処方物。
- 明細書に記載の発明。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37453002P | 2002-04-22 | 2002-04-22 | |
US60/374,530 | 2002-04-22 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003586176A Division JP2005523326A (ja) | 2002-04-22 | 2003-04-22 | プロテインキナーゼcのペプチドインヒビター |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012176978A JP2012176978A (ja) | 2012-09-13 |
JP2012176978A5 true JP2012176978A5 (ja) | 2013-04-18 |
Family
ID=29251202
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003586177A Pending JP2005527209A (ja) | 2002-04-22 | 2003-04-22 | 疼痛管理のためのプロテインキナーゼCγのペプチドインヒビター |
JP2003586176A Withdrawn JP2005523326A (ja) | 2002-04-22 | 2003-04-22 | プロテインキナーゼcのペプチドインヒビター |
JP2009010402A Pending JP2009091372A (ja) | 2002-04-22 | 2009-01-20 | 疼痛管理のためのプロテインキナーゼCγのペプチドインヒビター |
JP2009011456A Pending JP2009102392A (ja) | 2002-04-22 | 2009-01-21 | プロテインキナーゼcのペプチドインヒビター |
JP2012128849A Pending JP2012176978A (ja) | 2002-04-22 | 2012-06-06 | プロテインキナーゼcのペプチドインヒビター |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003586177A Pending JP2005527209A (ja) | 2002-04-22 | 2003-04-22 | 疼痛管理のためのプロテインキナーゼCγのペプチドインヒビター |
JP2003586176A Withdrawn JP2005523326A (ja) | 2002-04-22 | 2003-04-22 | プロテインキナーゼcのペプチドインヒビター |
JP2009010402A Pending JP2009091372A (ja) | 2002-04-22 | 2009-01-20 | 疼痛管理のためのプロテインキナーゼCγのペプチドインヒビター |
JP2009011456A Pending JP2009102392A (ja) | 2002-04-22 | 2009-01-21 | プロテインキナーゼcのペプチドインヒビター |
Country Status (6)
Country | Link |
---|---|
US (8) | US7507711B2 (ja) |
EP (3) | EP2332559A1 (ja) |
JP (5) | JP2005527209A (ja) |
AU (4) | AU2003234185C1 (ja) |
CA (3) | CA2481512C (ja) |
WO (2) | WO2003089457A2 (ja) |
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WO2004103266A2 (en) * | 2003-05-16 | 2004-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase c peptides for use in withdrawal |
AU2003264918A1 (en) * | 2003-10-02 | 2005-04-21 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase c peptides for use in withdrawal |
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US8507277B2 (en) * | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
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EP3180003B1 (en) | 2014-07-01 | 2022-01-12 | The Regents of the University of California | Pkc-epsilon inhibitors |
JP2017528452A (ja) | 2014-08-25 | 2017-09-28 | ユニバーシティ・オブ・キャンベラUniversity of Canberra | がん幹細胞を調節するための組成物およびその使用 |
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-
2003
- 2003-04-22 JP JP2003586177A patent/JP2005527209A/ja active Pending
- 2003-04-22 AU AU2003234185A patent/AU2003234185C1/en not_active Ceased
- 2003-04-22 WO PCT/US2003/012542 patent/WO2003089457A2/en active Application Filing
- 2003-04-22 US US10/421,503 patent/US7507711B2/en not_active Expired - Fee Related
- 2003-04-22 CA CA2481512A patent/CA2481512C/en not_active Expired - Fee Related
- 2003-04-22 EP EP10178878A patent/EP2332559A1/en not_active Withdrawn
- 2003-04-22 WO PCT/US2003/012541 patent/WO2003089456A2/en active Application Filing
- 2003-04-22 AU AU2003234186A patent/AU2003234186B2/en not_active Ceased
- 2003-04-22 EP EP03728495A patent/EP1501533A4/en not_active Withdrawn
- 2003-04-22 US US10/513,003 patent/US7393835B2/en not_active Expired - Fee Related
- 2003-04-22 EP EP03728494A patent/EP1501532A4/en not_active Withdrawn
- 2003-04-22 CA CA2785889A patent/CA2785889A1/en not_active Abandoned
- 2003-04-22 US US10/421,548 patent/US7459424B2/en not_active Expired - Fee Related
- 2003-04-22 CA CA2482598A patent/CA2482598C/en not_active Expired - Fee Related
- 2003-04-22 JP JP2003586176A patent/JP2005523326A/ja not_active Withdrawn
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2007
- 2007-07-16 US US11/879,414 patent/US7833984B2/en not_active Expired - Fee Related
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2008
- 2008-06-16 US US12/214,104 patent/US7939493B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/229,992 patent/US20090143293A1/en not_active Abandoned
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2009
- 2009-01-20 JP JP2009010402A patent/JP2009091372A/ja active Pending
- 2009-01-21 JP JP2009011456A patent/JP2009102392A/ja active Pending
- 2009-04-22 AU AU2009201593A patent/AU2009201593B2/en not_active Ceased
- 2009-05-04 AU AU2009201760A patent/AU2009201760B2/en not_active Ceased
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2011
- 2011-05-05 US US13/101,540 patent/US8658594B2/en not_active Expired - Fee Related
-
2012
- 2012-06-06 JP JP2012128849A patent/JP2012176978A/ja active Pending
-
2014
- 2014-02-21 US US14/187,070 patent/US9365837B2/en not_active Expired - Fee Related
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