|
US6770666B2
(en)
|
1999-12-27 |
2004-08-03 |
Japan Tobacco Inc. |
Fused-ring compounds and use thereof as drugs
|
|
SK13752001A3
(sk)
*
|
1999-12-27 |
2002-07-02 |
Japan Tobacco, Inc. |
Zlúčeniny s fúzovanými kruhmi a ich použitie ako liečiv
|
|
US6448281B1
(en)
*
|
2000-07-06 |
2002-09-10 |
Boehringer Ingelheim (Canada) Ltd. |
Viral polymerase inhibitors
|
|
US20020165781A1
(en)
*
|
2000-10-31 |
2002-11-07 |
Mckay Brent |
Interactive media management system and method for network applications
|
|
US7157487B2
(en)
*
|
2000-12-28 |
2007-01-02 |
Daiichi Pharmaceutical Co., Ltd. |
Vla-4 inhibitors
|
|
EP1382603B1
(en)
*
|
2001-04-26 |
2008-07-23 |
Eisai R&D Management Co., Ltd. |
Nitrogenous fused-ring compound having pyrazolyl group as substituent and medicinal composition thereof
|
|
US7030150B2
(en)
*
|
2001-05-11 |
2006-04-18 |
Trimeris, Inc. |
Benzimidazole compounds and antiviral uses thereof
|
|
AR035543A1
(es)
*
|
2001-06-26 |
2004-06-16 |
Japan Tobacco Inc |
Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
|
|
CA2448737C
(en)
|
2001-07-20 |
2010-06-01 |
Boehringer Ingelheim (Canada) Ltd. |
Viral polymerase inhibitors
|
|
EP2335700A1
(en)
*
|
2001-07-25 |
2011-06-22 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C virus polymerase inhibitors with a heterobicylic structure
|
|
US7294457B2
(en)
*
|
2001-08-07 |
2007-11-13 |
Boehringer Ingelheim (Canada) Ltd. |
Direct binding assay for identifying inhibitors of HCV polymerase
|
|
US6869964B2
(en)
|
2002-05-20 |
2005-03-22 |
Bristol-Myers Squibb Company |
Heterocyclicsulfonamide hepatitis C virus inhibitors
|
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
|
WO2004043339A2
(en)
|
2002-05-20 |
2004-05-27 |
Bristol-Myers Squibb Company |
Substituted cycloalkyl p1' hepatitis c virus inhibitors
|
|
US7041698B2
(en)
|
2002-05-20 |
2006-05-09 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
TW200400818A
(en)
|
2002-05-21 |
2004-01-16 |
Wyeth Corp |
Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus
|
|
TW200400963A
(en)
|
2002-05-21 |
2004-01-16 |
Wyeth Corp |
R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
|
|
CA2487211C
(en)
*
|
2002-06-04 |
2010-09-14 |
Neogenesis Pharmaceuticals, Inc. |
Pyrazolo(1,5a) pyrimidine compounds as antiviral agents
|
|
MXPA05000255A
(es)
|
2002-07-01 |
2005-07-15 |
Pharmacia & Upjohn Co Llc |
Inhibidores de polimerasa de ns5b de hcv.
|
|
EP1532128A1
(en)
|
2002-07-01 |
2005-05-25 |
Pharmacia & Upjohn Company LLC |
Inhibitors of hcv ns5b polymerase
|
|
GB0215293D0
(en)
|
2002-07-03 |
2002-08-14 |
Rega Foundation |
Viral inhibitors
|
|
US6812363B2
(en)
*
|
2002-10-15 |
2004-11-02 |
Usv Limited |
Racemization of optically active 2-substituted phenyl glycine esters
|
|
AU2003286776A1
(en)
*
|
2002-10-30 |
2004-06-07 |
Guilford Pharmaceuticals Inc. |
Novel inhibitors of dipeptidyl peptidase iv
|
|
US7902203B2
(en)
|
2002-11-01 |
2011-03-08 |
Abbott Laboratories, Inc. |
Anti-infective agents
|
|
US7151114B2
(en)
|
2003-01-09 |
2006-12-19 |
Boehringer Ingelheim International Gmbh |
Use of substituted 2-phenylbenzimidazoles as medicaments
|
|
US7223785B2
(en)
*
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US7098231B2
(en)
*
|
2003-01-22 |
2006-08-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
GB0307891D0
(en)
*
|
2003-04-04 |
2003-05-14 |
Angeletti P Ist Richerche Bio |
Chemical compounds,compositions and uses
|
|
DE602004019518D1
(de)
|
2003-04-16 |
2009-04-02 |
Bristol Myers Squibb Co |
Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus
|
|
KR101164070B1
(ko)
*
|
2003-05-09 |
2012-07-12 |
베링거 인겔하임 인터내셔날 게엠베하 |
C형 간염 바이러스 ns5b 폴리머라제 억제제 결합 포켓
|
|
SE0301446D0
(sv)
|
2003-05-16 |
2003-05-16 |
Astrazeneca Ab |
New Compounds
|
|
RU2375350C2
(ru)
*
|
2003-06-04 |
2009-12-10 |
Смитклайн Бичам Корпорейшн |
Азотсодержащие производные гетероарила
|
|
MXPA06000850A
(es)
|
2003-07-24 |
2006-03-30 |
Daiichi Seiyaku Co |
Compuesto de acido ciclohexancarboxilico.
|
|
CN1829709A
(zh)
*
|
2003-08-01 |
2006-09-06 |
健亚生物科技公司 |
对抗黄病毒的双环咪唑衍生物
|
|
WO2005014543A1
(ja)
*
|
2003-08-06 |
2005-02-17 |
Japan Tobacco Inc. |
縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用
|
|
US7521448B2
(en)
*
|
2003-08-21 |
2009-04-21 |
Osi Pharmaceuticals, Inc. |
N-substituted benzimidazolyl c-Kit inhibitors
|
|
EP1664032B1
(en)
|
2003-08-21 |
2008-11-05 |
OSI Pharmaceuticals, Inc. |
N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors
|
|
US7442709B2
(en)
|
2003-08-21 |
2008-10-28 |
Osi Pharmaceuticals, Inc. |
N3-substituted imidazopyridine c-Kit inhibitors
|
|
GB0321003D0
(en)
|
2003-09-09 |
2003-10-08 |
Angeletti P Ist Richerche Bio |
Compounds, compositions and uses
|
|
US7112601B2
(en)
*
|
2003-09-11 |
2006-09-26 |
Bristol-Myers Squibb Company |
Cycloalkyl heterocycles for treating hepatitis C virus
|
|
CN103145715B
(zh)
|
2003-10-14 |
2016-08-03 |
F·霍夫曼-罗须公司 |
作为hcv复制抑制剂的巨环羧酸和酰基磺酰胺
|
|
US7026339B2
(en)
|
2003-11-07 |
2006-04-11 |
Fan Yang |
Inhibitors of HCV NS5B polymerase
|
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7135462B2
(en)
|
2003-11-20 |
2006-11-14 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
US7309708B2
(en)
|
2003-11-20 |
2007-12-18 |
Birstol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
CA2548172A1
(en)
|
2003-12-04 |
2005-06-23 |
Vertex Pharmaceuticals Incorporated |
Quinoxalines useful as inhibitors of protein kinases
|
|
ES2381890T3
(es)
*
|
2003-12-22 |
2012-06-01 |
K.U.Leuven Research & Development |
Compuesto de imidazo[4,5-c]piridina y métodos de tratamiento antiviral
|
|
JP4682155B2
(ja)
|
2004-01-21 |
2011-05-11 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
C型肝炎ウイルスに対して活性な大環状ペプチド
|
|
US20050182252A1
(en)
|
2004-02-13 |
2005-08-18 |
Reddy K. R. |
Novel 2'-C-methyl nucleoside derivatives
|
|
IN2012DN04853A
(enExample)
*
|
2004-02-20 |
2015-09-25 |
Boehringer Ingelheim Int |
|
|
DE602005013922D1
(de)
|
2004-02-24 |
2009-05-28 |
Japan Tobacco Inc |
Kondensierte heterotetracyclische verbindungen und deren verwendung als hcv-polymerase-inhibitor
|
|
US20070049593A1
(en)
|
2004-02-24 |
2007-03-01 |
Japan Tobacco Inc. |
Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
|
|
US7618981B2
(en)
*
|
2004-05-06 |
2009-11-17 |
Cytokinetics, Inc. |
Imidazopyridinyl-benzamide anti-cancer agents
|
|
US7429604B2
(en)
*
|
2004-06-15 |
2008-09-30 |
Bristol Myers Squibb Company |
Six-membered heterocycles useful as serine protease inhibitors
|
|
JP5055564B2
(ja)
|
2004-06-15 |
2012-10-24 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Rna依存性rnaウイルスポリメラーゼの阻害剤としてのc−プリンヌクレオシド類似体
|
|
US20060040944A1
(en)
*
|
2004-06-23 |
2006-02-23 |
Gilles Gosselin |
5-Aza-7-deazapurine derivatives for treating Flaviviridae
|
|
EP1768954A4
(en)
|
2004-06-24 |
2008-05-28 |
Incyte Corp |
2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS
|
|
UY29017A1
(es)
|
2004-07-16 |
2006-02-24 |
Boehringer Ingelheim Int |
Inhibidores de polimerasa viral
|
|
US7790730B2
(en)
|
2004-07-27 |
2010-09-07 |
Gilead Sciences, Inc. |
Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
|
|
US7153848B2
(en)
|
2004-08-09 |
2006-12-26 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
JP2006077004A
(ja)
*
|
2004-08-11 |
2006-03-23 |
Chugai Pharmaceut Co Ltd |
抗hcv作用を有する化合物およびそれを含む医薬組成物
|
|
DE102004054054A1
(de)
*
|
2004-11-05 |
2006-05-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
|
|
US7659263B2
(en)
|
2004-11-12 |
2010-02-09 |
Japan Tobacco Inc. |
Thienopyrrole compound and use thereof as HCV polymerase inhibitor
|
|
CA2586334A1
(en)
*
|
2004-11-16 |
2006-06-08 |
Neurochem (International) Limited |
Compounds for the treatment of cns and amyloid associated diseases
|
|
AU2005312028A1
(en)
*
|
2004-12-01 |
2006-06-08 |
Osi Pharmaceuticals, Inc. |
N-substituted benzimidazolyl c-kit inhibitors and combinatorial benzimidazole library
|
|
PT1841765E
(pt)
*
|
2004-12-21 |
2009-05-14 |
Gilead Sciences Inc |
Anticorpos para mcp-1 humano
|
|
GB2438982A
(en)
|
2004-12-22 |
2007-12-12 |
Ambrx Inc |
Compostions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
WO2006076529A1
(en)
*
|
2005-01-14 |
2006-07-20 |
Genelabs Technologies, Inc. |
Indole derivatives for treating viral infections
|
|
WO2006093801A1
(en)
|
2005-02-25 |
2006-09-08 |
Abbott Laboratories |
Thiadiazine derivatives useful as anti-infective agents
|
|
JP2008535790A
(ja)
*
|
2005-03-03 |
2008-09-04 |
サートリス ファーマシューティカルズ, インコーポレイテッド |
サーチュインモジュレーターであるn−フェニルベンズアミド誘導体
|
|
EP1879885A1
(en)
|
2005-05-04 |
2008-01-23 |
F. Hoffmann-Roche AG |
Heterocyclic antiviral compounds
|
|
US7470664B2
(en)
|
2005-07-20 |
2008-12-30 |
Merck & Co., Inc. |
HCV NS3 protease inhibitors
|
|
JP4705984B2
(ja)
|
2005-08-01 |
2011-06-22 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Hcvns3プロテアーゼ阻害剤としての大環状ペプチド
|
|
AU2006278504B2
(en)
|
2005-08-04 |
2013-01-17 |
Sirtris Pharmaceuticals, Inc. |
Imidazopyridine derivatives as sirtuin modulating agents
|
|
US8088928B2
(en)
*
|
2005-08-04 |
2012-01-03 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US8093401B2
(en)
*
|
2005-08-04 |
2012-01-10 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US7855289B2
(en)
*
|
2005-08-04 |
2010-12-21 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
WO2007019674A1
(en)
|
2005-08-12 |
2007-02-22 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
GB0518390D0
(en)
*
|
2005-09-09 |
2005-10-19 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
US20090215857A1
(en)
*
|
2005-09-13 |
2009-08-27 |
Pfizer Products Inc. |
Therapeutic Pyrrolidines
|
|
JP2009001495A
(ja)
*
|
2005-10-13 |
2009-01-08 |
Taisho Pharmaceutical Co Ltd |
2−アリール−ベンゾイミダゾール−5−カルボキサミド誘導体
|
|
ATE500215T1
(de)
|
2005-11-08 |
2011-03-15 |
Ambrx Inc |
Beschleuniger für die modifikation nichtnatürlicher aminosäuren und nichtnatürlicher aminosäurepolypeptide
|
|
EP1968635B1
(en)
*
|
2005-12-14 |
2014-09-17 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
EP2345652A1
(en)
|
2005-12-21 |
2011-07-20 |
Abbott Laboratories |
Antiviral compounds
|
|
RU2441869C2
(ru)
|
2005-12-21 |
2012-02-10 |
Эбботт Лэборетриз |
Противовирусные соединения
|
|
EP1979349B1
(en)
|
2005-12-21 |
2010-07-28 |
Abbott Laboratories |
Anti-viral compounds
|
|
WO2007081517A2
(en)
|
2005-12-21 |
2007-07-19 |
Abbott Laboratories |
Anti-viral compounds
|
|
UY30048A1
(es)
*
|
2005-12-23 |
2007-07-31 |
Astrazeneca Ab |
Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
|
|
AU2006337137B2
(en)
*
|
2005-12-29 |
2012-06-14 |
Tersera Therapeutics Llc |
Multicyclic amino acid derivatives and methods of their use
|
|
US7816348B2
(en)
*
|
2006-02-03 |
2010-10-19 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US8017612B2
(en)
|
2006-04-18 |
2011-09-13 |
Japan Tobacco Inc. |
Piperazine compound and use thereof as a HCV polymerase inhibitor
|
|
GB0609492D0
(en)
|
2006-05-15 |
2006-06-21 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
GB0612423D0
(en)
|
2006-06-23 |
2006-08-02 |
Angeletti P Ist Richerche Bio |
Therapeutic agents
|
|
AR061969A1
(es)
*
|
2006-07-07 |
2008-08-10 |
Gilead Sciences Inc |
Derivados halogenados de imidazo-piridino, metodo de preparacion, composiciones farmaceuticas que los contienen y usos como agentes anti vhc
|
|
US20080051384A1
(en)
*
|
2006-07-14 |
2008-02-28 |
Genelabs Technologies, Inc. |
Antiviral agents
|
|
US7662958B2
(en)
|
2006-07-19 |
2010-02-16 |
Rolf Wagner |
Anti-infective agents
|
|
EP1886685A1
(en)
|
2006-08-11 |
2008-02-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition
|
|
TWI433839B
(zh)
*
|
2006-08-11 |
2014-04-11 |
Neomed Inst |
新穎的苯并咪唑衍生物290
|
|
BRPI0716060A2
(pt)
|
2006-08-17 |
2013-09-17 |
Boehringer Ingelheim Int |
inibidores de polimerase viral.
|
|
EP2084175B1
(en)
|
2006-10-10 |
2010-12-29 |
Medivir AB |
Hcv nucleoside inhibitor
|
|
EP2079480B1
(en)
|
2006-10-24 |
2013-06-05 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
|
AU2007309546A1
(en)
|
2006-10-24 |
2008-05-02 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
HCV NS3 protease inhibitors
|
|
AU2007309544B2
(en)
|
2006-10-24 |
2012-05-31 |
Msd Italia S.R.L. |
HCV NS3 protease inhibitors
|
|
EP2083844B1
(en)
|
2006-10-27 |
2013-11-27 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
|
AU2007318165B2
(en)
|
2006-10-27 |
2011-11-17 |
Msd Italia S.R.L. |
HCV NS3 protease inhibitors
|
|
EP2121707B1
(en)
|
2006-12-20 |
2012-12-05 |
Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. |
Antiviral indoles
|
|
WO2008133753A2
(en)
|
2006-12-20 |
2008-11-06 |
Abbott Laboratories |
Anti-viral compounds
|
|
GB0625345D0
(en)
|
2006-12-20 |
2007-01-31 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
|
AU2007342367B2
(en)
|
2007-01-05 |
2012-12-06 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
JP5211078B2
(ja)
|
2007-03-13 |
2013-06-12 |
ブリストル−マイヤーズ スクイブ カンパニー |
シクロプロピル縮合インドロベンズアゼピンhcvns5b阻害剤
|
|
EP2494991A1
(en)
|
2007-05-04 |
2012-09-05 |
Vertex Pharmaceuticals Incorporated |
Combination therapy for the treatment of HCV infection
|
|
CL2008001822A1
(es)
*
|
2007-06-20 |
2009-03-13 |
Sirtris Pharmaceuticals Inc |
Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
|
|
BRPI0813500A2
(pt)
|
2007-06-29 |
2015-01-06 |
Gilead Sciences Inc |
Compostos antivirais
|
|
JP5465667B2
(ja)
|
2007-06-29 |
2014-04-09 |
ギリアード サイエンシーズ, インコーポレイテッド |
抗ウイルス化合物
|
|
UA99466C2
(en)
|
2007-07-06 |
2012-08-27 |
Гилиад Сайенсиз, Инк. |
Crystalline pyridazine compound
|
|
CN101801982A
(zh)
|
2007-07-17 |
2010-08-11 |
P.安杰莱蒂分子生物学研究所 |
用于治疗丙型肝炎感染的大环吲哚衍生物
|
|
US8927569B2
(en)
|
2007-07-19 |
2015-01-06 |
Merck Sharp & Dohme Corp. |
Macrocyclic compounds as antiviral agents
|
|
EP2188274A4
(en)
*
|
2007-08-03 |
2011-05-25 |
Boehringer Ingelheim Int |
VIRAL POLYMERASE HEMMER
|
|
CA2693495A1
(en)
*
|
2007-08-03 |
2009-02-12 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US8940730B2
(en)
|
2007-09-18 |
2015-01-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions of treating a Flaviviridae family viral infection
|
|
US9101628B2
(en)
|
2007-09-18 |
2015-08-11 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and composition of treating a flaviviridae family viral infection
|
|
US9149463B2
(en)
|
2007-09-18 |
2015-10-06 |
The Board Of Trustees Of The Leland Standford Junior University |
Methods and compositions of treating a Flaviviridae family viral infection
|
|
JP5715820B2
(ja)
*
|
2007-09-18 |
2015-05-13 |
スタンフォード ユニバーシティー |
フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物
|
|
AU2008319267A1
(en)
*
|
2007-11-01 |
2009-05-07 |
Sirtris Pharmaceuticals, Inc. |
Amide derivatives as sirtuin modulators
|
|
EP2217606A1
(en)
*
|
2007-11-08 |
2010-08-18 |
Sirtris Pharmaceuticals, Inc. |
Solubilized thiazolopyridines
|
|
CA2705338A1
(en)
*
|
2007-11-16 |
2009-05-22 |
Boehringer Ingelheim International Gmbh |
Inhibitors of human immunodeficiency virus replication
|
|
CN101977621A
(zh)
|
2007-12-05 |
2011-02-16 |
益安药业 |
氟化三肽hcv丝氨酸蛋白酶抑制剂
|
|
EA201000948A1
(ru)
|
2007-12-19 |
2011-02-28 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Ингибиторы вирусной полимеразы
|
|
EP2250174B1
(en)
*
|
2008-02-04 |
2013-08-28 |
IDENIX Pharmaceuticals, Inc. |
Macrocyclic serine protease inhibitors
|
|
EP2271345B1
(en)
|
2008-04-28 |
2015-05-20 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
|
EP2540349B1
(en)
|
2008-07-22 |
2014-02-12 |
Merck Sharp & Dohme Corp. |
Pharmaceutical compositions comprising a macrocyclic quinoxaline compound which is an hcv ns3 protease inhibitor
|
|
US7906655B2
(en)
*
|
2008-08-07 |
2011-03-15 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
UA103195C2
(uk)
|
2008-08-11 |
2013-09-25 |
Глаксосмитклайн Ллк |
Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
|
|
CN102176911B
(zh)
|
2008-08-11 |
2014-12-10 |
葛兰素史密丝克莱恩有限责任公司 |
新的腺嘌呤衍生物
|
|
KR20110042116A
(ko)
|
2008-08-11 |
2011-04-22 |
글락소스미스클라인 엘엘씨 |
알레르기성, 염증성 및 감염성 질환의 치료에서 사용하기 위한 푸린 유도체
|
|
EP2341924A4
(en)
|
2008-10-02 |
2013-01-23 |
David Gladstone Inst |
METHOD FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS
|
|
WO2010065681A1
(en)
|
2008-12-03 |
2010-06-10 |
Presidio Pharmaceuticals, Inc. |
Inhibitors of hcv ns5a
|
|
CN104163816A
(zh)
|
2008-12-03 |
2014-11-26 |
普雷西迪奥制药公司 |
Hcv ns5a的抑制剂
|
|
CN102388054B
(zh)
|
2008-12-19 |
2015-03-04 |
西特里斯药业公司 |
噻唑并吡啶沉默调节蛋白调节剂的化合物
|
|
MX2011007195A
(es)
|
2009-01-07 |
2013-07-12 |
Scynexis Inc |
Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih).
|
|
JP2012514657A
(ja)
|
2009-01-09 |
2012-06-28 |
ユニバーシテイ・カレツジ・オブ・カーデイフ・コンサルタンツ・リミテツド |
ウィルス感染を治療するためのグアノシンヌクレオシド化合物のホスホルアミダート誘導体
|
|
WO2010082050A1
(en)
|
2009-01-16 |
2010-07-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
|
|
GB0900914D0
(en)
|
2009-01-20 |
2009-03-04 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
|
TWI438200B
(zh)
*
|
2009-02-17 |
2014-05-21 |
必治妥美雅史谷比公司 |
C型肝炎病毒抑制劑
|
|
TW201035083A
(en)
|
2009-03-06 |
2010-10-01 |
Hoffmann La Roche |
Heterocyclic antiviral compounds
|
|
EP2408449A4
(en)
|
2009-03-18 |
2012-08-08 |
Univ Leland Stanford Junior |
METHOD AND COMPOSITIONS FOR TREATING FLAVIVIRIDAE VIRUS INFECTIONS
|
|
KR20110131312A
(ko)
|
2009-03-27 |
2011-12-06 |
프레시디오 파마슈티칼스, 인코포레이티드 |
융합된 고리 c형 간염 억제제
|
|
US8377962B2
(en)
|
2009-04-08 |
2013-02-19 |
Idenix Pharmaceuticals, Inc. |
Macrocyclic serine protease inhibitors
|
|
WO2010122082A1
(en)
|
2009-04-25 |
2010-10-28 |
F. Hoffmann-La Roche Ag |
Heterocyclic antiviral compounds
|
|
MX2011012155A
(es)
|
2009-05-13 |
2012-02-28 |
Enanta Pharm Inc |
Compuestos macrociclicos como inhibidores del virus de hepatitis c.
|
|
WO2010149598A2
(en)
|
2009-06-24 |
2010-12-29 |
F. Hoffmann-La Roche Ag |
Heterocyclic antiviral compound
|
|
US8828930B2
(en)
|
2009-07-30 |
2014-09-09 |
Merck Sharp & Dohme Corp. |
Hepatitis C virus NS3 protease inhibitors
|
|
US9284307B2
(en)
|
2009-08-05 |
2016-03-15 |
Idenix Pharmaceuticals Llc |
Macrocyclic serine protease inhibitors
|
|
BR112012005616A2
(pt)
|
2009-09-21 |
2016-06-21 |
Hoffmann La Roche |
compostos antivirais heterocíclicos
|
|
AU2010303170B2
(en)
|
2009-10-11 |
2015-02-26 |
Rutgers, The State University Of New Jersey |
Biocompatible polymers for medical devices
|
|
US9169234B2
(en)
*
|
2009-10-15 |
2015-10-27 |
Children's Medical Center Corporation |
Sepiapterin reductase inhibitors for the treatment of pain
|
|
CN103079570A
(zh)
|
2009-11-06 |
2013-05-01 |
范德比尔特大学 |
芳基或者杂芳基砜类用作治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法
|
|
RU2012122637A
(ru)
|
2009-11-14 |
2013-12-20 |
Ф.Хоффманн-Ля Рош Аг |
Биомаркеры для прогнозирования быстрого ответа на лечение гепатита с
|
|
EP2501679A1
(en)
|
2009-11-21 |
2012-09-26 |
F. Hoffmann-La Roche AG |
Heterocyclic antiviral compounds
|
|
BR112012011393A2
(pt)
|
2009-12-02 |
2017-06-20 |
Hoffmann La Roche |
biomarcadores para a previsão da resposta sustentada ao tratamento de hcv
|
|
WO2011098451A1
(en)
|
2010-02-10 |
2011-08-18 |
Glaxosmithkline Llc |
Purine derivatives and their pharmaceutical uses
|
|
BR112012018904A2
(pt)
|
2010-02-10 |
2020-09-01 |
Glaxosmithkline Llc |
composto, adjuvante de vacina, composições imunogênica, de vacina e farmacêutica, e uso de um composto"
|
|
CA2800509A1
(en)
|
2010-05-24 |
2011-12-01 |
Presidio Pharmaceuticals, Inc. |
Inhibitors of hcv ns5a
|
|
EP2601188B1
(en)
*
|
2010-08-04 |
2017-10-18 |
Bristol-Myers Squibb Company |
Hepatitis c virus inhibitors
|
|
AR082619A1
(es)
|
2010-08-13 |
2012-12-19 |
Hoffmann La Roche |
Inhibidores del virus de la hepatitis c
|
|
GB201015411D0
(en)
|
2010-09-15 |
2010-10-27 |
Univ Leuven Kath |
Anti-cancer activity of novel bicyclic heterocycles
|
|
SG188618A1
(en)
|
2010-09-21 |
2013-04-30 |
Enanta Pharm Inc |
Macrocyclic proline derived hcv serine protease inhibitors
|
|
SG189985A1
(en)
|
2010-10-26 |
2013-06-28 |
Presidio Pharmaceuticals Inc |
Inhibitors of hepatitis c virus
|
|
EP2658857B1
(en)
|
2010-12-29 |
2016-11-02 |
Inhibitex, Inc. |
Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
|
|
US9353100B2
(en)
|
2011-02-10 |
2016-05-31 |
Idenix Pharmaceuticals Llc |
Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
|
|
WO2012107589A1
(en)
|
2011-02-11 |
2012-08-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment and prevention of hcv infections
|
|
WO2012123298A1
(en)
|
2011-03-11 |
2012-09-20 |
F. Hoffmann-La Roche Ag |
Antiviral compounds
|
|
EP2723717A2
(en)
|
2011-06-24 |
2014-04-30 |
Amgen Inc. |
Trpm8 antagonists and their use in treatments
|
|
WO2012175581A1
(en)
|
2011-06-24 |
2012-12-27 |
F. Hoffmann-La Roche Ag |
Antiviral compounds
|
|
MX2013015058A
(es)
|
2011-06-24 |
2014-01-20 |
Amgen Inc |
Antagonistas de melastatina 8 de potencial receptor transitorio y su uso en tratamientos.
|
|
EP2766365A1
(en)
|
2011-10-10 |
2014-08-20 |
F.Hoffmann-La Roche Ag |
Antiviral compounds
|
|
EP2780026B1
(en)
|
2011-11-15 |
2019-10-23 |
Merck Sharp & Dohme Corp. |
Hcv ns3 protease inhibitors
|
|
BR112014013649A2
(pt)
|
2011-12-06 |
2020-10-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
métodos e agentes para o tratamento de doenças virais e usos dos referidos agentes
|
|
RU2014127848A
(ru)
|
2011-12-16 |
2016-02-10 |
Ф. Хоффманн-Ля Рош Аг |
Ингибиторы hcv ns5a
|
|
US9108999B2
(en)
|
2011-12-20 |
2015-08-18 |
Riboscience Llc |
2′, 4′-difluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
|
|
PL2794628T3
(pl)
|
2011-12-20 |
2017-09-29 |
Riboscience Llc |
4'-azydo-3'-fluoro podstawione pochodne nukleozydów jako inhibitory replikacji RNA HCV
|
|
WO2013106344A1
(en)
|
2012-01-12 |
2013-07-18 |
Ligand Pharmaceuticals, Inc. |
2 '-c-methyl nucleosides containing a cyclic phosphate diester of 1, 3-propanediol (2-oxo-[1, 3, 2]-dioxaphosphorinane) at position 5'
|
|
US11472918B2
(en)
|
2012-02-03 |
2022-10-18 |
Rutgers, The State University Of New Jersey |
Polymeric biomaterials derived from phenolic monomers and their medical uses
|
|
WO2013116804A2
(en)
|
2012-02-03 |
2013-08-08 |
Rutgers, The State Of University Of New Jersey |
Polymeric biomaterials derived from phenolic monomers and their medical uses
|
|
WO2013124335A1
(en)
|
2012-02-24 |
2013-08-29 |
F. Hoffmann-La Roche Ag |
Antiviral compounds
|
|
US9580398B2
(en)
|
2012-04-02 |
2017-02-28 |
The Trustees Of Columbia University In The City Of New York |
Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
|
|
US20140010783A1
(en)
|
2012-07-06 |
2014-01-09 |
Hoffmann-La Roche Inc. |
Antiviral compounds
|
|
US8952009B2
(en)
|
2012-08-06 |
2015-02-10 |
Amgen Inc. |
Chroman derivatives as TRPM8 inhibitors
|
|
CN104603146B
(zh)
|
2012-09-29 |
2018-01-02 |
诺华股份有限公司 |
环肽类化合物及其作为药物的用途
|
|
CN103922999B
(zh)
*
|
2013-01-16 |
2016-05-04 |
上海医药工业研究院 |
一种达比加群酯中间体的制备方法及中间体化合物
|
|
EP2948440B1
(en)
|
2013-01-23 |
2017-04-12 |
F. Hoffmann-La Roche AG |
Antiviral triazole derivatives
|
|
WO2014121416A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
|
WO2014121418A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
|
WO2014121417A1
(en)
|
2013-02-07 |
2014-08-14 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
|
|
BR112015021429A2
(pt)
|
2013-03-05 |
2017-07-18 |
Hoffmann La Roche |
compostos antivirais
|
|
CN104030977B
(zh)
*
|
2013-03-07 |
2016-05-04 |
上海医药工业研究院 |
一种达比加群酯中间体的制备方法
|
|
RU2534613C2
(ru)
|
2013-03-22 |
2014-11-27 |
Александр Васильевич Иващенко |
Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения
|
|
BR112015028765A2
(pt)
|
2013-05-16 |
2017-07-25 |
Riboscience Llc |
derivados de nucleosídeo substituído 4'-azido, 3'-desoxi-3'-fluoro
|
|
SG11201509424VA
(en)
|
2013-05-16 |
2015-12-30 |
Riboscience Llc |
4'-fluor0-2'-methyl substituted nucleoside derivatives
|
|
US20180200280A1
(en)
|
2013-05-16 |
2018-07-19 |
Riboscience Llc |
4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
|
|
SG11201605810WA
(en)
|
2014-02-11 |
2016-08-30 |
Bayer Pharma AG |
Benzimidazol-2-amines as midh1 inhibitors
|
|
US9951027B2
(en)
|
2014-02-11 |
2018-04-24 |
Bayer Pharma Aktiengesellschaft |
Benzimidazol-2-amines as MIDH1 inhibitors
|
|
WO2015123352A1
(en)
|
2014-02-13 |
2015-08-20 |
Ligand Pharmaceuticals, Inc. |
Prodrug compounds and their uses
|
|
WO2015124591A1
(en)
|
2014-02-20 |
2015-08-27 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Pyrrolo[3,2] pyrimidine derivatives as inducers of human interferon
|
|
US9994600B2
(en)
|
2014-07-02 |
2018-06-12 |
Ligand Pharmaceuticals, Inc. |
Prodrug compounds and uses therof
|
|
CN107108554B
(zh)
|
2014-10-23 |
2020-11-06 |
德国癌症研究中心 |
作为midh1抑制剂用于治疗肿瘤的1-环己基-2-苯基氨基苯并咪唑
|
|
CA2965201A1
(en)
|
2014-10-23 |
2016-04-28 |
Bayer Pharma Aktiengesellschaft |
Benzimidazol-2-amines as midh1 inhibitors
|
|
US10584125B2
(en)
|
2014-11-13 |
2020-03-10 |
Glaxosmithkline Biologicals Sa |
Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions
|
|
US10774030B2
(en)
|
2014-12-23 |
2020-09-15 |
Rutgers, The State University Of New Jersey |
Polymeric biomaterials derived from phenolic monomers and their medical uses
|
|
CN107108863B
(zh)
|
2014-12-23 |
2021-03-19 |
新泽西鲁特格斯州立大学 |
生物相容性的碘化二酚单体和聚合物
|
|
US12091391B2
(en)
|
2015-04-30 |
2024-09-17 |
Oregon State University |
Reagents and methods for bioorthogonal labeling of biomolecules in living cells
|
|
CA3199601A1
(en)
*
|
2015-05-21 |
2016-11-24 |
Glaxosmithkline Intellectual Property Development Limited |
Benzoimidazole derivatives as pad4 inhibitors
|
|
JP6830909B2
(ja)
|
2015-06-08 |
2021-02-17 |
ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ |
mIDH1阻害剤としてのN−メンチルベンズイミダゾール
|
|
ES2877424T3
(es)
|
2015-07-07 |
2021-11-16 |
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts |
2-Aril- y 2-arilalquil-bencimidazoles como inhibidores de MIDH1
|
|
CN108026052B
(zh)
|
2015-07-16 |
2021-10-08 |
德国癌症研究公共权益基金会 |
作为mIDH1抑制剂的5-羟烷基苯并咪唑类
|
|
RU2020113165A
(ru)
|
2015-12-03 |
2020-06-09 |
Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед |
Циклические пуриновые динуклеотиды в качестве модуляторов sting
|
|
CN113549110B
(zh)
|
2016-04-07 |
2024-08-16 |
葛兰素史密斯克莱知识产权发展有限公司 |
用作蛋白质调节剂的杂环酰胺
|
|
JP2019510802A
(ja)
|
2016-04-07 |
2019-04-18 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
タンパク質調節物質として有用な複素環アミド
|
|
JP7299837B2
(ja)
|
2016-12-23 |
2023-06-28 |
アクイナ ファーマシューティカルズ, インコーポレイテッド |
化合物、組成物、および使用方法
|
|
GB201701087D0
(en)
|
2017-01-23 |
2017-03-08 |
Univ Leuven Kath |
Novel prodrugs of mizoribine
|
|
AU2018335411B2
(en)
|
2017-09-21 |
2024-06-27 |
Riboscience Llc |
4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
|
|
BR112020006780A2
(pt)
|
2017-10-05 |
2020-10-06 |
Glaxosmithkline Intellectual Property Development Limited |
moduladores do estimulador de genes do interferon (sting)
|
|
JP2020536106A
(ja)
|
2017-10-05 |
2020-12-10 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
Hivの処置に有用なインターフェロン遺伝子の刺激物質(sting)の調節物質
|
|
CN107602495B
(zh)
*
|
2017-10-13 |
2018-07-24 |
盐城工学院 |
一种制备手性氨基酸四氮唑类化合物的方法
|
|
AU2019207625A1
(en)
|
2018-01-09 |
2020-07-30 |
Ligand Pharmaceuticals, Inc. |
Acetal compounds and therapeutic uses thereof
|
|
GB201807924D0
(en)
|
2018-05-16 |
2018-06-27 |
Ctxt Pty Ltd |
Compounds
|
|
US20220099637A1
(en)
|
2018-12-04 |
2022-03-31 |
Bristol-Myers Squibb Company |
Methods of analysis using in-sample calibration curve by multiple isotopologue reaction monitoring
|
|
CN109942452B
(zh)
*
|
2019-03-01 |
2021-10-29 |
浙江工业大学 |
一种络氨酸烯烃化衍生物及其制备与应用
|
|
JP2022533390A
(ja)
|
2019-05-16 |
2022-07-22 |
スティングセラ インコーポレイテッド |
オキソアクリジニル酢酸誘導体および使用方法
|
|
EP3969452A1
(en)
|
2019-05-16 |
2022-03-23 |
Stingthera, Inc. |
Benzo[b][1,8]naphthyridine acetic acid derivatives and methods of use
|
|
GB201910304D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
GB201910305D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
CN110467539B
(zh)
*
|
2019-08-30 |
2023-01-06 |
浙江普洛家园药业有限公司 |
一种2,6-二甲基酪氨酸酯的拆分方法及其应用
|
|
CN114981265B
(zh)
|
2019-12-18 |
2025-01-03 |
Ctxt私人有限公司 |
化合物
|
|
TW202348228A
(zh)
|
2022-02-24 |
2023-12-16 |
德商艾斯巴赫生物有限公司 |
病毒組合療法
|
|
WO2025144935A1
(en)
*
|
2023-12-26 |
2025-07-03 |
Development Center For Biotechnology |
Heterocycle compounds as formyl peptide receptor modulators
|