ES2174921T3 - Inhibidores de la proteasa del vih. - Google Patents
Inhibidores de la proteasa del vih.Info
- Publication number
- ES2174921T3 ES2174921T3 ES95905886T ES95905886T ES2174921T3 ES 2174921 T3 ES2174921 T3 ES 2174921T3 ES 95905886 T ES95905886 T ES 95905886T ES 95905886 T ES95905886 T ES 95905886T ES 2174921 T3 ES2174921 T3 ES 2174921T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- hiv protease
- compounds
- protease inhibitors
- aids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE PRESENTAN COMPUESTOS DE LA FORMULA (I) QUE SON INHIBIDORES DE LA PROTEASA DEL VIH. ESTOS COMPUESTOS SON UTILES EN LA PREVENCION O EL TRATAMIENTO DE INFECCIONES POR VIH Y EN EL TRATAMIENTO DEL SIDA, TANTO COMO COMPUESTOS, SALES FARMACOLOGICAMENTE ACEPTABLES, INGREDIENTES PARA COMPOSICIONES FARMACEUTICAS, COMBINADOS O NO CON OTROS AGENTES ANTIVIRALES, INMUNOMODULADORES, ANTIBIOTICOS O VACUNAS. TAMBIEN SE DESCRIBEN METODOS PARA EL TRATAMIENTO DEL SIDA Y METODOS PARA EVITAR O TRATAR LAS INFECCIONES POR VIH.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16801393A | 1993-12-15 | 1993-12-15 | |
US17047593A | 1993-12-20 | 1993-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2174921T3 true ES2174921T3 (es) | 2002-11-16 |
Family
ID=26863718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95905886T Expired - Lifetime ES2174921T3 (es) | 1993-12-15 | 1994-12-12 | Inhibidores de la proteasa del vih. |
Country Status (19)
Country | Link |
---|---|
US (2) | US5646148A (es) |
EP (1) | EP0734387B1 (es) |
JP (1) | JP3000564B2 (es) |
KR (1) | KR100234863B1 (es) |
CN (1) | CN1046727C (es) |
AT (1) | ATE215952T1 (es) |
AU (1) | AU692509B2 (es) |
BG (1) | BG62093B1 (es) |
BR (1) | BR9408305A (es) |
CA (1) | CA2178760C (es) |
CZ (1) | CZ288312B6 (es) |
DE (1) | DE69430385T2 (es) |
ES (1) | ES2174921T3 (es) |
FI (1) | FI962488A (es) |
HU (1) | HUT74681A (es) |
NZ (1) | NZ278201A (es) |
PL (1) | PL314984A1 (es) |
SK (1) | SK75796A3 (es) |
WO (1) | WO1995016688A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69634959T2 (de) | 1995-11-13 | 2006-05-24 | Vitaleech Bioscience N.V. | Antivirale isolate von blutegeln |
MY126358A (en) * | 1996-03-22 | 2006-09-29 | Glaxo Group Ltd | Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs |
ZA984514B (en) * | 1997-05-29 | 1998-11-30 | Merck & Co Inc | Hiv protease inhibitor |
TW438799B (en) * | 1997-05-29 | 2001-06-07 | Merck & Co Inc | HIV protease inhibitor |
US6180634B1 (en) | 1997-11-13 | 2001-01-30 | Merck & Co., Inc. | Combination therapy for the treatment of AIDS |
CO4970782A1 (es) * | 1997-11-13 | 2000-11-07 | Merck & Co Inc | Terapia combinada para el tratamiento del sida |
US6251906B1 (en) | 1998-05-15 | 2001-06-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
FR2780649B1 (fr) | 1998-07-06 | 2001-03-09 | Univ Paris Vii Denis Diderot | Derives de la piperazine pour l'inhibition de la replication du virus de l'immunodeficience humaine |
GB2341385A (en) | 1998-09-14 | 2000-03-15 | Merck & Co Inc | Recovery of iodide from chemical process waste water |
US6440946B1 (en) * | 1999-02-25 | 2002-08-27 | Takeda Chemical Industries, Ltd. | Multiple-agents-binding compound, production and use thereof |
US6589962B1 (en) | 1999-07-20 | 2003-07-08 | Merck & Co., Inc. | Alpha-hydroxy-gamma-[[(carbocyclic-or heterocyclic-substituted)amino]carbonyl]alkanamide derivatives and uses thereof |
ES2295068T3 (es) | 1999-11-24 | 2008-04-16 | MERCK & CO., INC. | Gamma-hidroxi-2-(fluoroalquilaminocarbonil)-1-piperazinpentanamidas como inhibidores de la proteasa del vih. |
US6482952B2 (en) | 2000-06-20 | 2002-11-19 | Merck & Co., Inc. | Process for preparing acetonides |
US7049146B2 (en) | 2000-11-14 | 2006-05-23 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
US7122376B2 (en) * | 2001-11-01 | 2006-10-17 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
US20040131504A1 (en) * | 2002-09-17 | 2004-07-08 | Landers James P. | Remote temperature sensing of small volume and related apparatus thereof |
GB0720503D0 (en) * | 2007-10-22 | 2007-11-28 | Angeletti P Ist Richerche Bio | New compound |
EP2579892A2 (en) | 2010-06-09 | 2013-04-17 | Vaccine Technologies, Incorporated | Therapeutic immunization in hiv infected subjects receiving stable antiretroviral treatment |
CN108178764A (zh) * | 2018-01-09 | 2018-06-19 | 天津科技大学 | 呋喃并[2,3-b]吡啶类化合物及无金属催化的合成方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
WO1993008184A1 (en) * | 1991-10-23 | 1993-04-29 | Merck & Co., Inc. | Hiv protease inhibitors |
US5413999A (en) * | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
CA2081970C (en) * | 1991-11-08 | 1997-07-08 | Joseph P. Vacca | Hiv protease inhibitors useful for the treatment of aids |
SK279471B6 (sk) * | 1993-03-31 | 1998-11-04 | Merck & Co. | Kompozícia zlúčenín, farmaceutické prostriedky s i |
-
1994
- 1994-12-12 AU AU14331/95A patent/AU692509B2/en not_active Ceased
- 1994-12-12 BR BR9408305A patent/BR9408305A/pt not_active Application Discontinuation
- 1994-12-12 WO PCT/US1994/014187 patent/WO1995016688A1/en active Search and Examination
- 1994-12-12 JP JP7516855A patent/JP3000564B2/ja not_active Expired - Fee Related
- 1994-12-12 SK SK757-96A patent/SK75796A3/sk unknown
- 1994-12-12 NZ NZ278201A patent/NZ278201A/en unknown
- 1994-12-12 CA CA002178760A patent/CA2178760C/en not_active Expired - Fee Related
- 1994-12-12 AT AT95905886T patent/ATE215952T1/de not_active IP Right Cessation
- 1994-12-12 PL PL94314984A patent/PL314984A1/xx unknown
- 1994-12-12 ES ES95905886T patent/ES2174921T3/es not_active Expired - Lifetime
- 1994-12-12 KR KR1019960703165A patent/KR100234863B1/ko not_active IP Right Cessation
- 1994-12-12 DE DE69430385T patent/DE69430385T2/de not_active Expired - Fee Related
- 1994-12-12 EP EP95905886A patent/EP0734387B1/en not_active Expired - Lifetime
- 1994-12-12 CZ CZ19961586A patent/CZ288312B6/cs not_active IP Right Cessation
- 1994-12-12 HU HU9601649A patent/HUT74681A/hu unknown
- 1994-12-12 CN CN94194954A patent/CN1046727C/zh not_active Expired - Fee Related
-
1995
- 1995-03-29 US US08/412,509 patent/US5646148A/en not_active Expired - Fee Related
-
1996
- 1996-06-05 BG BG100643A patent/BG62093B1/bg unknown
- 1996-06-14 FI FI962488A patent/FI962488A/fi unknown
-
1997
- 1997-04-08 US US08/825,787 patent/US5807841A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR100234863B1 (ko) | 1999-12-15 |
SK75796A3 (en) | 1997-05-07 |
PL314984A1 (en) | 1996-09-30 |
ATE215952T1 (de) | 2002-04-15 |
US5646148A (en) | 1997-07-08 |
HU9601649D0 (en) | 1996-08-28 |
BR9408305A (pt) | 1997-08-26 |
CN1046727C (zh) | 1999-11-24 |
FI962488A0 (fi) | 1996-06-14 |
CA2178760C (en) | 2000-08-01 |
EP0734387B1 (en) | 2002-04-10 |
US5807841A (en) | 1998-09-15 |
AU1433195A (en) | 1995-07-03 |
NZ278201A (en) | 1998-01-26 |
WO1995016688A1 (en) | 1995-06-22 |
JP3000564B2 (ja) | 2000-01-17 |
CZ288312B6 (en) | 2001-05-16 |
CA2178760A1 (en) | 1995-06-22 |
EP0734387A1 (en) | 1996-10-02 |
AU692509B2 (en) | 1998-06-11 |
DE69430385T2 (de) | 2002-11-07 |
BG100643A (bg) | 1997-02-28 |
JPH09506619A (ja) | 1997-06-30 |
BG62093B1 (bg) | 1999-02-26 |
FI962488A (fi) | 1996-06-14 |
DE69430385D1 (de) | 2002-05-16 |
CZ158696A3 (en) | 1996-11-13 |
HUT74681A (en) | 1997-01-28 |
CN1142827A (zh) | 1997-02-12 |
EP0734387A4 (en) | 1997-03-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2174921T3 (es) | Inhibidores de la proteasa del vih. | |
ES2125251T3 (es) | Inhibidores de la proteasa del vih. | |
ES2177868T3 (es) | Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas. | |
MX9403380A (es) | Inhibidores de proteasa de vih utiles para el tratamiento de sida. | |
ES2181725T3 (es) | Inhibidores de hiv proteasa. | |
DE60214179D1 (de) | IMIDAZOi1,2-AöPYRIDIN-DERIVATE ZUR PROPHYLAXE UND BEHANDLUNG VON HERPES-INFEKTIONEN | |
BR112023020442A2 (pt) | Inibidor da protease 1 específica de ubiquitina (usp1) | |
ES2146300T3 (es) | Utilizacion de composiciones antihelminticas para el tratamiento de infecciones causadas por anoplocephala perfoliata en equidos. | |
EA200000594A1 (ru) | Новые макролиды | |
ES2178036T3 (es) | Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que le contienen. | |
ATE377011T1 (de) | Gamma-hydroxy-2-(fluoralkylaminocarbonyl)-1- piperazinpentanamide als hiv-proteasehemmer | |
MX9204720A (es) | Derivados de quinazolina como inhibidores de transcriptasa inversa de vih. | |
YU186291A (sh) | Novi derivati hidroksamske kiseline i n-hidroksikarbamida | |
ES2150933T3 (es) | Inhibidores de la proteasa vih utiles para el tratamiento del sida. | |
RU95107403A (ru) | Бензоксазиноновые соединения, фармацевтические композиции, способы ингибирования обратной транскритазы, профилактики или лечения, синергистические комбинации и способ получения (-)-6-хлор-4-циклопропилэтинил-4-трифторметил-1,4-дигидро-2н-3,1-бензоксазин-2-она | |
AR030068A1 (es) | Composiciones farmaceuticas para el tratamiento de condiciones dolorosas, inflamatorias y ulcerosas de superficies epiteliales humedas como por ejemplo mucositis, estomatitis y sindrome de behcet | |
ES2101252T3 (es) | Inhibidores de la proteasa del hiv utiles para el tratamiento del sida. | |
ATE364043T1 (de) | Pyrazolo-pyridine für die behandlung von herpes- ansteckungen | |
CR20230100A (es) | Compuestos fosfolípidos y usos de los mismos | |
AR019496A1 (es) | Azalidas de 13 miembros, composiciones farmaceuticas, uso en la preparacion de medicamentos y preparacion de los mismos | |
CO4130200A1 (es) | Inhibidores de proteasa del hiv utiles en el tratamiento del sida | |
MX9302681A (es) | Nuevas quinazolinas como inhibidores de transcriptasa inversa hiv. | |
ES2096874T3 (es) | Inhibidor de la proteasa de hiv util para el tratamiento del sida. | |
EA200001029A1 (ru) | Производные гигромицина | |
DE50113974D1 (de) | Kombinationspräparate von 3-n-formylhydroxylaminopropylphosphonsäurederivaten oder 3-n-acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 734387 Country of ref document: ES |