US5719147A
(en)
*
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
ATE207917T1
(de)
*
|
1993-12-29 |
2001-11-15 |
Merck Sharp & Dohme |
Substituierte morpholinderivate und ihre verwendung als arzneimittel
|
IL112778A0
(en)
*
|
1994-03-04 |
1995-05-26 |
Merck & Co Inc |
Substituted heterocycles, their preparation and pharmaceutical compositions containing them
|
WO1995030674A1
(en)
*
|
1994-05-05 |
1995-11-16 |
Merck Sharp & Dohme Limited |
Morpholine derivatives and their use as antagonists of tachikinins
|
GB9505491D0
(en)
*
|
1995-03-18 |
1995-05-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9523244D0
(en)
*
|
1995-11-14 |
1996-01-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
US6117855A
(en)
*
|
1996-10-07 |
2000-09-12 |
Merck Sharp & Dohme Ltd. |
Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
|
US5750549A
(en)
*
|
1996-10-15 |
1998-05-12 |
Merck & Co., Inc. |
Cycloalkyl tachykinin receptor antagonists
|
US6100256A
(en)
*
|
1996-12-02 |
2000-08-08 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptors antagonists for treating schizophrenic disorders
|
EP0942730A1
(en)
*
|
1996-12-02 |
1999-09-22 |
MERCK SHARP & DOHME LTD. |
Use of nk-1 receptor antagonists for treating bipolar disorders
|
US6613765B1
(en)
*
|
1996-12-02 |
2003-09-02 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating major depressive disorders
|
CA2273809A1
(en)
*
|
1996-12-02 |
1998-06-11 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating movement disorders
|
EP0942728A1
(en)
*
|
1996-12-02 |
1999-09-22 |
MERCK SHARP & DOHME LTD. |
Use of nk-1 receptor antagonists for treating sexual dysfunction
|
EP0942733B1
(en)
*
|
1996-12-02 |
2005-04-27 |
MERCK SHARP & DOHME LTD. |
Use of nk-1 receptor antagonists for treating cognitive disorders
|
US5977104A
(en)
*
|
1996-12-02 |
1999-11-02 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating bipolar disorders
|
US6114315A
(en)
*
|
1996-12-02 |
2000-09-05 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety
|
WO1998047513A1
(en)
*
|
1997-04-24 |
1998-10-29 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating eating disorders
|
GB9716463D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2298779A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
|
WO1999007376A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating mania
|
GB9716457D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
US6087348A
(en)
*
|
1997-12-01 |
2000-07-11 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating stress disorders
|
GB9813025D0
(en)
|
1998-06-16 |
1998-08-12 |
Merck Sharp & Dohme |
Chemical synthesis
|
GB9816897D0
(en)
*
|
1998-08-04 |
1998-09-30 |
Merck Sharp & Dohme |
Therapeutic use
|
CZ20013046A3
(cs)
|
1999-02-24 |
2002-02-13 |
F. Hoffmann-La Roche Ag |
Fenylové a pyridinylové deriváty
|
PT1157005E
(pt)
|
1999-02-24 |
2005-02-28 |
Hoffmann La Roche |
Derivados de 3-fenilpirina e a sua utilizacao como antagonistas do receptor nk-1
|
DK1035115T3
(da)
|
1999-02-24 |
2005-01-24 |
Hoffmann La Roche |
4-phenylpyridinderivater og anvendelse deraf som NK-1-receptorantagonister
|
US6291465B1
(en)
|
1999-03-09 |
2001-09-18 |
Hoffmann-La Roche Inc. |
Biphenyl derivatives
|
FR2792835B3
(fr)
*
|
1999-04-27 |
2001-05-25 |
Sanofi Sa |
Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
|
USRE39921E1
(en)
|
1999-10-07 |
2007-11-13 |
Smithkline Beecham Corporation |
Chemical compounds
|
GB9923748D0
(en)
*
|
1999-10-07 |
1999-12-08 |
Glaxo Group Ltd |
Chemical compounds
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
CN1414953A
(zh)
|
1999-11-03 |
2003-04-30 |
阿尔巴尼分子研究公司 |
芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途
|
US6552025B1
(en)
*
|
1999-11-24 |
2003-04-22 |
Emory University |
Diimino-piperazine derivatives for use as modulators of cell regulation
|
DE60006340T2
(de)
*
|
1999-11-29 |
2004-09-09 |
F. Hoffmann-La Roche Ag |
2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramid
|
US6452001B2
(en)
|
2000-05-25 |
2002-09-17 |
Hoffmann-La Roche Inc. |
Diazapane derivatives useful as antagonists of neurokinin 1 receptor and methods for their formation
|
US6482829B2
(en)
|
2000-06-08 |
2002-11-19 |
Hoffmann-La Roche Inc. |
Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
|
WO2002004455A2
(en)
|
2000-07-11 |
2002-01-17 |
Albany Molecular Research, Inc |
4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
|
RS50932B
(sr)
|
2000-07-14 |
2010-08-31 |
F. Hoffmann-La Roche Ag. |
N-oksidi kao prolekovi 4-fenil-piridinskih derivata koji su antagonisti nk1 receptora
|
TWI287003B
(en)
|
2000-07-24 |
2007-09-21 |
Hoffmann La Roche |
4-phenyl-pyridine derivatives
|
TWI259180B
(en)
|
2000-08-08 |
2006-08-01 |
Hoffmann La Roche |
4-Phenyl-pyridine derivatives
|
GB0025354D0
(en)
*
|
2000-10-17 |
2000-11-29 |
Glaxo Group Ltd |
Chemical compounds
|
YU39503A
(sh)
|
2000-11-22 |
2006-05-25 |
F. Hoffmann-La Roche Ag. |
Derivati pirimidina
|
US6642226B2
(en)
|
2001-02-06 |
2003-11-04 |
Hoffman-La Roche Inc. |
Substituted phenyl-piperidine methanone compounds
|
GB0108594D0
(en)
*
|
2001-04-05 |
2001-05-23 |
Glaxo Group Ltd |
Chemical compounds
|
US6667344B2
(en)
|
2001-04-17 |
2003-12-23 |
Dey, L.P. |
Bronchodilating compositions and methods
|
US20030055026A1
(en)
|
2001-04-17 |
2003-03-20 |
Dey L.P. |
Formoterol/steroid bronchodilating compositions and methods of use thereof
|
US6849624B2
(en)
|
2001-07-31 |
2005-02-01 |
Hoffmann-La Roche Inc. |
Aromatic and heteroaromatic substituted amides
|
US6638981B2
(en)
|
2001-08-17 |
2003-10-28 |
Epicept Corporation |
Topical compositions and methods for treating pain
|
MY130373A
(en)
*
|
2001-10-29 |
2007-06-29 |
Malesci Sas |
Linear basic compounds having nk-2 antagonist activity and formulations thereof
|
US6903129B2
(en)
*
|
2001-12-14 |
2005-06-07 |
Hoffman-La Roche Inc. |
D-proline prodrugs
|
WO2003066589A1
(en)
*
|
2002-02-08 |
2003-08-14 |
Glaxo Group Limited |
Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
|
GB0203022D0
(en)
*
|
2002-02-08 |
2002-03-27 |
Glaxo Group Ltd |
Chemical compounds
|
GB0203020D0
(en)
|
2002-02-08 |
2002-03-27 |
Glaxo Group Ltd |
Chemical compounds
|
AR039625A1
(es)
*
|
2002-04-18 |
2005-03-02 |
Merck & Co Inc |
Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
|
EP1556054A4
(en)
*
|
2002-05-29 |
2007-09-05 |
Univ California |
ANTAGONIZING NK1 RECEPTORS RESTRICT DRUG ABUSE
|
NZ537206A
(en)
*
|
2002-06-27 |
2007-06-29 |
Astellas Pharma Inc |
Aminoalcohol derivatives
|
US20040023935A1
(en)
*
|
2002-08-02 |
2004-02-05 |
Dey, L.P. |
Inhalation compositions, methods of use thereof, and process for preparation of same
|
US20040109826A1
(en)
*
|
2002-12-06 |
2004-06-10 |
Dey, L.P. |
Stabilized albuterol compositions and method of preparation thereof
|
CN100562320C
(zh)
*
|
2003-01-31 |
2009-11-25 |
弗·哈夫曼-拉罗切有限公司 |
2-(3,5-二-三氟甲基-苯基)-N-[6-(1,1-二氧代-1λ6-硫代吗啉-4-基)-4-(4-氟-2-甲基-苯基)-吡啶-3-基]-N-甲基-异丁酰胺的新晶体变体
|
CA2530886C
(en)
|
2003-07-03 |
2013-05-28 |
F. Hoffmann-La Roche Ag |
Dual nk1/nk3 antagonists for treating schizophrenia
|
TWI359675B
(en)
*
|
2003-07-10 |
2012-03-11 |
Dey L P |
Bronchodilating β-agonist compositions
|
TWI280239B
(en)
|
2003-07-15 |
2007-05-01 |
Hoffmann La Roche |
Process for preparation of pyridine derivatives
|
JP4795022B2
(ja)
*
|
2003-09-30 |
2011-10-19 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ヘテロ環化合物を含有する新規な抗真菌剤
|
US20070020299A1
(en)
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
|
US20070020298A1
(en)
*
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
|
KR20070007075A
(ko)
|
2003-12-31 |
2007-01-12 |
사이덱스 인크 |
술포알킬 에테르 시클로덱스트린 및 코르티코스테로이드를함유한 흡입용 제형
|
ES2246687B2
(es)
|
2004-02-11 |
2006-11-16 |
Miguel Muñoz Saez |
Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales.
|
WO2005088655A1
(en)
*
|
2004-03-12 |
2005-09-22 |
The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin |
A magnetoresistive medium
|
KR101725225B1
(ko)
|
2004-04-23 |
2017-04-12 |
사이덱스 파마슈티칼스, 인크. |
술포알킬 에테르 시클로덱스트린 함유 dpi 제형
|
NZ552397A
(en)
|
2004-07-15 |
2011-04-29 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
US20090227799A1
(en)
*
|
2004-08-09 |
2009-09-10 |
Kazutaka Nakamoto |
Novel Antimalarial Agent Containing Heterocyclic Compound
|
AU2005273961A1
(en)
*
|
2004-08-11 |
2006-02-23 |
Williamsburg Holdings Llc |
Noncardiotoxic pharmaceutical compounds
|
US7223737B1
(en)
|
2004-08-13 |
2007-05-29 |
Alcon, Inc. |
Method of treating dry eye disorders using glycosides
|
AR051475A1
(es)
*
|
2004-11-05 |
2007-01-17 |
Merck & Co Inc |
Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico
|
DE602006008900D1
(de)
|
2005-02-22 |
2009-10-15 |
Hoffmann La Roche |
Nk1-antagonisten
|
US20100047338A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
PT1863767E
(pt)
|
2005-03-23 |
2009-03-27 |
Hoffmann La Roche |
Metabolitos para antagonistas de nk-1 para vómitos
|
WO2006106711A1
(ja)
*
|
2005-03-30 |
2006-10-12 |
Eisai R & D Management Co., Ltd. |
ピリジン誘導体を含有する抗真菌剤
|
ATE550019T1
(de)
|
2005-05-17 |
2012-04-15 |
Merck Sharp & Dohme |
Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
|
KR101594898B1
(ko)
|
2005-07-15 |
2016-02-18 |
알바니 몰레큘라 리써치, 인크. |
아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
|
AU2006298898B2
(en)
|
2005-09-23 |
2011-06-30 |
F. Hoffmann-La Roche Ag |
Novel dosage formulation
|
BRPI0616463A2
(pt)
|
2005-09-29 |
2011-06-21 |
Merck & Co Inc |
composto, composição farmacêutica, e, uso de um composto
|
US8080656B2
(en)
*
|
2005-10-05 |
2011-12-20 |
Ranbaxy Laboratories Limited |
Process for the preparation of aprepitant
|
US7629331B2
(en)
|
2005-10-26 |
2009-12-08 |
Cydex Pharmaceuticals, Inc. |
Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
|
TWI385169B
(zh)
|
2005-10-31 |
2013-02-11 |
Eisai R&D Man Co Ltd |
經雜環取代之吡啶衍生物及含有彼之抗真菌劑
|
US20070185066A1
(en)
*
|
2005-12-20 |
2007-08-09 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids
|
US20070249572A1
(en)
*
|
2005-12-20 |
2007-10-25 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids
|
US20070178049A1
(en)
*
|
2005-12-20 |
2007-08-02 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
|
US20070160542A1
(en)
*
|
2005-12-20 |
2007-07-12 |
Verus Pharmaceuticals, Inc. |
Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
|
US20070197486A1
(en)
*
|
2005-12-20 |
2007-08-23 |
Verus Pharmaceuticals, Inc. |
Methods and systems for the delivery of corticosteroids
|
CA2640966A1
(en)
*
|
2006-02-03 |
2007-08-09 |
Glenmark Pharmaceuticals Limited |
Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
|
CA2642577A1
(en)
*
|
2006-02-15 |
2007-08-23 |
Tika Lakemedel Ab |
Methods of manufacturing corticosteroid solutions
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
EP2065377B1
(en)
*
|
2006-09-21 |
2011-11-23 |
Eisai R&D Management Co., Ltd. |
Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
|
CA2770486C
(en)
|
2006-09-22 |
2014-07-15 |
Merck Sharp & Dohme Corp. |
Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
EA016079B1
(ru)
|
2007-01-10 |
2012-01-30 |
Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти Спа |
Амидзамещенные индазолы в качестве ингибиторов поли(adp-рибоза)полимеразы (parp)
|
MX2009007916A
(es)
|
2007-01-24 |
2009-07-31 |
Glaxo Group Ltd |
Composiciones farmaceuticas que comprenden 3,5-diamino-6-(2,3-dicl orofenil)-l,2,4,-triazina; o r(-)-2,4-diamino-5-(2,3-diclorofenil) -6-fluorometil pirimidina y un receptor neuroquinina 1.
|
AU2008233662B2
(en)
|
2007-04-02 |
2012-08-23 |
Msd K.K. |
Indoledione derivative
|
WO2008128891A1
(en)
|
2007-04-20 |
2008-10-30 |
F. Hoffmann-La Roche Ag |
Pyrrolidine derivatives as dual nk1/nk3 receptor antagonists
|
CN101622251B
(zh)
*
|
2007-04-27 |
2012-07-04 |
卫材R&D管理有限公司 |
杂环取代吡啶衍生物的盐或其结晶
|
TW200841879A
(en)
|
2007-04-27 |
2008-11-01 |
Eisai R&D Man Co Ltd |
Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
|
EP1994930A1
(en)
*
|
2007-05-22 |
2008-11-26 |
Novartis AG |
Triazol compounds for treating biofilm formation
|
WO2009002495A1
(en)
|
2007-06-27 |
2008-12-31 |
Merck & Co., Inc. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
US12370352B2
(en)
|
2007-06-28 |
2025-07-29 |
Cydex Pharmaceuticals, Inc. |
Nasal and ophthalmic delivery of aqueous corticosteroid solutions
|
CN101778837A
(zh)
|
2007-08-07 |
2010-07-14 |
弗·哈夫曼-拉罗切有限公司 |
作为nk3受体拮抗剂的吡咯烷芳基-醚
|
US20090076007A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched aprepitant
|
US20090076008A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched fosaprepitant
|
US8513287B2
(en)
|
2007-12-27 |
2013-08-20 |
Eisai R&D Management Co., Ltd. |
Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
|
WO2009104080A2
(en)
|
2008-02-20 |
2009-08-27 |
Targia Pharmaceuticals |
Cns pharmaceutical compositions and methods of use
|
JP2011515343A
(ja)
|
2008-03-03 |
2011-05-19 |
タイガー ファーマテック |
チロシンキナーゼ阻害薬
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
US8623844B2
(en)
*
|
2008-07-17 |
2014-01-07 |
Navin Ganesh Bhatt |
Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations
|
US8188119B2
(en)
*
|
2008-10-24 |
2012-05-29 |
Eisai R&D Management Co., Ltd |
Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
|
CN102686600A
(zh)
|
2009-02-05 |
2012-09-19 |
托凯药业股份有限公司 |
甾体cyp17抑制剂/抗雄激素物质的新型药物前体
|
EP2409977A4
(en)
|
2009-03-17 |
2012-09-26 |
Daiichi Sankyo Co Ltd |
AMIDE DERIVATIVE
|
EP2413932A4
(en)
|
2009-04-01 |
2012-09-19 |
Merck Sharp & Dohme |
INHIBITORS OF AKT ACTIVITY
|
WO2010132487A1
(en)
|
2009-05-12 |
2010-11-18 |
Bristol-Myers Squibb Company |
CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
|
MX2011011901A
(es)
|
2009-05-12 |
2012-01-20 |
Albany Molecular Res Inc |
Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
|
CN102595902B
(zh)
|
2009-05-12 |
2015-04-29 |
阿尔巴尼分子研究公司 |
7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
|
UY32799A
(es)
*
|
2009-07-24 |
2011-02-28 |
Novartis Ag |
Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos
|
US8188079B2
(en)
*
|
2009-08-19 |
2012-05-29 |
Hoffman-La Roche Inc. |
3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
|
PH12012500713A1
(en)
|
2009-10-14 |
2012-11-26 |
Merck Sharp & Dohme |
Substituted piperidines that increase p53 activity and the uses thereof
|
WO2011045817A2
(en)
|
2009-10-15 |
2011-04-21 |
Sandoz Private Limited |
Process for the preparation of fosaprepitant, intermediate and pharmaceutical acceptable salt thereof
|
WO2011120044A1
(en)
*
|
2010-03-26 |
2011-09-29 |
Duke University |
Conjugated neuroactive steroid compositions and methods of use
|
US8487102B2
(en)
|
2010-04-20 |
2013-07-16 |
Hoffmann-La Roche Inc. |
Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists
|
WO2011163330A1
(en)
|
2010-06-24 |
2011-12-29 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
JP5128019B1
(ja)
*
|
2010-07-13 |
2013-01-23 |
ノバルティス アーゲー |
オキサジン誘導体および神経障害の処置におけるその使用
|
US9446029B2
(en)
|
2010-07-27 |
2016-09-20 |
Colorado State University Research Foundation |
Use of NK-1 receptor antagonists in management of visceral pain
|
WO2012018754A2
(en)
|
2010-08-02 |
2012-02-09 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
ES2376564B1
(es)
|
2010-08-12 |
2013-01-24 |
Manuel Vicente Salinas Martín |
Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer.
|
EP2606134B1
(en)
|
2010-08-17 |
2019-04-10 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
EP2615916B1
(en)
|
2010-09-16 |
2017-01-04 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel erk inhibitors
|
DK2632472T3
(en)
|
2010-10-29 |
2018-03-19 |
Sirna Therapeutics Inc |
RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
US8524897B2
(en)
|
2011-01-12 |
2013-09-03 |
Novartis Ag |
Crystalline oxazine derivative
|
PH12013501480A1
(en)
|
2011-01-13 |
2022-10-26 |
Novartis Ag |
Novel heterocyclic derivatives and their use in the treatment of neurological disorders
|
CN102127031B
(zh)
*
|
2011-01-17 |
2012-10-17 |
江苏江神药物化学有限公司 |
一种麻黄碱类化合物季胺盐及其合成方法和应用
|
US9067924B2
(en)
*
|
2011-03-04 |
2015-06-30 |
Hoffmann-La Roche Inc. |
1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
|
FR2973031B1
(fr)
*
|
2011-03-23 |
2013-11-29 |
Univ Strasbourg |
Derives de l'allopregnanolone et de l'epiallopregnanolone et leurs utilisations pour traiter un etat neuropathologique
|
JP2014508784A
(ja)
*
|
2011-03-25 |
2014-04-10 |
ユニヴェルシテ ラヴァル |
17β−HSD1、17β−HSD3、および17β−HSD10の阻害剤
|
WO2012143874A1
(en)
|
2011-04-21 |
2012-10-26 |
Piramal Healthcare Limited |
A process for the preparation of morpholino sulfonyl indole derivatives
|
WO2012146692A1
(en)
|
2011-04-29 |
2012-11-01 |
Sandoz Ag |
Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
|
BR112013031510A2
(pt)
*
|
2011-06-07 |
2016-12-27 |
Hoffmann La Roche |
[1,3]oxazinas
|
NO2729147T3
(cs)
|
2011-07-04 |
2018-02-03 |
|
|
CN102977142B
(zh)
*
|
2011-09-02 |
2017-03-29 |
江苏豪森药业集团有限公司 |
福沙匹坦二甲葡胺的制备方法
|
RU2665571C2
(ru)
|
2011-09-08 |
2018-08-31 |
Сейдж Терапьютикс, Инк. |
Нейроактивные стероиды, композиции и их применения
|
WO2013063214A1
(en)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
WO2013087964A1
(es)
|
2011-12-13 |
2013-06-20 |
Servicio Andaluz De Salud |
Uso de agentes modificadores del ambiente peritumoral para el tratamiento del cáncer
|
US8338413B1
(en)
|
2012-03-07 |
2012-12-25 |
Novartis Ag |
Oxazine derivatives and their use in the treatment of neurological disorders
|
WO2013168176A2
(en)
*
|
2012-03-30 |
2013-11-14 |
Glenmark Generics Limited |
Process for preparation of fosaprepitant and salt thereof
|
CZ304982B6
(cs)
*
|
2012-04-30 |
2015-03-11 |
Zentiva, K.S. |
Způsob přípravy a čištění nových polymorfů intermediátu fosaprepitantu
|
EP3919620A1
(en)
|
2012-05-02 |
2021-12-08 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
CN102675369B
(zh)
*
|
2012-05-16 |
2017-07-11 |
北京华众思康医药技术有限公司 |
一种制备[3‑[(2r)‑[(1r)‑1‑[3,5‑二(三氟甲基)苯基]乙氧基]‑3(s)‑(4‑氟苯基)吗啉‑4‑基]甲基]‑5‑氧代‑4,5‑二氢‑[1,2,4]‑三唑‑1‑基]膦酸一苄酯的新方法
|
AU2013267359C1
(en)
*
|
2012-05-31 |
2016-09-29 |
Allergan pharmaceuticals International Ltd. |
Formulations and methods for vaginal delivery of antiprogestins
|
HUE051147T2
(hu)
|
2012-07-06 |
2021-03-01 |
Pharmathen Sa |
Neurokinin-1-receptor antagonista stabil injektálható gyógyszerkészítmény és eljárás annak elõállítására
|
CA2882950A1
(en)
|
2012-09-28 |
2014-04-03 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
HK1213570A1
(zh)
*
|
2012-10-29 |
2016-07-08 |
Allergan, Inc. |
比馬前列素和前列腺酰胺的磷酸酯
|
US8778964B2
(en)
|
2012-11-05 |
2014-07-15 |
Bayer Pharma Aktiengesellschaft |
Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use
|
US9126998B2
(en)
|
2012-11-05 |
2015-09-08 |
Bayer Pharma AG |
Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
US8796305B2
(en)
|
2012-11-05 |
2014-08-05 |
Bayer Pharma Aktiengesellschaft |
Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
US9624214B2
(en)
|
2012-11-05 |
2017-04-18 |
Bayer Pharma Aktiengesellschaft |
Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
MX363243B
(es)
|
2012-11-28 |
2019-03-14 |
Merck Sharp & Dohme |
Composiciones para tratar cáncer y usos de dichas composiciones.
|
CN105073746B
(zh)
|
2012-12-20 |
2017-03-22 |
默沙东公司 |
作为hdm2抑制剂的取代的咪唑并吡啶
|
US9540377B2
(en)
|
2013-01-30 |
2017-01-10 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as HDM2 inhibitors
|
ES2493693B1
(es)
|
2013-02-11 |
2015-07-07 |
Servicio Andaluz De Salud |
Método para predecir o pronosticar la respuesta de un sujeto humano que padece un cáncer al tratamiento con un antagonista del receptor NK1
|
WO2014134413A2
(en)
*
|
2013-03-01 |
2014-09-04 |
Revlon Consumer Products Corporation |
Cyrrhetinic alkyl esters and protected derivatives thereof
|
CA3114062A1
(en)
|
2013-03-13 |
2014-10-02 |
Sage Therapeutics, Inc. |
Neuroactive steroids and methods of use thereof
|
AU2014236135A1
(en)
|
2013-03-14 |
2015-09-10 |
Thomas Jefferson University |
Androgen receptor down-regulating agents and uses thereof
|
KR102046415B1
(ko)
*
|
2013-04-18 |
2019-12-02 |
시안 리방 파마슈티컬 테크놀로지 컴퍼니 리미티드 |
항암 활성을 갖는 7-α-[9-(4,4,5,5,5-펜타플루오로펜틸설피닐)노닐]-에스트라-1,3,5(10)-트리엔-3,17β-디올의 에스테르 유도체 및 그의 제조 방법
|
WO2014195333A1
(de)
|
2013-06-04 |
2014-12-11 |
Bayer Pharma Aktiengesellschaft |
3-aryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung
|
WO2015023710A1
(en)
|
2013-08-12 |
2015-02-19 |
Tokai Pharmaceuticals, Inc. |
Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
CN105899223A
(zh)
|
2013-10-28 |
2016-08-24 |
加利福尼亚大学董事会 |
转移性前列腺癌的治疗
|
CN104650142B
(zh)
*
|
2013-11-25 |
2018-06-22 |
山东新时代药业有限公司 |
一种福沙匹坦二甲葡胺的制备方法
|
CN103694146B
(zh)
*
|
2013-12-04 |
2015-10-28 |
深圳万乐药业有限公司 |
2-(2-氯-1-亚乙基)酰肼甲酸甲酯的制备方法
|
ES2541870B1
(es)
|
2013-12-27 |
2016-05-12 |
Servicio Andaluz De Salud |
Uso de antagonistas no peptídicos de NK1 en una determinada dosis para el tratamiento del cáncer
|
EP3091977A2
(en)
|
2013-12-30 |
2016-11-16 |
Oncoprevent GmbH |
Neurokinin-1 receptor antagonists for use in a method of prevention of cancer
|
CN106459090A
(zh)
|
2014-02-19 |
2017-02-22 |
拜耳制药股份公司 |
3‑(嘧啶‑2‑基)咪唑并[1,2‑a]吡啶
|
WO2015140199A1
(de)
|
2014-03-21 |
2015-09-24 |
Bayer Pharma Aktiengesellschaft |
Cyano-substituierte imidazo[1,2-a]pyridincarboxamide und ihre verwendung
|
WO2015195967A1
(en)
|
2014-06-18 |
2015-12-23 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
TW201613888A
(en)
|
2014-09-26 |
2016-04-16 |
Helsinn Healthcare Sa |
Crystalline forms of an NK-1 antagonist
|
CA2969268A1
(en)
|
2014-12-02 |
2016-06-09 |
Bayer Pharma Aktiengesellschaft |
Heteroaryl-substituted imidazo[1,2-a]pyridines and their use
|
MA42410B1
(fr)
|
2015-07-06 |
2021-04-30 |
Sage Therapeutics Inc |
Oxystérols et leurs méthodes d'utilisation
|
MY197698A
(en)
|
2015-07-06 |
2023-07-06 |
Sage Therapeutics Inc |
Oxysterols and methods of use thereof
|
WO2017021880A1
(en)
|
2015-08-03 |
2017-02-09 |
Leiutis Pharmaceuticals Pvt Ltd |
Liquid formulations of fosaprepitant
|
US10005803B2
(en)
|
2015-10-06 |
2018-06-26 |
Helsinn Healthcare Sa |
Crystalline forms of fosnetupitant
|
US9913853B2
(en)
|
2015-11-03 |
2018-03-13 |
Cipla Limited |
Stabilized liquid fosaprepitant formulations
|
WO2017093899A1
(en)
|
2015-12-01 |
2017-06-08 |
Piramal Enterprises Limited |
A process for preparation of fosaprepitant dimeglumine and an intermediate thereof
|
CN105837526B
(zh)
*
|
2016-01-22 |
2018-02-27 |
浙江工业大学 |
一种阿瑞吡坦重要合成中间体(2s,3r)‑4‑苄基‑3‑(4‑氟苯基)吗啉‑2‑醇的制备方法
|
RS63280B1
(sr)
|
2016-04-01 |
2022-06-30 |
Sage Therapeutics Inc |
Oksisteroli i postupci za njihovu upotrebu
|
US10752653B2
(en)
|
2016-05-06 |
2020-08-25 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
CN107353303B
(zh)
|
2016-05-09 |
2020-09-01 |
上海奥博生物医药技术有限公司 |
一种福沙匹坦磷酸酯中间体的制备方法
|
AU2017276588B2
(en)
|
2016-06-06 |
2022-06-02 |
Helsinn Healthcare Sa |
Physiologically balanced injectable formulations of fosnetupitant
|
RS62222B1
(sr)
|
2016-07-07 |
2021-09-30 |
Sage Therapeutics Inc |
24-hidroksisteroli supstituisani na poziciji 11 za upotrebu u lečenju stanja povezanih sa nmda
|
AU2017337121B2
(en)
|
2016-09-30 |
2022-01-27 |
Sage Therapeutics, Inc. |
C7 substituted oxysterols and methods as NMDA modulators
|
WO2018071283A1
(en)
|
2016-10-12 |
2018-04-19 |
Merck Sharp & Dohme Corp. |
Kdm5 inhibitors
|
CN119350419A
(zh)
|
2016-10-18 |
2025-01-24 |
萨奇治疗股份有限公司 |
氧甾醇及其使用方法
|
TWI836485B
(zh)
|
2016-10-18 |
2024-03-21 |
美商賽吉醫療公司 |
氧固醇(oxysterol)及其使用方法
|
IL312486B2
(en)
|
2017-04-10 |
2025-05-01 |
Chase Therapeutics Corp |
NK1 antagonist combination and method for treating synucleinopathies
|
MX394350B
(es)
|
2017-06-30 |
2025-03-24 |
Chase Therapeutics Corp |
Composiciones antagonistas de nk-1 y métodos para su uso en el tratamiento de la depresión.
|
EP3672964A4
(en)
|
2017-08-21 |
2021-05-26 |
Leiutis Pharmaceuticals Pvt. Ltd. |
Novel triple combination formulations for antiemetic therapy
|
CN109694390A
(zh)
*
|
2017-10-24 |
2019-04-30 |
齐鲁制药有限公司 |
一种福沙匹坦氮氧化物
|
EP3706742B1
(en)
|
2017-11-08 |
2023-03-15 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
WO2019094312A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
AU2019223237A1
(en)
*
|
2018-02-26 |
2020-09-03 |
Ospedale San Raffaele S.R.L. |
NK-1 antagonists for use in the treatment of ocular pain
|
EP3833667B1
(en)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
KR20210046009A
(ko)
|
2018-08-07 |
2021-04-27 |
머크 샤프 앤드 돔 코포레이션 |
Prmt5 억제제
|
US20230134843A1
(en)
|
2020-03-11 |
2023-05-04 |
Ospedale San Raffaele S.R.L. |
Treatment of stem cell deficiency
|
CA3173697A1
(en)
|
2020-04-03 |
2021-10-07 |
Mike TROWER |
An nk-1 receptor antagonist for treating a disease selecting from sepsis, septic shock, acute respiratory distress syndrome (ards) or multiple organ dysfunction syndrome (mods)
|
BR112022024208A2
(pt)
|
2020-06-02 |
2022-12-20 |
Nerre Therapeutics Ltd |
Antagonistas do receptor de neurocinina (nk)-1 para uso no tratamento de condições de fibrose pulmonar promovidas por lesão mecânica aos pulmões
|
KR20230110283A
(ko)
|
2020-11-19 |
2023-07-21 |
니폰 카야쿠 가부시키가이샤 |
혈관 장애를 유발하는 수용성 의약 함유 조성물, 혈관 장애를 유발하는 수용성 의약 함유 투여액 조제용 용액, 키트, 혈관 장애 억제제 및 비이온계 계면활성제 함유 용액
|
EP4052696A1
(en)
|
2021-03-04 |
2022-09-07 |
Extrovis AG |
Stable ready-to-use parenteral compositions of fosaprepitant
|
CN113582982B
(zh)
*
|
2021-06-15 |
2023-06-16 |
山东罗欣药业集团股份有限公司 |
一种nk1受体拮抗剂的制备方法
|
WO2025008409A2
(en)
|
2023-07-03 |
2025-01-09 |
Preeti Jha |
Substituted 2-phenylpiperidine compounds for use in the diagnosis, treatment and/or prevention of cancer
|
WO2025085662A1
(en)
|
2023-10-17 |
2025-04-24 |
Vanderbilt University |
Compounds for tocolytic use
|