JP2018509182A5 - - Google Patents
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- JP2018509182A5 JP2018509182A5 JP2017567049A JP2017567049A JP2018509182A5 JP 2018509182 A5 JP2018509182 A5 JP 2018509182A5 JP 2017567049 A JP2017567049 A JP 2017567049A JP 2017567049 A JP2017567049 A JP 2017567049A JP 2018509182 A5 JP2018509182 A5 JP 2018509182A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- pdl1
- optionally
- activatable antibody
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003795 chemical substances by application Substances 0.000 claims description 31
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 29
- 102000048776 human CD274 Human genes 0.000 claims description 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 23
- 101100407306 Mus musculus Cd274 gene Proteins 0.000 claims description 20
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 19
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 18
- 239000003446 ligand Substances 0.000 claims description 18
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- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 12
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims description 12
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims description 12
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- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims description 4
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- WOWDZACBATWTAU-FEFUEGSOSA-N (2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-n-[(3r,4s,5s)-1-[(2s)-2-[(1r,2r)-3-[[(1s,2r)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical group CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1 WOWDZACBATWTAU-FEFUEGSOSA-N 0.000 claims description 2
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- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 229940122255 Microtubule inhibitor Drugs 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 206010039509 Scab Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims description 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 2
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- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 108010044540 auristatin Proteins 0.000 claims description 2
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims description 2
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- AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 claims description 2
- 229930188854 dolastatin Natural products 0.000 claims description 2
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims description 2
- 229960005501 duocarmycin Drugs 0.000 claims description 2
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- 206010017758 gastric cancer Diseases 0.000 claims description 2
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562133231P | 2015-03-13 | 2015-03-13 | |
| US62/133,231 | 2015-03-13 | ||
| US201562139596P | 2015-03-27 | 2015-03-27 | |
| US62/139,596 | 2015-03-27 | ||
| US201562218883P | 2015-09-15 | 2015-09-15 | |
| US62/218,883 | 2015-09-15 | ||
| PCT/US2016/022345 WO2016149201A2 (en) | 2015-03-13 | 2016-03-14 | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021004044A Division JP7165217B2 (ja) | 2015-03-13 | 2021-01-14 | 抗ｐｄｌ１抗体、活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509182A JP2018509182A (ja) | 2018-04-05 |
| JP2018509182A5 true JP2018509182A5 (enExample) | 2019-04-25 |
| JP6826055B2 JP6826055B2 (ja) | 2021-02-03 |
Family
ID=55586463
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567049A Active JP6826055B2 (ja) | 2015-03-13 | 2016-03-14 | 抗ｐｄｌ１抗体、活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| JP2021004044A Active JP7165217B2 (ja) | 2015-03-13 | 2021-01-14 | 抗ｐｄｌ１抗体、活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| JP2022168776A Pending JP2023002706A (ja) | 2015-03-13 | 2022-10-21 | 抗ｐｄｌ１抗体、活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021004044A Active JP7165217B2 (ja) | 2015-03-13 | 2021-01-14 | 抗ｐｄｌ１抗体、活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| JP2022168776A Pending JP2023002706A (ja) | 2015-03-13 | 2022-10-21 | 抗ｐｄｌ１抗体、活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10336824B2 (enExample) |
| EP (1) | EP3268392A2 (enExample) |
| JP (3) | JP6826055B2 (enExample) |
| KR (1) | KR20170135860A (enExample) |
| CN (2) | CN114702586A (enExample) |
| AU (2) | AU2016233495B2 (enExample) |
| BR (1) | BR112017019559B1 (enExample) |
| CA (1) | CA2978942A1 (enExample) |
| IL (2) | IL292449B2 (enExample) |
| MA (1) | MA42971A (enExample) |
| MX (2) | MX2017011644A (enExample) |
| MY (1) | MY194225A (enExample) |
| SG (2) | SG10201913297TA (enExample) |
| WO (1) | WO2016149201A2 (enExample) |
Families Citing this family (261)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011003195A (es) | 2008-09-26 | 2011-08-12 | Dana Farber Cancer Inst Inc | Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos. |
| US9175082B2 (en) | 2012-05-31 | 2015-11-03 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-L1 |
| CN107892719B (zh) | 2012-10-04 | 2022-01-14 | 达纳－法伯癌症研究所公司 | 人单克隆抗-pd-l1抗体和使用方法 |
| US20150087810A1 (en) | 2013-09-25 | 2015-03-26 | Cytomx Therapeutics, Inc. | Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| EP3628328B1 (en) | 2014-01-31 | 2022-09-14 | Cytomx Therapeutics Inc. | Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| JP6826055B2 (ja) | 2015-03-13 | 2021-02-03 | サイトメックス セラピューティクス インコーポレイテッド | 抗ｐｄｌ１抗体、活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| WO2016182064A1 (ja) | 2015-05-13 | 2016-11-17 | 中外製薬株式会社 | 多重抗原結合分子融合体、医薬組成物、線状エピトープの同定方法、および多重抗原結合分子融合体の製造方法 |
| US10513558B2 (en) * | 2015-07-13 | 2019-12-24 | Cytomx Therapeutics, Inc. | Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of use thereof |
| US10392442B2 (en) | 2015-12-17 | 2019-08-27 | Bristol-Myers Squibb Company | Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment |
| BR112018012801B1 (pt) | 2015-12-22 | 2024-03-12 | Regeneron Pharmaceuticals, Inc | Usos de uma combinação de anticorpos anti-pd-1 e anticorpos biespecíficos anti-cd20/anti-cd3 e de uma composição farmacêutica |
| SG10201912405TA (en) | 2016-01-11 | 2020-02-27 | Inhibrx Inc | Multivalent and multispecific 41bb-binding fusion proteins |
| US20170198051A1 (en) | 2016-01-11 | 2017-07-13 | Inhibrx Lp | Multivalent and multispecific ox40-binding fusion proteins |
| TWI786044B (zh) | 2016-05-13 | 2022-12-11 | 美商再生元醫藥公司 | 藉由投予ｐｄ-１抑制劑治療皮膚癌之方法 |
| HRP20230864T1 (hr) | 2016-06-02 | 2023-11-10 | Bristol-Myers Squibb Company | Pd-1 blokada nivolumabom kod refraktornog hodgkinovog limfoma |
| PT3464368T (pt) | 2016-06-02 | 2023-08-17 | Bristol Myers Squibb Co | Utilização de um anticorpo anti-pd-1 em combinação com um anticorpo anti-cd30 no tratamento de linfoma |
| CN109476753A (zh) | 2016-06-03 | 2019-03-15 | 百时美施贵宝公司 | 用于治疗肿瘤的方法的抗-pd-1抗体 |
| JP2019517498A (ja) | 2016-06-03 | 2019-06-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 再発性小細胞肺癌の処置方法において使用するための抗ｐｄ−１抗体 |
| KR20240134249A (ko) | 2016-06-03 | 2024-09-06 | 브리스톨-마이어스 스큅 컴퍼니 | 결장직장암을 갖는 환자의 치료에서의 항-pd-1 항체의 용도 |
| WO2018029474A2 (en) | 2016-08-09 | 2018-02-15 | Kymab Limited | Anti-icos antibodies |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| BR112018076684A2 (pt) * | 2016-06-29 | 2019-04-02 | Checkpoint Therapeutics, Inc | anticorpos pd-l1 específicos e métodos de uso dos mesmos |
| CA3029902A1 (en) | 2016-07-07 | 2018-01-11 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody adjuvant conjugates |
| KR20230044038A (ko) | 2016-08-09 | 2023-03-31 | 키맵 리미티드 | 항-icos 항체 |
| KR20240042177A (ko) * | 2016-10-05 | 2024-04-01 | 유니버시티 오브 센트럴 플로리다 리서치 파운데이션, 인코포레이티드 | Nk 세포 및 항-pdl1 암 요법과 관련된 방법 및 조성물 |
| KR20240019398A (ko) | 2016-10-28 | 2024-02-14 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체를 사용하여 요로상피 암종을 치료하는 방법 |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
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2016
- 2016-03-14 JP JP2017567049A patent/JP6826055B2/ja active Active
- 2016-03-14 KR KR1020177029321A patent/KR20170135860A/ko active Pending
- 2016-03-14 SG SG10201913297TA patent/SG10201913297TA/en unknown
- 2016-03-14 SG SG11201707383PA patent/SG11201707383PA/en unknown
- 2016-03-14 CN CN202210054138.4A patent/CN114702586A/zh active Pending
- 2016-03-14 BR BR112017019559-3A patent/BR112017019559B1/pt active IP Right Grant
- 2016-03-14 AU AU2016233495A patent/AU2016233495B2/en not_active Ceased
- 2016-03-14 EP EP16710662.4A patent/EP3268392A2/en active Pending
- 2016-03-14 US US15/069,622 patent/US10336824B2/en active Active
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- 2016-03-14 MX MX2017011644A patent/MX2017011644A/es unknown
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- 2016-03-14 IL IL292449A patent/IL292449B2/en unknown
- 2016-03-14 WO PCT/US2016/022345 patent/WO2016149201A2/en not_active Ceased
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2017
- 2017-09-11 MX MX2021013467A patent/MX2021013467A/es unknown
- 2017-09-12 IL IL254458A patent/IL254458B/en unknown
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2019
- 2019-05-31 US US16/428,708 patent/US11174316B2/en not_active Expired - Fee Related
- 2019-05-31 US US16/428,767 patent/US10669339B2/en active Active
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- 2022-10-21 JP JP2022168776A patent/JP2023002706A/ja active Pending
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