JP2013502423A5 - - Google Patents
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- JP2013502423A5 JP2013502423A5 JP2012525651A JP2012525651A JP2013502423A5 JP 2013502423 A5 JP2013502423 A5 JP 2013502423A5 JP 2012525651 A JP2012525651 A JP 2012525651A JP 2012525651 A JP2012525651 A JP 2012525651A JP 2013502423 A5 JP2013502423 A5 JP 2013502423A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- kinase
- compound
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 79
- 229910052757 nitrogen Inorganic materials 0.000 claims description 77
- -1 heterocycloalkyloxy Chemical class 0.000 claims description 71
- 125000004122 cyclic group Chemical group 0.000 claims description 55
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 52
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 44
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 44
- 150000001408 amides Chemical class 0.000 claims description 43
- 125000001072 heteroaryl group Chemical group 0.000 claims description 43
- 125000003545 alkoxy group Chemical group 0.000 claims description 42
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 42
- 150000003839 salts Chemical class 0.000 claims description 42
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 41
- 229910019142 PO4 Inorganic materials 0.000 claims description 41
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 41
- 125000002252 acyl group Chemical group 0.000 claims description 41
- 125000004423 acyloxy group Chemical group 0.000 claims description 41
- 125000003342 alkenyl group Chemical group 0.000 claims description 41
- 125000000304 alkynyl group Chemical group 0.000 claims description 41
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 41
- 239000004202 carbamide Substances 0.000 claims description 41
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 41
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 41
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 41
- 239000010452 phosphate Substances 0.000 claims description 41
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 40
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 40
- 229910052739 hydrogen Inorganic materials 0.000 claims description 34
- 239000001257 hydrogen Substances 0.000 claims description 34
- 229940124530 sulfonamide Drugs 0.000 claims description 34
- 150000003456 sulfonamides Chemical class 0.000 claims description 34
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 claims description 29
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 claims description 29
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 13
- 206010012601 diabetes mellitus Diseases 0.000 claims description 12
- 229910052717 sulfur Inorganic materials 0.000 claims description 10
- 201000004681 Psoriasis Diseases 0.000 claims description 8
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- 206010002198 Anaphylactic reaction Diseases 0.000 claims description 4
- 201000001320 Atherosclerosis Diseases 0.000 claims description 4
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 201000004624 Dermatitis Diseases 0.000 claims description 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 4
- 206010014561 Emphysema Diseases 0.000 claims description 4
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 4
- 206010020751 Hypersensitivity Diseases 0.000 claims description 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 4
- 208000007766 Kaposi sarcoma Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 108091007960 PI3Ks Proteins 0.000 claims description 4
- 206010033645 Pancreatitis Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 4
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims description 4
- 206010039710 Scleroderma Diseases 0.000 claims description 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 4
- 208000026935 allergic disease Diseases 0.000 claims description 4
- 230000007815 allergy Effects 0.000 claims description 4
- 230000036783 anaphylactic response Effects 0.000 claims description 4
- 208000003455 anaphylaxis Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 208000010668 atopic eczema Diseases 0.000 claims description 4
- 210000000481 breast Anatomy 0.000 claims description 4
- 201000008275 breast carcinoma Diseases 0.000 claims description 4
- 206010006451 bronchitis Diseases 0.000 claims description 4
- 210000001072 colon Anatomy 0.000 claims description 4
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 claims description 4
- 208000024908 graft versus host disease Diseases 0.000 claims description 4
- 201000011066 hemangioma Diseases 0.000 claims description 4
- 208000029824 high grade glioma Diseases 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 208000017169 kidney disease Diseases 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 4
- 201000005296 lung carcinoma Diseases 0.000 claims description 4
- 206010025135 lupus erythematosus Diseases 0.000 claims description 4
- 208000002780 macular degeneration Diseases 0.000 claims description 4
- 210000001672 ovary Anatomy 0.000 claims description 4
- 210000000496 pancreas Anatomy 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 201000008171 proliferative glomerulonephritis Diseases 0.000 claims description 4
- 210000002307 prostate Anatomy 0.000 claims description 4
- 201000001514 prostate carcinoma Diseases 0.000 claims description 4
- 208000037803 restenosis Diseases 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 3
- 230000007170 pathology Effects 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102200085789 rs121913279 Human genes 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 description 39
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 30
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 2
- 0 CC(C=CC(C1=CC=C2OC(*)=NC2C1)=C1)N1C(C(N1CCOCC1)=O)=NN Chemical compound CC(C=CC(C1=CC=C2OC(*)=NC2C1)=C1)N1C(C(N1CCOCC1)=O)=NN 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- YSXXCOCFTYLEKO-UHFFFAOYSA-N CC(C1)OCCN1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O Chemical compound CC(C1)OCCN1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O YSXXCOCFTYLEKO-UHFFFAOYSA-N 0.000 description 1
- HIQWQCPYCMOLJP-UHFFFAOYSA-N CCN(CC)CCCNC(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O Chemical compound CCN(CC)CCCNC(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O HIQWQCPYCMOLJP-UHFFFAOYSA-N 0.000 description 1
- LNOODYQAFGQBEB-UHFFFAOYSA-N CCN(CC)CCNC(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O Chemical compound CCN(CC)CCNC(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O LNOODYQAFGQBEB-UHFFFAOYSA-N 0.000 description 1
- MURMVHXCVCCZKC-UHFFFAOYSA-N CCNc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(Nc3ccc(C)nc3)=O)c2[o]1 Chemical compound CCNc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(Nc3ccc(C)nc3)=O)c2[o]1 MURMVHXCVCCZKC-UHFFFAOYSA-N 0.000 description 1
- KNWWEXOSAULKHT-UHFFFAOYSA-N CN(C)C(CC1)CCN1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O Chemical compound CN(C)C(CC1)CCN1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O KNWWEXOSAULKHT-UHFFFAOYSA-N 0.000 description 1
- LBPDVFVVCPERQL-UHFFFAOYSA-N CN(CC1)CCC1NC(c1cnc(cc2)[n]1nc2-c(cc1)cc2c1[o]c(N)n2)=O Chemical compound CN(CC1)CCC1NC(c1cnc(cc2)[n]1nc2-c(cc1)cc2c1[o]c(N)n2)=O LBPDVFVVCPERQL-UHFFFAOYSA-N 0.000 description 1
- LKFYTUQVWAVILJ-UHFFFAOYSA-N CN(CC1)CCN1C(C1)CN1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O Chemical compound CN(CC1)CCN1C(C1)CN1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O LKFYTUQVWAVILJ-UHFFFAOYSA-N 0.000 description 1
- VCCAQMQCZHPVKZ-UHFFFAOYSA-N CN1CCN(CCNC(c2cnc(cc3)[n]2cc3-c(cc2)cc3c2[o]c(N)n3)=O)CC1 Chemical compound CN1CCN(CCNC(c2cnc(cc3)[n]2cc3-c(cc2)cc3c2[o]c(N)n3)=O)CC1 VCCAQMQCZHPVKZ-UHFFFAOYSA-N 0.000 description 1
- MMELAEVXMCHEQO-UHFFFAOYSA-N Cc1n[n](C(CC2)CCN2C(c2cnc(cc3)[n]2cc3-c(cc2)cc3c2[o]c(N)n3)=O)cc1 Chemical compound Cc1n[n](C(CC2)CCN2C(c2cnc(cc3)[n]2cc3-c(cc2)cc3c2[o]c(N)n3)=O)cc1 MMELAEVXMCHEQO-UHFFFAOYSA-N 0.000 description 1
- ANVGIDSNUGKCAI-UHFFFAOYSA-N NC(C(CCC1)N1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O)=O Chemical compound NC(C(CCC1)N1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O)=O ANVGIDSNUGKCAI-UHFFFAOYSA-N 0.000 description 1
- KZHBSGHZZUNNKS-UHFFFAOYSA-N NC(CC1)CCN1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O Chemical compound NC(CC1)CCN1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O KZHBSGHZZUNNKS-UHFFFAOYSA-N 0.000 description 1
- ANVGIDSNUGKCAI-AWEZNQCLSA-N NC([C@H](CCC1)N1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O)=O Chemical compound NC([C@H](CCC1)N1C(c1cnc(cc2)[n]1cc2-c(cc1)cc2c1[o]c(N)n2)=O)=O ANVGIDSNUGKCAI-AWEZNQCLSA-N 0.000 description 1
- FRHBITMBDSNUNY-UHFFFAOYSA-N Nc1c[n](cc(cc2)-c3ccc4[o]c(N)nc4c3)c2n1 Chemical compound Nc1c[n](cc(cc2)-c3ccc4[o]c(N)nc4c3)c2n1 FRHBITMBDSNUNY-UHFFFAOYSA-N 0.000 description 1
- JAPVKYZNUBLMEB-UHFFFAOYSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(C3)CC3N3CCOCC3)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(C3)CC3N3CCOCC3)=O)c2[o]1 JAPVKYZNUBLMEB-UHFFFAOYSA-N 0.000 description 1
- OBORBDRLUWEHCP-UHFFFAOYSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CC3)CC3O)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CC3)CC3O)=O)c2[o]1 OBORBDRLUWEHCP-UHFFFAOYSA-N 0.000 description 1
- QNOQKQJTJAEMPT-UHFFFAOYSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CC3)CCN3C3CC3)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CC3)CCN3C3CC3)=O)c2[o]1 QNOQKQJTJAEMPT-UHFFFAOYSA-N 0.000 description 1
- OBORBDRLUWEHCP-CYBMUJFWSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CC3)C[C@@H]3O)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CC3)C[C@@H]3O)=O)c2[o]1 OBORBDRLUWEHCP-CYBMUJFWSA-N 0.000 description 1
- OBORBDRLUWEHCP-ZDUSSCGKSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CC3)C[C@H]3O)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CC3)C[C@H]3O)=O)c2[o]1 OBORBDRLUWEHCP-ZDUSSCGKSA-N 0.000 description 1
- FRSMQNSBEVGLOF-UHFFFAOYSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CCO)CCO)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(N(CCO)CCO)=O)c2[o]1 FRSMQNSBEVGLOF-UHFFFAOYSA-N 0.000 description 1
- LDBSVSTTWLVPJM-UHFFFAOYSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(NCCCN3CCCC3)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(NCCCN3CCCC3)=O)c2[o]1 LDBSVSTTWLVPJM-UHFFFAOYSA-N 0.000 description 1
- HJNWSJMQFMAOKO-UHFFFAOYSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(NCCCN3CCOCC3)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(NCCCN3CCOCC3)=O)c2[o]1 HJNWSJMQFMAOKO-UHFFFAOYSA-N 0.000 description 1
- GXTMGCNYYQINDM-UHFFFAOYSA-N Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(NCCN3CCCC3)=O)c2[o]1 Chemical compound Nc1nc(cc(cc2)-c(cc3)c[n]4c3ncc4C(NCCN3CCCC3)=O)c2[o]1 GXTMGCNYYQINDM-UHFFFAOYSA-N 0.000 description 1
- FSGMBPAXNUUHNZ-UHFFFAOYSA-O Nc1nc(cc(cc2)C(C=C3)=CN(C(c4cccnc4)=[NH2+])C3=N)c2[o]1 Chemical compound Nc1nc(cc(cc2)C(C=C3)=CN(C(c4cccnc4)=[NH2+])C3=N)c2[o]1 FSGMBPAXNUUHNZ-UHFFFAOYSA-O 0.000 description 1
- VIHUIOABFBIGJU-UHFFFAOYSA-N Nc1nc2cc(-c3c[n]4c(-c5ccncc5)nnc4cc3)ccc2[o]1 Chemical compound Nc1nc2cc(-c3c[n]4c(-c5ccncc5)nnc4cc3)ccc2[o]1 VIHUIOABFBIGJU-UHFFFAOYSA-N 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23461709P | 2009-08-17 | 2009-08-17 | |
| US61/234,617 | 2009-08-17 | ||
| PCT/US2010/045816 WO2011022439A1 (en) | 2009-08-17 | 2010-08-17 | Heterocyclic compounds and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015196033A Division JP6124971B2 (ja) | 2009-08-17 | 2015-10-01 | 複素環式化合物およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013502423A JP2013502423A (ja) | 2013-01-24 |
| JP2013502423A5 true JP2013502423A5 (https=) | 2013-09-19 |
| JP5819831B2 JP5819831B2 (ja) | 2015-11-24 |
Family
ID=43607312
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012525651A Active JP5819831B2 (ja) | 2009-08-17 | 2010-08-17 | 複素環式化合物およびそれらの使用 |
| JP2015196033A Active JP6124971B2 (ja) | 2009-08-17 | 2015-10-01 | 複素環式化合物およびそれらの使用 |
| JP2017074477A Active JP6749858B2 (ja) | 2009-08-17 | 2017-04-04 | 複素環式化合物およびそれらの使用 |
| JP2019079432A Active JP7123851B2 (ja) | 2009-08-17 | 2019-04-18 | 複素環式化合物およびそれらの使用 |
| JP2022127616A Active JP7338013B2 (ja) | 2009-08-17 | 2022-08-10 | 複素環式化合物およびそれらの使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015196033A Active JP6124971B2 (ja) | 2009-08-17 | 2015-10-01 | 複素環式化合物およびそれらの使用 |
| JP2017074477A Active JP6749858B2 (ja) | 2009-08-17 | 2017-04-04 | 複素環式化合物およびそれらの使用 |
| JP2019079432A Active JP7123851B2 (ja) | 2009-08-17 | 2019-04-18 | 複素環式化合物およびそれらの使用 |
| JP2022127616A Active JP7338013B2 (ja) | 2009-08-17 | 2022-08-10 | 複素環式化合物およびそれらの使用 |
Country Status (35)
Families Citing this family (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0643322Y2 (ja) | 1990-08-20 | 1994-11-09 | 米夫 城埜 | 目地被覆用テープ |
| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
| NZ598220A (en) * | 2009-08-17 | 2014-02-28 | Intellikine Llc | Heterocyclic compounds and uses thereof |
| JP5728683B2 (ja) * | 2009-09-04 | 2015-06-03 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | チロシンスレオニンキナーゼ阻害剤としての置換アミノキノキサリン |
| GB201008134D0 (en) * | 2010-05-14 | 2010-06-30 | Medical Res Council Technology | Compounds |
| CN103153062B (zh) * | 2010-05-24 | 2015-07-15 | 因特利凯有限责任公司 | 杂环化合物及其用途 |
| CA2806332C (en) * | 2010-07-30 | 2017-11-14 | Oncotherapy Science, Inc. | Quinoline derivatives and melk inhibitors containing the same |
| JP2013545749A (ja) * | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環化合物及びその使用 |
| WO2012065297A1 (en) * | 2010-11-16 | 2012-05-24 | Impact Therapeutics, Inc. | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
| US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
| CN102219755B (zh) * | 2011-05-05 | 2013-04-03 | 南京大学 | Stat3的小分子选择性抑制剂及其制备方法和应用 |
| WO2012154610A1 (en) * | 2011-05-06 | 2012-11-15 | Intellikine, Llc | Reactive pi3k kinase inhibitors and uses thereof |
| JP6122420B2 (ja) * | 2011-05-06 | 2017-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 多発性嚢胞疾患の治療 |
| PL2710018T3 (pl) | 2011-05-19 | 2022-04-04 | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Związki makrocykliczne jako inhibitory kinaz białkowych |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| HK1202333A1 (en) * | 2011-11-11 | 2015-09-25 | Intellikine, Llc | Combination of kinase inhibitors and uses thereof |
| US9403820B2 (en) * | 2011-11-11 | 2016-08-02 | Intellikine Llc | Kinase inhibitor polymorphs |
| US20140323721A1 (en) * | 2011-11-23 | 2014-10-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
| US10280168B2 (en) | 2012-03-30 | 2019-05-07 | Agency For Science, Technology And Research | Bicyclic heteroaryl derivatives as MNK1 and MNK2 modulators and uses thereof |
| MX2014011843A (es) * | 2012-03-30 | 2014-12-10 | Novartis Ag | Compuestos para usarse en el tratamiento de neuroblastoma, sarcoma de ewing o rabdomiosarcoma. |
| GB201205669D0 (en) * | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
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