JP2005514336A5

JP2005514336A5 -

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Publication number: JP2005514336A5
Authority: JP; Japan
Prior art keywords: residue; alkyl; mmol; acyl; residues
Prior art date: 2002-08-09
Legal status : Pending

Application number

JP2003536263A

Other languages

English (en)

Japanese (ja)

Other versions

JP2005514336A (ja

Filing date

2002-08-09

Publication date

2006-01-05

2001-10-12 Priority claimed from DE10150203A external-priority patent/DE10150203A1/de

2002-08-09 Application filed filed Critical

2005-05-19 Publication of JP2005514336A publication Critical patent/JP2005514336A/ja

2006-01-05 Publication of JP2005514336A5 publication Critical patent/JP2005514336A5/ja

Status Pending legal-status Critical Current

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150000001875 compounds Chemical class 0.000 claims description 82
125000000217 alkyl group Chemical group 0.000 claims description 50
230000000694 effects Effects 0.000 claims description 45
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 30
239000008103 glucose Substances 0.000 claims description 30
150000003839 salts Chemical class 0.000 claims description 30
125000002252 acyl group Chemical group 0.000 claims description 28
206010012601 diabetes mellitus Diseases 0.000 claims description 28
-1 N-protected amino Chemical group 0.000 claims description 21
125000003118 aryl group Chemical group 0.000 claims description 21
108090000765 processed proteins & peptides Proteins 0.000 claims description 20
150000001413 amino acids Chemical class 0.000 claims description 18
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
108010016626 Dipeptides Proteins 0.000 claims description 17
125000000539 amino acid group Chemical group 0.000 claims description 17
125000001072 heteroaryl group Chemical group 0.000 claims description 16
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 16
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JP2003536263A 2001-10-12 2002-08-09 Ｄｐｉｖ阻害剤としてのペプチジルケトン Pending JP2005514336A (ja)