JP2004502761A - ウイルスポリメラーゼ阻害剤 - Google Patents

ウイルスポリメラーゼ阻害剤 Download PDF

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Publication number
JP2004502761A
JP2004502761A JP2002509292A JP2002509292A JP2004502761A JP 2004502761 A JP2004502761 A JP 2004502761A JP 2002509292 A JP2002509292 A JP 2002509292A JP 2002509292 A JP2002509292 A JP 2002509292A JP 2004502761 A JP2004502761 A JP 2004502761A
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Prior art keywords
alkyl
cooh
aryl
phenyl
alkenyl
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Pending
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JP2002509292A
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Japanese (ja)
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JP2004502761A5 (enExample
Inventor
ボーリウー　ピエール　ルイ
ファザル　ギュルレズ
ジラール　ジャメ
クコリ　ジョルジュ
アウステル　フォルクハルト
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ベーリンガー　インゲルハイム　（カナダ）　リミテッド
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Publication of JP2004502761A publication Critical patent/JP2004502761A/ja
Publication of JP2004502761A5 publication Critical patent/JP2004502761A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2002509292A 2000-07-06 2001-07-04 ウイルスポリメラーゼ阻害剤 Pending JP2004502761A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21608400P 2000-07-06 2000-07-06
US27437401P 2001-03-08 2001-03-08
US28134301P 2001-04-05 2001-04-05
PCT/CA2001/000989 WO2002004425A2 (en) 2000-07-06 2001-07-04 Viral polymerase inhibitors

Publications (2)

Publication Number Publication Date
JP2004502761A true JP2004502761A (ja) 2004-01-29
JP2004502761A5 JP2004502761A5 (enExample) 2010-09-09

Family

ID=27396228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002509292A Pending JP2004502761A (ja) 2000-07-06 2001-07-04 ウイルスポリメラーゼ阻害剤

Country Status (11)

Country Link
US (4) US6448281B1 (enExample)
EP (1) EP1301487B1 (enExample)
JP (1) JP2004502761A (enExample)
AR (1) AR035038A1 (enExample)
AT (1) ATE346049T1 (enExample)
AU (1) AU2001272258A1 (enExample)
CA (1) CA2412718C (enExample)
DE (1) DE60124718T2 (enExample)
ES (1) ES2276803T3 (enExample)
MX (1) MXPA02012906A (enExample)
WO (1) WO2002004425A2 (enExample)

Cited By (12)

* Cited by examiner, † Cited by third party
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JP2005501827A (ja) * 2001-07-20 2005-01-20 ベーリンガー インゲルハイム （カナダ） リミテッド ウイルスポリメラーゼインヒビター
JP2006077004A (ja) * 2004-08-11 2006-03-23 Chugai Pharmaceut Co Ltd 抗ｈｃｖ作用を有する化合物およびそれを含む医薬組成物
WO2007043653A1 (ja) * 2005-10-13 2007-04-19 Taisho Pharmaceutical Co., Ltd. ベンゾイミダゾール－５－カルボキサミド誘導体
JP2007537163A (ja) * 2004-05-06 2007-12-20 サイトキネティクス・インコーポレーテッド 化合物、組成物、および方法
JP2008506638A (ja) * 2004-07-16 2008-03-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
JP2009525287A (ja) * 2006-02-03 2009-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
JP2011503119A (ja) * 2007-11-16 2011-01-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ヒト免疫不全ウイルス複製のインヒビター
JP2011530531A (ja) * 2008-08-07 2011-12-22 ブリストル−マイヤーズ スクイブ カンパニー Ｃ型肝炎ウイルス阻害剤としてのｂｉ−１ｈ−ベンズアミダゾール
JP2013532725A (ja) * 2010-08-04 2013-08-19 ブリストル−マイヤーズ スクイブ カンパニー Ｃ型肝炎ウイルス阻害剤
JP2018520105A (ja) * 2015-05-21 2018-07-26 グラクソスミスクライン、インテレクチュアル、プロパテ Ｐａｄ４阻害剤としてのベンゾイミダゾール誘導体
JP2018522886A (ja) * 2015-07-07 2018-08-16 バイエル・ファルマ・アクティエンゲゼルシャフト ｍＩＤＨ１阻害剤としての２−アリール−および２−アリールアルキル−ベンズイミダゾール
JP2020503314A (ja) * 2016-12-23 2020-01-30 アクイナ ファーマシューティカルズ， インコーポレイテッド 化合物、組成物、および使用方法

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US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
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