US5719147A
(en)
*
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
SG52217A1
(en)
*
|
1993-12-29 |
1998-09-28 |
Merck Sharp & Dohme |
Substituted morpholine derivatives and their use as therapeutic agents
|
IL112778A0
(en)
*
|
1994-03-04 |
1995-05-26 |
Merck & Co Inc |
Substituted heterocycles, their preparation and pharmaceutical compositions containing them
|
EP0758329A1
(en)
*
|
1994-05-05 |
1997-02-19 |
MERCK SHARP & DOHME LTD. |
Morpholine derivatives and their use as antagonists of tachikinins
|
GB9505491D0
(en)
*
|
1995-03-18 |
1995-05-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9523244D0
(en)
*
|
1995-11-14 |
1996-01-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
US6117855A
(en)
*
|
1996-10-07 |
2000-09-12 |
Merck Sharp & Dohme Ltd. |
Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
|
US5750549A
(en)
*
|
1996-10-15 |
1998-05-12 |
Merck & Co., Inc. |
Cycloalkyl tachykinin receptor antagonists
|
JP2001507678A
(ja)
*
|
1996-12-02 |
2001-06-12 |
メルク シヤープ エンド ドーム リミテツド |
運動障害の治療のためのnk−1受容体拮抗薬の使用
|
US5977104A
(en)
*
|
1996-12-02 |
1999-11-02 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating bipolar disorders
|
US6613765B1
(en)
*
|
1996-12-02 |
2003-09-02 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating major depressive disorders
|
US6114315A
(en)
*
|
1996-12-02 |
2000-09-05 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety
|
AU731349B2
(en)
*
|
1996-12-02 |
2001-03-29 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating sexual dysfunctions
|
AU734860B2
(en)
*
|
1996-12-02 |
2001-06-21 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating cognitive disorders
|
WO1998024443A1
(en)
*
|
1996-12-02 |
1998-06-11 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating bipolar disorders
|
US6100256A
(en)
*
|
1996-12-02 |
2000-08-08 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptors antagonists for treating schizophrenic disorders
|
EP0977572A1
(en)
*
|
1997-04-24 |
2000-02-09 |
Merck Sharp & Dohme Ltd. |
Use of nk-1 receptor antagonists for treating eating disorders
|
WO1999007376A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating mania
|
GB9716463D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2298779A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
|
GB9716457D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
US6087348A
(en)
*
|
1997-12-01 |
2000-07-11 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating stress disorders
|
GB9813025D0
(en)
|
1998-06-16 |
1998-08-12 |
Merck Sharp & Dohme |
Chemical synthesis
|
GB9816897D0
(en)
*
|
1998-08-04 |
1998-09-30 |
Merck Sharp & Dohme |
Therapeutic use
|
RU2238264C2
(ru)
|
1999-02-24 |
2004-10-20 |
Ф.Хоффманн-Ля Рош Аг |
Производные бензола или пиридина и фармацевтическая композиция на их основе
|
RU2236402C2
(ru)
|
1999-02-24 |
2004-09-20 |
Ф.Хоффманн-Ля Рош Аг |
Производные 3-фенилпиридина и фармацевтическая композиция на их основе
|
PT1394150E
(pt)
|
1999-02-24 |
2011-02-17 |
Hoffmann La Roche |
Derivados de 4-fenilpiridina e a sua utilização como antagonistas dos receptores de nc-1
|
US6291465B1
(en)
|
1999-03-09 |
2001-09-18 |
Hoffmann-La Roche Inc. |
Biphenyl derivatives
|
FR2792835B3
(fr)
*
|
1999-04-27 |
2001-05-25 |
Sanofi Sa |
Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
|
GB9923748D0
(en)
|
1999-10-07 |
1999-12-08 |
Glaxo Group Ltd |
Chemical compounds
|
USRE39921E1
(en)
|
1999-10-07 |
2007-11-13 |
Smithkline Beecham Corporation |
Chemical compounds
|
US6552025B1
(en)
*
|
1999-11-24 |
2003-04-22 |
Emory University |
Diimino-piperazine derivatives for use as modulators of cell regulation
|
EP1103545B1
(en)
*
|
1999-11-29 |
2003-11-05 |
F. Hoffmann-La Roche Ag |
2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide
|
US6452001B2
(en)
|
2000-05-25 |
2002-09-17 |
Hoffmann-La Roche Inc. |
Diazapane derivatives useful as antagonists of neurokinin 1 receptor and methods for their formation
|
US6482829B2
(en)
|
2000-06-08 |
2002-11-19 |
Hoffmann-La Roche Inc. |
Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
|
SI1303490T1
(sl)
|
2000-07-14 |
2008-10-31 |
Hoffmann La Roche |
N-oksidi kot predzdravila NK 1 receptorskega antagonista 4-fenil-piridin derivatov
|
TWI287003B
(en)
|
2000-07-24 |
2007-09-21 |
Hoffmann La Roche |
4-phenyl-pyridine derivatives
|
TWI259180B
(en)
|
2000-08-08 |
2006-08-01 |
Hoffmann La Roche |
4-Phenyl-pyridine derivatives
|
GB0025354D0
(en)
*
|
2000-10-17 |
2000-11-29 |
Glaxo Group Ltd |
Chemical compounds
|
YU39503A
(sh)
|
2000-11-22 |
2006-05-25 |
F. Hoffmann-La Roche Ag. |
Derivati pirimidina
|
US6642226B2
(en)
|
2001-02-06 |
2003-11-04 |
Hoffman-La Roche Inc. |
Substituted phenyl-piperidine methanone compounds
|
GB0108594D0
(en)
*
|
2001-04-05 |
2001-05-23 |
Glaxo Group Ltd |
Chemical compounds
|
US20030055026A1
(en)
*
|
2001-04-17 |
2003-03-20 |
Dey L.P. |
Formoterol/steroid bronchodilating compositions and methods of use thereof
|
US6667344B2
(en)
|
2001-04-17 |
2003-12-23 |
Dey, L.P. |
Bronchodilating compositions and methods
|
US6849624B2
(en)
|
2001-07-31 |
2005-02-01 |
Hoffmann-La Roche Inc. |
Aromatic and heteroaromatic substituted amides
|
US6638981B2
(en)
|
2001-08-17 |
2003-10-28 |
Epicept Corporation |
Topical compositions and methods for treating pain
|
MY130373A
(en)
*
|
2001-10-29 |
2007-06-29 |
Malesci Sas |
Linear basic compounds having nk-2 antagonist activity and formulations thereof
|
US6903129B2
(en)
*
|
2001-12-14 |
2005-06-07 |
Hoffman-La Roche Inc. |
D-proline prodrugs
|
EP1472222A1
(en)
*
|
2002-02-08 |
2004-11-03 |
Glaxo Group Limited |
Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
|
GB0203022D0
(en)
*
|
2002-02-08 |
2002-03-27 |
Glaxo Group Ltd |
Chemical compounds
|
GB0203020D0
(en)
*
|
2002-02-08 |
2002-03-27 |
Glaxo Group Ltd |
Chemical compounds
|
AR039625A1
(es)
*
|
2002-04-18 |
2005-03-02 |
Merck & Co Inc |
Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
|
US20060205724A1
(en)
*
|
2002-05-29 |
2006-09-14 |
The Regents Of The University Of California |
Antagonizing nk-1 receptors inhibits consumption of substances of abuse
|
US20040023935A1
(en)
*
|
2002-08-02 |
2004-02-05 |
Dey, L.P. |
Inhalation compositions, methods of use thereof, and process for preparation of same
|
US20040109826A1
(en)
*
|
2002-12-06 |
2004-06-10 |
Dey, L.P. |
Stabilized albuterol compositions and method of preparation thereof
|
RU2330022C2
(ru)
|
2003-01-31 |
2008-07-27 |
Ф.Хоффманн-Ля Рош Аг |
НОВАЯ КРИСТАЛЛИЧЕСКАЯ МОДИФИКАЦИЯ 2-(3, 5-БИС-ТРИФТОРМЕТИЛФЕНИЛ)-N-[6-(1, 1-ДИОКСО-1 λ6-ТИОМОРФОЛИН-4-ИЛ)-4-(4-ФТОР-2-МЕТИЛФЕНИЛ)ПИРИДИН-3-ИЛ]-N-МЕТИЛИЗОБУТИРАМИДА
|
EP1643998B1
(en)
|
2003-07-03 |
2007-08-29 |
F. Hoffmann-La Roche Ag |
Dual nk1/nk3 antagonists for treating schizophrenia
|
TWI359675B
(en)
|
2003-07-10 |
2012-03-11 |
Dey L P |
Bronchodilating β-agonist compositions
|
TWI280239B
(en)
|
2003-07-15 |
2007-05-01 |
Hoffmann La Roche |
Process for preparation of pyridine derivatives
|
EP1669348A4
(en)
*
|
2003-09-30 |
2009-03-11 |
Eisai R&D Man Co Ltd |
NEW ANTIPILIC AGENT CONTAINING A HETEROCYCLIC COMPOUND
|
US20070020298A1
(en)
*
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
|
BRPI0418386A
(pt)
|
2003-12-31 |
2007-05-22 |
Cydex Inc |
formulação inalante contendo éter sulfoalquìlico gama-ciclodextrina e corticosteróide
|
US20070020299A1
(en)
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
|
ES2246687B2
(es)
|
2004-02-11 |
2006-11-16 |
Miguel Muñoz Saez |
Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales.
|
DE602004023765D1
(de)
*
|
2004-03-12 |
2009-12-03 |
Trinity College Dublin |
Magnetoresistives medium
|
JP2007534693A
(ja)
|
2004-04-23 |
2007-11-29 |
サイデックス・インコーポレイテッド |
スルホアルキルエーテルシクロデキストリンを含有するdpi製剤
|
CA2573271C
(en)
|
2004-07-15 |
2015-10-06 |
Amr Technology, Inc. |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
JPWO2006016548A1
(ja)
*
|
2004-08-09 |
2008-05-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
ヘテロ環化合物を含有する新規な抗マラリア剤
|
SG169238A1
(en)
*
|
2004-08-11 |
2011-03-30 |
Williamsburg Holdings Llc |
Noncardiotoxic pharmaceutical compounds
|
US7223737B1
(en)
|
2004-08-13 |
2007-05-29 |
Alcon, Inc. |
Method of treating dry eye disorders using glycosides
|
AR051475A1
(es)
*
|
2004-11-05 |
2007-01-17 |
Merck & Co Inc |
Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico
|
AU2006218179B2
(en)
|
2005-02-22 |
2010-12-23 |
F. Hoffmann-La Roche Ag |
NK1 antagonists
|
ATE425144T1
(de)
|
2005-03-23 |
2009-03-15 |
Hoffmann La Roche |
Metaboliten für nk-i-antagonisten zur emesis
|
EP1864980A4
(en)
*
|
2005-03-30 |
2010-08-18 |
Eisai R&D Man Co Ltd |
A PYRIDINE DERIVATIVE ANTIPILIC AGENT
|
EP1888050B1
(en)
|
2005-05-17 |
2012-03-21 |
Merck Sharp & Dohme Ltd. |
cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
|
JP5258561B2
(ja)
|
2005-07-15 |
2013-08-07 |
アルバニー モレキュラー リサーチ, インコーポレイテッド |
アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
|
BRPI0616108A2
(pt)
|
2005-09-23 |
2011-06-07 |
Hoffmann La Roche |
formulação de dosagem
|
KR20080048502A
(ko)
|
2005-09-29 |
2008-06-02 |
머크 앤드 캄파니 인코포레이티드 |
멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
|
EP1934204A2
(en)
*
|
2005-10-05 |
2008-06-25 |
Ranbaxy Laboratories, Ltd. |
Process for preparation of aprepitant
|
US7629331B2
(en)
|
2005-10-26 |
2009-12-08 |
Cydex Pharmaceuticals, Inc. |
Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
|
TWI385169B
(zh)
*
|
2005-10-31 |
2013-02-11 |
Eisai R&D Man Co Ltd |
經雜環取代之吡啶衍生物及含有彼之抗真菌劑
|
US20070197486A1
(en)
*
|
2005-12-20 |
2007-08-23 |
Verus Pharmaceuticals, Inc. |
Methods and systems for the delivery of corticosteroids
|
US20070160542A1
(en)
*
|
2005-12-20 |
2007-07-12 |
Verus Pharmaceuticals, Inc. |
Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
|
US20070178049A1
(en)
*
|
2005-12-20 |
2007-08-02 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
|
US20070185066A1
(en)
*
|
2005-12-20 |
2007-08-09 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids
|
US20070249572A1
(en)
*
|
2005-12-20 |
2007-10-25 |
Verus Pharmaceuticals, Inc. |
Systems and methods for the delivery of corticosteroids
|
EP1984359A1
(en)
*
|
2006-02-03 |
2008-10-29 |
Glenmark Pharmaceuticals Limited |
Amorphous and crystalline forms of aprepitant and processes for the preparation thereof
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
CA2642577A1
(en)
*
|
2006-02-15 |
2007-08-23 |
Tika Lakemedel Ab |
Methods of manufacturing corticosteroid solutions
|
EP2065377B1
(en)
*
|
2006-09-21 |
2011-11-23 |
Eisai R&D Management Co., Ltd. |
Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
|
WO2008039327A2
(en)
|
2006-09-22 |
2008-04-03 |
Merck & Co., Inc. |
Method of treatment using fatty acid synthesis inhibitors
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
MX2009007200A
(es)
|
2007-01-10 |
2009-07-15 |
Angeletti P Ist Richerche Bio |
Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).
|
EP2129381A1
(en)
|
2007-01-24 |
2009-12-09 |
Glaxo Group Limited |
Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
|
JP5319518B2
(ja)
|
2007-04-02 |
2013-10-16 |
Msd株式会社 |
インドールジオン誘導体
|
AU2008240804B2
(en)
|
2007-04-20 |
2013-02-21 |
F. Hoffmann-La Roche Ag |
Pyrrolidine derivatives as dual NK1/NK3 receptor antagonists
|
KR20100015897A
(ko)
*
|
2007-04-27 |
2010-02-12 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
헤테로환 치환 피리딘 유도체의 염 또는 그의 결정
|
TW200841879A
(en)
*
|
2007-04-27 |
2008-11-01 |
Eisai R&D Man Co Ltd |
Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
|
EP1994930A1
(en)
*
|
2007-05-22 |
2008-11-26 |
Novartis AG |
Triazol compounds for treating biofilm formation
|
AU2008269154B2
(en)
|
2007-06-27 |
2014-06-12 |
Merck Sharp & Dohme Llc |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
CA2695211A1
(en)
|
2007-08-07 |
2009-02-12 |
F. Hoffmann-La Roche Ag |
Pyrrolidine aryl-ether as nk3 receptor antagonists
|
US20090076008A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched fosaprepitant
|
US20090076007A1
(en)
*
|
2007-09-17 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched aprepitant
|
US8513287B2
(en)
|
2007-12-27 |
2013-08-20 |
Eisai R&D Management Co., Ltd. |
Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
|
EP2254420A4
(en)
|
2008-02-20 |
2012-02-15 |
Targia Pharmaceuticals |
CNS PHARMACEUTICALS AND METHOD FOR THEIR USE
|
JP2011515343A
(ja)
|
2008-03-03 |
2011-05-19 |
タイガー ファーマテック |
チロシンキナーゼ阻害薬
|
US20100048524A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
EP2303901B2
(en)
|
2008-07-17 |
2018-05-09 |
Glenmark Pharmaceuticals Limited |
Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations
|
US8188119B2
(en)
*
|
2008-10-24 |
2012-05-29 |
Eisai R&D Management Co., Ltd |
Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
|
JP2012516900A
(ja)
|
2009-02-05 |
2012-07-26 |
トーカイ ファーマシューティカルズ,インク. |
ステロイド性cyp17阻害剤/抗アンドロゲン剤の新しいプロドラッグ
|
RU2011141794A
(ru)
|
2009-03-17 |
2013-04-27 |
Дайити Санкио Компани, Лимитед |
Амидное производное
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
WO2010132437A1
(en)
|
2009-05-12 |
2010-11-18 |
Albany Molecular Research, Inc. |
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
|
AU2010247763B2
(en)
|
2009-05-12 |
2015-12-24 |
Albany Molecular Research, Inc. |
7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
|
KR20120023072A
(ko)
|
2009-05-12 |
2012-03-12 |
브리스톨-마이어스 스큅 컴퍼니 |
(S)-7-(〔1,2,4〕트리아졸〔1,5-a〕피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
|
AR077328A1
(es)
*
|
2009-07-24 |
2011-08-17 |
Novartis Ag |
Derivados de oxazina y su uso en el tratamiento de trastornos neurologicos
|
US8188079B2
(en)
*
|
2009-08-19 |
2012-05-29 |
Hoffman-La Roche Inc. |
3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
|
EA023838B1
(ru)
|
2009-10-14 |
2016-07-29 |
Мерк Шарп Энд Домэ Корп. |
ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ
|
WO2011045817A2
(en)
|
2009-10-15 |
2011-04-21 |
Sandoz Private Limited |
Process for the preparation of fosaprepitant, intermediate and pharmaceutical acceptable salt thereof
|
US20130245253A1
(en)
*
|
2010-03-26 |
2013-09-19 |
Department Of Veterans Affairs |
Conjugated Neuroactive Steroid Compositions And Methods Of Use
|
US8487102B2
(en)
|
2010-04-20 |
2013-07-16 |
Hoffmann-La Roche Inc. |
Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists
|
EP2584903B1
(en)
|
2010-06-24 |
2018-10-24 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
JP5128019B1
(ja)
*
|
2010-07-13 |
2013-01-23 |
ノバルティス アーゲー |
オキサジン誘導体および神経障害の処置におけるその使用
|
US9446029B2
(en)
|
2010-07-27 |
2016-09-20 |
Colorado State University Research Foundation |
Use of NK-1 receptor antagonists in management of visceral pain
|
WO2012018754A2
(en)
|
2010-08-02 |
2012-02-09 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
ES2376564B1
(es)
|
2010-08-12 |
2013-01-24 |
Manuel Vicente Salinas Martín |
Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer.
|
CA2807307C
(en)
|
2010-08-17 |
2021-02-09 |
Merck Sharp & Dohme Corp. |
Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
US8946216B2
(en)
|
2010-09-01 |
2015-02-03 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as ERK inhibitors
|
EP2615916B1
(en)
|
2010-09-16 |
2017-01-04 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel erk inhibitors
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
US8524897B2
(en)
|
2011-01-12 |
2013-09-03 |
Novartis Ag |
Crystalline oxazine derivative
|
PT2663561E
(pt)
|
2011-01-13 |
2016-06-07 |
Novartis Ag |
Derivados heterocíclicos novos e sua utilização no tratamento de distúrbios neurológicos
|
CN102127031B
(zh)
*
|
2011-01-17 |
2012-10-17 |
江苏江神药物化学有限公司 |
一种麻黄碱类化合物季胺盐及其合成方法和应用
|
US9067924B2
(en)
*
|
2011-03-04 |
2015-06-30 |
Hoffmann-La Roche Inc. |
1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
|
FR2973031B1
(fr)
*
|
2011-03-23 |
2013-11-29 |
Univ Strasbourg |
Derives de l'allopregnanolone et de l'epiallopregnanolone et leurs utilisations pour traiter un etat neuropathologique
|
AU2012234682A1
(en)
*
|
2011-03-25 |
2013-10-10 |
Universite Laval |
Inhibitors of 17beta-HSD1, 17beta-HSD3 and 17beta-HSD10
|
AU2012245971A1
(en)
|
2011-04-21 |
2013-10-17 |
Piramal Enterprises Limited |
A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
|
WO2012146692A1
(en)
|
2011-04-29 |
2012-11-01 |
Sandoz Ag |
Novel intermediates for the preparation of highly pure aprepitant or fosaprepitant
|
KR20140041590A
(ko)
*
|
2011-06-07 |
2014-04-04 |
에프. 호프만-라 로슈 아게 |
[1,3]옥사진
|
DK2729147T3
(en)
|
2011-07-04 |
2017-12-18 |
Irbm - Science Park S P A |
NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA
|
CN102977142B
(zh)
*
|
2011-09-02 |
2017-03-29 |
江苏豪森药业集团有限公司 |
福沙匹坦二甲葡胺的制备方法
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
WO2013087964A1
(es)
|
2011-12-13 |
2013-06-20 |
Servicio Andaluz De Salud |
Uso de agentes modificadores del ambiente peritumoral para el tratamiento del cáncer
|
US8338413B1
(en)
|
2012-03-07 |
2012-12-25 |
Novartis Ag |
Oxazine derivatives and their use in the treatment of neurological disorders
|
WO2013168176A2
(en)
*
|
2012-03-30 |
2013-11-14 |
Glenmark Generics Limited |
Process for preparation of fosaprepitant and salt thereof
|
CZ304982B6
(cs)
*
|
2012-04-30 |
2015-03-11 |
Zentiva, K.S. |
Způsob přípravy a čištění nových polymorfů intermediátu fosaprepitantu
|
EP3453762B1
(en)
|
2012-05-02 |
2021-04-21 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
CN102675369B
(zh)
*
|
2012-05-16 |
2017-07-11 |
北京华众思康医药技术有限公司 |
一种制备[3‑[(2r)‑[(1r)‑1‑[3,5‑二(三氟甲基)苯基]乙氧基]‑3(s)‑(4‑氟苯基)吗啉‑4‑基]甲基]‑5‑氧代‑4,5‑二氢‑[1,2,4]‑三唑‑1‑基]膦酸一苄酯的新方法
|
SG11201407397WA
(en)
*
|
2012-05-31 |
2014-12-30 |
Repros Therapeutics Inc |
Formulations and methods for vaginal delivery of antiprogestins
|
RS60599B1
(sr)
|
2012-07-06 |
2020-08-31 |
Pharmathen Sa |
Stabilna injektibilna farmaceutska kompozicija antagonista neurokinin-1-receptora i postupak za njeno dobijanje
|
JP6280554B2
(ja)
|
2012-09-28 |
2018-02-14 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
Erk阻害剤である新規化合物
|
CN104822693A
(zh)
*
|
2012-10-29 |
2015-08-05 |
阿勒根公司 |
比马前列素和前列腺酰胺的磷酸酯
|
US8796305B2
(en)
|
2012-11-05 |
2014-08-05 |
Bayer Pharma Aktiengesellschaft |
Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
US9624214B2
(en)
|
2012-11-05 |
2017-04-18 |
Bayer Pharma Aktiengesellschaft |
Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
US9126998B2
(en)
|
2012-11-05 |
2015-09-08 |
Bayer Pharma AG |
Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
|
US8778964B2
(en)
|
2012-11-05 |
2014-07-15 |
Bayer Pharma Aktiengesellschaft |
Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use
|
ME02925B
(me)
|
2012-11-28 |
2018-04-20 |
Merck Sharp & Dohme |
Kompozicije i postupci za liječenje kancera
|
TW201429969A
(zh)
|
2012-12-20 |
2014-08-01 |
Merck Sharp & Dohme |
作爲hdm2抑制劑之經取代咪唑吡啶
|
EP2951180B1
(en)
|
2013-01-30 |
2018-05-02 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
ES2493693B1
(es)
|
2013-02-11 |
2015-07-07 |
Servicio Andaluz De Salud |
Método para predecir o pronosticar la respuesta de un sujeto humano que padece un cáncer al tratamiento con un antagonista del receptor NK1
|
WO2014134413A2
(en)
*
|
2013-03-01 |
2014-09-04 |
Revlon Consumer Products Corporation |
Cyrrhetinic alkyl esters and protected derivatives thereof
|
ES2886506T3
(es)
|
2013-03-13 |
2021-12-20 |
Sage Therapeutics Inc |
Esteroides neuroactivos
|
BR112015023098A2
(pt)
|
2013-03-14 |
2017-07-18 |
Univ Jefferson |
agentes de infrarregulação do receptor de andrógeno e usos dos mesmos
|
AU2013386732B2
(en)
*
|
2013-04-18 |
2018-10-18 |
Xi'an Libang Pharmaceutical Technology Co., Ltd. |
Ester derivative of 7-alpha-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17beta-diol having antitumour activity and preparation method thereof
|
CA2914100A1
(en)
|
2013-06-04 |
2014-12-11 |
Bayer Pharma Aktiengesellschaft |
3-aryl-substituted imidazo[1,2-a]pyridines and the use thereof
|
JP2016528252A
(ja)
|
2013-08-12 |
2016-09-15 |
トーカイ ファーマシューティカルズ, インコーポレイテッド |
アンドロゲン標的治療を使用する新生物障害の処置のためのバイオマーカー
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
EP3062808B1
(en)
|
2013-10-28 |
2021-09-29 |
The Regents of the University of California |
Treatment of metastatic prostate cancer
|
CN104650142B
(zh)
*
|
2013-11-25 |
2018-06-22 |
山东新时代药业有限公司 |
一种福沙匹坦二甲葡胺的制备方法
|
CN103694146B
(zh)
*
|
2013-12-04 |
2015-10-28 |
深圳万乐药业有限公司 |
2-(2-氯-1-亚乙基)酰肼甲酸甲酯的制备方法
|
ES2541870B1
(es)
|
2013-12-27 |
2016-05-12 |
Servicio Andaluz De Salud |
Uso de antagonistas no peptídicos de NK1 en una determinada dosis para el tratamiento del cáncer
|
EP3091977A2
(en)
*
|
2013-12-30 |
2016-11-16 |
Oncoprevent GmbH |
Neurokinin-1 receptor antagonists for use in a method of prevention of cancer
|
WO2015124544A1
(de)
|
2014-02-19 |
2015-08-27 |
Bayer Pharma Aktiengesellschaft |
3-(pyrimidin-2-yl)imidazo[1,2-a]pyridine
|
EP3119777A1
(de)
|
2014-03-21 |
2017-01-25 |
Bayer Pharma Aktiengesellschaft |
Cyano-substituierte imidazo[1,2-a]pyridincarboxamide und ihre verwendung
|
TW201613888A
(en)
|
2014-09-26 |
2016-04-16 |
Helsinn Healthcare Sa |
Crystalline forms of an NK-1 antagonist
|
WO2016087343A1
(de)
|
2014-12-02 |
2016-06-09 |
Bayer Pharma Aktiengesellschaft |
Heteroaryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung
|
MA54851A
(fr)
|
2015-07-06 |
2021-12-08 |
Sage Therapeutics Inc |
Oxystérols et leurs procédés d'utilisation
|
US10610532B2
(en)
|
2015-08-03 |
2020-04-07 |
Leiutis Pharmaceuticals Pvt. Ltd. |
Liquid formulations of fosaprepitant
|
US10005803B2
(en)
|
2015-10-06 |
2018-06-26 |
Helsinn Healthcare Sa |
Crystalline forms of fosnetupitant
|
US9913853B2
(en)
|
2015-11-03 |
2018-03-13 |
Cipla Limited |
Stabilized liquid fosaprepitant formulations
|
EP3383829B1
(en)
|
2015-12-01 |
2020-10-21 |
Piramal Enterprises Limited |
A process for preparation of fosaprepitant dimeglumine and an intermediate thereof
|
CN105837526B
(zh)
*
|
2016-01-22 |
2018-02-27 |
浙江工业大学 |
一种阿瑞吡坦重要合成中间体(2s,3r)‑4‑苄基‑3‑(4‑氟苯基)吗啉‑2‑醇的制备方法
|
PT3436022T
(pt)
|
2016-04-01 |
2022-07-04 |
Sage Therapeutics Inc |
Oxisteróis e métodos de utilização dos mesmos
|
US10752653B2
(en)
|
2016-05-06 |
2020-08-25 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
CN107353303B
(zh)
|
2016-05-09 |
2020-09-01 |
上海奥博生物医药技术有限公司 |
一种福沙匹坦磷酸酯中间体的制备方法
|
PE20190347A1
(es)
|
2016-06-06 |
2019-03-07 |
Helsinn Healthcare Sa |
Formulaciones inyectables fisiologicamente balanceadas de fosnetupitant
|
EP3481846B1
(en)
|
2016-07-07 |
2021-05-12 |
Sage Therapeutics, Inc. |
11-substituted 24-hydroxysterols for use in the treatment of nmda related conditions
|
BR112019006365A2
(pt)
|
2016-09-30 |
2019-08-06 |
Sage Therapeutics Inc |
oxisteróis substituídos c7 e métodos de utilização dos mesmos
|
EP3529257B1
(en)
|
2016-10-18 |
2023-05-10 |
Sage Therapeutics, Inc. |
Oxysterols and methods of use thereof
|
JP2019532079A
(ja)
|
2016-10-18 |
2019-11-07 |
セージ セラピューティクス, インコーポレイテッド |
オキシステロールおよびその使用方法
|
IL269875B2
(en)
|
2017-04-10 |
2024-06-01 |
Chase Therapeutics Corp |
NK1 antagonist combination and a method for the treatment of synucleinopathies
|
CN111032158A
(zh)
|
2017-06-30 |
2020-04-17 |
才思治疗公司 |
用于治疗抑郁的nk-1拮抗剂组合物和方法
|
WO2019038656A1
(en)
|
2017-08-21 |
2019-02-28 |
Leiutis Pharmaceuticals Pvt, Ltd |
NEW TRIPLE COMBINATION FORMULATIONS FOR ANTIEMETIC THERAPY
|
CN109694390A
(zh)
*
|
2017-10-24 |
2019-04-30 |
齐鲁制药有限公司 |
一种福沙匹坦氮氧化物
|
WO2019094311A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
RU2020131446A
(ru)
|
2018-02-26 |
2022-03-28 |
Оспедале Сан Раффаэле С.Р.Л. |
Антагонисты nk-1 для применения в лечении глазной боли
|
US11993602B2
(en)
|
2018-08-07 |
2024-05-28 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
EP3833667B1
(en)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
EP4117673A1
(en)
|
2020-03-11 |
2023-01-18 |
Ospedale San Raffaele S.r.l. |
Treatment of stem cell deficiency
|
EP4125875A1
(en)
|
2020-04-03 |
2023-02-08 |
NeRRe Therapeutics Limited |
An nk-1 receptor antagonist for treating a disease selecting from sepsis, septic shock,, acute respiratory distress syndrome (ards) or multiple organ dysfunction syndrome (mods)
|
BR112022024208A2
(pt)
|
2020-06-02 |
2022-12-20 |
Nerre Therapeutics Ltd |
Antagonistas do receptor de neurocinina (nk)-1 para uso no tratamento de condições de fibrose pulmonar promovidas por lesão mecânica aos pulmões
|
US20240024339A1
(en)
|
2020-11-19 |
2024-01-25 |
Nippon Kayaku Kabushiki Kaisha |
Composition containing water-soluble drug causing vascular disorder, solution for use in preparation of administration solution containing water-soluble drug causing vascular disorder, kit, agent for suppressing vascular disorder, and solution containing nonionic surfactant
|
EP4052696A1
(en)
|
2021-03-04 |
2022-09-07 |
Extrovis AG |
Stable ready-to-use parenteral compositions of fosaprepitant
|
CN113582982B
(zh)
*
|
2021-06-15 |
2023-06-16 |
山东罗欣药业集团股份有限公司 |
一种nk1受体拮抗剂的制备方法
|