ES2116131T3 - Derivados de naftaleno, su procedimiento de preparacion y productos intermediarios adecuados, y las composiciones farmaceuticas que los contienen. - Google Patents

Derivados de naftaleno, su procedimiento de preparacion y productos intermediarios adecuados, y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2116131T3
ES2116131T3 ES96304033T ES96304033T ES2116131T3 ES 2116131 T3 ES2116131 T3 ES 2116131T3 ES 96304033 T ES96304033 T ES 96304033T ES 96304033 T ES96304033 T ES 96304033T ES 2116131 T3 ES2116131 T3 ES 2116131T3
Authority
ES
Spain
Prior art keywords
sup
substituted
protected
naftalene
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96304033T
Other languages
English (en)
Inventor
Tatsuzo Ukita
Katsuo Ikezawa
Shinsuke Yamagata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2116131T3 publication Critical patent/ES2116131T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

DERIVADOS DE NAFTALENO DE FORMULA [L]: EN DONDE R 1 Y R{SUP,2} SON IGUALES O DIFERENTES Y SON CADA UNO H, OH PROTEGIDO O DESPROTEGIDO, UNO DE R{SUP,3} Y R{SUP,4} ES HIDROXIMETILO PROTEGIDO O DESPROTEGIDO, EL OTRO ES H, ALQUILO DE CADENA CORTA, O HIDROXIMETILO PROTEGIDO O DESPROTEGIDO, R{SUP,5} Y R{SUP,6} SON IGUALES O DIFERENTES Y SON CADA UNO H, ALQUILO DE CADENA CORTA SUSTITUIDO O NO SUSTITUIDO, FENILO SUSTITUIDO O NO SUSTITUIDO O NH{SUB,2} PROTEGIDO O DESPROTEGIDO, O AMBOS SE COMBINAN JUNTOS CON EL N ADYACENTE PARA FORMAR UN GRUPO HETEROCICLICO SUSTITUIDO O NO SUSTITUIDO, Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. ESTOS COMPUESTOS MUESTRAN UNA EXCELENTE ACTIVIDAD INHIBITORIA DE LA BRONCOCONSTRICCION, Y POR LO TANTO, SON UTILES EN LA PROFILAXIS O EN EL TRATAMIENTO DEL ASMA.
ES96304033T 1995-06-15 1996-06-04 Derivados de naftaleno, su procedimiento de preparacion y productos intermediarios adecuados, y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2116131T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14928895 1995-06-15

Publications (1)

Publication Number Publication Date
ES2116131T3 true ES2116131T3 (es) 1998-07-01

Family

ID=15471914

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96304033T Expired - Lifetime ES2116131T3 (es) 1995-06-15 1996-06-04 Derivados de naftaleno, su procedimiento de preparacion y productos intermediarios adecuados, y las composiciones farmaceuticas que los contienen.

Country Status (21)

Country Link
US (3) US6005106A (es)
EP (1) EP0748805B1 (es)
KR (1) KR100435247B1 (es)
CN (1) CN1063748C (es)
AR (1) AR002483A1 (es)
AT (1) ATE164843T1 (es)
AU (1) AU706156B2 (es)
BG (1) BG62521B1 (es)
BR (1) BR9602802A (es)
CA (1) CA2178974C (es)
DE (1) DE69600221T2 (es)
ES (1) ES2116131T3 (es)
HK (1) HK1010116A1 (es)
HU (1) HU222340B1 (es)
IL (1) IL118469A (es)
MY (1) MY121606A (es)
NO (1) NO310109B1 (es)
RU (1) RU2129120C1 (es)
SG (1) SG47152A1 (es)
TW (1) TW349098B (es)
ZA (1) ZA964652B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
JPH1171351A (ja) * 1997-08-29 1999-03-16 Ss Pharmaceut Co Ltd 置換キノロン誘導体及びこれを含有する医薬
ATE409215T1 (de) 1998-05-05 2008-10-15 Massachusetts Inst Technology Emittierende polymere und vorrichtungen diese polymere enthaltend
US20050147534A1 (en) 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
JP5038568B2 (ja) 1999-08-21 2012-10-03 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 協力剤の組合せ物
MXPA03010679A (es) 2001-05-23 2004-03-02 Tanabe Seiyaku Co Una composicion para acelerar la cicatrizacion de fractura osea.
KR20040007583A (ko) 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 연골 질환의 재생치료용 조성물
TWI221838B (en) 2001-08-09 2004-10-11 Tanabe Seiyaku Co Pyrazinoisoquinoline compound or naphthalene compound
PL373484A1 (en) * 2001-12-10 2005-09-05 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US20050043315A1 (en) * 2002-01-02 2005-02-24 Hideo Tsutsumi Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them
MXPA04011472A (es) * 2002-05-22 2005-02-14 Amgen Inc Derivados de amino-piridina, piridina y piridazina para usarse como ligandos del receptor vaniloide para el tratamiento del dolor.
WO2004014871A1 (en) * 2002-08-08 2004-02-19 Amgen Inc. Vanilloid receptor ligands and their use in treatments
BRPI0408332A (pt) 2003-03-14 2006-03-21 Ono Pharmaceutical Co derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo
BRPI0409229A (pt) 2003-04-01 2006-03-28 Applied Research Systems inibidores das fosfodiesterases na infertilidade
WO2004104551A2 (en) * 2003-05-16 2004-12-02 University Of Chicago Optical fractionation methods and apparatus
AU2004278382B2 (en) * 2003-09-30 2008-09-18 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MY139645A (en) * 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
US7534798B2 (en) * 2004-02-11 2009-05-19 Amgen Inc. Vanilloid receptor ligands and their use in treatments
CN101775013A (zh) * 2004-09-13 2010-07-14 小野药品工业株式会社 含氮杂环衍生物及含有其作为活性成分的药物
US8617819B2 (en) 2004-09-17 2013-12-31 Massachusetts Institute Of Technology Polymers for analyte detection
TWI339578B (en) * 2004-10-29 2011-04-01 Mitsubishi Tanabe Pharma Corp Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions
WO2006089311A1 (en) * 2005-02-15 2006-08-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
EP1877400A1 (en) * 2005-04-15 2008-01-16 Amgen, Inc Vanilloid receptor ligands and their use in treatments
US7989627B2 (en) 2005-10-04 2011-08-02 Mitsubishi Tanabe Pharma Corporation Optically active cyclic alcohol compound and method for preparing the same
JP4658134B2 (ja) 2005-10-04 2011-03-23 田辺三菱製薬株式会社 光学活性４−ヒドロキシ−１，２，３，４−テトラヒドロキノリン化合物の製法
US7868019B2 (en) 2005-10-05 2011-01-11 Mitsubishi Tanabe Pharma Corporation Dermatitis treating agent
WO2007105637A1 (ja) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8283423B2 (en) 2006-09-29 2012-10-09 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
EP1958947A1 (en) * 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
WO2008124812A1 (en) * 2007-04-10 2008-10-16 The Trustees Of The University Of Pennsylvania Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US20140121240A1 (en) * 2011-06-28 2014-05-01 Maruho Co., Ltd. Novel pharmaceutical composition
JPWO2013027835A1 (ja) 2011-08-25 2015-03-19 田辺三菱製薬株式会社 光学活性ナフタレン化合物の製法
US11970440B1 (en) 2023-10-30 2024-04-30 King Faisal University 8-(3-chlorobenzylideneamino)naphthalene-1,3-disulfonic acid as an antioxidant compound
US11932593B1 (en) 2023-10-31 2024-03-19 King Faisal University 8-(3-bromobenzylideneamino)naphthalene-1,3-disulfonic acid as an antioxidant compound

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JP3042156B2 (ja) * 1992-02-20 2000-05-15 田辺製薬株式会社 ナフタレン誘導体、その製法及びその合成中間体
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
DE59609705D1 (de) * 1995-03-03 2002-10-31 Rolic Ag Zug Photovernetzbare Naphthylderivate

Also Published As

Publication number Publication date
NO310109B1 (no) 2001-05-21
CA2178974C (en) 2006-06-06
KR970001343A (ko) 1997-01-24
NO962527D0 (no) 1996-06-14
AR002483A1 (es) 1998-03-25
HUP9601652A1 (en) 1997-09-29
AU5469396A (en) 1997-01-02
BG100656A (en) 1997-09-30
EP0748805B1 (en) 1998-04-08
BG62521B1 (bg) 2000-01-31
US5969140A (en) 1999-10-19
RU2129120C1 (ru) 1999-04-20
HU9601652D0 (en) 1996-08-28
IL118469A0 (en) 1996-09-12
MY121606A (en) 2006-02-28
NO962527L (no) 1996-12-16
AU706156B2 (en) 1999-06-10
US6005106A (en) 1999-12-21
BR9602802A (pt) 1998-10-06
KR100435247B1 (ko) 2004-09-10
CN1142497A (zh) 1997-02-12
ATE164843T1 (de) 1998-04-15
CA2178974A1 (en) 1996-12-16
TW349098B (en) 1999-01-01
HK1010116A1 (en) 1999-06-11
CN1063748C (zh) 2001-03-28
IL118469A (en) 2000-08-13
ZA964652B (en) 1996-12-12
HU222340B1 (hu) 2003-06-28
SG47152A1 (en) 1998-03-20
DE69600221D1 (de) 1998-05-14
US6214996B1 (en) 2001-04-10
EP0748805A1 (en) 1996-12-18
DE69600221T2 (de) 1998-08-06

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