CN110974975A - 一种快速释放的抗体药物偶联物 - Google Patents
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Abstract
Description
时间(min) | 流速(ml/min) | SEC流动相(%) |
0 | 0.8 | 100 |
12 | 0.8 | 100 |
时间(min) | 流速(ml/min) | RP流动相A(%) | RP流动相B(%) |
0 | 0.5 | 75 | 25 |
3 | 0.5 | 75 | 25 |
28 | 0.5 | 50 | 50 |
30 | 0.5 | 5 | 95 |
32 | 0.5 | 5 | 95 |
33 | 0.5 | 75 | 25 |
40 | 0.5 | 75 | 25 |
ADC | BXPC-3 | Fadu | SW620 | A431 |
C-06 | 33.08 | 1.37 | 2.64 | 2.64 |
C-07 | ~200 | 1.90 | 223.18 | 5.88 |
Claims (13)
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CN201911271143.5A CN110974975B (zh) | 2019-12-12 | 2019-12-12 | 一种快速释放的抗体药物偶联物 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111686259A (zh) * | 2019-05-26 | 2020-09-22 | 四川百利药业有限责任公司 | 一种含sn38的抗体药物偶联物 |
WO2022015656A1 (en) * | 2020-07-13 | 2022-01-20 | Regeneron Pharmaceuticals, Inc. | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
WO2024067754A1 (zh) * | 2022-09-30 | 2024-04-04 | 成都百利多特生物药业有限责任公司 | 一种带有高稳定性亲水连接单元的奥瑞他汀类药物及其偶联物 |
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