|
JPS5736816A
(ja)
|
1980-08-14 |
1982-02-27 |
Toshiba Corp |
Chodendokoirunoseizohoho
|
|
JPS60165712A
(ja)
|
1984-02-08 |
1985-08-28 |
パイオニア株式会社 |
可変調整部品の自動調整方法
|
|
JPS6137764A
(ja)
|
1984-07-31 |
1986-02-22 |
Suntory Ltd |
抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
|
|
CA1309805C
(en)
|
1985-04-16 |
1992-11-03 |
Naoki Higuchi |
Dipeptide derivative and synthesis and use thereof
|
|
EP0201743B1
(en)
|
1985-04-16 |
1992-04-01 |
Suntory Limited |
Dipeptide derivatives of fatty acids, process for preparing them, pharmaceutical composition and use
|
|
JPH0623190B2
(ja)
|
1985-04-16 |
1994-03-30 |
サントリー株式会社 |
インヒビタ−活性を有するn−アシルピロリジン誘導体及びその製法並びに用途
|
|
JPS62114957A
(ja)
|
1985-11-13 |
1987-05-26 |
Suntory Ltd |
プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジン誘導体およびその製法並びに用途
|
|
JPH0714878B2
(ja)
|
1985-11-14 |
1995-02-22 |
サントリー株式会社 |
ピロリジンアミドを有効成分とするプロリルエンドペプチダーゼ阻害剤
|
|
JPH0764834B2
(ja)
|
1985-11-29 |
1995-07-12 |
サントリー株式会社 |
プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途
|
|
US5198458A
(en)
|
1986-02-04 |
1993-03-30 |
Suntory Limited |
Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same
|
|
CA1320734C
(en)
|
1986-02-04 |
1993-07-27 |
Suntory Limited |
Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
|
|
JPH08806B2
(ja)
|
1986-11-18 |
1996-01-10 |
サントリー株式会社 |
プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
|
|
DE3786229T2
(de)
|
1986-11-20 |
1993-10-07 |
Ono Pharmaceutical Co |
Prolinalderivate.
|
|
US5254550A
(en)
|
1986-11-20 |
1993-10-19 |
Ono Pharmaceutical Co., Ltd. |
Prolinal derivatives and pharmaceutical compositions thereof
|
|
JPS63162672A
(ja)
|
1986-12-25 |
1988-07-06 |
Ono Pharmaceut Co Ltd |
新規なプロリナ−ル誘導体、それらの製造方法およびそれらを含有する抗健忘症剤
|
|
US5262431A
(en)
|
1986-12-29 |
1993-11-16 |
Ono Pharmaceutical Co., Ltd. |
Prolinal derivatives and pharmaceutical compositions thereof
|
|
JPH089591B2
(ja)
|
1986-12-29 |
1996-01-31 |
小野薬品工業株式会社 |
新規なプロリナール誘導体
|
|
DE3783754T2
(de)
|
1986-12-29 |
1993-08-05 |
Ono Pharmaceutical Co |
Prolin-derivate.
|
|
JP2528343B2
(ja)
|
1987-02-04 |
1996-08-28 |
小野薬品工業株式会社 |
新規なプロリナ―ル誘導体
|
|
EP0277588B1
(en)
|
1987-02-04 |
1993-03-24 |
Ono Pharmaceutical Co., Ltd. |
Prolinal derivatives
|
|
DE3875361T2
(de)
|
1987-02-23 |
1993-03-25 |
Ono Pharmaceutical Co |
Thiazolidin-derivate.
|
|
DE3712365A1
(de)
|
1987-04-11 |
1988-10-27 |
Hoechst Ag |
Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
|
|
JPS6442465A
(en)
|
1987-08-07 |
1989-02-14 |
Wakunaga Pharma Co Ltd |
N-acylprolylpyrrolidine derivative, production and use thereof
|
|
JP2649237B2
(ja)
|
1988-03-07 |
1997-09-03 |
キッセイ薬品工業 株式会社 |
チアゾリジン誘導体
|
|
US4857524A
(en)
|
1987-08-08 |
1989-08-15 |
Kissei Pharmaceutical Co., Ltd. |
Thiazolidine compounds and therapeutic method
|
|
JP2515558B2
(ja)
|
1987-09-10 |
1996-07-10 |
株式会社ヤクルト本社 |
新規なペプチドおよびそれを有効成分とする抗健忘症剤
|
|
JPH0742309B2
(ja)
|
1987-11-30 |
1995-05-10 |
キッセイ薬品工業株式会社 |
チアゾリジン誘導体
|
|
JPH01250370A
(ja)
|
1987-12-23 |
1989-10-05 |
Zeria Pharmaceut Co Ltd |
新規アミノ酸イミド誘導体、製法ならびに用途
|
|
US5053414A
(en)
|
1988-04-08 |
1991-10-01 |
Ono Pharmaceutical Co., Ltd. |
Heterocyclic compounds
|
|
US5328899A
(en)
|
1988-07-15 |
1994-07-12 |
The Salk Institute For Biological Studies |
NPY peptide analogs
|
|
ZA896376B
(en)
|
1988-08-26 |
1990-05-30 |
Merrell Dow Pharma |
Neuropeptide y agonists
|
|
ZA896374B
(en)
|
1988-08-26 |
1990-05-30 |
Merrell Dow Pharma |
Neuropeptide y antagonists
|
|
JP2531989B2
(ja)
|
1988-09-14 |
1996-09-04 |
吉富製薬株式会社 |
ピリジン化合物
|
|
US5137905A
(en)
|
1988-10-27 |
1992-08-11 |
The Upjohn Company |
Heterocyclic acetylenic amines having central nervous system activity
|
|
CA2004028C
(en)
|
1988-12-08 |
1998-09-22 |
Motoki Torizuka |
Condensed benzene derivative
|
|
JPH02207070A
(ja)
|
1989-02-07 |
1990-08-16 |
Zeria Pharmaceut Co Ltd |
アミノ酸イミド誘導体、それを含有する医薬及び該化合物の製造中間体
|
|
JP2691442B2
(ja)
|
1989-02-20 |
1997-12-17 |
株式会社ヤクルト本社 |
新規なプロリン誘導体
|
|
EP0419683A4
(en)
|
1989-04-13 |
1992-03-11 |
Japan Tobacco Inc. |
New amino acid derivatives having prolylendopeptidase inhibitor activity
|
|
JPH0331298A
(ja)
|
1989-06-28 |
1991-02-12 |
Ajinomoto Co Inc |
プロリルエンドペプチターゼ阻害ペプチド
|
|
JPH07103101B2
(ja)
|
1989-07-24 |
1995-11-08 |
キッセイ薬品工業株式会社 |
ピログルタミン酸誘導体
|
|
JPH082869B2
(ja)
|
1989-07-24 |
1996-01-17 |
キッセイ薬品工業株式会社 |
健忘症治療剤およびプロリン誘導体
|
|
JPH0776211B2
(ja)
|
1989-07-24 |
1995-08-16 |
キッセイ薬品工業株式会社 |
ピログルタミン酸誘導体
|
|
JPH082791B2
(ja)
|
1989-07-24 |
1996-01-17 |
キッセイ薬品工業株式会社 |
健忘症治療剤
|
|
DE3939797A1
(de)
|
1989-12-01 |
1991-06-06 |
Basf Ag |
Neue vom neuropeptid y abgeleitete peptide
|
|
JPH04211648A
(ja)
|
1990-07-27 |
1992-08-03 |
Nippon Kayaku Co Ltd |
ケト酸アミド誘導体
|
|
JPH03255080A
(ja)
|
1990-03-05 |
1991-11-13 |
Yoshitomi Pharmaceut Ind Ltd |
ベンゼン化合物
|
|
US4999349A
(en)
|
1990-03-22 |
1991-03-12 |
Bristol-Myers Squibb Co. |
BU-4164E - A and B, prolyl endopeptidase inhibitors
|
|
US5073549A
(en)
|
1990-03-22 |
1991-12-17 |
Bristol-Myers Squibb Company |
BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use
|
|
US5091432A
(en)
|
1990-03-28 |
1992-02-25 |
Glasky Alvin J |
9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
|
|
JPH049367A
(ja)
|
1990-04-26 |
1992-01-14 |
Zeria Pharmaceut Co Ltd |
アリールアルカノイル誘導体,該化合物の製造中間体及びそれらを含有する医薬
|
|
FI925500A7
(fi)
|
1990-06-04 |
1992-12-03 |
Pfizer |
Aromaattisia pyrrolidiini- ja tiatsolidiiniamideja
|
|
AU643300B2
(en)
|
1990-06-07 |
1993-11-11 |
Zeria Pharmaceutical Co., Ltd. |
Novel arylalkanoylamine derivative and drug containing the same
|
|
JPH07108897B2
(ja)
|
1990-07-27 |
1995-11-22 |
日本たばこ産業株式会社 |
新規なプロリン誘導体
|
|
EP0468469A2
(en)
|
1990-07-27 |
1992-01-29 |
Japan Tobacco Inc. |
Proline derivatives
|
|
JPH05186498A
(ja)
|
1991-12-27 |
1993-07-27 |
Japan Tobacco Inc |
プロリン誘導体
|
|
US5506256A
(en)
|
1990-07-27 |
1996-04-09 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Proline derivatives possessing prolyl endopeptidase-inhibitory activity
|
|
JPH04235162A
(ja)
|
1990-08-09 |
1992-08-24 |
Zeria Pharmaceut Co Ltd |
新規コハク酸アミド誘導体およびそれを含有する医薬
|
|
JPH04208299A
(ja)
|
1990-11-30 |
1992-07-29 |
Ajinomoto Co Inc |
プロリルエンドペプチターゼ阻害ペプチド
|
|
US5260303A
(en)
*
|
1991-03-07 |
1993-11-09 |
G. D. Searle & Co. |
Imidazopyridines as serotonergic 5-HT3 antagonists
|
|
US5449750A
(en)
|
1991-06-20 |
1995-09-12 |
Snow Brand Milk Products Co., Ltd. |
Prolyl endopeptidase inhibitors SNA-115 and SNA-115T, and process for the production and productive strain thereof
|
|
JP3010795B2
(ja)
|
1991-07-04 |
2000-02-21 |
不二製油株式会社 |
ペプチドの苦味除去方法
|
|
JPH08501055A
(ja)
|
1991-12-19 |
1996-02-06 |
ガーヴァン インスティチュート オブ メディカル リサーチ |
神経ペプチドチロシンの生物学的機能を抑制する新規な分子
|
|
JPH05301826A
(ja)
|
1991-12-24 |
1993-11-16 |
Snow Brand Milk Prod Co Ltd |
プロリルエンドペプチダーゼ阻害剤
|
|
JPH05201970A
(ja)
|
1992-01-24 |
1993-08-10 |
Japan Tobacco Inc |
新規プロリン誘導体
|
|
JP3318622B2
(ja)
|
1992-05-27 |
2002-08-26 |
独立行政法人産業技術総合研究所 |
プロリルエンドペプチダーゼ阻害剤
|
|
GB9213215D0
(en)
|
1992-06-20 |
1992-08-05 |
Wellcome Found |
Peptides
|
|
JPH06116284A
(ja)
|
1992-10-02 |
1994-04-26 |
Yamanouchi Pharmaceut Co Ltd |
新規ペプチド
|
|
EP0670309A1
(en)
|
1992-11-20 |
1995-09-06 |
Japan Tobacco Inc. |
Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof
|
|
JPH06192298A
(ja)
|
1992-12-24 |
1994-07-12 |
Mitsui Toatsu Chem Inc |
新規機能性ペプチド
|
|
DE4326465A1
(de)
|
1993-01-20 |
1995-02-09 |
Thomae Gmbh Dr K |
Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
|
|
JPH06234693A
(ja)
|
1993-02-09 |
1994-08-23 |
Snow Brand Milk Prod Co Ltd |
新規イソテトラセノン系物質及びその製造法
|
|
FR2701480B1
(fr)
|
1993-02-15 |
1995-05-24 |
Sanofi Elf |
Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.
|
|
FR2703050B1
(fr)
|
1993-03-24 |
1995-04-28 |
Adir |
Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
|
|
CA2165200A1
(en)
|
1993-06-18 |
1995-01-05 |
Ambikaipakan Balasubramaniam |
Neuropeptide y antagonists and agonists
|
|
AU6983894A
(en)
|
1993-06-30 |
1995-01-24 |
Zeria Pharmaceutical Co., Ltd. |
Thiazolidine derivative and medicine containing the same
|
|
EP0709373B1
(en)
|
1993-07-23 |
2001-10-17 |
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai |
Pyrrolidine derivative
|
|
NZ276600A
(en)
|
1993-12-02 |
1997-09-22 |
Merrell Pharma Inc |
2-acylpyrrolidines; compounds, preparation and pharmaceutical compositions
|
|
IL111785A0
(en)
|
1993-12-03 |
1995-01-24 |
Ferring Bv |
Dp-iv inhibitors and pharmaceutical compositions containing them
|
|
JPH07267988A
(ja)
|
1994-03-31 |
1995-10-17 |
Yamanouchi Pharmaceut Co Ltd |
新規ペプチド
|
|
US5552426A
(en)
*
|
1994-04-29 |
1996-09-03 |
Eli Lilly And Company |
Methods for treating a physiological disorder associated with β-amyloid peptide
|
|
US6562862B1
(en)
|
1994-10-20 |
2003-05-13 |
Eli Lilly And Company |
Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
|
|
EP0895781A3
(en)
|
1994-10-20 |
1999-07-07 |
Eli Lilly And Company |
Use of benzofurans, benzothiophenes or indoles for the manufacture of a medicament for the treatment of conditions associated with an excess of tachykinins
|
|
US5663192A
(en)
|
1994-10-20 |
1997-09-02 |
Eli Lilly And Company |
Heterocyclic neuropeptide Y receptor antagonists
|
|
GB9500601D0
(en)
|
1995-01-12 |
1995-03-01 |
Wellcome Found |
Modified peptides
|
|
ES2160790T3
(es)
*
|
1995-02-08 |
2001-11-16 |
Novartis Ag |
10-aminoalifatil-dibenzo(b,f)oxepinas de accion antineurodegenerativa.
|
|
US5552411A
(en)
|
1995-05-26 |
1996-09-03 |
Warner-Lambert Company |
Sulfonylquinolines as central nervous system and cardiovascular agents
|
|
DE69619381T2
(de)
*
|
1995-05-30 |
2002-11-21 |
Gliatech, Inc. |
1h-4(5)substituierte imidazolderivate
|
|
US6448282B1
(en)
*
|
1995-05-30 |
2002-09-10 |
Gliatech, Inc. |
1H-4(5)-substituted imidazole derivatives
|
|
US5554621A
(en)
|
1995-06-07 |
1996-09-10 |
Bristol-Myers Squibb Company |
Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
|
|
IL117997A0
(en)
|
1995-06-07 |
1996-10-31 |
Pfizer |
Neuropeptide Y1 specific ligands
|
|
US5635503A
(en)
|
1995-06-07 |
1997-06-03 |
Bristol-Myers Squibb Company |
Dihydropyridine npy antagonists: piperazine derivatives
|
|
US5668151A
(en)
|
1995-06-07 |
1997-09-16 |
Bristol-Myers Squibb Company |
Dihydropyridine NPY antagonists: piperidine derivatives
|
|
JP3727383B2
(ja)
|
1995-07-31 |
2005-12-14 |
月桂冠株式会社 |
プロリルエンドペプチダーゼ阻害剤
|
|
IL120724A0
(en)
|
1995-09-01 |
1997-08-14 |
Lilly Co Eli |
Indolyl neuropeptide Y receptor antagonists
|
|
DE19544687A1
(de)
|
1995-11-30 |
1997-06-05 |
Thomae Gmbh Dr K |
Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
|
|
DE19544685A1
(de)
|
1995-11-30 |
1997-06-05 |
Thomae Gmbh Dr K |
Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
|
|
DE19544686A1
(de)
|
1995-11-30 |
1997-06-05 |
Thomae Gmbh Dr K |
Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
|
|
WO1997020822A1
(en)
|
1995-12-01 |
1997-06-12 |
Novartis Ag |
Quinazolin-2,4-diazirines as npy receptor antagonist
|
|
AU7692696A
(en)
|
1995-12-01 |
1997-06-27 |
Novartis Ag |
Heteroaryl derivatives
|
|
AU7692996A
(en)
|
1995-12-01 |
1997-06-27 |
Ciba-Geigy Ag |
Receptor antagonists
|
|
AU1328197A
(en)
|
1995-12-01 |
1997-06-19 |
Synaptic Pharmaceutical Corporation |
Aryl sulfonamide and sulfamide derivatives and uses thereof
|
|
AU7626496A
(en)
|
1995-12-01 |
1997-06-27 |
Ciba-Geigy Ag |
Heteroaryl compounds
|
|
JPH09157253A
(ja)
|
1995-12-12 |
1997-06-17 |
Yamanouchi Pharmaceut Co Ltd |
新規アミノ酸誘導体
|
|
EP0871442A1
(en)
|
1996-01-09 |
1998-10-21 |
Eli Lilly And Company |
Benzimidzolyl neuropeptide y receptor antagonists
|
|
US5662723A
(en)
|
1996-03-22 |
1997-09-02 |
Libbey Glass Inc. |
Apparatus and method for forming a decorative pattern on glassware having an edge
|
|
DE122010000020I1
(de)
|
1996-04-25 |
2010-07-08 |
Prosidion Ltd |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
|
AU3295297A
(en)
|
1996-06-04 |
1998-01-05 |
Synaptic Pharmaceutical Corporation |
Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)
|
|
WO1998003493A1
(en)
|
1996-07-23 |
1998-01-29 |
Neurogen Corporation |
Certain substituted benzylamine derivatives; a new class of neuropeptide-y1 specific ligands
|
|
ES2197354T3
(es)
|
1996-07-23 |
2004-01-01 |
Neurogen Corporation |
Derivados de bencilamina sustituidos con amido y amino; una nueva clase de ligandos especificos del neuropeptido y1.
|
|
ATE230403T1
(de)
|
1996-07-23 |
2003-01-15 |
Neurogen Corp |
Einige amido- und ammo- substituierte benzylaminderivate: eine neue klasse von neuropeptid y1 spezifische ligande
|
|
AU4159297A
(en)
|
1996-08-23 |
1998-03-06 |
Agouron Acquisition Corp. |
Neuropeptide-y ligands
|
|
JP3880664B2
(ja)
|
1996-09-04 |
2007-02-14 |
月桂冠株式会社 |
プロリルエンドペプチダーゼ阻害ペプチド
|
|
AU4944297A
(en)
*
|
1996-10-08 |
1998-05-05 |
Novartis Ag |
Modulation of apoptosis
|
|
WO1998017651A1
(en)
*
|
1996-10-21 |
1998-04-30 |
Neurosearch A/S |
1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators
|
|
FR2754709B1
(fr)
|
1996-10-23 |
1999-03-05 |
Sanofi Sa |
Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
|
|
TW492957B
(en)
|
1996-11-07 |
2002-07-01 |
Novartis Ag |
N-substituted 2-cyanopyrrolidnes
|
|
US6011155A
(en)
|
1996-11-07 |
2000-01-04 |
Novartis Ag |
N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
|
JP3255080B2
(ja)
|
1997-05-28 |
2002-02-12 |
日新電機株式会社 |
ガス絶縁開閉装置
|
|
SE9703414D0
(sv)
|
1997-09-23 |
1997-09-23 |
Astra Ab |
New compounds
|
|
EP2583675A1
(en)
|
1998-02-02 |
2013-04-24 |
Trustees Of Tufts College |
Use of dipeptidylpeptidase inhibitors to regulate glucose metabolism
|
|
JP2002506075A
(ja)
|
1998-03-09 |
2002-02-26 |
フォンダテッヒ・ベネルクス・ナムローゼ・フェンノートシャップ |
セリンペプチダーゼ調節剤
|
|
DE19823831A1
(de)
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
|
|
JP2002518555A
(ja)
|
1998-06-24 |
2002-06-25 |
アヴェンティス ファーマシューティカルズ プロダクツ インコーポレイテッド |
フルオロフェニル樹脂化合物
|
|
DE19828113A1
(de)
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
|
DE19828114A1
(de)
|
1998-06-24 |
2000-01-27 |
Probiodrug Ges Fuer Arzneim |
Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
|
|
DE19834591A1
(de)
|
1998-07-31 |
2000-02-03 |
Probiodrug Ges Fuer Arzneim |
Verfahren zur Steigerung des Blutglukosespiegels in Säugern
|
|
ATE251465T1
(de)
|
1998-07-31 |
2003-10-15 |
Novo Nordisk As |
In-vitro stimulation von beta zellen vermehrung
|
|
WO2000030674A1
(en)
|
1998-11-26 |
2000-06-02 |
Ferring Bv |
Neuropeptide y y4 agents in the treatment of reproductive disorders
|
|
CO5150173A1
(es)
*
|
1998-12-10 |
2002-04-29 |
Novartis Ag |
Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
|
|
GB2389113B
(en)
|
1999-02-10 |
2004-02-04 |
Elan Pharm Inc |
B-secretase inhibitor
|
|
US6211182B1
(en)
*
|
1999-03-08 |
2001-04-03 |
Schering Corporation |
Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
|
|
US6121311A
(en)
|
1999-04-28 |
2000-09-19 |
Japan Tobacco Inc. |
Method for treating cocainism
|
|
HK1041263A1
(zh)
|
1999-05-05 |
2002-07-05 |
Ortho-Mcneil Pharmaceutical, Inc. |
可用於治疗肥胖和其他疾病的3a,4,5,9b-四氢-1h-苯并[e]吲-2-基胺衍生的神经肽y受体配体
|
|
US7087399B1
(en)
*
|
1999-05-13 |
2006-08-08 |
Scios, Inc. |
β-secretase and modulation of β-secretase activity
|
|
JP3148739B2
(ja)
|
1999-05-19 |
2001-03-26 |
ドーマー株式会社 |
プロリルエンドペプチダーゼ阻害剤
|
|
IL146403A0
(en)
*
|
1999-06-22 |
2002-07-25 |
Neurosearch As |
Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
|
|
US6107317A
(en)
|
1999-06-24 |
2000-08-22 |
Novartis Ag |
N-(substituted glycyl)-thiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
|
US6110949A
(en)
|
1999-06-24 |
2000-08-29 |
Novartis Ag |
N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
|
US6172081B1
(en)
|
1999-06-24 |
2001-01-09 |
Novartis Ag |
Tetrahydroisoquinoline 3-carboxamide derivatives
|
|
JP2003535034A
(ja)
|
1999-11-12 |
2003-11-25 |
ギルフォード ファーマシューティカルズ インコーポレイテッド |
ジペプチジルペプチダーゼiv阻害剤並びにジペプチジルペプチダーゼiv阻害剤の製造及び使用法
|
|
GB9928330D0
(en)
|
1999-11-30 |
2000-01-26 |
Ferring Bv |
Novel antidiabetic agents
|
|
US6380398B2
(en)
|
2000-01-04 |
2002-04-30 |
Novo Nordisk A/S |
Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
|
|
WO2001055105A1
(en)
|
2000-01-24 |
2001-08-02 |
Novo Nordisk A/S |
N-substituted 2-cyanopyroles and -pyrrolines which are inhibitors of the enzyme dpp-iv
|
|
US6395767B2
(en)
|
2000-03-10 |
2002-05-28 |
Bristol-Myers Squibb Company |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
|
|
WO2001072324A1
(en)
*
|
2000-03-28 |
2001-10-04 |
Bristol-Myers Squibb Pharma Company |
Lactams as inhibitors of a-beta protein production
|
|
GB0010188D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
|
GB0010183D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
|
AR028385A1
(es)
|
2000-04-28 |
2003-05-07 |
Acadia Pharm Inc |
Agonistas muscarinicos
|
|
CA2407088A1
(en)
|
2000-05-19 |
2001-11-22 |
Takeda Chemical Industries, Ltd. |
Beta-secretase inhibitors
|
|
AU2001268958B2
(en)
|
2000-07-04 |
2006-03-09 |
Novo Nordisk A/S |
Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv
|
|
WO2002004610A2
(en)
|
2000-07-10 |
2002-01-17 |
Bayer Aktiengesellschaft |
Regulation of human dipeptidyl-peptidase iv-like enzyme
|
|
JP4101053B2
(ja)
|
2000-08-10 |
2008-06-11 |
田辺三菱製薬株式会社 |
プロリン誘導体及びその医薬用途
|
|
WO2002013821A1
(en)
*
|
2000-08-17 |
2002-02-21 |
Gliatech, Inc. |
Novel alicyclic imidazoles as h3 agents
|
|
ATE447557T1
(de)
*
|
2000-08-17 |
2009-11-15 |
Pfizer Ltd |
Substitutuierte imidazole als tafia inhibitoren
|
|
EP1203584A1
(en)
*
|
2000-10-13 |
2002-05-08 |
M.D.M. S.r.l. |
Cholinergic precursor (in particular choline alfoscerate) associated with an acetylcholinesterase inhibitor (such as rivastigmine, donepezil)
|
|
JP4184077B2
(ja)
|
2000-11-02 |
2008-11-19 |
ワイス |
5−ヒドロキシトリプトアミン−6リガンドとしての1−アリールまたは1−アルキルスルホニル−ヘテロシクリルベンザゾール
|
|
TWI243162B
(en)
|
2000-11-10 |
2005-11-11 |
Taisho Pharmaceutical Co Ltd |
Cyanopyrrolidine derivatives
|
|
CA2433090A1
(en)
|
2000-12-27 |
2002-07-04 |
Kyowa Hakko Kogyo Co., Ltd. |
Dipeptidyl peptidase iv inhibitor
|
|
DE10100053A1
(de)
*
|
2001-01-02 |
2002-08-22 |
Keyneurotek Ag I G |
Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen
|
|
EP1392676B1
(en)
|
2001-02-16 |
2006-12-13 |
Aventis Pharmaceuticals Inc. |
Heterocyclic urea derivatives and their use as dopamine d3 receptor ligands
|
|
EP1233021A3
(en)
|
2001-02-20 |
2002-11-20 |
Pfizer Products Inc. |
An inhibitor of Beta amyloid cleavage enzyme
|
|
EP1368349B1
(de)
|
2001-02-24 |
2007-02-14 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Xanthinderivate, deren herstellung und deren verwendung als arzneimittel
|
|
EP1385508B1
(en)
|
2001-03-27 |
2008-05-21 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
|
US6573287B2
(en)
|
2001-04-12 |
2003-06-03 |
Bristo-Myers Squibb Company |
2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
|
|
US20030013177A1
(en)
|
2001-05-23 |
2003-01-16 |
Ebens Allen J. |
Polynucleotides encoding insect glutaminyl cyclase and uses thereof
|
|
CA2450579A1
(en)
|
2001-06-20 |
2003-01-03 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment of diabetes
|
|
ES2257555T3
(es)
|
2001-06-20 |
2006-08-01 |
MERCK & CO., INC. |
Inhibidores de dipeptidilpeptidasa para el tratamiento de la diabetes.
|
|
GB0115517D0
(en)
|
2001-06-25 |
2001-08-15 |
Ferring Bv |
Novel antidiabetic agents
|
|
CN1723196A
(zh)
|
2001-06-27 |
2006-01-18 |
史密丝克莱恩比彻姆公司 |
作为二肽酶抑制剂的氟代吡咯烷
|
|
DE10150203A1
(de)
|
2001-10-12 |
2003-04-17 |
Probiodrug Ag |
Peptidylketone als Inhibitoren der DPIV
|
|
RU2003105463A
(ru)
|
2001-06-27 |
2004-11-27 |
Пробиодруг Аг (De) |
Пептидные структуры, пригодные для конкурентного модулирования катализа, осуществляемого дипептидилпептидазой iv
|
|
DE10154689A1
(de)
|
2001-11-09 |
2003-05-22 |
Probiodrug Ag |
Substituierte Aminoketonverbindungen
|
|
ATE380175T1
(de)
|
2001-06-27 |
2007-12-15 |
Smithkline Beecham Corp |
Pyrrolidine als dipeptidyl peptidase inhibitoren
|
|
JP4357293B2
(ja)
|
2001-06-27 |
2009-11-04 |
スミスクライン ビーチャム コーポレーション |
ジペプチジルペプチダーゼ阻害剤としてのフルオロピロリジン類
|
|
DE60225556D1
(de)
|
2001-07-03 |
2008-04-24 |
Novo Nordisk As |
Dpp-iv-inhibierende purin-derivative zur behandlung von diabetes
|
|
UA74912C2
(en)
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
|
US6948038B2
(en)
*
|
2001-07-24 |
2005-09-20 |
Microsoft Corporation |
System and method for backing up and restoring data
|
|
KR20040033048A
(ko)
|
2001-09-14 |
2004-04-17 |
미츠비시 웰파마 가부시키가이샤 |
티아졸리딘 유도체 및 이의 약학적 용도
|
|
AU2002331311A1
(en)
|
2001-09-19 |
2003-04-01 |
Novo Nordisk A/S |
Heterocyclic compounds that are inhibitors of the enzyme dpp-iv
|
|
GB0125445D0
(en)
|
2001-10-23 |
2001-12-12 |
Ferring Bv |
Protease Inhibitors
|
|
GB0125446D0
(en)
|
2001-10-23 |
2001-12-12 |
Ferring Bv |
Novel anti-diabetic agents
|
|
US6861440B2
(en)
|
2001-10-26 |
2005-03-01 |
Hoffmann-La Roche Inc. |
DPP IV inhibitors
|
|
EP2316470A3
(en)
|
2001-11-26 |
2011-08-24 |
Trustees Of Tufts College |
Peptidomimetic inhibitors of post-proline cleaving enzymes
|
|
CH698246B1
(de)
|
2001-12-20 |
2009-06-30 |
Hoffmann La Roche |
Test zur Identifizierung von Inhibitoren von Beta-Sekretasen.
|
|
AU2002367106A1
(en)
*
|
2001-12-26 |
2003-07-15 |
Takeda Chemical Industries, Ltd. |
Remedies for mild recognition deflict
|
|
AU2002360732A1
(en)
|
2001-12-26 |
2003-07-24 |
Guilford Pharmaceuticals |
Change inhibitors of dipeptidyl peptidase iv
|
|
US6727261B2
(en)
|
2001-12-27 |
2004-04-27 |
Hoffman-La Roche Inc. |
Pyrido[2,1-A]Isoquinoline derivatives
|
|
IL162838A0
(en)
|
2002-01-04 |
2005-11-20 |
Univ Rockefeller |
Compositions and methods for prevention and treatment peptide-of amyloid- related disorders
|
|
AU2003235799A1
(en)
|
2002-01-08 |
2003-07-24 |
Nordic Bioscience A/S |
Modulation of iamt (pimt or pcmt) in immune system
|
|
ES2252656T3
(es)
|
2002-02-13 |
2006-05-16 |
F. Hoffmann-La Roche Ag |
Nuevos derivados de piridina y quinolina.
|
|
JP4359146B2
(ja)
|
2002-02-13 |
2009-11-04 |
エフ.ホフマン−ラ ロシュ アーゲー |
新規なピリジン−およびピリミジン−誘導体
|
|
CA2476681A1
(en)
*
|
2002-02-19 |
2003-08-28 |
Bruce N. Rogers |
Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
|
|
HUP0200849A2
(hu)
|
2002-03-06 |
2004-08-30 |
Sanofi-Synthelabo |
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
|
|
AU2003257300B2
(en)
|
2002-08-07 |
2010-01-21 |
Neuraxon Inc. |
Amino benzothiazole compounds with NOS inhibitory activity
|
|
JP4648703B2
(ja)
|
2002-09-05 |
2011-03-09 |
アベンティス・ファーマ・ソシエテ・アノニム |
医薬としての新規なアミノインダゾール誘導体及びこれらを含む医薬組成物
|
|
WO2004039773A2
(en)
|
2002-10-30 |
2004-05-13 |
Nordic Bioscience A/S |
Coumpounds modulating the activity of gapdh and/or iamt
|
|
PL377777A1
(pl)
|
2002-12-11 |
2006-02-20 |
Pharmacia & Upjohn Company Llc |
Leczenie chorób połączeniami agonistów receptora alfa 7-nikotynowego i innych związków
|
|
FR2848452B1
(fr)
|
2002-12-12 |
2007-04-06 |
Aventis Pharma Sa |
Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
|
|
EP1622870A2
(en)
*
|
2003-05-05 |
2006-02-08 |
Prosidion Ltd. |
Glutaminyl based dp iv-inhibitors
|
|
EP1961416B1
(en)
*
|
2003-05-05 |
2013-01-23 |
Probiodrug AG |
Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis.
|
|
US8338120B2
(en)
*
|
2003-05-05 |
2012-12-25 |
Probiodrug Ag |
Method of treating inflammation with glutaminyl cyclase inhibitors
|
|
US7732162B2
(en)
*
|
2003-05-05 |
2010-06-08 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
|
|
WO2004098591A2
(en)
*
|
2003-05-05 |
2004-11-18 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
|
|
CN1784220B
(zh)
*
|
2003-05-05 |
2011-08-03 |
前体生物药物股份公司 |
谷氨酰胺酰基和谷氨酸环化酶效应物的应用
|
|
DE10337074A1
(de)
*
|
2003-08-12 |
2005-03-17 |
Keyneurotek Ag |
Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention von chronischen neurodegenerativen Erkrankungen
|
|
BRPI0415409A
(pt)
*
|
2003-10-15 |
2006-12-05 |
Probiodrug Ag |
uso de efetuadores de ciclases de glutaminila e glutamato
|