JP2011527686A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011527686A5 JP2011527686A5 JP2011517520A JP2011517520A JP2011527686A5 JP 2011527686 A5 JP2011527686 A5 JP 2011527686A5 JP 2011517520 A JP2011517520 A JP 2011517520A JP 2011517520 A JP2011517520 A JP 2011517520A JP 2011527686 A5 JP2011527686 A5 JP 2011527686A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- amino
- salt
- oxadiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C*(C)Nc1n[o]nc1C(N1c2ccc(*)c(*)c2)=NOC1=O)CNS(*)(=O)=O Chemical compound C*(C*(C)Nc1n[o]nc1C(N1c2ccc(*)c(*)c2)=NOC1=O)CNS(*)(=O)=O 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7887608P | 2008-07-08 | 2008-07-08 | |
| US61/078,876 | 2008-07-08 | ||
| US15087309P | 2009-02-09 | 2009-02-09 | |
| US61/150,873 | 2009-02-09 | ||
| PCT/US2009/049794 WO2010005958A2 (en) | 2008-07-08 | 2009-07-07 | 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014009612A Division JP5819451B2 (ja) | 2008-07-08 | 2014-01-22 | インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011527686A JP2011527686A (ja) | 2011-11-04 |
| JP2011527686A5 true JP2011527686A5 (https=) | 2012-08-23 |
| JP5465720B2 JP5465720B2 (ja) | 2014-04-09 |
Family
ID=41128289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517520A Expired - Fee Related JP5465720B2 (ja) | 2008-07-08 | 2009-07-07 | インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール |
| JP2014009612A Active JP5819451B2 (ja) | 2008-07-08 | 2014-01-22 | インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014009612A Active JP5819451B2 (ja) | 2008-07-08 | 2014-01-22 | インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール |
Country Status (36)
Families Citing this family (180)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| US8450351B2 (en) * | 2005-12-20 | 2013-05-28 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| WO2008036642A2 (en) * | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| JP5465720B2 (ja) | 2008-07-08 | 2014-04-09 | インサイト・コーポレイション | インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール |
| US8299295B2 (en) | 2009-10-15 | 2012-10-30 | Johnson Matthey Public Limited Company | Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs |
| GB0919757D0 (en) * | 2009-11-12 | 2009-12-30 | Johnson Matthey Plc | Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs |
| NO2694640T3 (https=) | 2011-04-15 | 2018-03-17 | ||
| EP3312173B1 (en) | 2011-11-09 | 2021-12-22 | Kyowa Kirin Co., Ltd. | Nitrogen-containing heterocyclic compounds |
| GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| CA2889182A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
| KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
| ES2799582T3 (es) * | 2013-11-08 | 2020-12-18 | Incyte Holdings Corp | Proceso para la síntesis de un inhibidor de indoleamina 2,3-dioxigenasa |
| SG11201606428UA (en) * | 2014-02-04 | 2016-09-29 | Incyte Corp | Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer |
| SG11201607969XA (en) | 2014-03-31 | 2016-10-28 | Genentech Inc | Anti-ox40 antibodies and methods of use |
| KR20160146747A (ko) | 2014-03-31 | 2016-12-21 | 제넨테크, 인크. | 항혈관신생제 및 ox40 결합 효능제를 포함하는 조합 요법 |
| SI3148579T1 (sl) | 2014-05-28 | 2021-07-30 | Agenus Inc. | Proti GITR antitelesa in postopki z njihovo uporabo |
| RU2016149812A (ru) | 2014-06-06 | 2018-07-17 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
| AU2015289492B2 (en) * | 2014-07-17 | 2020-02-20 | Chdi Foundation, Inc. | Methods and compositions for treating HIV-related disorders |
| CN105481789B (zh) * | 2014-09-15 | 2020-05-19 | 中国科学院上海有机化学研究所 | 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法 |
| BR112017008809A2 (pt) | 2014-11-05 | 2017-12-19 | Flexus Biosciences Inc | agentes imunorreguladores |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| US10525035B2 (en) | 2014-12-18 | 2020-01-07 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of retinopathy and other ocular diseases |
| US11786457B2 (en) | 2015-01-30 | 2023-10-17 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| US9670205B2 (en) | 2015-03-04 | 2017-06-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| MX2017011951A (es) * | 2015-03-17 | 2018-06-15 | Pfizer | Derivados sustituidos de indol 3 novedosos, composiciones farmaceuticas y metodos para uso. |
| WO2016155545A1 (zh) * | 2015-03-31 | 2016-10-06 | 江苏恒瑞医药股份有限公司 | 含氨磺酰基的1,2,5-噁二唑类衍生物、其制备方法及其在医药上的应用 |
| KR20180002653A (ko) | 2015-04-07 | 2018-01-08 | 제넨테크, 인크. | 효능작용 활성을 갖는 항원 결합 복합체 및 사용 방법 |
| EP3287461B1 (en) | 2015-04-21 | 2020-03-18 | Jiangsu Hengrui Medicine Co., Ltd. | Imidazo isoindole derivative, preparation method therefor and medical use thereof |
| MA53355A (fr) | 2015-05-29 | 2022-03-16 | Agenus Inc | Anticorps anti-ctla-4 et leurs procédés d'utilisation |
| US9891882B2 (en) * | 2015-06-01 | 2018-02-13 | Nagravision S.A. | Methods and systems for conveying encrypted data to a communication device |
| JP2018521019A (ja) | 2015-06-08 | 2018-08-02 | ジェネンテック， インコーポレイテッド | 抗ｏｘ４０抗体を使用して癌を治療する方法 |
| MX2017015937A (es) | 2015-06-08 | 2018-12-11 | Genentech Inc | Métodos de tratamiento del cáncer con anticuerpos anti-ox40 y antagonistas de unión al eje de pd-1. |
| EP3317287B1 (en) * | 2015-07-02 | 2019-07-31 | GlaxoSmithKline Intellectual Property Development Limited | Inhibitors of indoleamine 2,3-dioxygenase |
| TW201713332A (zh) | 2015-07-14 | 2017-04-16 | 協和醱酵麒麟有限公司 | 包含與抗體組合投予之ｉｄｏ抑制物之腫瘤治療劑 |
| US10786547B2 (en) | 2015-07-16 | 2020-09-29 | Biokine Therapeutics Ltd. | Compositions, articles of manufacture and methods for treating cancer |
| EP4659747A2 (en) | 2015-07-24 | 2025-12-10 | Lumos Pharma, Inc. | Salts and prodrugs of 1-methyl-d-tryptophan |
| CN107001271B (zh) * | 2015-08-07 | 2019-05-10 | 江苏恒瑞医药股份有限公司 | 羟基脒类衍生物、其制备方法及其在医药上的应用 |
| US20210292327A1 (en) | 2015-08-26 | 2021-09-23 | Gilead Sciences, Inc. | Deuterated toll-like receptor modulators |
| AU2016317915B2 (en) | 2015-09-01 | 2021-02-18 | Agenus Inc. | Anti-PD-1 antibodies and methods of use thereof |
| CN105120571B (zh) | 2015-09-14 | 2018-05-01 | 昂宝电子（上海）有限公司 | 用于发光二极管照明系统中的电流调节的系统和方法 |
| CN106565696B (zh) * | 2015-10-09 | 2020-07-28 | 江苏恒瑞医药股份有限公司 | 噁二唑类衍生物、其制备方法及其在医药上的应用 |
| WO2017079669A1 (en) * | 2015-11-04 | 2017-05-11 | Incyte Corporation | Pharmaceutical compositions and methods for indoleamine 2,3-dioxygenase inhibition and indications therefor |
| JP2018532406A (ja) | 2015-11-09 | 2018-11-08 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｉｄｏ１および／またはｔｄｏ修飾因子を同定するためのスクリーニングアッセイ |
| CN108883173B (zh) | 2015-12-02 | 2022-09-06 | 阿吉纳斯公司 | 抗体和其使用方法 |
| WO2017106062A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Novel compounds as indoleamine 2,3-dioxygenase inhibitors |
| CN106883193B (zh) * | 2015-12-15 | 2021-10-15 | 上海翰森生物医药科技有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用 |
| MX2018008797A (es) | 2016-01-19 | 2018-11-29 | Pfizer | Vacunas contra el cancer. |
| US9624185B1 (en) * | 2016-01-20 | 2017-04-18 | Yong Xu | Method for preparing IDO inhibitor epacadostat |
| CN105646389B (zh) * | 2016-01-28 | 2019-06-28 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途 |
| WO2017140835A1 (en) | 2016-02-19 | 2017-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of obesity |
| CN108602786B (zh) * | 2016-02-25 | 2019-04-23 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的噁二唑类化合物及包含该化合物的组合物及其用途 |
| CN107176933B (zh) * | 2016-03-09 | 2020-10-09 | 中国科学院上海有机化学研究所 | 一种含氮烷基化和芳基化亚砜亚胺的吲哚胺-2,3-双加氧酶抑制剂 |
| CN107304191B (zh) * | 2016-04-20 | 2023-09-29 | 上海翰森生物医药科技有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用 |
| WO2017181849A1 (zh) * | 2016-04-20 | 2017-10-26 | 江苏豪森药业集团有限公司 | 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用 |
| JP6948345B2 (ja) * | 2016-04-29 | 2021-10-13 | イオメット ファーマ リミテッド | インドールアミン２，３−ジオキシゲナーゼ及び／又はトリプトファン−２，３−ジオキシゲナーゼの阻害薬としての新規置換イミダゾピリジン化合物 |
| EP3452450A1 (en) | 2016-05-04 | 2019-03-13 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| EP3464360B1 (en) | 2016-05-27 | 2025-11-12 | Agenus Inc. | Anti-tim-3 antibodies and methods of use thereof |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| EA201892375A1 (ru) | 2016-05-27 | 2019-08-30 | Джилид Сайэнс, Инк. | Способы лечения инфекций, вызываемых вирусом гепатита b |
| AR108586A1 (es) | 2016-06-10 | 2018-09-05 | Lilly Co Eli | Compuestos de 2,3-dihidro-1h-indol |
| CN106109472A (zh) * | 2016-06-13 | 2016-11-16 | 中山大学 | 氯氮卓作为吲哚胺2,3-双加氧酶-1抑制剂的用途 |
| BR112019001980A2 (pt) * | 2016-08-02 | 2019-05-07 | Shandong Luye Pharmaceutical Co., Ltd. | inibidor de ido1 e método de preparação e aplicação do mesmo |
| WO2018027204A1 (en) | 2016-08-05 | 2018-02-08 | Genentech, Inc. | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
| WO2018039430A1 (en) * | 2016-08-24 | 2018-03-01 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Radiofluorinated carboximidamides as ido targeting pet tracer for cancer imaging |
| US11351164B2 (en) | 2016-08-26 | 2022-06-07 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| AU2017318601B2 (en) | 2016-09-02 | 2020-09-03 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
| CA3037333A1 (en) | 2016-09-19 | 2018-03-22 | University Of South Florida | Method of targeting oncolytic viruses to tumors |
| JP7066696B2 (ja) | 2016-10-11 | 2022-05-13 | アジェナス インコーポレイテッド | 抗ｌａｇ－３抗体及びその使用方法 |
| JP7623784B2 (ja) | 2016-10-13 | 2025-01-29 | ジュノー セラピューティクス インコーポレイテッド | トリプトファン代謝経路調節剤を含む免疫療法の方法および組成物 |
| KR20230010826A (ko) | 2016-10-14 | 2023-01-19 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| WO2018072697A1 (zh) * | 2016-10-17 | 2018-04-26 | 上海医药集团股份有限公司 | 含噁二唑环化合物、制备方法、中间体、组合物及应用 |
| WO2018081648A2 (en) | 2016-10-29 | 2018-05-03 | Genentech, Inc. | Anti-mic antibidies and methods of use |
| UY37466A (es) | 2016-11-03 | 2018-01-31 | Phenex Discovery Verwaltungs Gmbh | N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa |
| MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
| CN110139857B (zh) * | 2016-11-28 | 2023-07-21 | 重庆复尚源创医药技术有限公司 | 作为吲哚胺2,3-双加氧酶抑制剂的亚砜亚胺、磺酰亚胺酰胺、磺酰二亚胺和二酰亚胺磺酰胺化合物 |
| DK3551660T5 (da) | 2016-12-07 | 2024-09-02 | Agenus Inc | Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf |
| CN110300599B (zh) | 2016-12-07 | 2024-07-02 | 艾吉纳斯公司 | 抗体和其使用方法 |
| CN114989205A (zh) | 2016-12-22 | 2022-09-02 | 卡里塞拉生物科学股份公司 | 用于抑制精氨酸酶活性的组合物和方法 |
| CN108218807A (zh) | 2016-12-22 | 2018-06-29 | 上海长森药业有限公司 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的砜脒及其制备方法和用途 |
| JP2020503883A (ja) | 2017-01-13 | 2020-02-06 | アジェナス インコーポレイテッド | Ｎｙ−ｅｓｏ−１に結合するｔ細胞受容体およびその使用方法 |
| CA3047002A1 (en) | 2017-01-17 | 2018-07-26 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| TW202510891A (zh) | 2017-01-31 | 2025-03-16 | 美商基利科學股份有限公司 | 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型 |
| UY37581A (es) | 2017-02-02 | 2018-08-31 | Gilead Sciences Inc | Compuestos para el tratamiento de la infección por virus de la hepatitis b |
| CA3057312A1 (en) * | 2017-03-29 | 2018-10-04 | Merck Sharp & Dohme Corp. | Novel substituted n'-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| US11439623B2 (en) | 2017-04-04 | 2022-09-13 | Case Western Reserve University | Method of modulating ribonucleotide reductase |
| CN108689958B (zh) * | 2017-04-05 | 2021-09-17 | 南京华威医药科技集团有限公司 | 一种含有肼基的吲哚胺2,3-双加氧化酶抑制剂 |
| CN106967005B (zh) * | 2017-04-07 | 2019-07-16 | 上海肇钰医药科技有限公司 | 一种能抑制ido的化合物、其制备方法及其用途 |
| KR20240017409A (ko) | 2017-04-13 | 2024-02-07 | 아게누스 인코포레이티드 | 항-cd137 항체 및 이의 사용 방법 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CN108794423B (zh) * | 2017-04-27 | 2022-07-19 | 鲁南制药集团股份有限公司 | 亚氨脲衍生物 |
| LT3618863T (lt) | 2017-05-01 | 2023-10-10 | Agenus Inc. | Anti-tigit antikūnai ir jų panaudojimo būdai |
| CN109081818B (zh) * | 2017-06-14 | 2022-04-22 | 南京华威医药科技集团有限公司 | 新型吲哚胺2,3-双加氧化酶抑制剂 |
| CN109111438B (zh) * | 2017-06-26 | 2021-11-02 | 正大天晴药业集团股份有限公司 | 用于ido抑制剂的脒类化合物 |
| KR20200027551A (ko) | 2017-07-11 | 2020-03-12 | 화이자 인코포레이티드 | Cea muc1 및 tert를 포함하는 면역원성 조성물 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| TW201920202A (zh) | 2017-08-17 | 2019-06-01 | 瑞士商愛杜西亞製藥有限公司 | 吲哚胺2,3-二氧酶及/或色胺酸2,3-二氧酶的抑制劑 |
| CN107311956A (zh) * | 2017-08-22 | 2017-11-03 | 合肥圣迪利克医药科技有限公司 | 一种艾卡跺司他合成方法 |
| CA3073055A1 (en) | 2017-09-04 | 2019-03-07 | Agenus Inc. | T cell receptors that bind to mixed lineage leukemia (mll)-specific phosphopeptides and methods of use thereof |
| IL304863B2 (en) | 2017-09-11 | 2025-08-01 | Atossa Therapeutics Inc | Methods for making and using endoxifen |
| CN108863976B (zh) * | 2017-09-11 | 2022-09-16 | 郑州泰基鸿诺医药股份有限公司 | 用作ido调节剂的化合物及其应用 |
| JP2020534289A (ja) | 2017-09-14 | 2020-11-26 | ランケナー インスティテュート フォー メディカル リサーチ | がんの治療のための方法および組成物 |
| CN110248931B (zh) * | 2017-09-20 | 2022-12-23 | 上海翰森生物医药科技有限公司 | 一种双加氧酶抑制剂的盐及其制备方法和用途 |
| CN109897011B (zh) * | 2017-12-08 | 2023-10-31 | 上海华汇拓医药科技有限公司 | 一类ido抑制剂及其应用 |
| CN109928922A (zh) * | 2017-12-18 | 2019-06-25 | 成都华健未来科技有限公司 | 一类环己烷类化合物 |
| CN109942565B (zh) | 2017-12-20 | 2021-03-26 | 海创药业股份有限公司 | 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法和用途 |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| US11813280B2 (en) | 2018-01-05 | 2023-11-14 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and IDO expression to potentiate immunotherapy |
| ES2907282T3 (es) | 2018-01-15 | 2022-04-22 | Idorsia Pharmaceuticals Ltd | Inhibidores de la indoleamina 2,3-dioxigenasa y/o de la triptófano dioxigenasa |
| CN108586378B (zh) | 2018-01-22 | 2020-06-19 | 南京华威医药科技集团有限公司 | 吲哚胺2,3-双加氧化酶抑制剂及其制备方法和用途 |
| CN110066253B (zh) * | 2018-01-24 | 2023-06-23 | 江苏柯菲平医药股份有限公司 | 1,2,5-噁二唑类衍生物，其制备方法及其在医药中的应用 |
| US11369589B2 (en) | 2018-01-24 | 2022-06-28 | Nanjing Carephar Shenghui Pharmaceutical Co., Ltd. | Modulator of indoleamine 2,3-dioxygenase, preparation method and use thereof |
| CN110577501A (zh) * | 2018-06-07 | 2019-12-17 | 江苏柯菲平医药股份有限公司 | 吲哚胺2,3-双加氧酶调节剂，其制备方法及用途 |
| CN110128367A (zh) | 2018-02-02 | 2019-08-16 | 成都海创药业有限公司 | 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法和用途 |
| CN108101899B (zh) * | 2018-02-11 | 2021-01-26 | 中国药科大学 | IDO1抑制剂Epacadostat中间体的制备方法 |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| US10870691B2 (en) | 2018-04-05 | 2020-12-22 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis B virus protein X |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| US20190314324A1 (en) | 2018-04-13 | 2019-10-17 | The University Of Chicago | Combination of micheliolide derivatives or nanoparticles with ionizing radiation and checkpoint inhibitors for cancer therapy |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| MA52363A (fr) | 2018-04-26 | 2021-03-03 | Agenus Inc | Compositions peptidiques de liaison à une protéine de choc thermique (hsp) et leurs méthodes d'utilisation |
| CN110407765B (zh) * | 2018-04-28 | 2022-12-06 | 上海挚盟医药科技有限公司 | 1,2,5-噁二唑类衍生物、其制备方法及其在医药上的应用 |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| GB201809050D0 (en) | 2018-06-01 | 2018-07-18 | E Therapeutics Plc | Modulators of tryptophan catabolism |
| SG11202012425QA (en) | 2018-07-13 | 2021-01-28 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| WO2020018670A1 (en) | 2018-07-17 | 2020-01-23 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| CN109180603A (zh) * | 2018-10-10 | 2019-01-11 | 中国药科大学 | Epacadostat关键中间体的制备方法 |
| WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| CN111617078B (zh) * | 2019-02-28 | 2023-02-03 | 四川科伦博泰生物医药股份有限公司 | 用于疾病治疗和/或预防的药物组合物、方法及其用途 |
| WO2020178770A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| CA3140708A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| WO2020263830A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
| JP7662204B2 (ja) | 2019-07-03 | 2025-04-15 | アトッサ・セラピューティクス・インコーポレイテッド | エンドキシフェンの徐放性組成物 |
| CN110204537B (zh) * | 2019-07-10 | 2021-10-08 | 盛世泰科生物医药技术(苏州)有限公司 | 一种用作吲哚胺2，3-双加氧酶的抑制剂的1，2，5-噁二唑衍生物 |
| EP3997083A1 (en) | 2019-07-11 | 2022-05-18 | Idorsia Pharmaceuticals Ltd | Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase |
| US20220257619A1 (en) | 2019-07-18 | 2022-08-18 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| KR20220044527A (ko) | 2019-08-01 | 2022-04-08 | 인사이트 코포레이션 | Ido 억제제의 투여 요법 |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| TW202122420A (zh) | 2019-08-30 | 2021-06-16 | 美商艾吉納斯公司 | 抗ｃｄ９６抗體及其使用方法 |
| TWI755055B (zh) * | 2019-09-18 | 2022-02-11 | 台灣神隆股份有限公司 | 用於製備惡拉戈利鈉及其中間體的方法 |
| DK4037708T3 (da) | 2019-09-30 | 2024-09-30 | Gilead Sciences Inc | HBV-vacciner og fremgangsmåder til at behandle HBV |
| AU2020384481B2 (en) | 2019-11-12 | 2025-12-11 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing IDO antagonist prodrugs useful in the treatment of cancer and methods thereof |
| DK4069729T3 (da) | 2019-12-06 | 2025-04-07 | Prec Biosciences Inc | Optimerede, modificerede meganukleaser med specificitet for en genkendelsessekvens i hepatitis b-virusgenomet |
| CN113045655A (zh) | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| WO2021188959A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| EP4192474B1 (en) | 2020-08-07 | 2025-09-10 | Gilead Sciences, Inc. | Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use |
| WO2022064526A1 (en) * | 2020-09-25 | 2022-03-31 | Msn Laboratories Private Limited, R&D Center | Solid state forms of epacadostat and their processes for preparation thereof |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
| MX2023010371A (es) | 2021-03-05 | 2024-02-12 | Univ Basel | Composiciones para el tratamiento de enfermedades o condiciones asociadas al veb. |
| WO2022241134A1 (en) | 2021-05-13 | 2022-11-17 | Gilead Sciences, Inc. | COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS |
| MX2023014762A (es) | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| GB202303250D0 (en) | 2023-03-06 | 2023-04-19 | King S College London | Method and compounds |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240243A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with bulevirtide and an inhibitory nucleic acid targeting hepatitis b virus |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240244A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection |
| CN119841748B (zh) * | 2025-03-21 | 2025-06-10 | 济南大学 | 一种对甲苯磺酰脲的制备方法 |
Family Cites Families (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3236855A (en) | 1964-01-17 | 1966-02-22 | Merck & Co Inc | Certain n-phenyl(thiazole-hydroxamidine) compounds and their preparation |
| US3354174A (en) | 1964-02-19 | 1967-11-21 | Sterling Drug Inc | 1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines |
| US3553228A (en) * | 1967-09-26 | 1971-01-05 | Colgate Palmolive Co | 3-substituted-4h(1)benzopyrano(3,4-d) isoxazoles |
| DE2040628A1 (de) | 1970-08-17 | 1972-02-24 | Fahlberg List Veb | Neue herbizide Mittel |
| US3948928A (en) * | 1972-03-17 | 1976-04-06 | Dainippon Pharmaceutical Co., Ltd. | 3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable acid addition salts thereof |
| JPS5621033B2 (https=) | 1973-09-05 | 1981-05-16 | ||
| CA1080234A (en) * | 1975-09-11 | 1980-06-24 | Daniel Farge | Derivatives of amidoximes |
| FR2323683A1 (fr) | 1975-09-11 | 1977-04-08 | Philagro Sa | Nouveaux derives d'amidoximes, leur preparation et les compositions qui les contiennent |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4323681A (en) * | 1980-09-29 | 1982-04-06 | American Home Products Corporation | 4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides |
| US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| JPS58208275A (ja) | 1982-05-20 | 1983-12-03 | Lion Corp | ５−アミノ−ピラゾ−ル誘導体及び該化合物を含有する抗腫瘍剤 |
| EP0132680B1 (de) * | 1983-07-22 | 1987-01-28 | Bayer Ag | Substituierte Furazane |
| US4507485A (en) | 1984-01-23 | 1985-03-26 | Bristol-Myers Company | 3,4-Disubstituted-1,2,5-oxadiazoles having histamine H2 -receptor antagonist activity |
| JPS60193968A (ja) | 1984-03-13 | 1985-10-02 | Toyo Jozo Co Ltd | シクロペンテン環を有するイミダゾ−ルアミドオキシムおよびその製造法 |
| JPS6259283A (ja) | 1985-09-10 | 1987-03-14 | Kaken Pharmaceut Co Ltd | セフアロスポリン化合物 |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| JPS6320710A (ja) | 1986-07-11 | 1988-01-28 | Matsushita Electric Ind Co Ltd | 薄膜磁気ヘツドの製造方法 |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| JP2696342B2 (ja) | 1988-06-27 | 1998-01-14 | 日本曹達株式会社 | アミジン誘導体、その製造方法及び殺ダニ剤・農園芸用殺菌剤 |
| ES2051986T3 (es) | 1988-07-05 | 1994-07-01 | Akzo Nv | Compuestos con actividad broncodilatadora. |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| JPH04297449A (ja) | 1991-03-27 | 1992-10-21 | Hokko Chem Ind Co Ltd | Ｎ−ヒドロキシベンジルグアニジン誘導体および農園芸用殺菌剤 |
| JPH05186458A (ja) | 1991-04-26 | 1993-07-27 | Japan Tobacco Inc | 新規なベンゾピラン誘導体 |
| FR2677019B1 (fr) * | 1991-05-27 | 1994-11-25 | Pf Medicament | Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique. |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| JP2709677B2 (ja) | 1992-06-19 | 1998-02-04 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
| SI9200344B (sl) | 1992-11-26 | 1998-06-30 | Lek, | Postopek za pripravo amlodipin benzensulfonata |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| FR2720396B1 (fr) * | 1994-05-27 | 1996-06-28 | Adir | Nouveaux N-pyridyl carboxamides et dérivés leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5731315A (en) | 1995-06-07 | 1998-03-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| TR199800697T2 (xx) | 1995-10-17 | 1998-07-21 | Astra Pharmaceuticals Limited | Farmas�tik olarak aktif kinazolin bile�imleri. |
| WO1997030047A1 (en) | 1996-02-17 | 1997-08-21 | Agrevo Uk Limited | Fungicidal 1,2,4-oxadiazoles and analogues |
| US5955495A (en) | 1996-05-03 | 1999-09-21 | Hoffmann-La Roche Inc. | Method of treating diseases of the CNS |
| JPH11171702A (ja) | 1997-09-24 | 1999-06-29 | Takeda Chem Ind Ltd | 害虫防除方法 |
| US6451840B1 (en) | 1997-12-05 | 2002-09-17 | Medical College Of Georgia Research Institute, Inc. | Regulation of T cell-mediated immunity by tryptophan |
| DE69822204T2 (de) | 1997-12-10 | 2005-02-17 | Dainippon Ink And Chemicals, Inc. | Oximderivate und sie enthaltende landwirtschaftliche chemikalien |
| US6288088B1 (en) | 1998-06-02 | 2001-09-11 | Takeda Chemical Industries, Ltd. | Oxadiazoline derivative and their use as insecticides |
| PT1107964E (pt) | 1998-08-11 | 2010-06-11 | Novartis Ag | Derivados de isoquinolina com actividade inibidora da angiogénese |
| FR2784678B1 (fr) | 1998-09-23 | 2002-11-29 | Sod Conseils Rech Applic | Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| US6133031A (en) | 1999-08-19 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense inhibition of focal adhesion kinase expression |
| EP1424072A1 (en) | 1999-03-03 | 2004-06-02 | Samjin Pharmaceutical Co., Ltd. | N'-(pyridin-3-yl)-(4-phenylpiperazin-1-yl)-carboxyimidamide and -iminothiolate derivatives for the treatment of tumors |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| PL352824A1 (en) | 1999-04-09 | 2003-09-08 | Abbott Gmbh & Co.Kg | Prodrugs of thrombin inhibitors |
| ES2244438T3 (es) | 1999-05-24 | 2005-12-16 | Mitsubishi Pharma Corporation | Compuestos de fenoxipropilamina. |
| JP2001158785A (ja) | 1999-11-30 | 2001-06-12 | Takeda Chem Ind Ltd | 農薬組成物 |
| JP2001158786A (ja) | 1999-11-30 | 2001-06-12 | Takeda Chem Ind Ltd | 哺乳動物の外部寄生虫防除剤 |
| CA2397575A1 (en) | 2000-01-13 | 2001-07-19 | Tularik Inc. | Antibacterial agents |
| JP2001233861A (ja) | 2000-02-22 | 2001-08-28 | Ube Ind Ltd | ピラゾールオキシム化合物、その製法及び用途 |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| KR100786927B1 (ko) | 2000-06-28 | 2007-12-17 | 스미스클라인비이참피이엘시이 | 습식 분쇄방법 |
| AU2002227984B8 (en) * | 2000-12-18 | 2007-01-04 | Actelion Pharmaceuticals Ltd. | Novel sulfamides and their use as endothelin receptor antagonists |
| GB0108102D0 (en) | 2001-03-30 | 2001-05-23 | Pfizer Ltd | Compounds |
| KR20040030678A (ko) | 2001-06-18 | 2004-04-09 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 피롤리딘 옥사디아졸 및 티아디아졸 유도체 |
| BR0212760A (pt) | 2001-09-19 | 2004-12-07 | Aventis Pharma Sa | Compostos quìmicos |
| DE60213842T2 (de) | 2001-10-30 | 2007-09-06 | Novartis Ag | Staurosporin-derivate als hemmer der flt3-rezeptor-tyrosinkinase-wirkung |
| MXPA04005939A (es) | 2002-01-22 | 2005-01-25 | Warner Lambert Co | 2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas. |
| US20050176796A1 (en) | 2002-02-19 | 2005-08-11 | D'alessio Roberto | Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents |
| WO2003076442A1 (en) * | 2002-03-05 | 2003-09-18 | Eli Lilly And Company | Purine derivatives as kinase inhibitors |
| GB0208224D0 (en) | 2002-04-10 | 2002-05-22 | Celltech R&D Ltd | Chemical compounds |
| CA2483451C (en) | 2002-04-12 | 2014-07-29 | Medical College Of Georgia Research Institute, Inc. | Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance |
| US7138530B2 (en) | 2002-05-28 | 2006-11-21 | 3-Dimensional Pharmaceuticals, Inc. | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
| PE20040522A1 (es) | 2002-05-29 | 2004-09-28 | Novartis Ag | Derivados de diarilurea dependientes de la cinasa de proteina |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US7015321B2 (en) | 2002-10-12 | 2006-03-21 | The Scripps Research Institute | Synthesis of non-symmetrical sulfamides using burgess-type reagents |
| TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| CA2512729C (en) | 2003-01-09 | 2014-09-16 | Macrogenics, Inc. | Identification and engineering of antibodies with variant fc regions and methods of using same |
| WO2004065416A2 (en) | 2003-01-16 | 2004-08-05 | Genentech, Inc. | Synthetic antibody phage libraries |
| WO2004072266A2 (en) | 2003-02-13 | 2004-08-26 | Kalobios Inc. | Antibody affinity engineering by serial epitope-guided complementarity replacement |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| US7714139B2 (en) | 2003-03-27 | 2010-05-11 | Lankenau Institute For Medcial Research | IDO inhibitors and methods of use |
| US7598287B2 (en) | 2003-04-01 | 2009-10-06 | Medical College Of Georgia Research Institute, Inc. | Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities |
| EP1639014B1 (en) | 2003-06-13 | 2010-09-22 | Biogen Idec MA Inc. | Aglycosyl anti-cd154 (cd40 ligand) antibodies and uses thereof |
| CA2536253A1 (en) | 2003-08-20 | 2005-03-03 | Vertex Pharmaceuticals Incorporated | Aminofurazan compounds useful as protein kinase inhibitors |
| AU2004266159A1 (en) | 2003-08-22 | 2005-03-03 | Biogen Idec Ma Inc. | Improved antibodies having altered effector function and methods for making the same |
| AR045944A1 (es) | 2003-09-24 | 2005-11-16 | Novartis Ag | Derivados de isoquinolina 1.4-disustituidas |
| DE10348022A1 (de) | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| DE10348023A1 (de) * | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| RU2401265C2 (ru) | 2004-06-10 | 2010-10-10 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеинкиназы |
| IN2014CN03493A (https=) | 2004-09-08 | 2015-07-03 | Mitsubishi Tanabe Pharma Corp | |
| AU2005309019A1 (en) | 2004-11-24 | 2006-06-01 | Novartis Ag | Combinations of JAK inhibitors and at least one of Bcr-Abl, Flt-3, FAK or RAF kinase inhibitors |
| EP1838706A1 (en) | 2004-12-24 | 2007-10-03 | Prosidion Limited | G-protein coupled receptor agonists |
| US7429667B2 (en) * | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
| DK2439273T3 (da) * | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| WO2006133417A1 (en) | 2005-06-07 | 2006-12-14 | Valeant Pharmaceuticals International | Phenylamino isothiazole carboxamidines as mek inhibitors |
| AU2006265601A1 (en) | 2005-06-30 | 2007-01-11 | Anthrogenesis Corporation | Repair of tympanic membrane using placenta derived collagen biofabric |
| DE102005060466A1 (de) | 2005-12-17 | 2007-06-28 | Bayer Cropscience Ag | Carboxamide |
| US8450351B2 (en) * | 2005-12-20 | 2013-05-28 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| WO2007095050A2 (en) * | 2006-02-09 | 2007-08-23 | Incyte Corporation | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase |
| JP4297449B2 (ja) | 2006-05-12 | 2009-07-15 | 株式会社サクラクレパス | 墨汁 |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| WO2008036642A2 (en) | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| WO2008036643A2 (en) | 2006-09-19 | 2008-03-27 | Incyte Corporation | Amidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| US20080146624A1 (en) * | 2006-09-19 | 2008-06-19 | Incyte Corporation | Amidines as modulators of indoleamine 2,3-dioxygenase |
| WO2008058178A1 (en) * | 2006-11-08 | 2008-05-15 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| KR20090094125A (ko) | 2006-12-08 | 2009-09-03 | 엑셀리시스, 인코포레이티드 | Ｌｘｒ 및 ｆｘｒ 조절자 |
| TW200845991A (en) * | 2007-01-12 | 2008-12-01 | Smithkline Beecham Corp | N-substituted glycine derivatives: hydroxylase inhibitors |
| EA201001030A1 (ru) | 2007-12-19 | 2011-02-28 | Амген Инк. | Конденсированные соединения пиридина, пиримидина и триазина в качестве ингибиторов клеточного цикла |
| WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| JP5465720B2 (ja) | 2008-07-08 | 2014-04-09 | インサイト・コーポレイション | インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール |
| PA8852901A1 (es) | 2008-12-22 | 2010-07-27 | Lilly Co Eli | Inhibidores de proteina cinasa |
| UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
| MX338327B (es) | 2010-10-25 | 2016-04-12 | G1 Therapeutics Inc | Inhibidores de cdk. |
| EP2937349B1 (en) | 2011-03-23 | 2016-12-28 | Amgen Inc. | Fused tricyclic dual inhibitors of cdk 4/6 and flt3 |
| CA2889182A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
| ES2799582T3 (es) | 2013-11-08 | 2020-12-18 | Incyte Holdings Corp | Proceso para la síntesis de un inhibidor de indoleamina 2,3-dioxigenasa |
| SG11201606428UA (en) | 2014-02-04 | 2016-09-29 | Incyte Corp | Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer |
| KR20170066546A (ko) | 2014-10-03 | 2017-06-14 | 노파르티스 아게 | 조합 요법 |
| HUE068868T2 (hu) | 2015-07-30 | 2025-02-28 | Macrogenics Inc | PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások |
| PE20181295A1 (es) | 2015-09-01 | 2018-08-07 | First Wave Bio Inc | Metodos y composiciones para tratar afecciones asociadas a una respuesta inflamatoria anomala |
| WO2017079669A1 (en) | 2015-11-04 | 2017-05-11 | Incyte Corporation | Pharmaceutical compositions and methods for indoleamine 2,3-dioxygenase inhibition and indications therefor |
| JP2018020710A (ja) | 2016-08-05 | 2018-02-08 | 三井造船株式会社 | 船舶用舵及び船舶 |
| US11813280B2 (en) | 2018-01-05 | 2023-11-14 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and IDO expression to potentiate immunotherapy |
| KR20220044527A (ko) | 2019-08-01 | 2022-04-08 | 인사이트 코포레이션 | Ido 억제제의 투여 요법 |
-
2009
- 2009-07-07 JP JP2011517520A patent/JP5465720B2/ja not_active Expired - Fee Related
- 2009-07-07 WO PCT/US2009/049794 patent/WO2010005958A2/en not_active Ceased
- 2009-07-07 BR BR122019015876A patent/BR122019015876B8/pt active IP Right Grant
- 2009-07-07 ME MEP-2018-108A patent/ME03065B/me unknown
- 2009-07-07 SI SI200931066T patent/SI2315756T1/sl unknown
- 2009-07-07 MY MYPI2019006844A patent/MY192633A/en unknown
- 2009-07-07 KR KR1020117002993A patent/KR101649548B1/ko active Active
- 2009-07-07 KR KR1020187035102A patent/KR102031538B1/ko active Active
- 2009-07-07 TW TW098122966A patent/TWI453204B/zh active
- 2009-07-07 ES ES09790108.6T patent/ES2524266T3/es active Active
- 2009-07-07 KR KR1020167022154A patent/KR101783004B1/ko active Active
- 2009-07-07 LT LTEP14175271.7T patent/LT2824100T/lt unknown
- 2009-07-07 BR BRPI0915692A patent/BRPI0915692B8/pt active IP Right Grant
- 2009-07-07 CA CA3012229A patent/CA3012229C/en active Active
- 2009-07-07 DK DK09790108.6T patent/DK2315756T5/en active
- 2009-07-07 US US12/498,782 patent/US8088803B2/en active Active
- 2009-07-07 HU HUE14175271A patent/HUE036813T2/hu unknown
- 2009-07-07 MY MYPI2016001235A patent/MY177058A/en unknown
- 2009-07-07 SI SI200931815T patent/SI2824100T1/en unknown
- 2009-07-07 MY MYPI2011000042A patent/MY171866A/en unknown
- 2009-07-07 RS RS20180471A patent/RS57132B1/sr unknown
- 2009-07-07 EP EP17211181.7A patent/EP3360873A1/en not_active Withdrawn
- 2009-07-07 DK DK14175271.7T patent/DK2824100T3/en active
- 2009-07-07 CN CN200980134351.9A patent/CN102164902B/zh active Active
- 2009-07-07 HR HRP20141094AT patent/HRP20141094T1/hr unknown
- 2009-07-07 SG SG10201805844QA patent/SG10201805844QA/en unknown
- 2009-07-07 SG SG2013052485A patent/SG192485A1/en unknown
- 2009-07-07 PT PT97901086T patent/PT2315756E/pt unknown
- 2009-07-07 EA EA201170161A patent/EA022669B1/ru unknown
- 2009-07-07 PE PE2011000008A patent/PE20110308A1/es active IP Right Grant
- 2009-07-07 AU AU2009268739A patent/AU2009268739B2/en not_active Ceased
- 2009-07-07 NZ NZ590268A patent/NZ590268A/xx unknown
- 2009-07-07 PL PL14175271T patent/PL2824100T3/pl unknown
- 2009-07-07 NO NO14175271A patent/NO2824100T3/no unknown
- 2009-07-07 CN CN201410287499.9A patent/CN104042611B/zh active Active
- 2009-07-07 EP EP09790108.6A patent/EP2315756B9/en active Active
- 2009-07-07 PL PL09790108T patent/PL2315756T3/pl unknown
- 2009-07-07 EA EA201500530A patent/EA029781B1/ru unknown
- 2009-07-07 KR KR1020177026919A patent/KR101847107B1/ko not_active Expired - Fee Related
- 2009-07-07 MX MX2011000235A patent/MX2011000235A/es active IP Right Grant
- 2009-07-07 SM SM20180206T patent/SMT201800206T1/it unknown
- 2009-07-07 EP EP14175271.7A patent/EP2824100B1/en active Active
- 2009-07-07 PT PT141752717T patent/PT2824100T/pt unknown
- 2009-07-07 KR KR1020187009436A patent/KR101927291B1/ko not_active Expired - Fee Related
- 2009-07-07 RS RS20140655A patent/RS53688B9/sr unknown
- 2009-07-07 CA CA2743975A patent/CA2743975C/en active Active
- 2009-07-07 ES ES14175271.7T patent/ES2665419T3/es active Active
- 2009-07-08 AR ARP090102608A patent/AR072490A1/es active IP Right Grant
- 2009-07-08 CL CL2009001554A patent/CL2009001554A1/es unknown
-
2010
- 2010-12-23 CR CR11871A patent/CR11871A/es unknown
- 2010-12-30 CO CO10165103A patent/CO6341622A2/es active IP Right Grant
- 2010-12-30 IL IL210402A patent/IL210402A/en active IP Right Grant
-
2011
- 2011-02-02 EC EC2011010798A patent/ECSP11010798A/es unknown
- 2011-11-11 US US13/294,711 patent/US8796319B2/en active Active
-
2013
- 2013-09-20 US US14/033,117 patent/US8822511B2/en active Active
-
2014
- 2014-01-22 JP JP2014009612A patent/JP5819451B2/ja active Active
- 2014-02-13 CL CL2014000363A patent/CL2014000363A1/es unknown
- 2014-04-29 PH PH12014500947A patent/PH12014500947B1/en unknown
- 2014-07-02 US US14/322,362 patent/US8993605B2/en active Active
- 2014-08-08 AU AU2014210662A patent/AU2014210662A1/en not_active Abandoned
- 2014-11-24 IL IL235870A patent/IL235870A/en active IP Right Grant
- 2014-11-25 SM SM201400179T patent/SMT201400179B/xx unknown
-
2015
- 2015-03-18 US US14/661,191 patent/US9320732B2/en active Active
-
2016
- 2016-04-07 US US15/093,420 patent/US9789094B2/en not_active Expired - Fee Related
- 2016-07-13 AU AU2016204914A patent/AU2016204914A1/en not_active Abandoned
-
2017
- 2017-02-27 US US15/442,876 patent/US10034864B2/en active Active
-
2018
- 2018-01-19 AU AU2018200457A patent/AU2018200457A1/en not_active Ceased
- 2018-02-23 US US15/903,414 patent/US10369137B2/en active Active
- 2018-04-25 HR HRP20180662TT patent/HRP20180662T1/hr unknown
- 2018-05-02 CY CY181100453T patent/CY1120617T1/el unknown
- 2018-11-20 AU AU2018267589A patent/AU2018267589B2/en not_active Ceased
-
2019
- 2019-06-19 US US16/446,253 patent/US10653677B2/en active Active
-
2020
- 2020-04-15 US US16/849,610 patent/US11207302B2/en not_active Expired - Fee Related
- 2020-09-25 AU AU2020239772A patent/AU2020239772B2/en not_active Ceased
-
2021
- 2021-11-16 US US17/527,833 patent/US20220331296A1/en not_active Abandoned
-
2023
- 2023-06-22 US US18/213,019 patent/US20240173303A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011527686A5 (https=) | ||
| AU2021240103B2 (en) | Substituted pyrrolizine compounds and uses thereof | |
| JP7012668B2 (ja) | ジヒドロピリミジニルベンズアゼピンジカルボキサミド化合物 | |
| AU2014222641B2 (en) | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of Hepatitis B | |
| JP6266617B2 (ja) | 置換ヘテロアゼピノン | |
| JP2021011495A5 (https=) | ||
| JP2022525069A5 (https=) | ||
| JP2023537632A5 (https=) | ||
| JP2019070042A (ja) | インドールアミン２，３−ジオキシゲナーゼの阻害剤としての活性を有するベンゾイミダゾールおよびイミダゾピリジンカルボキシミドアミド化合物 | |
| HRP20141094T1 (hr) | 1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze | |
| RU2011140064A (ru) | Ингибиторы тирозинкиназы брутона | |
| KR20150128891A (ko) | 인돌아민 2,3-디옥시게나제 (ido)의 억제제 | |
| US20160166575A1 (en) | Pyrrolo[2,3-d]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors | |
| JP2007511504A5 (https=) | ||
| HU228960B1 (hu) | Ftalazinon-származékok | |
| JP7419503B2 (ja) | 置換フェニル又はピリジニル部分を有するｓｅｒｄ三環化合物の製造方法 | |
| RU2010113358A (ru) | Гуанидинсодержащие соединения, применимые в качестве антагонистов мускариновых рецепторов | |
| JP2012500249A5 (https=) | ||
| RU2011108485A (ru) | Новые (поли)аминоалкиламиноалкиламидные, алкилмочевинные или алкилсульфонамидные производные эпиподофиллотоксина, способ их получения и их применение в терапии в качестве противораковых средств | |
| JP2024535128A5 (https=) | ||
| JP2017137323A (ja) | 新規抗がん剤 | |
| CN107531634A (zh) | 作为wnt信号通路抑制剂的3‑氨基甲酰基苯基‑4‑甲酰胺和间苯二甲酰胺衍生物 | |
| JP2017522383A5 (https=) | ||
| JP2007509052A5 (https=) | ||
| JP2010535203A5 (https=) |