BG100656A - Derivatives of naphthalene, method and intermediate compounds for their preparation - Google Patents

Derivatives of naphthalene, method and intermediate compounds for their preparation

Info

Publication number
BG100656A
BG100656A BG100656A BG10065696A BG100656A BG 100656 A BG100656 A BG 100656A BG 100656 A BG100656 A BG 100656A BG 10065696 A BG10065696 A BG 10065696A BG 100656 A BG100656 A BG 100656A
Authority
BG
Bulgaria
Prior art keywords
protected
group
substituted
hydrogen atom
naphthalene
Prior art date
Application number
BG100656A
Other languages
Bulgarian (bg)
Other versions
BG62521B1 (en
Inventor
Tatsuzo Ukita
Katsuo Ikezawa
Shinsuke Yamagata
Original Assignee
Tanabe Seiyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co., Ltd. filed Critical Tanabe Seiyaku Co., Ltd.
Publication of BG100656A publication Critical patent/BG100656A/en
Publication of BG62521B1 publication Critical patent/BG62521B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

The derivatives of naphthalene have the formula where R1 and R2 are identical or different and each is a hydrogen atom or protected and unpotected hydroxygroup; one of the radicals R3 & R4 is a protected or unprotected hydroxymethyl group, and the other - hydrogen atom, lower alkyl group or protected or unprotected hydroxymethyl group; R5 & R6 are identical or different and each is a hydrogen atom, substituted or unsubstituted lower alkyl group, substituted or unsubstituted phenyl group, or protected or unprotected aminogroup, or both are combined togehter with the adjacent nitrogen atom forming a substituted or unsubstituted heterocylic group. The invention also relates to their pharmaceutically acceptable salts. The compounds show excellent inhibition effect on the bronchostenosis and are useful for the asthma prophylaxy or treatment.
BG100656A 1995-06-15 1996-06-12 Naphthelene derivatives, method and intermediate compounds for their preparation BG62521B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14928895 1995-06-15

Publications (2)

Publication Number Publication Date
BG100656A true BG100656A (en) 1997-09-30
BG62521B1 BG62521B1 (en) 2000-01-31

Family

ID=15471914

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100656A BG62521B1 (en) 1995-06-15 1996-06-12 Naphthelene derivatives, method and intermediate compounds for their preparation

Country Status (21)

Country Link
US (3) US6005106A (en)
EP (1) EP0748805B1 (en)
KR (1) KR100435247B1 (en)
CN (1) CN1063748C (en)
AR (1) AR002483A1 (en)
AT (1) ATE164843T1 (en)
AU (1) AU706156B2 (en)
BG (1) BG62521B1 (en)
BR (1) BR9602802A (en)
CA (1) CA2178974C (en)
DE (1) DE69600221T2 (en)
ES (1) ES2116131T3 (en)
HK (1) HK1010116A1 (en)
HU (1) HU222340B1 (en)
IL (1) IL118469A (en)
MY (1) MY121606A (en)
NO (1) NO310109B1 (en)
RU (1) RU2129120C1 (en)
SG (1) SG47152A1 (en)
TW (1) TW349098B (en)
ZA (1) ZA964652B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID19155A (en) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co PYRIDINES, THEIR PRODUCTS AND THE INTERMEDIETS FOR THE PRODUCTION
JPH1171351A (en) * 1997-08-29 1999-03-16 Ss Pharmaceut Co Ltd Substituted quinolone derivative and medicine containing the same
WO1999057222A1 (en) 1998-05-05 1999-11-11 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
US20050147534A1 (en) 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
ATE320800T1 (en) 1999-08-21 2006-04-15 Altana Pharma Ag SYNERGISTIC COMBINATION OF ROFLUMILAST AND SALMETEROL
EP1389468A4 (en) * 2001-05-23 2007-01-10 Tanabe Seiyaku Co Compositions for promoting healing of bone fracture
KR20040007583A (en) * 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 Therapeutic compositions for repairing chondropathy
TWI221838B (en) 2001-08-09 2004-10-11 Tanabe Seiyaku Co Pyrazinoisoquinoline compound or naphthalene compound
WO2003049702A2 (en) * 2001-12-10 2003-06-19 Amgen Inc. Vanilloid receptor ligands and their use in treatments
WO2003057689A1 (en) * 2002-01-02 2003-07-17 Fujisawa Pharmaceutical Co., Ltd. Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them
US7053088B2 (en) * 2002-05-22 2006-05-30 Amgen Inc. Vanilloid receptor ligands and their use in treatments
KR20050055694A (en) * 2002-08-08 2005-06-13 암젠 인코포레이티드 Vanilloid receptor ligands and their use in treatments
AU2004220225B2 (en) 2003-03-14 2010-06-17 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
BRPI0409229A (en) 2003-04-01 2006-03-28 Applied Research Systems phosphodiesterase inhibitors in infertility
US7233423B2 (en) * 2003-05-16 2007-06-19 University Of Chicago Optical fractionation methods and apparatus
US7390907B2 (en) * 2003-09-30 2008-06-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MY139645A (en) * 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
WO2005077938A1 (en) * 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
PE20090123A1 (en) 2004-09-13 2009-03-10 Ono Pharmaceutical Co A HETEROCYCLIC DERIVATIVE CONTAINING NITROGEN AND A DRUG CONTAINING THE SAME AS THE ACTIVE INGREDIENT
WO2006034081A2 (en) 2004-09-17 2006-03-30 Massachusetts Institute Of Technology Polymers for analyte detection
TWI339578B (en) 2004-10-29 2011-04-01 Mitsubishi Tanabe Pharma Corp Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions
US7301022B2 (en) * 2005-02-15 2007-11-27 Amgen Inc. Vanilloid receptor ligands and their use in treatments
EP1877400A1 (en) * 2005-04-15 2008-01-16 Amgen, Inc Vanilloid receptor ligands and their use in treatments
PL1944291T3 (en) * 2005-10-04 2012-11-30 Mitsubishi Tanabe Pharma Corp Optically active cyclic alcohol compound and method for producing same
JP4658134B2 (en) 2005-10-04 2011-03-23 田辺三菱製薬株式会社 Process for producing optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound
CN103030628A (en) 2005-10-05 2013-04-10 田边三菱制药株式会社 Dermatitis treating agent
BRPI0708731A2 (en) 2006-03-10 2011-06-07 Ono Pharmaceutical Co nitrogenous heterocyclic derivative, and pharmaceutical agent comprising the derivative as an active ingredient
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8283423B2 (en) 2006-09-29 2012-10-09 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
EP1958947A1 (en) * 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
JP2010524857A (en) * 2007-04-10 2010-07-22 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア Fen-naphthalene and phen-quinoline derivatives and use to bind and image amyloid plaques
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
WO2013002196A1 (en) 2011-06-28 2013-01-03 田辺三菱製薬株式会社 Novel pharmaceutical composition
US9181217B2 (en) 2011-08-25 2015-11-10 Mitsubishi Tanabe Pharma Corporation Method for producing optically active naphthalene compound
US11970440B1 (en) 2023-10-30 2024-04-30 King Faisal University 8-(3-chlorobenzylideneamino)naphthalene-1,3-disulfonic acid as an antioxidant compound
US11932593B1 (en) 2023-10-31 2024-03-19 King Faisal University 8-(3-bromobenzylideneamino)naphthalene-1,3-disulfonic acid as an antioxidant compound

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JP3042156B2 (en) * 1992-02-20 2000-05-15 田辺製薬株式会社 Naphthalene derivative, its production method and its synthetic intermediate
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
DE59609705D1 (en) * 1995-03-03 2002-10-31 Rolic Ag Zug Photocrosslinkable naphthyl derivatives

Also Published As

Publication number Publication date
NO962527L (en) 1996-12-16
AU706156B2 (en) 1999-06-10
KR970001343A (en) 1997-01-24
CA2178974C (en) 2006-06-06
US5969140A (en) 1999-10-19
TW349098B (en) 1999-01-01
HU9601652D0 (en) 1996-08-28
NO310109B1 (en) 2001-05-21
HU222340B1 (en) 2003-06-28
ES2116131T3 (en) 1998-07-01
NO962527D0 (en) 1996-06-14
ZA964652B (en) 1996-12-12
MY121606A (en) 2006-02-28
EP0748805B1 (en) 1998-04-08
ATE164843T1 (en) 1998-04-15
BR9602802A (en) 1998-10-06
US6005106A (en) 1999-12-21
AU5469396A (en) 1997-01-02
DE69600221D1 (en) 1998-05-14
EP0748805A1 (en) 1996-12-18
AR002483A1 (en) 1998-03-25
CN1142497A (en) 1997-02-12
SG47152A1 (en) 1998-03-20
KR100435247B1 (en) 2004-09-10
HUP9601652A1 (en) 1997-09-29
CA2178974A1 (en) 1996-12-16
RU2129120C1 (en) 1999-04-20
US6214996B1 (en) 2001-04-10
DE69600221T2 (en) 1998-08-06
IL118469A (en) 2000-08-13
HK1010116A1 (en) 1999-06-11
BG62521B1 (en) 2000-01-31
IL118469A0 (en) 1996-09-12
CN1063748C (en) 2001-03-28

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