BG100656A - Производни на нафтален, метод и междинни съединения за тяхното получаване - Google Patents

Производни на нафтален, метод и междинни съединения за тяхното получаване

Info

Publication number
BG100656A
BG100656A BG100656A BG10065696A BG100656A BG 100656 A BG100656 A BG 100656A BG 100656 A BG100656 A BG 100656A BG 10065696 A BG10065696 A BG 10065696A BG 100656 A BG100656 A BG 100656A
Authority
BG
Bulgaria
Prior art keywords
protected
group
substituted
hydrogen atom
naphthalene
Prior art date
Application number
BG100656A
Other languages
English (en)
Other versions
BG62521B1 (bg
Inventor
Tatsuzo Ukita
Katsuo Ikezawa
Shinsuke Yamagata
Original Assignee
Tanabe Seiyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co., Ltd. filed Critical Tanabe Seiyaku Co., Ltd.
Publication of BG100656A publication Critical patent/BG100656A/bg
Publication of BG62521B1 publication Critical patent/BG62521B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Производните на нафтален имат формулав която R1 иR2 са еднакви или различни и всеки представлява водороден атом или защитена или незащитена хидроксигрупа; един от радикалите R3 и R4 е защитена или незащитена хидроксиметилова група, а другият - водороден атом, нисша алкилова група или защитена или незащитена хидроксиметилова група; R5 и R6 са еднаквиили различни и всеки представлява водороден атом, заместена или незаместена нисша алкилова група,заместена или незаместена фенилова група или защитена, или незащитена аминогрупа, или двете се комбинират заедно със съседния азотен атом и образуватзаместена или незаместена хетероциклична група. Изобретението се отнася и до техни фармацевтично приемливи соли. Съединенията показват отлично инхибиращо действие върху бронхосвиването и са полезни запрофилактика или лечениена астма.
BG100656A 1995-06-15 1996-06-12 Производни на нафтален, метод и междинни съединения затяхното получаване BG62521B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14928895 1995-06-15

Publications (2)

Publication Number Publication Date
BG100656A true BG100656A (bg) 1997-09-30
BG62521B1 BG62521B1 (bg) 2000-01-31

Family

ID=15471914

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100656A BG62521B1 (bg) 1995-06-15 1996-06-12 Производни на нафтален, метод и междинни съединения затяхното получаване

Country Status (21)

Country Link
US (3) US6005106A (bg)
EP (1) EP0748805B1 (bg)
KR (1) KR100435247B1 (bg)
CN (1) CN1063748C (bg)
AR (1) AR002483A1 (bg)
AT (1) ATE164843T1 (bg)
AU (1) AU706156B2 (bg)
BG (1) BG62521B1 (bg)
BR (1) BR9602802A (bg)
CA (1) CA2178974C (bg)
DE (1) DE69600221T2 (bg)
ES (1) ES2116131T3 (bg)
HK (1) HK1010116A1 (bg)
HU (1) HU222340B1 (bg)
IL (1) IL118469A (bg)
MY (1) MY121606A (bg)
NO (1) NO310109B1 (bg)
RU (1) RU2129120C1 (bg)
SG (1) SG47152A1 (bg)
TW (1) TW349098B (bg)
ZA (1) ZA964652B (bg)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID19155A (id) * 1996-12-13 1998-06-18 Tanabe Seiyaku Co Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya
JPH1171351A (ja) * 1997-08-29 1999-03-16 Ss Pharmaceut Co Ltd 置換キノロン誘導体及びこれを含有する医薬
US20050147534A1 (en) 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
EP1080162B1 (en) 1998-05-05 2004-03-10 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
CA2381802C (en) 1999-08-21 2010-12-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Synergistic combination of roflumilast and salmeterol
JP4510384B2 (ja) * 2001-05-23 2010-07-21 田辺三菱製薬株式会社 骨折治癒促進用組成物
JP4510383B2 (ja) 2001-05-23 2010-07-21 田辺三菱製薬株式会社 軟骨疾患修復治療用組成物
TWI221838B (en) * 2001-08-09 2004-10-11 Tanabe Seiyaku Co Pyrazinoisoquinoline compound or naphthalene compound
JP2005518371A (ja) * 2001-12-10 2005-06-23 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び治療に於けるこれらの使用
US20050043315A1 (en) * 2002-01-02 2005-02-24 Hideo Tsutsumi Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them
EP1542692B1 (en) * 2002-05-22 2011-01-05 Amgen Inc. Aminopyrimidine derivatives for use as vanilloid receptor ligands for the treatment of pain
CA2493667C (en) * 2002-08-08 2010-04-27 Amgen Inc. Vanilloid receptor ligands and their use in treatments
CA2517888C (en) 2003-03-14 2012-05-01 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
JP2007516095A (ja) * 2003-05-16 2007-06-21 ユニヴァーシティ・オヴ・シカゴ 光学分別装置および光学分別方法
AU2004278382B2 (en) * 2003-09-30 2008-09-18 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MY139645A (en) * 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
CA2556239A1 (en) 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
TWI400232B (zh) 2004-09-13 2013-07-01 Ono Pharmaceutical Co 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑
WO2006034081A2 (en) 2004-09-17 2006-03-30 Massachusetts Institute Of Technology Polymers for analyte detection
TWI339578B (en) 2004-10-29 2011-04-01 Mitsubishi Tanabe Pharma Corp Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions
WO2006089311A1 (en) * 2005-02-15 2006-08-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
EP1877400A1 (en) * 2005-04-15 2008-01-16 Amgen, Inc Vanilloid receptor ligands and their use in treatments
ES2386904T3 (es) * 2005-10-04 2012-09-05 Mitsubishi Tanabe Pharma Corporation Compuestos de alcohol cíclico ópticamente activo y procedimiento para producir el mismo
US7972836B2 (en) 2005-10-04 2011-07-05 Mitsubishi Tanabe Pharma Corporation Method of enzymatic optical resolution of racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline
ES2502515T3 (es) 2005-10-05 2014-10-03 Mitsubishi Tanabe Pharma Corporation Derivados de naftaleno para el tratamiento de la dermatitis y la psoriasis
CA2644368A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
WO2007112347A1 (en) * 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2008042289A2 (en) 2006-09-29 2008-04-10 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
EP1958947A1 (en) * 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
US20100215579A1 (en) * 2007-04-10 2010-08-26 The Trustees Of The University Of Pennsylvania Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
EP2727594B1 (en) 2011-06-28 2017-12-20 Mitsubishi Tanabe Pharma Corporation Naphtalene compounds to treat itch
WO2013027835A1 (ja) 2011-08-25 2013-02-28 田辺三菱製薬株式会社 光学活性ナフタレン化合物の製法
US11970440B1 (en) 2023-10-30 2024-04-30 King Faisal University 8-(3-chlorobenzylideneamino)naphthalene-1,3-disulfonic acid as an antioxidant compound
US11932593B1 (en) 2023-10-31 2024-03-19 King Faisal University 8-(3-bromobenzylideneamino)naphthalene-1,3-disulfonic acid as an antioxidant compound
US11987543B1 (en) 2023-10-31 2024-05-21 King Faisal University 8-(4-bromobenzylideneamino)naphthalene-1,3-disulfonic acid as an antioxidant compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3042156B2 (ja) * 1992-02-20 2000-05-15 田辺製薬株式会社 ナフタレン誘導体、その製法及びその合成中間体
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
DE59609705D1 (de) * 1995-03-03 2002-10-31 Rolic Ag Zug Photovernetzbare Naphthylderivate

Also Published As

Publication number Publication date
ES2116131T3 (es) 1998-07-01
IL118469A0 (en) 1996-09-12
US5969140A (en) 1999-10-19
BG62521B1 (bg) 2000-01-31
SG47152A1 (en) 1998-03-20
CA2178974A1 (en) 1996-12-16
BR9602802A (pt) 1998-10-06
RU2129120C1 (ru) 1999-04-20
DE69600221D1 (de) 1998-05-14
AU706156B2 (en) 1999-06-10
HK1010116A1 (en) 1999-06-11
ZA964652B (en) 1996-12-12
CA2178974C (en) 2006-06-06
HUP9601652A1 (en) 1997-09-29
MY121606A (en) 2006-02-28
AU5469396A (en) 1997-01-02
KR970001343A (ko) 1997-01-24
AR002483A1 (es) 1998-03-25
NO310109B1 (no) 2001-05-21
KR100435247B1 (ko) 2004-09-10
EP0748805A1 (en) 1996-12-18
US6214996B1 (en) 2001-04-10
DE69600221T2 (de) 1998-08-06
US6005106A (en) 1999-12-21
NO962527L (no) 1996-12-16
ATE164843T1 (de) 1998-04-15
HU222340B1 (hu) 2003-06-28
CN1063748C (zh) 2001-03-28
EP0748805B1 (en) 1998-04-08
NO962527D0 (no) 1996-06-14
CN1142497A (zh) 1997-02-12
TW349098B (en) 1999-01-01
HU9601652D0 (en) 1996-08-28
IL118469A (en) 2000-08-13

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