PT1264836E - Processos para a preparacao de derivados de indolopirrolocarbazole - Google Patents

Processos para a preparacao de derivados de indolopirrolocarbazole

Info

Publication number
PT1264836E
PT1264836E PT02018235T PT02018235T PT1264836E PT 1264836 E PT1264836 E PT 1264836E PT 02018235 T PT02018235 T PT 02018235T PT 02018235 T PT02018235 T PT 02018235T PT 1264836 E PT1264836 E PT 1264836E
Authority
PT
Portugal
Prior art keywords
indoloprolocarbazole
derivatives
processes
preparation
compounds
Prior art date
Application number
PT02018235T
Other languages
English (en)
Inventor
Hisao Kondo
Hiroharu Arakawa
Mitsuru Ohkubo
Hiroyuki Suda
Kojiri Katsuhisa C O Banyu Ltd
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of PT1264836E publication Critical patent/PT1264836E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT02018235T 1994-05-09 1995-05-02 Processos para a preparacao de derivados de indolopirrolocarbazole PT1264836E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11948394 1994-05-09
JP14564894 1994-06-03

Publications (1)

Publication Number Publication Date
PT1264836E true PT1264836E (pt) 2005-02-28

Family

ID=26457215

Family Applications (2)

Application Number Title Priority Date Filing Date
PT95917506T PT760375E (pt) 1994-05-09 1995-05-02 Derivado de indolopiprolocarbazole anti-tumoral
PT02018235T PT1264836E (pt) 1994-05-09 1995-05-02 Processos para a preparacao de derivados de indolopirrolocarbazole

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT95917506T PT760375E (pt) 1994-05-09 1995-05-02 Derivado de indolopiprolocarbazole anti-tumoral

Country Status (14)

Country Link
EP (2) EP0760375B1 (pt)
JP (1) JP3038921B2 (pt)
KR (1) KR100312473B1 (pt)
CN (2) CN1285605C (pt)
AT (2) ATE283863T1 (pt)
AU (1) AU683749B2 (pt)
CA (1) CA2190007C (pt)
CL (1) CL2004001117A1 (pt)
DE (2) DE69532198T2 (pt)
DK (2) DK0760375T3 (pt)
ES (2) ES2206501T3 (pt)
HK (2) HK1000890A1 (pt)
PT (2) PT760375E (pt)
TW (1) TW313566B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018495A1 (ja) * 2002-08-23 2004-03-04 Banyu Pharmaceutical Co., Ltd. インドロピロロカルバゾール誘導体の製造法
CN101585861B (zh) * 2009-07-03 2012-10-24 复旦大学 N-糖基萘并咔唑化合物及其合成方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
ATE158298T1 (de) * 1990-05-11 1997-10-15 Banyu Pharma Co Ltd Be-13793c-derivat mit antitumorwirkung
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
WO1995034663A1 (fr) * 1994-06-13 1995-12-21 Banyu Pharmaceutical Co., Ltd. Gene codant la glycosyl-transferase et utilisation de ce gene
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles

Also Published As

Publication number Publication date
DE69532198D1 (de) 2004-01-08
EP0760375A4 (en) 2002-03-27
CN1106400C (zh) 2003-04-23
CN1513865A (zh) 2004-07-21
CN1285605C (zh) 2006-11-22
ES2230433T3 (es) 2005-05-01
CA2190007C (en) 2003-04-15
HK1000890A1 (en) 2004-01-09
DE69533833D1 (de) 2005-01-05
AU2353595A (en) 1995-11-29
ES2206501T3 (es) 2004-05-16
CN1153518A (zh) 1997-07-02
DE69533833T2 (de) 2005-12-15
TW313566B (pt) 1997-08-21
PT760375E (pt) 2004-04-30
AU683749B2 (en) 1997-11-20
DE69532198T2 (de) 2004-08-26
DK1264836T3 (da) 2005-03-07
JP3038921B2 (ja) 2000-05-08
ATE255121T1 (de) 2003-12-15
EP0760375A1 (en) 1997-03-05
KR100312473B1 (ko) 2002-06-24
HK1067948A1 (en) 2005-04-22
EP0760375B1 (en) 2003-11-26
ATE283863T1 (de) 2004-12-15
DK0760375T3 (da) 2003-12-29
CA2190007A1 (en) 1995-11-16
EP1264836A1 (en) 2002-12-11
EP1264836B1 (en) 2004-12-01
KR970702869A (ko) 1997-06-10
CL2004001117A1 (es) 2005-04-22

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