CN102977142B - 福沙匹坦二甲葡胺的制备方法 - Google Patents
福沙匹坦二甲葡胺的制备方法 Download PDFInfo
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- CN102977142B CN102977142B CN201110257970.6A CN201110257970A CN102977142B CN 102977142 B CN102977142 B CN 102977142B CN 201110257970 A CN201110257970 A CN 201110257970A CN 102977142 B CN102977142 B CN 102977142B
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- 0 C[C@](c1cc(*)cc(*)c1)O[C@]1OCC*(CC(*2C)=**(C)C2=O)[C@@]1c(cc1)ccc1N Chemical compound C[C@](c1cc(*)cc(*)c1)O[C@]1OCC*(CC(*2C)=**(C)C2=O)[C@@]1c(cc1)ccc1N 0.000 description 1
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CN201110257970.6A CN102977142B (zh) | 2011-09-02 | 2011-09-02 | 福沙匹坦二甲葡胺的制备方法 |
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CN201110257970.6A CN102977142B (zh) | 2011-09-02 | 2011-09-02 | 福沙匹坦二甲葡胺的制备方法 |
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CN102977142A CN102977142A (zh) | 2013-03-20 |
CN102977142B true CN102977142B (zh) | 2017-03-29 |
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Families Citing this family (4)
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CN103204878A (zh) * | 2013-03-29 | 2013-07-17 | 山东罗欣药业股份有限公司 | 一种福沙吡坦二甲葡胺的合成方法 |
CN106432337A (zh) * | 2015-08-08 | 2017-02-22 | 陕西合成药业股份有限公司 | 福沙匹坦衍生物、合成和在长效制剂中的用途 |
CN111662329B (zh) * | 2020-06-22 | 2021-03-30 | 连云港贵科药业有限公司 | 一种福沙匹坦双葡甲胺的合成方法 |
CN113583044B (zh) * | 2021-06-15 | 2023-11-14 | 山东罗欣药业集团股份有限公司 | 一种用于预防化疗相关性恶心呕吐的药物的制备方法 |
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IL112778A0 (en) * | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
AR051475A1 (es) * | 2004-11-05 | 2007-01-17 | Merck & Co Inc | Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico |
EP2303901B2 (en) * | 2008-07-17 | 2018-05-09 | Glenmark Pharmaceuticals Limited | Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations |
WO2011045817A2 (en) * | 2009-10-15 | 2011-04-21 | Sandoz Private Limited | Process for the preparation of fosaprepitant, intermediate and pharmaceutical acceptable salt thereof |
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs;Jeffrey J. Hale et al.;《J. Med. Chem.》;20000225;第43卷;第1234-1241页 * |
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Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: Jiangsu best Pharmaceutical Co.,Ltd. Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: Jiangsu best Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. |
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