DE60026155D1 - Einige alkylendiamin-substituierte heterocyclen - Google Patents
Einige alkylendiamin-substituierte heterocyclenInfo
- Publication number
- DE60026155D1 DE60026155D1 DE60026155T DE60026155T DE60026155D1 DE 60026155 D1 DE60026155 D1 DE 60026155D1 DE 60026155 T DE60026155 T DE 60026155T DE 60026155 T DE60026155 T DE 60026155T DE 60026155 D1 DE60026155 D1 DE 60026155D1
- Authority
- DE
- Germany
- Prior art keywords
- alkylendiamine
- substituted heterocycles
- novel compounds
- neuropeptide
- vii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/5755—Neuropeptide Y
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15687099P | 1999-09-30 | 1999-09-30 | |
US156870P | 1999-09-30 | ||
PCT/US2000/026886 WO2001023389A2 (en) | 1999-09-30 | 2000-09-29 | Certain alkylene diamine-substituted heterocycles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60026155D1 true DE60026155D1 (de) | 2006-04-27 |
DE60026155T2 DE60026155T2 (de) | 2006-08-10 |
Family
ID=22561438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60026155T Expired - Fee Related DE60026155T2 (de) | 1999-09-30 | 2000-09-29 | Einige alkylendiamin-substituierte heterocyclen |
Country Status (21)
Country | Link |
---|---|
US (3) | US6506762B1 (de) |
EP (1) | EP1224187B1 (de) |
JP (2) | JP2003510327A (de) |
KR (1) | KR20020043223A (de) |
CN (1) | CN1377356A (de) |
AT (1) | ATE318267T1 (de) |
AU (1) | AU7738000A (de) |
BG (1) | BG106508A (de) |
CA (1) | CA2379640C (de) |
CZ (1) | CZ20021086A3 (de) |
DE (1) | DE60026155T2 (de) |
EA (1) | EA200200424A1 (de) |
ES (1) | ES2258476T3 (de) |
HU (1) | HUP0202636A3 (de) |
IL (1) | IL148903A0 (de) |
NO (1) | NO20021358L (de) |
NZ (1) | NZ517575A (de) |
OA (1) | OA12050A (de) |
PL (1) | PL354784A1 (de) |
WO (1) | WO2001023389A2 (de) |
ZA (1) | ZA200202518B (de) |
Families Citing this family (150)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000064880A1 (en) | 1999-04-22 | 2000-11-02 | Synaptic Pharmaceutical Corporation | Selective npy (y5) antagonists |
US6989379B1 (en) | 1999-04-22 | 2006-01-24 | H. Lundbick A/S | Selective NPY (Y5) antagonists |
US6340683B1 (en) | 1999-04-22 | 2002-01-22 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (triazines) |
US7273880B2 (en) | 1999-06-30 | 2007-09-25 | H. Lunbeck A/S | Selective NPY (Y5) antagonists |
US6506762B1 (en) * | 1999-09-30 | 2003-01-14 | Neurogen Corporation | Certain alkylene diamine-substituted heterocycles |
US6372743B1 (en) * | 1999-09-30 | 2002-04-16 | Neurogen Corporation | Certain alkylene diamine-substituted pyrazlo (1,5-a)-1,5-pyrimidines and pyrazolo (1,5-a) 1,3,5-triazines |
EP1263768A4 (de) * | 2000-01-28 | 2004-05-12 | Neurogen Corp | Chimäre neuropeptid y rezeptoren |
YU83302A (sh) * | 2000-06-26 | 2005-09-19 | Pfizer Products Inc. | Jedinjenja pirolo (2,3-d) pirimidina kao imunosupresivni agensi |
JP2004520299A (ja) | 2000-12-12 | 2004-07-08 | ニューロジェン・コーポレーション | スピロ[イソベンゾフラン−1,4’−ピペリジン]−3−オン類及び3h−スピロイソベンゾフラン−1,4’−ピペリジン類 |
HUP0304054A2 (hu) | 2001-04-30 | 2004-04-28 | Glaxo Group Limited | A kortikotropin-realising faktor (CRF) antagonistáiként alkalmazható kondenzált pirimidinek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
CN100343258C (zh) * | 2001-04-30 | 2007-10-17 | 美国拜尔公司 | 新的4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物 |
JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
US7458374B2 (en) * | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
WO2002094242A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of rizatriptan or zolmitriptan through an inhalation route |
US7090830B2 (en) * | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
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-
2000
- 2000-09-29 US US09/676,941 patent/US6506762B1/en not_active Expired - Fee Related
- 2000-09-29 CN CN00813704A patent/CN1377356A/zh active Pending
- 2000-09-29 KR KR1020027004150A patent/KR20020043223A/ko not_active Application Discontinuation
- 2000-09-29 DE DE60026155T patent/DE60026155T2/de not_active Expired - Fee Related
- 2000-09-29 CA CA002379640A patent/CA2379640C/en not_active Expired - Fee Related
- 2000-09-29 ES ES00967133T patent/ES2258476T3/es not_active Expired - Lifetime
- 2000-09-29 PL PL00354784A patent/PL354784A1/xx not_active Application Discontinuation
- 2000-09-29 AU AU77380/00A patent/AU7738000A/en not_active Abandoned
- 2000-09-29 NZ NZ517575A patent/NZ517575A/en unknown
- 2000-09-29 CZ CZ20021086A patent/CZ20021086A3/cs unknown
- 2000-09-29 OA OA1200200089A patent/OA12050A/en unknown
- 2000-09-29 EA EA200200424A patent/EA200200424A1/ru unknown
- 2000-09-29 AT AT00967133T patent/ATE318267T1/de not_active IP Right Cessation
- 2000-09-29 EP EP00967133A patent/EP1224187B1/de not_active Expired - Lifetime
- 2000-09-29 IL IL14890300A patent/IL148903A0/xx unknown
- 2000-09-29 WO PCT/US2000/026886 patent/WO2001023389A2/en active IP Right Grant
- 2000-09-29 JP JP2001526541A patent/JP2003510327A/ja active Pending
- 2000-09-29 HU HU0202636A patent/HUP0202636A3/hu unknown
-
2002
- 2002-03-11 BG BG106508A patent/BG106508A/xx unknown
- 2002-03-19 NO NO20021358A patent/NO20021358L/no not_active Application Discontinuation
- 2002-03-28 ZA ZA200202518A patent/ZA200202518B/xx unknown
- 2002-11-08 US US10/291,446 patent/US6696445B2/en not_active Expired - Fee Related
-
2003
- 2003-11-10 US US10/705,446 patent/US7074929B2/en not_active Expired - Fee Related
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2007
- 2007-08-22 JP JP2007215782A patent/JP2008007515A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA200202518B (en) | 2003-08-27 |
OA12050A (en) | 2006-05-02 |
ATE318267T1 (de) | 2006-03-15 |
CA2379640C (en) | 2006-11-28 |
EA200200424A1 (ru) | 2002-12-26 |
IL148903A0 (en) | 2002-09-12 |
US20030158197A1 (en) | 2003-08-21 |
WO2001023389A2 (en) | 2001-04-05 |
US6506762B1 (en) | 2003-01-14 |
HUP0202636A3 (en) | 2004-06-28 |
US20040229870A1 (en) | 2004-11-18 |
WO2001023389A3 (en) | 2002-05-10 |
NO20021358L (no) | 2002-05-27 |
NO20021358D0 (no) | 2002-03-19 |
ES2258476T3 (es) | 2006-09-01 |
US6696445B2 (en) | 2004-02-24 |
EP1224187B1 (de) | 2006-02-22 |
US7074929B2 (en) | 2006-07-11 |
AU7738000A (en) | 2001-04-30 |
JP2008007515A (ja) | 2008-01-17 |
CZ20021086A3 (cs) | 2002-10-16 |
EP1224187A2 (de) | 2002-07-24 |
JP2003510327A (ja) | 2003-03-18 |
CA2379640A1 (en) | 2001-04-05 |
CN1377356A (zh) | 2002-10-30 |
NZ517575A (en) | 2004-04-30 |
DE60026155T2 (de) | 2006-08-10 |
HUP0202636A2 (hu) | 2002-12-28 |
KR20020043223A (ko) | 2002-06-08 |
PL354784A1 (en) | 2004-02-23 |
BG106508A (en) | 2003-02-28 |
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