MA59115B2 - Analogues de camptothécine conjugués à un résidu de glutamine dans une protéine et leur utilisation - Google Patents

Analogues de camptothécine conjugués à un résidu de glutamine dans une protéine et leur utilisation

Info

Publication number
MA59115B2
MA59115B2 MA59115A MA59115A MA59115B2 MA 59115 B2 MA59115 B2 MA 59115B2 MA 59115 A MA59115 A MA 59115A MA 59115 A MA59115 A MA 59115A MA 59115 B2 MA59115 B2 MA 59115B2
Authority
MA
Morocco
Prior art keywords
protein
camptothecin analogues
relates
camptothecin
glutamine residue
Prior art date
Application number
MA59115A
Other languages
English (en)
Other versions
MA59115A1 (fr
Inventor
Amy Han
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of MA59115A1 publication Critical patent/MA59115A1/fr
Publication of MA59115B2 publication Critical patent/MA59115B2/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne des conjugués protéine-médicament et des compositions de ceux-ci qui sont utiles, par exemple, pour administrer spécifiquement à une cible des fractions thérapeutiques, par exemple des analogues de camptothécine et/ou des dérivés. Dans certains modes de réalisation, l'invention concerne des procédés spécifiques et efficaces pour produire des constructions protéine-médicament (par exemple, des conjugués anticorps-médicament) à l'aide d'une combinaison de transglutaminase et de techniques de 1,3-cycloaddition. L'invention concerne des analogues de camptothécine, des conjugués anticorps-médicament, ainsi que des compositions qui contiennent des anticorps modifiés par glutaminyle et des charges utiles analogues de camptothécine.
MA59115A 2020-07-13 2021-07-12 Analogues de camptothécine conjugués à un résidu de glutamine dans une protéine et leur utilisation MA59115B2 (fr)

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