ATE283863T1 - Verfahren zur herstellung von indolopyrrolocarbazol-derivaten - Google Patents

Verfahren zur herstellung von indolopyrrolocarbazol-derivaten

Info

Publication number
ATE283863T1
ATE283863T1 AT02018235T AT02018235T ATE283863T1 AT E283863 T1 ATE283863 T1 AT E283863T1 AT 02018235 T AT02018235 T AT 02018235T AT 02018235 T AT02018235 T AT 02018235T AT E283863 T1 ATE283863 T1 AT E283863T1
Authority
AT
Austria
Prior art keywords
producing
indolopyrrolocarbazole derivatives
compounds
indolopyrrolocarbazole
derivatives
Prior art date
Application number
AT02018235T
Other languages
English (en)
Inventor
Katsuhisa Kojiri
Hisao Kondo
Hiroharu Arakawa
Mitsuru Ohkubo
Hiroyuki Suda
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Application granted granted Critical
Publication of ATE283863T1 publication Critical patent/ATE283863T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02018235T 1994-05-09 1995-05-02 Verfahren zur herstellung von indolopyrrolocarbazol-derivaten ATE283863T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11948394 1994-05-09
JP14564894 1994-06-03

Publications (1)

Publication Number Publication Date
ATE283863T1 true ATE283863T1 (de) 2004-12-15

Family

ID=26457215

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02018235T ATE283863T1 (de) 1994-05-09 1995-05-02 Verfahren zur herstellung von indolopyrrolocarbazol-derivaten
AT95917506T ATE255121T1 (de) 1994-05-09 1995-05-02 Antitumor-indolopyrolocarbazolderivat

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT95917506T ATE255121T1 (de) 1994-05-09 1995-05-02 Antitumor-indolopyrolocarbazolderivat

Country Status (14)

Country Link
EP (2) EP1264836B1 (de)
JP (1) JP3038921B2 (de)
KR (1) KR100312473B1 (de)
CN (2) CN1106400C (de)
AT (2) ATE283863T1 (de)
AU (1) AU683749B2 (de)
CA (1) CA2190007C (de)
CL (1) CL2004001117A1 (de)
DE (2) DE69533833T2 (de)
DK (2) DK0760375T3 (de)
ES (2) ES2230433T3 (de)
HK (2) HK1000890A1 (de)
PT (2) PT1264836E (de)
TW (1) TW313566B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2337105C2 (ru) * 2002-08-23 2008-10-27 Баниу Фармасьютикал Ко., Лтд. Способ получения производного индолопирролокарбазола
CN101585861B (zh) * 2009-07-03 2012-10-24 复旦大学 N-糖基萘并咔唑化合物及其合成方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
ATE158298T1 (de) * 1990-05-11 1997-10-15 Banyu Pharma Co Ltd Be-13793c-derivat mit antitumorwirkung
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
ES2206506T3 (es) * 1994-06-13 2004-05-16 Banyu Pharmaceutical Co., Ltd. Gen que codifica glicosil-transferasa, y su utilizacion.
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles

Also Published As

Publication number Publication date
EP1264836B1 (de) 2004-12-01
AU2353595A (en) 1995-11-29
HK1000890A1 (en) 2004-01-09
PT1264836E (pt) 2005-02-28
EP0760375A4 (de) 2002-03-27
KR100312473B1 (ko) 2002-06-24
ATE255121T1 (de) 2003-12-15
JP3038921B2 (ja) 2000-05-08
DK0760375T3 (da) 2003-12-29
DK1264836T3 (da) 2005-03-07
EP0760375A1 (de) 1997-03-05
DE69532198T2 (de) 2004-08-26
KR970702869A (ko) 1997-06-10
CA2190007A1 (en) 1995-11-16
DE69533833D1 (de) 2005-01-05
TW313566B (de) 1997-08-21
ES2230433T3 (es) 2005-05-01
HK1067948A1 (en) 2005-04-22
PT760375E (pt) 2004-04-30
EP1264836A1 (de) 2002-12-11
AU683749B2 (en) 1997-11-20
CN1106400C (zh) 2003-04-23
DE69533833T2 (de) 2005-12-15
ES2206501T3 (es) 2004-05-16
EP0760375B1 (de) 2003-11-26
CN1285605C (zh) 2006-11-22
CN1513865A (zh) 2004-07-21
CL2004001117A1 (es) 2005-04-22
DE69532198D1 (de) 2004-01-08
CA2190007C (en) 2003-04-15
CN1153518A (zh) 1997-07-02

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