ES2160790T3 - 10-aminoalifatil-dibenzo(b,f)oxepinas de accion antineurodegenerativa. - Google Patents
10-aminoalifatil-dibenzo(b,f)oxepinas de accion antineurodegenerativa.Info
- Publication number
- ES2160790T3 ES2160790T3 ES96810062T ES96810062T ES2160790T3 ES 2160790 T3 ES2160790 T3 ES 2160790T3 ES 96810062 T ES96810062 T ES 96810062T ES 96810062 T ES96810062 T ES 96810062T ES 2160790 T3 ES2160790 T3 ES 2160790T3
- Authority
- ES
- Spain
- Prior art keywords
- oxepins
- dibenzo
- aminoalifatil
- antineurodegenerative
- action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
10-AMINOALIFAYIL-DIBENZO[B,F]OXEPINAS DE FORMULA I, DONDE ALK SIGNIFICA UN RADICAL ALIFATICO BIVALENTE, R UN GRUPO AMINO INSUSTITUIDO O SUSTITUIDO POR UN RADICAL ALIFATICO O ARAL HETEROCICLICO; Y N REPRESENTA 0, 1 O 2; TAMBIEN SE PRESENTAN LAS SALES FARMACOLOGICAMENTE ACEPTABLES DE LOS COMPUESTOS. ESTOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA DE LA ADMISION DE LA ADENOSINA Y SON UTILES PARA LA PROTECCION DEL MIOCARDIO Y PARA LA PREVENCION O EL TRATAMIENTO DE INFLAMACIONES TALES COMO EL EDEMA DEL PIE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH36795 | 1995-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2160790T3 true ES2160790T3 (es) | 2001-11-16 |
Family
ID=4185416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96810062T Expired - Lifetime ES2160790T3 (es) | 1995-02-08 | 1996-01-30 | 10-aminoalifatil-dibenzo(b,f)oxepinas de accion antineurodegenerativa. |
Country Status (27)
Country | Link |
---|---|
US (2) | US5780500A (es) |
EP (1) | EP0726265B1 (es) |
JP (2) | JP3625559B2 (es) |
KR (1) | KR100485538B1 (es) |
CN (1) | CN1216052C (es) |
AR (1) | AR004474A1 (es) |
AT (1) | ATE203528T1 (es) |
AU (1) | AU715245B2 (es) |
BR (1) | BR9600339A (es) |
CA (1) | CA2168937C (es) |
CY (1) | CY2333B1 (es) |
DE (1) | DE59607332D1 (es) |
DK (1) | DK0726265T3 (es) |
ES (1) | ES2160790T3 (es) |
FI (1) | FI120400B (es) |
GR (1) | GR3036656T3 (es) |
HU (1) | HU229227B1 (es) |
IL (1) | IL117067A (es) |
MX (1) | MX9600503A (es) |
MY (1) | MY113427A (es) |
NO (1) | NO314356B1 (es) |
NZ (1) | NZ280940A (es) |
PT (1) | PT726265E (es) |
RU (1) | RU2160734C2 (es) |
SA (1) | SA01220313A (es) |
TW (1) | TW420672B (es) |
ZA (1) | ZA96960B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5840749A (en) * | 1989-08-25 | 1998-11-24 | Hoechst Marion Roussel, Inc. | N-hydroxy-dibenz b,e!oxepinalkylamines, N-hydroxy-dibenz b,e!oxepinalkanoic acid amides and related heterocyclic analogues |
AR008371A1 (es) * | 1996-05-30 | 2000-01-19 | Novartis Ag | Una sal de adicion con acido de una 10-aminoalifatil-dibenz[b,f],oxepina, su empleo; procedimiento para su elaboracion, una 10-aminoalifatil-dibenz[b,f]oxepina, una preparacion farmaceutica que contiene dicha sal o dicha oxepina y un procedimiento para el tratamiento de enfermedades neurodegenerativ |
AU3172397A (en) * | 1996-06-05 | 1998-01-05 | Novartis Ag | Anti-neurodegeneratively effective xanthene derivatives |
WO1998015647A1 (en) * | 1996-10-08 | 1998-04-16 | Novartis Ag | Modulation of apoptosis |
EP0979073A4 (en) * | 1997-03-31 | 2004-04-07 | Childrens Medical Center | NITROSYLATION FOR INACTIVATING APOPTOTIC ENZYMS |
WO2000075127A1 (fr) | 1999-06-03 | 2000-12-14 | Nippon Suisan Kaisha, Ltd. | Composes heterocycliques condenses a trois cycles, procede de preparation correspondant et utilisation de tels composes |
AU2003235799A1 (en) * | 2002-01-08 | 2003-07-24 | Nordic Bioscience A/S | Modulation of iamt (pimt or pcmt) in immune system |
WO2004066993A1 (en) * | 2003-01-29 | 2004-08-12 | Novartis Ag | Use of 10-aminoaliphatyl-dibenz[b,f]oxepines for the treatment of degenerative ocular disorders |
US20050137142A1 (en) * | 2003-11-03 | 2005-06-23 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
US7906180B2 (en) * | 2004-02-27 | 2011-03-15 | Molecular Imprints, Inc. | Composition for an etching mask comprising a silicon-containing material |
EP1757284A1 (en) | 2005-08-25 | 2007-02-28 | Santhera Pharmaceuticals (Schweiz) AG | Use of N-(dibenz(b,f)oxepin-10ylmethyl)-N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of muscular dystrophy |
EP1842539A1 (en) * | 2006-04-05 | 2007-10-10 | Santhera Pharmaceuticals (Schweiz) AG | Use of N- (dibenz(b,f)oxepin-10-ylmethyl)N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of congenital muscular dystrophy or myopathy resulting from collagen VI deficiency |
KR20110087582A (ko) * | 2010-01-26 | 2011-08-03 | 삼성전자주식회사 | 식각액 조성물 및 이를 이용한 식각 방법 |
WO2014120885A1 (en) | 2013-01-30 | 2014-08-07 | The Johns Hopkins University | Treatment of drug abuse by preventing gapdh nitrosylation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3100207A (en) * | 1959-07-08 | 1963-08-06 | Smith Kline French Lab | 10-aminoalkylbenzo[b,f]thiepin and -dibenz[b,f]oxepin derivatives |
NL124626C (es) * | 1964-06-29 | |||
DE1493782B1 (de) * | 1964-06-29 | 1969-12-11 | Geigy Ag J R | Basisch substituierte Dibenzo[b,f]-oxepine und deren nicht-toxische Salze |
CH440318A (de) * | 1964-11-03 | 1967-07-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen Thiepin- und Oxepinderivaten |
US3641056A (en) * | 1970-01-06 | 1972-02-08 | Ciba Geigy Corp | 10-(aminomethyl)- and (aminoethyl)-dibenz (b f)oxepins |
US3928383A (en) * | 1973-06-08 | 1975-12-23 | Hoffmann La Roche | Propynylamine-substituted dibenzo{8 b,f{9 thiepins and dibenz{8 b,f{9 oxepins |
IE62754B1 (en) * | 1988-08-26 | 1995-02-22 | Akzo Nv | Tetracyclic antidepressants |
-
1996
- 1996-01-30 DK DK96810062T patent/DK0726265T3/da active
- 1996-01-30 TW TW085101112A patent/TW420672B/zh not_active IP Right Cessation
- 1996-01-30 EP EP96810062A patent/EP0726265B1/de not_active Expired - Lifetime
- 1996-01-30 DE DE59607332T patent/DE59607332D1/de not_active Expired - Lifetime
- 1996-01-30 AT AT96810062T patent/ATE203528T1/de active
- 1996-01-30 PT PT96810062T patent/PT726265E/pt unknown
- 1996-01-30 ES ES96810062T patent/ES2160790T3/es not_active Expired - Lifetime
- 1996-02-01 AU AU43307/96A patent/AU715245B2/en not_active Expired
- 1996-02-05 FI FI960529A patent/FI120400B/fi not_active IP Right Cessation
- 1996-02-05 NZ NZ280940A patent/NZ280940A/en not_active IP Right Cessation
- 1996-02-06 MX MX9600503A patent/MX9600503A/es unknown
- 1996-02-06 RU RU96102419/04A patent/RU2160734C2/ru active
- 1996-02-06 CA CA002168937A patent/CA2168937C/en not_active Expired - Lifetime
- 1996-02-06 JP JP01962496A patent/JP3625559B2/ja not_active Expired - Lifetime
- 1996-02-06 BR BR9600339A patent/BR9600339A/pt not_active Application Discontinuation
- 1996-02-07 IL IL11706796A patent/IL117067A/xx not_active IP Right Cessation
- 1996-02-07 HU HU9600272A patent/HU229227B1/hu unknown
- 1996-02-07 AR ARP960101302A patent/AR004474A1/es active IP Right Grant
- 1996-02-07 KR KR1019960002903A patent/KR100485538B1/ko not_active IP Right Cessation
- 1996-02-07 CN CN961035226A patent/CN1216052C/zh not_active Expired - Lifetime
- 1996-02-07 MY MYPI96000457A patent/MY113427A/en unknown
- 1996-02-07 ZA ZA96960A patent/ZA96960B/xx unknown
- 1996-02-07 NO NO19960499A patent/NO314356B1/no not_active IP Right Cessation
-
1997
- 1997-04-18 US US08/844,135 patent/US5780500A/en not_active Expired - Lifetime
- 1997-07-08 US US08/889,769 patent/US5780501A/en not_active Expired - Lifetime
-
2001
- 2001-09-02 SA SA01220313A patent/SA01220313A/ar unknown
- 2001-09-18 GR GR20010401514T patent/GR3036656T3/el unknown
-
2002
- 2002-12-12 CY CY0200067A patent/CY2333B1/xx unknown
-
2004
- 2004-10-07 JP JP2004295186A patent/JP2005008646A/ja active Pending
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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