FI119437B - Ei-toksinen, ei-toksigeeninen, ei-patogeeninen Fusarium-ekspressiojärjestelmä ja siinä käytettäviä promoottereita ja terminaattoreita - Google Patents

Ei-toksinen, ei-toksigeeninen, ei-patogeeninen Fusarium-ekspressiojärjestelmä ja siinä käytettäviä promoottereita ja terminaattoreita Download PDF

Info

Publication number
FI119437B
FI119437B FI965220A FI965220A FI119437B FI 119437 B FI119437 B FI 119437B FI 965220 A FI965220 A FI 965220A FI 965220 A FI965220 A FI 965220A FI 119437 B FI119437 B FI 119437B
Authority
FI
Finland
Prior art keywords
host cell
cell according
promoter
sequence
seq
Prior art date
Application number
FI965220A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI965220A (fi
FI965220A0 (fi
Inventor
John C Royer
Donna L Moyer
Wendy Yoder
Jeffrey R Shuster
Original Assignee
Novo Nordisk Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Biotech Inc filed Critical Novo Nordisk Biotech Inc
Publication of FI965220A0 publication Critical patent/FI965220A0/fi
Publication of FI965220A publication Critical patent/FI965220A/fi
Application granted granted Critical
Publication of FI119437B publication Critical patent/FI119437B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • C12N9/20Triglyceride splitting, e.g. by means of lipase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6427Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/911Microorganisms using fungi
    • Y10S435/929Fusarium

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI965220A 1994-06-30 1996-12-27 Ei-toksinen, ei-toksigeeninen, ei-patogeeninen Fusarium-ekspressiojärjestelmä ja siinä käytettäviä promoottereita ja terminaattoreita FI119437B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US26944994A 1994-06-30 1994-06-30
US26944994 1994-06-30
US40467895A 1995-03-15 1995-03-15
US40467895 1995-03-15
US9507743 1995-06-15
PCT/US1995/007743 WO1996000787A1 (en) 1994-06-30 1995-06-15 Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein

Publications (3)

Publication Number Publication Date
FI965220A0 FI965220A0 (fi) 1996-12-27
FI965220A FI965220A (fi) 1997-02-25
FI119437B true FI119437B (fi) 2008-11-14

Family

ID=26953701

Family Applications (1)

Application Number Title Priority Date Filing Date
FI965220A FI119437B (fi) 1994-06-30 1996-12-27 Ei-toksinen, ei-toksigeeninen, ei-patogeeninen Fusarium-ekspressiojärjestelmä ja siinä käytettäviä promoottereita ja terminaattoreita

Country Status (9)

Country Link
US (1) US5837847A (ja)
EP (2) EP1559776A3 (ja)
JP (2) JP3167729B2 (ja)
CN (2) CN1151762A (ja)
AT (1) ATE294871T1 (ja)
AU (1) AU2705895A (ja)
DE (1) DE69534185T2 (ja)
FI (1) FI119437B (ja)
WO (1) WO1996000787A1 (ja)

Families Citing this family (689)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3634797A (en) * 1996-07-24 1998-02-10 Meiji Seika Kaisha Ltd. Enzyme endoglucanase and cellulase preparations containing the same
US7883872B2 (en) * 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
US5811381A (en) * 1996-10-10 1998-09-22 Mark A. Emalfarb Cellulase compositions and methods of use
DK0981630T3 (da) 1997-05-16 2009-03-09 Novozymes Inc Polypeptider med prolyldipeptidylaminopeptidaseaktivitet og nukleinsyrer, der koder for samme
ATE395424T1 (de) * 1998-05-20 2008-05-15 Novozymes Inc Verfahren zur herstellung von heterologen polypeptiden in trichothecene mangelmutanten filamentlösen pilzen
KR100618495B1 (ko) * 1998-10-06 2006-08-31 마크 아론 에말파브 섬유상의 진균성 숙주 영역에서의 형질전환 시스템:크리소스포륨속에서
EP1124949B1 (en) 1998-10-26 2006-07-12 Novozymes A/S Constructing and screening a dna library of interest in filamentous fungal cells
ES2296606T3 (es) * 1999-01-13 2008-05-01 Novozymes, Inc. Metodos de produccion de polipeptidos en celulas deficientes en ciclohexadepsipeptido.
JP4620253B2 (ja) * 1999-03-22 2011-01-26 ノボザイムス,インコーポレイティド 菌類細胞中で遺伝子を発現させるためのプロモーター
US6361973B1 (en) 1999-03-22 2002-03-26 Novozymes Biotech, Inc. Promoters for expressing genes in a fungal cell
NZ517409A (en) 1999-08-31 2004-05-28 Novozymes As RP-II properties with amino acid substitutions used in detergent compositions and additives
AU782580B2 (en) 2000-01-10 2005-08-11 Maxygen, Inc. G-CSF conjugates
ATE428445T1 (de) 2000-02-11 2009-05-15 Bayer Healthcare Llc Gerinnungsfaktor vii oder viia konjugate
CN1425068B (zh) 2000-03-14 2011-05-18 诺维信公司 在制备多肽的方法中有效的真菌转录激活因子
EP1383881A2 (en) 2000-06-26 2004-01-28 Novozymes A/S Lipolytic enzymes from strains of fusarium and acremonium
AU2001279614B2 (en) 2000-08-21 2006-08-17 Novozymes A/S Subtilase enzymes
US7456001B2 (en) 2000-09-05 2008-11-25 Novozymes A/S Lipoxygenase
YU48703A (sh) 2001-02-27 2006-05-25 Maxygen Aps Novi interferonu beta-slični molekuli
US7264954B2 (en) 2001-04-20 2007-09-04 Novozymes A/S Lipoxygenase
EP2298868B1 (en) 2001-06-26 2015-01-07 Novozymes A/S Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same
DE10207702C1 (de) * 2002-02-22 2003-08-28 Albrecht Gmbh Einstellbare Gelenkorthese
US20030199038A1 (en) 2002-04-22 2003-10-23 Novozymes Biotech, Inc. Method for preparing polypeptide variants
WO2003089617A2 (en) 2002-04-22 2003-10-30 Novozymes Biotech, Inc. Methods for increasing homologous recombination of a nucleic acid sequence
AU2003273256A1 (en) * 2002-08-30 2004-03-19 Novozymes Biotech, Inc. Methods for producing mammalian trypsins
ATE452184T1 (de) * 2002-09-24 2010-01-15 Novozymes Inc Mikrobielle trypsinvarianten mit chymotrypsinaktivität und diese codierende nukleinsäuren
ATE494368T1 (de) 2002-10-01 2011-01-15 Novozymes As Polypeptide der gh-61-familie
EP1585822B1 (en) 2002-11-18 2012-01-25 Novozymes, Inc. Promoter variants for expressing genes in a fungal cell
ATE438711T1 (de) 2002-12-20 2009-08-15 Novozymes As Polypeptide mit cellobiohydrolase ii-aktivität und dafür kodierende polynucleotide
US7303877B2 (en) 2003-03-31 2007-12-04 Novozymes, Inc. Methods for producing biological substances in enzyme-deficient mutants of Aspergillus
NZ542924A (en) 2003-04-28 2008-01-31 Novozymes As Method of producing a phospholipase which comprises processing an expressed fungal peptide so as to cleave off a peptide from the C- terminal end and/or a peptide from the N-terminal end to obtain a core peptide
ES2393058T3 (es) 2003-05-02 2012-12-18 Novozymes Inc. Variantes de beta-glucosidasa
DK1639106T3 (da) 2003-06-19 2010-09-27 Novozymes As Proteaser
US20060236414A1 (en) 2003-06-19 2006-10-19 Novozymes A/S Proteases and methods for producing them
CA2538349C (en) 2003-06-25 2014-08-12 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
CN103088001A (zh) 2003-08-25 2013-05-08 诺维信股份有限公司 糖苷水解酶的变体
CN1871344A (zh) 2003-10-23 2006-11-29 诺和酶股份有限公司 在洗涤剂中具有改善稳定性的蛋白酶
US7244605B2 (en) 2003-10-28 2007-07-17 Novozymes, Inc. Polypeptides having beta-glucosidase activity and polynucleotides encoding same
JP2007509630A (ja) 2003-10-28 2007-04-19 ノボザイムス ノース アメリカ,インコーポレイティド ハイブリッド酵素
WO2005066339A2 (en) 2004-01-06 2005-07-21 Novozymes A/S Polypeptides of alicyclobacillus sp.
ES2469874T3 (es) 2004-01-30 2014-06-20 Novozymes Inc Polip�ptidos con actividad de mejora celulol�tica y polinucle�tidos que los codifican
WO2006078256A2 (en) 2004-02-12 2006-07-27 Novozymes, Inc. Polypeptides having xylanase activity and polynucleotides encoding same
EP1718742B1 (en) 2004-02-25 2014-12-24 Novozymes A/S Fungal cell wall degrading enzyme
CA2561020C (en) 2004-03-25 2014-05-13 Novozymes Inc. Methods for degrading or converting plant cell wall polysaccharides
US8211667B2 (en) 2004-04-16 2012-07-03 Dsm Ip Assets B.V. Fungal promoter for expressing a gene in a fungal cell
US7148404B2 (en) 2004-05-04 2006-12-12 Novozymes A/S Antimicrobial polypeptides
EP1766040B1 (en) 2004-05-27 2017-08-09 Novozymes, Inc. Methods for transforming and expression screening of filamentous fungal cells with a dna library
WO2005118795A2 (en) 2004-05-27 2005-12-15 Genencor International, Inc. Aspergillus kawachi acid-stable alpha amylase and applications in granular starch hydrolysis
US7413887B2 (en) 2004-05-27 2008-08-19 Genecor International, Inc. Trichoderma reesei glucoamylase and homologs thereof
WO2005121333A1 (en) 2004-06-14 2005-12-22 Novozymes A/S Signal peptide for producing a polypeptide
MXPA06014649A (es) 2004-06-21 2007-03-12 Novozymes As Proteasas.
EP1766002B1 (en) 2004-06-21 2015-11-18 Novozymes A/S Stably maintained multiple copies of at least two orf in the same orientation
WO2006005032A2 (en) 2004-06-29 2006-01-12 Novozymes, Inc. Polypeptides having alpha-glucosidase activity and polynucleotides encoding same
EP2302042A3 (en) 2004-09-30 2011-08-10 Novozymes A/S Polypeptides having lipase activity and polynucleotides encoding same
AR050895A1 (es) 2004-10-04 2006-11-29 Novozymes As Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican
BRPI0517539A (pt) 2004-10-04 2008-10-14 Novozymes As polipeptìdeo isolado, polinucleotìdeo isolado, construto de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, métodos para produzir o polipeptìdeo, e para melhorar o valor nutricional de uma ração animal, célula de planta, parte de planta ou planta transgênica, animal não-humano, transgênico, ou produtos, ou elementos do mesmo, uso de pelo menos um polipeptìdeo, aditivo de ração animal, e, composição de ração animal
WO2006053565A2 (en) 2004-11-19 2006-05-26 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
ES2543131T3 (es) 2004-12-22 2015-08-14 Novozymes North America, Inc. Enzimas para tratamiento de almidón
US7888489B2 (en) 2005-01-24 2011-02-15 Dsm Ip Assets B.V. Method for producing a compound of interest in a filamentous fungal cell
ES2375150T3 (es) 2005-03-16 2012-02-27 Novozymes Adenium Biotech A/S Expresión recombinante de defensinas de insecto en aspergillus.
AU2006226729B2 (en) 2005-03-22 2012-02-16 Novozymes A/S Polypeptides and nucleic acids encoding same
AR053066A1 (es) 2005-04-26 2007-04-18 Novozymes As Arabinofuranosidasas
ATE447013T1 (de) 2005-04-27 2009-11-15 Novozymes Inc Polypeptide mit endoglucanase-aktivtät und dafür codierende polynukleotide
ATE503010T1 (de) 2005-08-16 2011-04-15 Novozymes As Polypeptide von stammbakterien sp p203
WO2007023163A1 (en) 2005-08-26 2007-03-01 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
EP1941023B1 (en) 2005-09-30 2017-04-05 Novozymes Inc. Methods for enhancing the degradation or conversion of cellulosic material
EP1941025B1 (en) 2005-10-17 2011-06-29 Novozymes A/S Use of fungal mutants for expression of antibodies
AU2006319353B2 (en) 2005-11-29 2012-12-13 Dsm Ip Assets B.V. DNA binding site of a transcriptional activator useful in gene expression
CN103740674A (zh) 2006-03-20 2014-04-23 诺维信股份有限公司 具有内切葡聚糖酶活性的多肽和编码该多肽的多核苷酸
EP2004817A2 (en) 2006-03-30 2008-12-24 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
MX2008012632A (es) 2006-04-04 2008-10-13 Novozymes As Variantes de fitasa.
US8198046B2 (en) 2006-07-11 2012-06-12 Danisco Us Inc. KEX2 cleavage regions of recombinant fusion proteins
US20080026376A1 (en) 2006-07-11 2008-01-31 Huaming Wang KEX2 cleavage regions of recombinant fusion proteins
CN103451164A (zh) 2006-07-14 2013-12-18 诺维信股份有限公司 用于产生具有生物学活性的分泌型多肽的方法
JP2009543560A (ja) 2006-07-14 2009-12-10 ノボザイムス,インコーポレイティド 真菌細胞中の遺伝子発現を上昇させる方法
US8546106B2 (en) 2006-07-21 2013-10-01 Novozymes, Inc. Methods of increasing secretion of polypeptides having biological activity
DK2069512T3 (da) 2006-09-22 2010-09-20 Danisco Us Inc Genencor Div Acetolaktat-syntase fra Trichoderma reesei som selektionsmarkør
US9447397B2 (en) 2006-10-10 2016-09-20 Danisco Us Inc. Glucoamylase variants with altered properties
CN103540562A (zh) 2006-11-30 2014-01-29 诺维信公司 重组宿主细胞中的脱氧核糖核酸酶表达
EP2102366A4 (en) 2006-12-10 2010-01-27 Dyadic International Inc EXPRESSION AND HIGH-DROP SCREENING OF COMPLEX EXPRESSED DNA LIBRARIES IN FADENED MUSHROOMS
US9862956B2 (en) 2006-12-10 2018-01-09 Danisco Us Inc. Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
EP2094842B1 (en) 2006-12-18 2012-06-13 Danisco US Inc. Novel laccases, compositions and methods of use
US8143046B2 (en) 2007-02-07 2012-03-27 Danisco Us Inc., Genencor Division Variant Buttiauxella sp. phytases having altered properties
US20080220498A1 (en) 2007-03-06 2008-09-11 Cervin Marguerite A Variant Buttiauxella sp. phytases having altered properties
EP2115145A1 (en) 2007-02-15 2009-11-11 DSM IP Assets B.V. A recombinant host cell for the production of a compound of interest
KR20100014593A (ko) 2007-03-26 2010-02-10 노보자임스 에이/에스 하프니아 파이타제
DE102007016139A1 (de) 2007-03-30 2008-10-02 Jenabios Gmbh Verfahren zur regioselektiven Oxygenierung von N-Heterozyklen
JP5497632B2 (ja) 2007-05-09 2014-05-21 ノボザイムス アクティーゼルスカブ 関心対象のポリペプチドを産生するライブラリークローンの選択に適した発現クローニング法
US8093016B2 (en) 2007-05-21 2012-01-10 Danisco Us Inc. Use of an aspartic protease (NS24) signal sequence for heterologous protein expression
US7977078B2 (en) 2007-08-24 2011-07-12 Codexis, Inc. Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
WO2009033071A2 (en) * 2007-09-07 2009-03-12 Dyadic International, Inc. Novel fungal enzymes
EP2195435B1 (en) 2007-09-12 2012-10-10 Danisco US Inc. Trichoderma promoter
EP2193195B1 (en) 2007-09-18 2014-12-17 Novozymes A/S Polypeptides having tyrosinase activity and polynucleotides encoding same
US8592194B2 (en) 2007-10-09 2013-11-26 Danisco Us Inc. Glucoamylase variants with altered properties
DK2481796T3 (da) 2007-10-09 2014-08-04 Danisco Us Inc Glucoamylasevarianter
EP2222842B1 (en) 2007-11-20 2014-10-15 Danisco US Inc. Glucoamylase variants with altered properties
DK2215224T3 (da) 2007-11-27 2014-01-27 Novozymes As Polypeptider med alfa-glucuronidaseaktivitet og polynukleotider, der koder for dem
EP2224822B1 (en) 2007-12-06 2014-05-21 Novozymes A/S Polypeptides having acetylxylan esterase activity and polynucleotides encoding same
JP2011507525A (ja) 2007-12-19 2011-03-10 ノボザイムス アクティーゼルスカブ セルロース分解増強活性を有するポリペプチドとこれをコードするポリヌクレオチド
HUE052318T2 (hu) 2008-04-18 2021-04-28 Danisco Us Inc Bittiauxella sp. fitáz változatok
EP2674488A1 (en) 2008-06-06 2013-12-18 Novozymes A/S Variants of a family 44 xyloglucanase
ES2438576T3 (es) 2008-06-24 2014-01-17 Codexis, Inc. Procesos biocatalíticos para la preparación de compuestos de prolina bicíclica fusionada considerablemente pura estereoméricamente
HUE026181T2 (en) 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine
EP2650364B1 (en) 2008-09-26 2015-05-20 Novozymes A/S Hafnia phytase variants
WO2010059413A2 (en) 2008-11-20 2010-05-27 Novozymes, Inc. Polypeptides having amylolytic enhancing activity and polynucleotides encoding same
CN102300986A (zh) 2008-12-04 2011-12-28 诺维信股份有限公司 具有纤维素分解增强活性的多肽和编码该多肽的多核苷酸
WO2010068800A1 (en) 2008-12-12 2010-06-17 Novozymes, Inc. Polypeptides having aspartic endopeptidase activity and polynucleotides encoding same
EP2376527A1 (en) 2008-12-12 2011-10-19 Novozymes Inc. Polypeptides having lipase activity and polynucleotides encoding same
US20110269206A1 (en) 2008-12-15 2011-11-03 Novozymes, Inc Polypeptides Having Catalase Activity And Polynucleotides Encoding Same
WO2010074955A1 (en) 2008-12-16 2010-07-01 Novozymes, Inc. Polypeptides having carboxypeptidase activity and polynucleotides encoding same
WO2010077775A1 (en) 2008-12-16 2010-07-08 Novozymes, Inc. Polypeptides having alpha-mannosidase activity and polynucleotides encoding same
WO2010080407A2 (en) 2008-12-19 2010-07-15 Novozymes, Inc. Methods for increasing hydrolysis of cellulosic material
CN102325893A (zh) 2008-12-19 2012-01-18 诺维信股份有限公司 在过氧化物酶存在下增加纤维素材料酶法水解的方法
WO2010080532A1 (en) 2008-12-19 2010-07-15 Novozymes, Inc. Methods for increasing hydrolysis of cellulosic material in the presence of cellobiose dehydrogenase
WO2010080527A1 (en) 2008-12-19 2010-07-15 Novozymes, Inc. Methods for determining cellulolytic enhancing activity of a polypeptide
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
CA2747223C (en) 2008-12-23 2020-07-21 Danisco A/S Polypeptides with xylanase activity
EP2385983B1 (en) 2009-01-08 2017-12-20 Codexis, Inc. Transaminase polypeptides
CN102361973B (zh) 2009-01-21 2015-09-02 诺维信公司 具有酯酶活性的多肽和编码该多肽的核酸
US8604277B2 (en) 2009-01-28 2013-12-10 Novozymes, Inc. Polypeptides having beta-glucosidase activity and polynucleotides encoding same
WO2010088463A2 (en) 2009-01-30 2010-08-05 Novozymes, Inc. Polypeptides having expansin activity and polynucleotides encoding same
WO2010088447A1 (en) 2009-01-30 2010-08-05 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
WO2010091221A1 (en) 2009-02-06 2010-08-12 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
WO2010106068A1 (en) 2009-03-17 2010-09-23 Novozymes A/S Polypeptides having tyrosinase activity and polynucleotides encoding same
WO2010108918A1 (en) 2009-03-24 2010-09-30 Novozymes A/S Polypeptides having acetyl xylan esterase activity and polynucleotides encoding same
BRPI1010239A2 (pt) 2009-03-31 2016-10-11 Codexis Inc endoglucanases aprimoradas, derivados e seus usos
CA2758404A1 (en) 2009-04-22 2010-10-28 Dsm Ip Assets B.V. Process for the production of a recombinant polypeptide of interest
EP2248893A1 (en) 2009-05-06 2010-11-10 Novozymes A/S DFPase Enzymes from Octopus Vulgaris
US20100298612A1 (en) 2009-05-22 2010-11-25 Codexis, Inc. Engineered biosynthesis of fatty alcohols
DK2435561T3 (en) 2009-05-29 2018-11-05 Novozymes Inc PROCEDURES FOR IMPROVING THE DEGRADATION OR CONVERSION OF CELLULOSE SUBSTANCES
CN104480088A (zh) 2009-06-02 2015-04-01 诺维信股份有限公司 具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸
DK3409765T3 (da) 2009-06-22 2021-09-27 Codexis Inc Ketoreduktase-medieret stereoselektiv rute til alpha-chloralkoholer
EP2446029B1 (en) 2009-06-26 2016-08-10 Novozymes North America, Inc. Heat-stable carbonic anhydrases and their use
EP2449124B1 (en) 2009-06-30 2015-05-27 Codexis, Inc. Production of fatty alcohols with fatty alcohol forming acyl-coa reductases (far)
US8143021B2 (en) 2009-07-07 2012-03-27 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
CN102597241B (zh) 2009-07-22 2015-09-02 帝斯曼知识产权资产管理有限公司 用于生产感兴趣的化合物的经改进的宿主细胞
EP2456865A1 (en) 2009-07-24 2012-05-30 Novozymes A/S Carbohydrate oxidases
WO2011014458A1 (en) 2009-07-28 2011-02-03 Novozymes, Inc. Polypeptides having phytase activity and polynucleotides encoding same
CN102498126A (zh) 2009-08-07 2012-06-13 诺维信公司 用于产生甜蛋白的方法
WO2011022465A1 (en) 2009-08-19 2011-02-24 Danisco Us Inc. Combinatorial variants of glucoamylase with improved specific activity and/or thermostability
CA2770607C (en) 2009-08-19 2019-02-26 Danisco A/S Variants of glucoamylase
US8409830B2 (en) 2009-08-21 2013-04-02 Novozymes A/S Polypeptides having isoamylase activity and methods of use
US8741611B2 (en) 2009-09-01 2014-06-03 Novozymes, Inc. Methods for improving malic acid production in filamentous fungi
EP3269804B1 (en) 2009-09-17 2020-11-11 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
CN102712916B (zh) 2009-09-18 2015-11-25 诺维信股份有限公司 具有β-葡糖苷酶活性的多肽和编码该多肽的多核苷酸
JP6204018B2 (ja) 2009-09-25 2017-09-27 ノボザイムス アクティーゼルスカブ プロテアーゼ変異体の使用
EP2480650B1 (en) 2009-09-25 2017-03-22 Novozymes A/S Subtilase variants
DK2483403T3 (en) 2009-09-29 2018-02-12 Novozymes Inc POLYPEPTIDES WITH XYLANASE ACTIVITY AND POLYNUCLEOTIDES CODING THEM
MX2012003473A (es) 2009-09-29 2012-05-22 Novozymes Inc Polipeptidos que tienen actividad celulitica mejorada y polinucleotidos que codifican para los mismos.
US8586829B2 (en) 2009-09-30 2013-11-19 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2011041594A1 (en) 2009-09-30 2011-04-07 Codexis, Inc. Recombinant c1 b-glucosidase for production of sugars from cellulosic biomass
US8586827B2 (en) 2009-09-30 2013-11-19 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
WO2011050037A1 (en) 2009-10-23 2011-04-28 Novozymes, Inc. Cellobiohydrolase variants and polynucleotides encoding same
CN102666847B (zh) 2009-10-29 2015-12-09 诺维信股份有限公司 具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸
EP2496692B1 (en) 2009-11-06 2016-03-16 Novozymes, Inc. Polypeptides having xylanase activity and polynucleotides encoding same
BR112012008260A2 (pt) 2009-11-06 2015-09-15 Novozymes Inc E Novozymes As polipeptídeo, polinucleotídeo, métodos para produzir o polipeptídeo, para produzir um mutante de uma célula precursora, para inibir a expressão de um polipeptídeo, para produzir uma proteína, para degradar ou converter um material celulósico, para produzir um produto de fermentação, para fermentar um material celulósico, planta transgênica, parte da planta ou célula da planta,e, molécula de rna inibitória de filamento duplo.
EP2496694B1 (en) 2009-11-06 2017-04-19 Novozymes, Inc. Compositions for saccharification of cellulosic material
CN102666848B (zh) 2009-11-25 2014-09-24 科德克希思公司 用于从纤维素生物质产生可发酵的糖的重组嗜热子囊菌β-葡糖苷酶变体
MX355841B (es) 2009-11-25 2018-05-02 Codexis Inc Variantes de beta-glucosidasa recombinante para producción de azúcares solubles de biomasa celulósica.
WO2011066576A1 (en) 2009-11-30 2011-06-03 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
CA2782128C (en) 2009-11-30 2019-01-15 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
AU2010276471B2 (en) 2009-12-01 2015-05-14 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
WO2011067349A1 (en) 2009-12-03 2011-06-09 Novozymes A/S Variants of a polypeptide with lipolytic activity and improved stability
US8951770B2 (en) 2009-12-09 2015-02-10 Novozymes A/S GH8 xylanase variants
WO2011072191A2 (en) 2009-12-11 2011-06-16 Novozymes A/S Protease variants
CN102762714B (zh) 2009-12-18 2015-11-25 诺维信股份有限公司 用于在木霉属的蛋白酶缺陷突变体中产生多肽的方法
EP2501792A2 (en) 2009-12-29 2012-09-26 Novozymes A/S Gh61 polypeptides having detergency enhancing effect
CN102918149A (zh) 2010-01-04 2013-02-06 诺维信公司 α-淀粉酶
US8617856B2 (en) 2010-01-07 2013-12-31 Wisconsin Alumni Research Foundation Fatty acid-producing hosts
EP2534244A1 (en) 2010-02-11 2012-12-19 DSM IP Assets B.V. Host cell capable of producing enzymes useful for degradation of lignocellulosic material
WO2011104284A1 (en) 2010-02-25 2011-09-01 Novozymes A/S Polypeptides having antimicrobial activity
CN102858968B (zh) 2010-02-25 2015-07-01 诺维信公司 溶菌酶的变体及编码该变体的多核苷酸
BR112012020309A2 (pt) 2010-03-03 2015-11-03 Novozymes As "variante isolado de uma xilanase precursora, polinucleotídeo isolado, célula hospedeira, métodos para produzir e para obter um variante, planta transgênica, parte da planta ou célula da planta, e, métodos para degradar um material contendo xilano, para tratar uma polpa, e para produzir xilose."
US20110229921A1 (en) 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
AU2011231563B2 (en) 2010-03-26 2015-01-29 Novozymes A/S Thermostable phytase variants
US8828701B2 (en) 2010-03-31 2014-09-09 Novozymes, Inc. Cellobiohydrolase variants and polynucleotides encoding same
ES2565060T3 (es) 2010-04-14 2016-03-31 Novozymes A/S Polipéptidos que tienen actividad de glucoamilasa y polinucleótidos que codifican los mismos
CA2798937A1 (en) 2010-05-28 2011-12-01 Codexis, Inc. Pentose fermentation by a recombinant microorganism
WO2011153317A1 (en) 2010-06-04 2011-12-08 Novozymes, Inc. C4 dicarboxylic acid production in filamentous fungi
US8835604B2 (en) 2010-06-12 2014-09-16 Adenium Biotech Aos Antimicrobial peptide variants and polynucleotides encoding same
AU2011271094B2 (en) 2010-06-21 2015-01-22 Novozymes, Inc. Aspergillus aculeatus derived polypeptides having C4-dicarboxylic acid transporter activity and polynucleotides encoding same
WO2011163270A1 (en) 2010-06-21 2011-12-29 Novozymes, Inc. Methods for improved c4-dicarboxylic acid production in filamentous fungi
CN103068978B (zh) 2010-06-25 2017-01-18 诺维信公司 具有前导序列功能的多核苷酸
WO2011161207A1 (en) 2010-06-25 2011-12-29 Novozymes A/S Polynucleotides having promoter activity
EP2585601A1 (en) 2010-06-25 2013-05-01 Novozymes A/S Polynucleotides having promoter activity
WO2011163558A1 (en) 2010-06-25 2011-12-29 Abbott Laboratories Materials and methods for assay of anti-hepatitis c virus (hcv) antibodies
US8574878B2 (en) 2010-06-28 2013-11-05 Behnaz Behrouzian Fatty alcohol forming acyl reductases (FARs) and methods of use thereof
US8581042B2 (en) 2010-06-30 2013-11-12 Novozymes A/S Polypeptides having beta-glucosidase activity and polynucleotides encoding same
US8945898B2 (en) 2010-07-01 2015-02-03 Dsm Ip Assets B.V. Recombinant host cell with deficiency in non-ribosomal peptide synthase production
US8865448B2 (en) 2010-07-30 2014-10-21 Cleanvantage Llc Aspergillus containing beta-glucosidase, beta-glucosidases and nucleic acids encoding the same
EP2603595A1 (en) 2010-08-12 2013-06-19 Novozymes, Inc. Compositions comprising a polypeptide having cellulolytic enhancing activity and a dioxy compound and uses thereof
US20130280375A1 (en) 2010-08-17 2013-10-24 Carlsberg Breweries A/S Brewing method
CA2807702C (en) 2010-08-20 2018-07-24 Codexis, Inc. Use of glycoside hydrolase 61 family proteins in processing of cellulose
WO2012025577A1 (en) 2010-08-24 2012-03-01 Novozymes A/S Heat-stable persephonella carbonic anhydrases and their use
WO2012030849A1 (en) 2010-08-30 2012-03-08 Novozymes A/S Polypeptides having xylanase activity and polynucleotides encoding same
US20130212746A1 (en) 2010-08-30 2013-08-15 Novoyzmes A/S Polypeptides Having Hemicellulolytic Activity And Polynucleotides Encoding Same
DK2735611T3 (en) 2010-08-30 2019-01-28 Novozymes As POLYPEPTIDES WITH CELLULOLYSE INCREASING ACTIVITY AND POLYNUCLEOTIDES CODING THEM
US9267126B2 (en) 2010-08-30 2016-02-23 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
EP2611901B1 (en) 2010-08-30 2016-05-11 Novozymes A/S Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
WO2012030811A1 (en) 2010-08-30 2012-03-08 Novozymes A/S Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
WO2012035103A1 (en) 2010-09-16 2012-03-22 Novozymes A/S Lysozymes
MX2013003237A (es) 2010-09-30 2013-05-30 Novozymes Inc Variantes de polipeptidos que tienen actividad potenciadora celulolitica y polinucleotidos que codifican a los mismos.
CN103282489B (zh) 2010-09-30 2016-12-14 诺维信股份有限公司 具有纤维素分解增强活性的多肽变体及其编码多核苷酸
EP2622071B1 (en) 2010-10-01 2015-12-09 Novozymes A/S Polypeptides having endopeptidase activity and polynucleotides encoding same
US9688975B2 (en) 2010-10-01 2017-06-27 Novozymes, Inc. Beta-glucosidase variants and polynucleotides encoding same
BR112013009817B1 (pt) 2010-10-26 2020-02-04 Novozymes As métodos de degradar ou converter refugo de cana de açúcar, de produzir um produto de fermentação, e, de fermentar refugo de cana de açúcar
BR112013010379A2 (pt) 2010-10-29 2016-08-02 Novozymes As complexo proteico isolado, polinucleotídeo isolado, construto de ácido nucléico ou vetor de expressão, e, célula hospedeira recombinante
CA2810903A1 (en) 2010-10-29 2012-05-03 Novozymes A/S Recombinant n-propanol and isopropanol production
EP2635689B1 (en) 2010-11-02 2015-04-15 Novozymes, Inc. Methods of pretreating cellulosic material with a gh61 polypeptide
US9212354B2 (en) 2010-11-04 2015-12-15 Novozymes Inc. Polypeptides having cellobiohydrolase activitiy and polynucleotides encoding same
CN103298932B (zh) 2010-11-08 2016-08-10 诺维信公司 具有葡糖淀粉酶活性的多肽和编码该多肽的多核苷酸
EP2637515B1 (en) 2010-11-08 2017-09-06 Novozymes A/S Polypeptides having glucoamylase activity and polynucleotides encoding same
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
WO2012062817A1 (en) 2010-11-12 2012-05-18 Novozymes A/S Polypeptides having phospholipase c activity and polynucleotides encoding same
WO2012062220A1 (en) 2010-11-12 2012-05-18 Novozymes A/S Polypeptides having endoglucanase activity and polynucleotides encoding same
WO2012068509A1 (en) 2010-11-18 2012-05-24 Novozymes, Inc. Chimeric polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
CN105420267A (zh) 2010-11-30 2016-03-23 诺维信股份有限公司 用于在真菌细胞中表达基因的启动子
WO2012078656A1 (en) 2010-12-06 2012-06-14 Novozymes North America, Inc. Methods of hydrolyzing oligomers in hemicellulosic liquor
WO2012078712A2 (en) 2010-12-07 2012-06-14 Vnomics Corp. System and method for measuring and reducing vehicle fuel waste
US9284588B2 (en) 2010-12-16 2016-03-15 Novozymes, Inc. Promoters for expressing genes in a fungal cell
CN103443268A (zh) 2011-01-20 2013-12-11 诺维信公司 植物过氧化物酶在丝状真菌中的表达
EP3235903B1 (en) 2011-01-26 2021-07-07 Novozymes A/S Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
MX337942B (es) 2011-01-26 2016-03-29 Novozymes As Polipeptidos que tienen actividad de endoglucanasa y polinucleotidos que codifican los mismos.
EP2668270B1 (en) 2011-01-26 2018-11-21 Novozymes A/S Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
CN105838698B (zh) 2011-01-26 2019-10-11 诺维信公司 具有纤维二糖水解酶活性的多肽及编码该多肽的多核苷酸
MX2013007720A (es) 2011-01-26 2013-08-09 Novozymes As Polipeptidos que tienen actividad celobiohidrolasa y polinucleotidos que codifican para los mismos.
WO2012134626A2 (en) 2011-01-31 2012-10-04 Novozymes North America, Inc. Processes for enzymatic refining of pretreated cellulosic material for saccharification
CA2825628A1 (en) 2011-02-23 2012-08-30 Dupont Nutrition Biosciences Aps Method
CN103384678B (zh) 2011-02-23 2017-01-18 诺维信股份有限公司 具有纤维素水解增强活性的多肽及其编码多核苷酸
WO2012118848A1 (en) 2011-02-28 2012-09-07 Novozymes, Inc. Microorganism for c4-dicarboxylic acid production
DK3339442T3 (da) 2011-03-09 2022-06-20 Novozymes Inc Fremgangsmåder til forøgelse af den cellulolyseforbedrende aktivitet af et polypeptid
WO2012122477A1 (en) 2011-03-10 2012-09-13 Novozymes A/S Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
US20140106398A1 (en) 2011-03-11 2014-04-17 Dsm Ip Assets B.V. Vector-host system
US9879294B2 (en) 2011-03-25 2018-01-30 Novozymes A/S Methods for degrading or converting cellulosic material
US8663962B2 (en) 2011-03-30 2014-03-04 Codexis, Inc. Pentose fermentation by a recombinant microorganism
WO2012135659A2 (en) 2011-03-31 2012-10-04 Novozymes A/S Methods for enhancing the degradation or conversion of cellulosic material
WO2012135719A1 (en) 2011-03-31 2012-10-04 Novozymes, Inc. Cellulose binding domain variants and polynucleotides encoding same
BR112013027333A2 (pt) 2011-04-28 2016-11-29 Novozymes As célula hospedeira microbiana transgênica, construto de ácido nucleico, vetor de expressão, polipeptídeo isolado tendo atividade de endoglucanase, polinucleotídeo isolado, métodos para produzir um polipeptídeo com atividade de endoglucanase, para produzir um mutante de uma célula precursora, para inibir a expressão de um polipeptídeo com atividade de endoglucanase em uma célula, para produzir uma proteína, para degradar ou converter um material celulósico, para produzir um produto de fermentação, e para fermentar um material celulósico.
MX2013011827A (es) 2011-04-29 2014-01-08 Novozymes Inc Metodos para mejorar la degradacion o conversion de material celulosico.
US8993286B2 (en) 2011-05-19 2015-03-31 Novozymes, Inc. Methods for enhancing the degradation of cellulosic material with chitin binding proteins
WO2012159007A1 (en) 2011-05-19 2012-11-22 Novozymes, Inc. Methods for enhancing the degradation of cellulosic material with chitin binding proteins
EP2527448A1 (en) 2011-05-23 2012-11-28 Novozymes A/S Simultaneous site-specific integrations of multiple gene-copies in filamentous fungi
EP2527432A1 (en) 2011-05-23 2012-11-28 Novozymes A/S Bi-directional cytosine deaminase-encoding selection marker
WO2012175708A2 (en) 2011-06-24 2012-12-27 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
DK2726651T3 (en) 2011-06-28 2019-01-28 Codexis Inc PROTEIN INVARIANT GENERATION BY REGION SHUFFLING
US8778652B2 (en) 2011-06-30 2014-07-15 Codexis, Inc. Pentose fermentation by a recombinant microorganism
KR20140056237A (ko) 2011-06-30 2014-05-09 노보자임스 에이/에스 알파-아밀라제 변이체
DK3543333T3 (da) 2011-06-30 2022-02-14 Novozymes As Fremgangsmåde til screening af alfa-amylaser
CA2840962C (en) 2011-07-06 2021-04-13 Novozymes A/S Alpha amylase variants and polynucleotides encoding same
WO2013010783A1 (en) 2011-07-15 2013-01-24 Novozymes A/S Lipase variants and polynucleotides encoding same
BR112013032861A2 (pt) 2011-07-22 2017-01-24 Novozymes North America Inc métodos para aumentar a atividade da enzima celulolítica durante a hidrólise do material celulósico, para hidrolisar um material celulósico pré-tratado, para a produção de um produto da fermentação, e para a fermentação de um material celulósico pré-tratado
US8951767B2 (en) 2011-08-04 2015-02-10 Novozymes A/S Polypeptides having endoglucanase activity and polynucleotides encoding same
US8859227B2 (en) 2011-08-04 2014-10-14 Novozymes, Inc. Polypeptides having xylanase activity and polynucleotides encoding same
US9506044B2 (en) 2011-08-10 2016-11-29 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
CN103732740B (zh) 2011-08-10 2018-07-31 诺维信公司 具有过氧化酶活性的多肽及编码该多肽的多核苷酸
WO2013021064A1 (en) 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013021062A1 (en) 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013021059A1 (en) 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
WO2013021065A1 (en) 2011-08-10 2013-02-14 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
US9382559B2 (en) 2011-08-10 2016-07-05 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
MX2014001594A (es) 2011-08-15 2014-04-25 Novozymes As Polipeptidos que tienen actividad de celulasa y polinucleotidos que los codifican.
CN103917649A (zh) 2011-08-19 2014-07-09 诺维信股份有限公司 用于生产c4-二羧酸的重组微生物
CN103764822B (zh) 2011-08-19 2016-11-23 诺维信公司 具有蛋白酶活性的多肽
BR112014004171A2 (pt) 2011-08-22 2018-11-06 Codexis Inc variantes da proteína glicósideo hidrolase gh61 e cofatores que aumentam a atividade de gh61
WO2013028915A2 (en) 2011-08-24 2013-02-28 Novozymes, Inc. Methods for obtaining positive transformants of a filamentous fungal host cell
CN108179139A (zh) 2011-08-24 2018-06-19 诺维信股份有限公司 纤维素分解酶组合物及其用途
WO2013028912A2 (en) 2011-08-24 2013-02-28 Novozymes, Inc. Methods for producing multiple recombinant polypeptides in a filamentous fungal host cell
EP2748314B1 (en) 2011-08-24 2016-12-28 Novozymes, Inc. Aspergillus fumigatus cellulolytic enzyme compositions and uses thereof
EP2748188A4 (en) 2011-08-26 2015-03-18 Novozymes As POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING THESE POLYPEPTIDES
US9534239B2 (en) 2011-09-06 2017-01-03 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
CN103998461B (zh) 2011-09-08 2018-02-02 科德克希思公司 用于合成取代的内酰胺的生物催化剂和方法
WO2013034106A1 (en) 2011-09-09 2013-03-14 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
WO2013039776A1 (en) 2011-09-13 2013-03-21 Novozymes North America, Inc. Methods of hydrolyzing and fermenting cellulosic material
US20140308705A1 (en) 2011-09-20 2014-10-16 Novozymes A/S Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same
EP2751266B1 (en) 2011-09-22 2017-03-29 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
US20140329284A1 (en) 2011-09-30 2014-11-06 Novozymes, Inc. Chimeric Polypeptides Having Beta-Glucosidase Activity and Polynucleotides Encoding Same
ES2632011T3 (es) 2011-09-30 2017-09-07 Novozymes A/S Polipéptidos con actividad de alfa-amilasa y polinucleótidos que codifican los mismos
BR112014007647A2 (pt) 2011-09-30 2017-04-18 Novozymes As “variante de 3-hpdh, polipeptídeo tendo atividade de 3-hpdh, polinucleotídeo isolado, célula hospedeira microbiana transgênica, e, método para produzir 3-hp
CN104204197A (zh) 2011-10-04 2014-12-10 美国佛罗里达大学研究基金会公司 具有d-乳酸脱氢酶活性的甘油脱氢酶变体及其用途
EP2766476B1 (en) 2011-10-11 2017-05-31 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
WO2013057143A2 (en) 2011-10-17 2013-04-25 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
CA2852601C (en) 2011-10-17 2023-05-23 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
WO2013067028A1 (en) 2011-10-31 2013-05-10 Bp Corporation North America Inc. Use of mammalian promoters in filamentous fungi
WO2013067026A1 (en) 2011-10-31 2013-05-10 Bp Corporation North America Inc. Use of plant promoters in filamentous fungi
EP2773656B1 (en) 2011-10-31 2019-06-19 Novozymes, Inc. Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
US9562222B2 (en) 2011-11-18 2017-02-07 Novozymes A/S Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same
CA2855451A1 (en) 2011-11-21 2013-08-15 Novozymes, Inc. Gh61 polypeptide variants and polynucleotides encoding same
WO2013075644A1 (en) 2011-11-22 2013-05-30 Novozymes, Inc. Polypeptides having beta-xylosidase activity and polynucleotides encoding same
ES2631605T3 (es) 2011-11-25 2017-09-01 Novozymes A/S Polipéptidos con actividad de lisozima y polinucleótidos que codifican los mismos
BR112014012417A2 (pt) 2011-12-01 2017-06-06 Novozymes Inc polipeptídeo e polinucleotídeo isolados, célula hospedeira recombinante, métodos para a produção de um polipeptídeo, de um mutante de uma célula de origem, e de uma proteína, e para a inibição da expressão de um polipeptídeo, planta transgênica, parte da planta ou célula de planta, molécula de rna, processos para degradar ou converter um material celulósico ou contendo xilano, para produzir um produto de fermentação, e de fermentação de um material celulósico ou contendo xilano, e, formulação de caldo integral ou composição de cultura de células
US9169469B2 (en) 2011-12-02 2015-10-27 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
US9404093B2 (en) 2011-12-02 2016-08-02 Novozymes A/S Polypeptides having peroxygenase activity and polynucleotides encoding same
US20140329309A1 (en) 2011-12-09 2014-11-06 Danisco Us Inc. Ribosomal Promoters for Production in Microorganisms
EP2791330B1 (en) 2011-12-16 2017-07-26 Novozymes, Inc. Polypeptides having laccase activity and polynucleotides encoding same
BR112014014697A2 (pt) 2011-12-19 2020-10-27 Novozymes, Inc. polipeptídeo isolado, composição, polinucleotídeo isolado, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, métodos para produzir um polipeptídeo e uma proteína, para gerar oxigênio molecular, e para remover peróxido de hidrogênio do tecido, processos para degradar ou converter um material celulósico, e para produzir um produto de fermentação, e, formulação de caldo integral ou composição de cultura de células
CN103998605B (zh) 2011-12-20 2021-08-03 诺维信股份有限公司 纤维二糖水解酶变体和编码它们的多核苷酸
BR112014015030A2 (pt) 2011-12-20 2017-06-13 Codexis Inc variantes da endoflucanase 1b (eg1b)
BR112014015705A8 (pt) 2011-12-28 2017-07-04 Novozymes A / S polipeptídeo isolado, composição, polinucleotídeo isolado,, construção de ácido nucleico ou vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo, para melhorar o valor nutritivo de uma ração parar animais e para o tratamento de proteínas, planta transgênica, parte de planta ou célula vegetal, uso de pelo menos um polipeptídeo, aditivo de ração para animal, ração para animais, e, composição detergente
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
AU2013213601B8 (en) 2012-01-26 2018-01-18 Novozymes A/S Use of polypeptides having protease activity in animal feed and detergents
DK2623586T3 (da) 2012-02-03 2017-11-13 Procter & Gamble Sammensætninger og fremgangsmåder til overfladebehandling med lipaser
ES2794644T3 (es) 2012-02-03 2020-11-18 Novozymes As Variantes de lipasa y polinucleótidos que las codifican
BR112014018876A2 (pt) 2012-02-20 2017-07-04 Novozymes As polipeptídeo isolado com atividade endoglicanase, composição, polinucleotídeo isolado, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, método de produção de um polipeptídeo
DK2828385T3 (en) 2012-03-23 2018-03-12 Codexis Inc BIOCATALIZATORS AND METHODS FOR SYNTHETIZING DERIVATIVES AND TRYPTAMIN AND TRYPTAMINE ANALOGS
WO2013149858A1 (en) 2012-04-02 2013-10-10 Novozymes A/S Lipase variants and polynucleotides encoding same
CN104245929A (zh) 2012-04-23 2014-12-24 诺维信公司 具有α-葡糖醛酸糖苷酶活性的多肽以及编码其的多核苷酸
BR112014024804A2 (pt) 2012-04-23 2017-07-11 Novozymes As polipeptídeo isolado tendo atividade de glucuronil esterase, composição, polinucleotídeo isolado, construção de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, métodos para a produção de um polipeptídeo, para a degradação ou conversão de um material celulósico e para a produção de um produto de fermentação
CA2868308A1 (en) 2012-04-27 2013-10-31 Novozymes, Inc. Gh61 polypeptide variants and polynucleotides encoding same
WO2013167581A1 (en) 2012-05-07 2013-11-14 Novozymes A/S Polypeptides having xanthan degrading activity and polynucleotides encoding same
US9790527B2 (en) 2012-05-08 2017-10-17 Codexis, Inc. Engineered proline hydroxylase polypeptides
WO2013170050A1 (en) 2012-05-11 2013-11-14 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP2855659A1 (en) 2012-05-31 2015-04-08 Novozymes A/S Improved selection in fungi
CN109234250A (zh) 2012-05-31 2019-01-18 诺维信公司 具有有机磷水解酶活性的多肽
BR112014031024A2 (pt) 2012-06-11 2017-06-27 Codexis Inc xilanases e xilosidases fúngicas.
US20150197760A1 (en) 2012-06-19 2015-07-16 Dsm Ip Assets B.V. Promoters for expressing a gene in a cell
AU2013279440B2 (en) 2012-06-20 2016-10-06 Novozymes A/S Use of polypeptides having protease activity in animal feed and detergents
MX2015000312A (es) 2012-07-12 2015-04-10 Novozymes As Polipeptidos que tienen actividad lipasa y polinucleotidos que los codifican.
MX357482B (es) 2012-07-19 2018-07-11 Dsm Ip Assets Bv Cepa deficiente en agse.
AU2013302535B2 (en) 2012-08-16 2018-12-06 Bangladesh Jute Research Institute Pectin degrading enzymes from Macrophomina phaseolina and uses thereof
DK2885406T3 (en) 2012-08-16 2018-11-26 Bangladesh Jute Res Institute CELLULOSE AND / OR HEMICELLULOSE DEGRADING ENZYMERS FROM MACROPHOMINA PHASEOLINA AND APPLICATIONS THEREOF
EP2884852B1 (en) 2012-08-17 2019-05-15 Novozymes A/S Thermostable asparaginase variants and polynucleotides encoding same
WO2014028833A1 (en) 2012-08-17 2014-02-20 Novozymes A/S Methods for co-silencing expression of genes in filamentous fungal strains and uses thereof
MX2015002099A (es) 2012-08-22 2015-05-11 Dupont Nutrition Biosci Aps Variantes que tienen actividad glucoamilasa.
US9315791B2 (en) 2012-08-22 2016-04-19 Novozymes A/S Metalloproteases from alicyclobacillus
EP2888361A1 (en) 2012-08-22 2015-07-01 Novozymes A/S Metalloprotease from exiguobacterium
EP2893012B1 (en) 2012-09-05 2018-08-15 Novozymes A/S Polypeptides having protease activity
US20140073022A1 (en) 2012-09-10 2014-03-13 Wisconsin Alumni Research Foundation Production of polyhydroxyalkanoates with a defined composition from an unrelated carbon source
DK2898076T3 (en) 2012-09-19 2018-06-14 Dsm Ip Assets Bv METHOD OF CELL MODIFICATION USING ESSENTIAL GENES AS MARKERS AND EVEN RECYCLING THESE
WO2014092832A2 (en) 2012-09-19 2014-06-19 Novozymes, Inc. Methods for enhancing the degradation or conversion of cellulosic material
CN105861469B (zh) 2012-10-08 2020-04-14 诺维信公司 具有纤维素分解增强活性的多肽以及编码它们的多核苷酸
US9404094B2 (en) 2012-10-12 2016-08-02 Novozymes A/S Polypeptides having peroxygenase activity
WO2014056916A2 (en) 2012-10-12 2014-04-17 Novozymes A/S Polypeptides having peroxygenase activity
US9453207B2 (en) 2012-10-12 2016-09-27 Novozymes A/S Polypeptides having peroxygenase activity
US9611459B2 (en) 2012-10-12 2017-04-04 Novozymes A/S Polypeptides having peroxygenase activity
EP2906686B1 (en) 2012-10-12 2018-08-29 Novozymes A/S Polypeptides having peroxygenase activity
EP2906685B1 (en) 2012-10-12 2018-08-15 Novozymes A/S Polypeptides having peroxygenase activity
US9719072B2 (en) 2012-10-12 2017-08-01 Novozymes A/S Polypeptides having peroxygenase activity
US20150275194A1 (en) 2012-10-24 2015-10-01 Novozymes A/S Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same
WO2014076232A2 (en) 2012-11-19 2014-05-22 Novozymes A/S Isopropanol production by recombinant hosts using an hmg-coa intermediate
CA2891482A1 (en) 2012-11-20 2014-05-30 Codexis, Inc. Pentose fermentation by a recombinant microorganism
US9624270B2 (en) 2012-11-29 2017-04-18 Mississippi State University Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species
US20150307871A1 (en) 2012-12-07 2015-10-29 Novozymes A/S Method for generating site-specific mutations in filamentous fungi
EP2931744B1 (en) 2012-12-11 2021-08-18 Novozymes A/S Polypeptides having phospholipase c activity and polynucleotides encoding same
CN104870639A (zh) 2012-12-14 2015-08-26 诺维信公司 具有纤维素分解增强活性的多肽以及编码它们的多核苷酸
CA2894261C (en) 2012-12-17 2022-01-04 Novozymes A/S Alpha-amylases and polynucleotides encoding same
WO2014099798A1 (en) 2012-12-19 2014-06-26 Novozymes A/S Polypeptides having cellulolytic enhancinc activity and polynucleotides encoding same
HUE051359T2 (hu) 2012-12-21 2021-03-01 Codexis Inc Génmódosított biokatalizátorok és eljárások királis aminok szintetizálására
US10023872B2 (en) 2012-12-21 2018-07-17 Novozymes, Inc. Methods for producing heterologous polypeptides in mutants of trichoderma
CN104869841A (zh) 2012-12-21 2015-08-26 诺维信公司 具有蛋白酶活性的多肽和编码它的多核苷酸
EP2938628A4 (en) 2012-12-24 2016-10-19 Novozymes As POLYPEPTIDES WITH ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES FOR CODING THEREOF
WO2014106593A1 (en) 2013-01-03 2014-07-10 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
US9540622B2 (en) 2013-01-18 2017-01-10 Codexis, Inc. Engineered biocatalysts useful for carbapenem synthesis
EP2951296A2 (en) 2013-02-04 2015-12-09 DSM IP Assets B.V. Carbohydrate degrading polypeptide and uses thereof
EP2953481A2 (en) 2013-02-06 2015-12-16 Novozymes A/S Use of polypeptides having protease activity in animal feed
HUE042206T2 (hu) 2013-02-28 2019-06-28 Codexis Inc Módosított transzamináz polipeptidek ipari biokatalízishez
EP2964760B1 (en) 2013-03-08 2021-05-12 Novozymes A/S Cellobiohydrolase variants and polynucleotides encoding same
WO2014145768A2 (en) 2013-03-15 2014-09-18 Bp Corporation North America Inc. Use of non-fungal 5' utrs in filamentous fungi
WO2014151748A1 (en) 2013-03-15 2014-09-25 Dsm Ip Assets B.V. Use of thermophilic nucleases for degrading nucleic acids
MX363261B (es) 2013-03-21 2019-03-19 Novozymes As Polipéptidos que tienen actividad de la fosfolipasa a y polinucleótidos que los codifican.
US9631164B2 (en) 2013-03-21 2017-04-25 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
EP2981610A1 (en) 2013-04-05 2016-02-10 Université du Luxembourg Biotechnological production of itaconic acid
TR201819061T4 (tr) 2013-04-18 2019-01-21 Novozymes As Proteaz Aktivitesine Sahip Polipeptitler Ve Bunları Kodlayan Polinükleotitler
ES2729048T3 (es) 2013-04-18 2019-10-30 Codexis Inc Polipéptidos de fenilalanina amoníaco-liasa modificados
BR112015026972B1 (pt) 2013-04-30 2023-05-02 Novozymes A/S Variantes de glucoamilase, composição, uso de um polipeptídeo, processo de produção de um produto de fermentação e processo de produção de um produto de xarope a partir de material contendo amido
US9963690B2 (en) 2013-04-30 2018-05-08 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
EP2994529B1 (en) 2013-05-10 2018-11-21 Novozymes A/S Polypeptides having xylanase activity and polynucleotides encoding same
CN105209612A (zh) 2013-05-14 2015-12-30 诺维信公司 洗涤剂组合物
US20160083703A1 (en) 2013-05-17 2016-03-24 Novozymes A/S Polypeptides having alpha amylase activity
EP3786269A1 (en) 2013-06-06 2021-03-03 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
WO2014202624A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202620A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202622A2 (en) 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
WO2014202621A1 (en) 2013-06-20 2014-12-24 Dsm Ip Assets B.V. Carbohydrate degrading polypeptide and uses thereof
JP2016523098A (ja) 2013-07-04 2016-08-08 ノボザイムス アクティーゼルスカブ 再付着防止効果を有するポリペプチドおよびそれをコードするポリヌクレオチド
EP3019603A1 (en) 2013-07-09 2016-05-18 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
CN105980552A (zh) 2013-07-10 2016-09-28 诺华股份有限公司 多种蛋白酶缺陷的丝状真菌细胞及其使用方法
HUE040545T2 (hu) 2013-07-17 2019-03-28 Novozymes As Pullulanáz kimérák és az azokat kódoló polinukleotidok
WO2015011285A2 (en) 2013-07-26 2015-01-29 Biomethodes Novel variant trichoderma reesei endoglucanases
EP3033420B1 (en) 2013-08-15 2018-02-21 Novozymes A/S Polypeptides having beta-1,3-galactanase activity and polynucleotides encoding same
US9708630B1 (en) 2013-10-08 2017-07-18 Wisconsin Alumni Research Foundation Cells and methods for producing fatty alcohols
WO2015059133A1 (en) 2013-10-22 2015-04-30 Novozymes A/S Cellobiose dehydrogenase variants and polynucleotides encoding same
WO2015058700A1 (en) 2013-10-25 2015-04-30 Novozymes A/S Polypeptides having endoglucanase activity and polynucleotides encoding same
WO2015073555A1 (en) 2013-11-13 2015-05-21 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
EP3074513A1 (en) 2013-11-26 2016-10-05 Novozymes A/S Enzyme compositions and uses thereof
EP2876156A1 (en) 2013-11-26 2015-05-27 Commissariat A L'energie Atomique Et Aux Energies Alternatives New enzymes and method for preparing hydroxylated L-lysine or L-ornithine and analogs thereof
WO2015079064A2 (en) 2013-11-29 2015-06-04 Novozymes A/S Peroxygenase variants
CN105992822A (zh) 2013-12-02 2016-10-05 帝斯曼知识产权资产管理有限公司 冰结构蛋白质
KR102268532B1 (ko) 2013-12-11 2021-06-24 노보자임스 에이/에스 큐티나아제 변이체 및 이를 암호화하는 폴리뉴클레오티드
EP2886656A1 (en) 2013-12-18 2015-06-24 Commissariat A L'energie Atomique Et Aux Energies Alternatives New enzyme and method for preparing 4-hydroxyl benzyl alcohol and derivatives thereof
WO2015091989A1 (en) 2013-12-20 2015-06-25 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
EP3097112B1 (en) 2014-01-22 2020-05-13 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
DK3415624T3 (da) 2014-01-22 2021-11-08 Novozymes As Pullulanasevarianter og polynukleotider, som koder for dem
US10123535B2 (en) 2014-03-05 2018-11-13 Novozymes A/S Compositions and methods for improving post-harvest properties of agricultural crops
WO2015134691A1 (en) 2014-03-05 2015-09-11 Novozymes A/S Formulations comprising polymeric xyloglucan as a carrier for agriculturally beneficial agents
US20160333292A1 (en) 2014-03-05 2016-11-17 Novozymes A/S Compositions and Methods for Improving Properties of Cellulosic Textile Materials with Xyloglucan Endotransglycosylase
CN106062276B (zh) 2014-03-05 2019-06-11 诺维信公司 用于将材料功能化并且进行连接的组合物和方法
US20160348035A1 (en) 2014-03-05 2016-12-01 Novozymes A/S Compositions and Methods for Improving Properties of Non-Cellulosic Textile Materials with Xyloglucan Endotransglycosylase
WO2015135464A1 (en) 2014-03-12 2015-09-17 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
WO2015150457A1 (en) 2014-04-01 2015-10-08 Novozymes A/S Polypeptides having alpha amylase activity
EP3550015B1 (en) 2014-04-10 2021-11-10 Novozymes A/S Alpha-amylase variants and polynucleotides encoding same
CN112899086A (zh) 2014-04-11 2021-06-04 诺维信公司 洗涤剂组合物
US10030215B2 (en) 2014-04-15 2018-07-24 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
HUE056444T2 (hu) 2014-04-16 2022-02-28 Codexis Inc Génmódosított tirozin-ammónia-liáz
WO2015177153A1 (en) 2014-05-19 2015-11-26 Dsm Ip Assets B.V. Proline-specific endoprotease
JP6601630B2 (ja) 2014-05-19 2019-11-06 ディーエスエム アイピー アセッツ ビー.ブイ. プロリン特異的エンドプロテアーゼ
WO2015177152A1 (en) 2014-05-19 2015-11-26 Dsm Ip Assets B.V. Proline-specific endoprotease
WO2015181118A1 (en) 2014-05-27 2015-12-03 Novozymes A/S Methods for producing lipases
EP3149178B1 (en) 2014-05-27 2020-07-15 Novozymes A/S Lipase variants and polynucleotides encoding same
WO2015183710A1 (en) 2014-05-30 2015-12-03 Novozymes A/S Variants of gh family 11 xylanase and polynucleotides encoding same
EP3152315B1 (en) 2014-06-06 2018-08-15 Novozymes A/S Enzyme compositions and uses thereof
EP3161133B1 (en) 2014-06-25 2018-12-12 Novozymes A/S Xylanase variants and polynucleotides encoding same
US9708587B2 (en) 2014-07-09 2017-07-18 Codexis, Inc. P450-BM3 variants with improved activity
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
WO2016028999A1 (en) 2014-08-20 2016-02-25 Novozymes A/S Xyloglucan endotransglycosylase variants and polynucleotides encoding same
US11390898B2 (en) 2014-09-05 2022-07-19 Novozymes A/S Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
EP3209788B1 (en) 2014-10-23 2019-06-05 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
WO2016079305A1 (en) 2014-11-20 2016-05-26 Novozymes A/S Alicyclobacillus variants and polynucleotides encoding same
SG11201703258PA (en) 2014-11-25 2017-05-30 Codexis Inc Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US10781428B2 (en) 2014-12-02 2020-09-22 Novozymes A/S Laccase variants and polynucleotides encoding same
CN107002054A (zh) 2014-12-05 2017-08-01 诺维信公司 脂肪酶变体以及编码它们的多核苷酸
WO2016096996A1 (en) 2014-12-16 2016-06-23 Novozymes A/S Polypeptides having n-acetyl glucosamine oxidase activity
DK3234143T3 (da) 2014-12-19 2023-09-04 Novozymes As Sammensætninger omfattende polypeptider med xylanaseaktivitet og polypeptider med arabinofuranosidaseaktivitet
US20170362613A1 (en) 2014-12-19 2017-12-21 Novozymes A/S Recombinant Host Cells For The Production Of 3-Hydroxypropionic Acid
HUE062016T2 (hu) 2014-12-22 2023-09-28 Codexis Inc Humán alfa-galaktozidáz variánsok
EP3242950B1 (en) 2015-01-06 2021-10-06 DSM IP Assets B.V. A crispr-cas system for a filamentous fungal host cell
EP3256577B1 (en) 2015-02-10 2020-08-26 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
WO2016138167A2 (en) 2015-02-24 2016-09-01 Novozymes A/S Cellobiohydrolase variants and polynucleotides encoding same
EP3262161B1 (en) 2015-02-27 2021-06-30 Novozymes A/S Mutant host cells for the production of 3-hydroxypropionic acid
EP3268482B1 (en) 2015-03-09 2019-12-11 Novozymes A/S Methods of introducing multiple expression constructs into a eukaryotic cell
US20180355404A1 (en) 2015-04-07 2018-12-13 Novozymes A/S Methods for selecting enzymes having lipase activity
US20180073017A1 (en) 2015-04-07 2018-03-15 Novozymes A/S Methods for selecting enzymes having enhanced activity
AR104205A1 (es) 2015-04-09 2017-07-05 Dsm Ip Assets Bv Fosfolipasa c
KR102604503B1 (ko) 2015-05-07 2023-11-20 코덱시스, 인코포레이티드 페니실린-g 아실라아제
US9920102B2 (en) 2015-05-15 2018-03-20 Albert Einstein College Of Medicine, Inc. Fusion tags for protein expression
CN107636151B (zh) 2015-05-22 2023-04-04 杜邦营养生物科学有限公司 乙酰乳酸脱羧酶
CN116676293A (zh) 2015-05-27 2023-09-01 国投生物科技投资有限公司 具有纤维二糖水解酶活性的多肽以及对其进行编码的多核苷酸
US20180160695A1 (en) 2015-06-02 2018-06-14 Dsm Ip Assets B.V. Use of ice structuring protein afp19 expressed in filamentous fungal strains for preparing food
WO2016202739A1 (en) 2015-06-16 2016-12-22 Novozymes A/S Polypeptides with lipase activity and polynucleotides encoding same
WO2016205127A1 (en) 2015-06-18 2016-12-22 Novozymes A/S Polypeptides having trehalase activity and the use thereof in process of producing fermentation products
EP3313990A4 (en) 2015-06-26 2019-01-23 Novozymes A/S BIOLOGICAL FINISHING TREATMENT SYSTEM
WO2016207373A1 (en) 2015-06-26 2016-12-29 Novozymes A/S Polypeptides having peroxygenase activity
EP3313193B1 (en) 2015-06-26 2021-03-24 Novozymes A/S Method for producing a coffee extract
US10920203B2 (en) 2015-07-01 2021-02-16 Novozymes A/S Methods of reducing odor
AU2016286612B2 (en) 2015-07-02 2021-01-28 Novozymes A/S Animal feed compositions and uses thereof
US10822598B2 (en) 2015-07-06 2020-11-03 Novozymes A/S Lipase variants and polynucleotides encoding same
WO2017007547A1 (en) 2015-07-07 2017-01-12 Codexis, Inc. Novel p450-bm3 variants with improved activity
WO2017019491A1 (en) 2015-07-24 2017-02-02 Novozymes Inc. Polypeptides having beta-xylosidase activity and polynucleotides encoding same
BR112018001041A2 (pt) 2015-07-24 2018-09-11 Novozymes Inc polipeptídeo isolado, composição, formulação de caldo inteiro ou composição de cultura de células, célula hospedeira recombinante, métodos para produção de um polipeptídeo e para produção de uma proteína, planta, parte de planta ou célula de planta transgênica, e, processos para degradação de um material celulósico ou hemicelulósico, para produção de um produto de fermentação e para fermentação de um material celulósico ou hemicelulósico.
EP3330375A1 (en) 2015-07-29 2018-06-06 Abengoa Bioenergía Nuevas Tecnologías, S. A. Expression of recombinant beta-xylosidase enzymes
EP3341475A1 (en) 2015-08-24 2018-07-04 Novozymes A/S Beta-alanine aminotransferases for the production of 3-hydroxypropionic acid
CN108348585B (zh) 2015-09-02 2023-12-15 杜邦营养生物科学有限公司 糖苷水解酶及其在预防和/或治疗动物中的病原体感染中的用途
WO2017040907A1 (en) 2015-09-04 2017-03-09 Novozymes A/S Methods of inhibiting aa9 lytic polysaccharide monooxygenase catalyzed inactivation of enzyme compositions
CA2991114A1 (en) 2015-09-17 2017-03-23 Novozymes A/S Polypeptides having xanthan degrading activity and polynucleotides encoding same
CN108350044B (zh) 2015-09-22 2022-05-24 诺维信公司 具有纤维二糖水解酶活性的多肽以及对其进行编码的多核苷酸
WO2017050652A1 (en) 2015-09-25 2017-03-30 Dsm Ip Assets B.V. Asparaginase
CN108350441B (zh) 2015-10-07 2022-09-27 诺维信公司 多肽
ES2891339T3 (es) 2015-10-14 2022-01-27 Novozymes As Variantes de glucoamilasa y polinucleótidos que codifican las mismas
US10479981B2 (en) 2015-10-14 2019-11-19 Novozymes A/S DNase variants
WO2017064253A1 (en) 2015-10-14 2017-04-20 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
WO2017070219A1 (en) 2015-10-20 2017-04-27 Novozymes A/S Lytic polysaccharide monooxygenase (lpmo) variants and polynucleotides encoding same
US20190078097A1 (en) 2015-10-30 2019-03-14 Novozymes A/S Polynucleotide Constructs For In Vitro and In Vivo Expression
EP3380608A1 (en) 2015-11-24 2018-10-03 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
EP3384019B1 (en) 2015-12-01 2020-06-24 Novozymes A/S Methods for producing lipases
MX2018006610A (es) 2015-12-02 2019-05-27 Inst Nat De La Rech Agronomique Inra Nuevos peptidos que tienen actividad antimicrobiana y nueva enzima capaces de convertir un residuo de configuracion l en un aminoacido de configuracion d en un peptido.
CN108431204A (zh) 2015-12-22 2018-08-21 阿尔布梅迪克斯医疗有限公司 改良的表达蛋白质的菌株
WO2017114891A1 (en) 2015-12-30 2017-07-06 Novozymes A/S Enzyme variants and polynucleotides encoding the same
MX2018008051A (es) 2016-01-29 2018-08-23 Novozymes As Variantes de beta-glucanasa y polinucleotidos que las codifican.
US11685911B2 (en) 2016-02-16 2023-06-27 Monaghan Mushroom S Group Fungal polypeptides having lysozyme activity
CN108699600A (zh) 2016-02-23 2018-10-23 诺维信公司 改进的新一代测序
EP3423577B1 (en) 2016-03-02 2024-05-08 Novozymes A/S Cellobiohydrolase variants and polynucleotides encoding same
DK3419991T3 (da) 2016-03-04 2023-01-16 Danisco Us Inc Modificerede ribosomale genpromotorer til proteinproduktion i mikroorganismer
EP3433358B1 (en) 2016-03-24 2022-07-06 Novozymes A/S Cellobiohydrolase variants and polynucleotides encoding same
US20190161786A1 (en) 2016-04-07 2019-05-30 Novozymes A/S Methods for selecting enzymes having protease activity
CN108779155A (zh) 2016-04-19 2018-11-09 诺维信公司 RlmA灭活的丝状真菌宿主细胞
MX2018013139A (es) 2016-04-29 2019-02-13 Novozymes As Composiciones detergentes y sus usos.
EP3452497B1 (en) 2016-05-03 2021-02-17 Novozymes A/S Alpha-amylase variants and polynucleotides encoding the same
JP7128519B2 (ja) 2016-05-05 2022-08-31 コデクシス, インコーポレイテッド ペニシリンgアシラーゼ
EP3455352A1 (en) 2016-05-09 2019-03-20 Novozymes A/S Variant polypeptides with improved performance and use of the same
EP3246401A1 (en) 2016-05-20 2017-11-22 Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives New fatty acid decarboxylase and its uses
MX2018014234A (es) 2016-05-24 2019-03-28 Novozymes As Polipeptidos que tienen actividad alfa-galactosidasa y polinucleotidos que los codifican.
EP3464580A1 (en) 2016-05-24 2019-04-10 Novozymes A/S Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity
AU2017270269A1 (en) 2016-05-24 2018-11-15 Novozymes A/S Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity
EP3462904A1 (en) 2016-05-24 2019-04-10 Novozymes A/S Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
WO2017205535A1 (en) 2016-05-27 2017-11-30 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
WO2017211803A1 (en) 2016-06-07 2017-12-14 Novozymes A/S Co-expression of heterologous polypeptides to increase yield
CN109715817B (zh) 2016-06-09 2022-12-09 科德克希思公司 用于化合物的羟基化的生物催化剂和方法
EP3469076B1 (en) 2016-06-10 2020-09-02 DSM IP Assets B.V. Mutant lipase and use thereof
KR20190018512A (ko) 2016-06-15 2019-02-22 코덱시스, 인코포레이티드 조작된 베타-글루코시다아제 및 글루코실화 방법
US10421951B2 (en) 2016-06-22 2019-09-24 Wisconsin Alumni Research Foundation Gene construct encoding mutant thioesterase, mutant thioesterase encoded thereby, transformed host cell containing the gene construct, and method of using them to produce medium-chain fatty acids
RU2019102378A (ru) 2016-06-30 2020-07-30 ДАНИСКО ЮЭс ИНК. Аспарагиновые протеазы
EP3263699B1 (en) 2016-06-30 2020-07-01 Fornia BioSolutions, Inc. Novel phytases and uses thereof
WO2018002261A1 (en) 2016-07-01 2018-01-04 Novozymes A/S Detergent compositions
EP3481949B1 (en) 2016-07-05 2021-06-09 Novozymes A/S Pectate lyase variants and polynucleotides encoding same
WO2018009520A1 (en) 2016-07-06 2018-01-11 Novozymes A/S Improving a microorganism by crispr-inhibition
CN109415709A (zh) 2016-07-08 2019-03-01 诺维信公司 具有木聚糖酶活性的多肽以及编码其的多核苷酸
MX2019000140A (es) 2016-07-08 2019-06-10 Novozymes As Variantes de xilanasa y polinucleotidos que las codifican.
WO2018007573A1 (en) 2016-07-08 2018-01-11 Novozymes A/S Detergent compositions with galactanase
WO2018011276A1 (en) 2016-07-13 2018-01-18 The Procter & Gamble Company Bacillus cibi dnase variants and uses thereof
WO2018015295A1 (en) 2016-07-18 2018-01-25 Novozymes A/S Lipase variants, polynucleotides encoding same and the use thereof
WO2018017792A1 (en) 2016-07-20 2018-01-25 Novozymes A/S Heat-stable metagenomic carbonic anhydrases and their use
US11891645B2 (en) 2016-07-21 2024-02-06 Novozymes A/S Serine protease variants and polynucleotides encoding same
CN109642225A (zh) 2016-07-21 2019-04-16 诺维信公司 丝氨酸蛋白酶变体以及对其进行编码的多核苷酸
WO2018015444A1 (en) 2016-07-22 2018-01-25 Novozymes A/S Crispr-cas9 genome editing with multiple guide rnas in filamentous fungi
CN109476714A (zh) 2016-07-22 2019-03-15 诺维信公司 改善的丝状真菌宿主
WO2018026868A1 (en) 2016-08-01 2018-02-08 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
EP3504313A1 (en) 2016-08-24 2019-07-03 Henkel AG & Co. KGaA Detergent composition comprising gh9 endoglucanase variants i
KR102483218B1 (ko) 2016-08-24 2023-01-02 헨켈 아게 운트 코. 카게아아 크산탄 리아제 변이체 i을 포함하는 세제 조성물
CN109844110B (zh) 2016-08-24 2023-06-06 诺维信公司 黄原胶裂解酶变体以及编码它们的多核苷酸
WO2018037062A1 (en) 2016-08-24 2018-03-01 Novozymes A/S Gh9 endoglucanase variants and polynucleotides encoding same
IL264686B1 (en) 2016-08-26 2024-03-01 Codexis Inc Engineered imine reductases and methods for reversible amination of ketone and amine compounds
CN109563522A (zh) 2016-09-15 2019-04-02 诺维信公司 真菌宿主细胞中dna片段的基因组整合
DK3512941T3 (da) 2016-09-16 2021-06-28 Dupont Nutrition Biosci Aps Acetolactatdecarboxylasevarianter med forbedret specifik aktivitet
WO2018077938A1 (en) 2016-10-25 2018-05-03 Novozymes A/S Detergent compositions
US20210284991A1 (en) 2016-11-21 2021-09-16 Novozymes A/S Yeast Cell Extract Assisted Construction of DNA Molecules
EP3565893A4 (en) 2017-01-05 2020-12-09 Codexis, Inc. PENICILLIN G ACYLASES
ES2965826T3 (es) 2017-02-01 2024-04-17 Procter & Gamble Composiciones limpiadoras que comprenden variantes de amilasa
JP7242535B2 (ja) 2017-02-01 2023-03-20 ノボザイムス アクティーゼルスカブ α-アミラーゼ変異体
WO2018144679A2 (en) 2017-02-03 2018-08-09 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
EP3579867A4 (en) 2017-02-13 2021-03-10 Codexis, Inc. MANIPULATED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
JP2020508698A (ja) 2017-02-20 2020-03-26 ノボザイムス アクティーゼルスカブ 焼成に使用するための脂肪分解酵素
EP3592429A1 (en) 2017-03-06 2020-01-15 DuPont Nutrition Biosciences ApS Novel fungal fucosidases and their use in preventing and/or treating a pathogenic infection in an animal
CN110431224A (zh) 2017-03-13 2019-11-08 帝斯曼知识产权资产管理有限公司 锌双核簇转录调控因子缺陷型菌株
WO2018167153A1 (en) 2017-03-17 2018-09-20 Novozymes A/S Improved filamentous fungal host cell
WO2018172155A1 (en) 2017-03-23 2018-09-27 Novozymes A/S Improved filamentous fungal host cells
WO2018177936A1 (en) 2017-03-31 2018-10-04 Novozymes A/S Polypeptides having dnase activity
EP3601551A1 (en) 2017-03-31 2020-02-05 Novozymes A/S Polypeptides having rnase activity
EP3601550A1 (en) 2017-03-31 2020-02-05 Novozymes A/S Polypeptides having dnase activity
EP3606936B1 (en) 2017-04-03 2021-10-20 Novozymes A/S Recovery process
WO2018185150A1 (en) 2017-04-04 2018-10-11 Novozymes A/S Polypeptides
CN114480034A (zh) 2017-04-04 2022-05-13 诺维信公司 糖基水解酶
US20200109352A1 (en) 2017-04-04 2020-04-09 Novozymes A/S Polypeptide compositions and uses thereof
CA3057896A1 (en) 2017-04-11 2018-10-18 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
CA3061133A1 (en) 2017-04-27 2018-11-01 Codexis, Inc. Ketoreductase polypeptides and polynucleotides
CN110651038A (zh) 2017-05-05 2020-01-03 诺维信公司 包含脂肪酶和亚硫酸盐的组合物
WO2018206535A1 (en) 2017-05-08 2018-11-15 Novozymes A/S Carbohydrate-binding domain and polynucleotides encoding the same
EP3622064A1 (en) 2017-05-08 2020-03-18 Novozymes A/S Mannanase variants and polynucleotides encoding same
EP3622063A1 (en) 2017-05-08 2020-03-18 Novozymes A/S Mannanase variants and polynucleotides encoding same
EP3401385A1 (en) 2017-05-08 2018-11-14 Henkel AG & Co. KGaA Detergent composition comprising polypeptide comprising carbohydrate-binding domain
WO2018208665A1 (en) 2017-05-08 2018-11-15 Codexis, Inc. Engineered ligase variants
CA3064574A1 (en) 2017-06-14 2018-12-20 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
US11130979B2 (en) 2017-06-20 2021-09-28 Albumedix Ltd Protein expression strains
WO2018234465A1 (en) 2017-06-22 2018-12-27 Novozymes A/S XYLANASE VARIANTS AND POLYNUCLEOTIDES ENCODING THE SAME
US11643642B2 (en) 2017-06-27 2023-05-09 Codexis, Inc. Penicillin-g acylases
MX2019014889A (es) 2017-06-28 2020-02-13 Novozymes As Polipeptidos que tienen actividad trehalasa y polinucleotidos que los codifican.
CA3066767A1 (en) 2017-06-30 2019-01-03 Codexis, Inc. T7 rna polymerase variants
EP3645711A4 (en) 2017-06-30 2021-04-21 Codexis, Inc. T7 RNA POLYMERASE VARIANTS
ES2971299T3 (es) 2017-07-24 2024-06-04 Novozymes As GH5 y GH30 en la molienda húmeda
JP2020529221A (ja) 2017-07-28 2020-10-08 ザ・トラスティーズ・オブ・プリンストン・ユニバーシティThe Trustees Of Princeton University 組み換えタンパク質発現のための融合タグ
US10081800B1 (en) 2017-08-03 2018-09-25 Fornia Biosolutions, Inc. Lactonase enzymes and methods of using same
BR112020002115A2 (pt) 2017-08-08 2020-08-11 Novozymes A/S polipeptídeo variante de trealase, polinucleotídeo, construto de ácido nucleico, vetor de expressão, célula hospedeira, composição, formulação de caldo inteiro ou composição de cultura de células, método de produção de uma variante de trealase, e, processo de produção de um produto de fermentação
US20210130744A1 (en) 2017-08-24 2021-05-06 Henkel Ag & Co. Kgaa Detergent composition comprising xanthan lyase variants ii
EP3673057A1 (en) 2017-08-24 2020-07-01 Novozymes A/S Xanthan lyase variants and polynucleotides encoding same
WO2019038058A1 (en) 2017-08-24 2019-02-28 Novozymes A/S GH9 ENDOGLUCANASE VARIANTS AND POLYNUCLEOTIDES ENCODING SUCH VARIANTS
US11624059B2 (en) 2017-08-24 2023-04-11 Henkel Ag & Co. Kgaa Detergent compositions comprising GH9 endoglucanase variants II
EP3675646A1 (en) 2017-09-01 2020-07-08 Novozymes A/S Animal feed additives comprising polypeptide having protease activity and uses thereof
US11744263B2 (en) 2017-09-01 2023-09-05 Novozymes A/S Animal feed additives comprising a polypeptide having protease activity and uses thereof
WO2019046703A1 (en) 2017-09-01 2019-03-07 Novozymes A/S METHODS OF ENHANCING GENOME EDITION IN FUNGI
CN111712568A (zh) 2017-09-26 2020-09-25 邦吉全球创新有限责任公司 从基于三酰基甘油的油酶促除去叶绿素底物
EP3461892A3 (en) 2017-09-27 2019-06-12 The Procter & Gamble Company Detergent compositions comprising lipases
JP7317811B2 (ja) 2017-09-27 2023-07-31 ノボザイムス アクティーゼルスカブ リパーゼ変異体及びかかるリパーゼ変異体を含むマイクロカプセル組成物
WO2019068715A1 (en) 2017-10-02 2019-04-11 Novozymes A/S POLYPEPTIDES HAVING MANNANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING THESE POLYPEPTIDES
EP3692147A1 (en) 2017-10-02 2020-08-12 Novozymes A/S Polypeptides having mannanase activity and polynucleotides encoding same
US20230416706A1 (en) 2017-10-27 2023-12-28 Novozymes A/S Dnase Variants
CN111247245A (zh) 2017-10-27 2020-06-05 宝洁公司 包含多肽变体的洗涤剂组合物
DE102017125559A1 (de) 2017-11-01 2019-05-02 Henkel Ag & Co. Kgaa Reinigungszusammensetzungen, die dispersine ii enthalten
DE102017125558A1 (de) 2017-11-01 2019-05-02 Henkel Ag & Co. Kgaa Reinigungszusammensetzungen, die dispersine i enthalten
DE102017125560A1 (de) 2017-11-01 2019-05-02 Henkel Ag & Co. Kgaa Reinigungszusammensetzungen, die dispersine iii enthalten
US11319531B2 (en) 2017-11-07 2022-05-03 Codexis, Inc. Transglutaminase variants
WO2019092042A1 (en) 2017-11-10 2019-05-16 Novozymes A/S Temperature-sensitive cas9 protein
WO2019096903A1 (en) 2017-11-20 2019-05-23 Novozymes A/S New galactanases (ec 3.2.1.89) for use in soy processing
EP3485734A1 (en) 2017-11-21 2019-05-22 Technische Universität München Method for preparing food products comprising rye
EP3488854A1 (en) 2017-11-22 2019-05-29 Technische Universität München Method for preparing xyloglucan-oligosaccharides
EP3720954A1 (en) 2017-12-04 2020-10-14 Novozymes A/S Lipase variants and polynucleotides encoding same
AU2018383752A1 (en) 2017-12-13 2020-05-21 Codexis, Inc. Carboxyesterase polypeptides for amide coupling
US11408009B2 (en) 2017-12-18 2022-08-09 Whitehead Institute For Biomedical Research Host cell expression of 4-hydroxyphenylacetaldehyde synthase for production of salidroside, icariside D2, and precursors
EP3502242A1 (en) 2017-12-20 2019-06-26 Technische Universität München New xylanase with improved thermostability and increased enzyme activity on arabinoxylan
US20210017544A1 (en) 2017-12-22 2021-01-21 Novozymes A/S Counter-Selection by Inhibition of Conditionally Essential Genes
EP3749761A1 (en) 2018-02-08 2020-12-16 Novozymes A/S Lipases, lipase variants and compositions thereof
WO2019154954A1 (en) 2018-02-08 2019-08-15 Novozymes A/S Lipase variants and compositions thereof
US20230272353A1 (en) 2018-02-23 2023-08-31 Novozymes A/S Long Non-Coding RNA-Expression In Fungal Hosts
EP3530744A1 (en) 2018-02-23 2019-08-28 University of Limerick A polypeptide having xylanase and/or cellulase activity
DK3775222T3 (da) 2018-03-26 2024-02-19 Novozymes As Chaperoneproteiner fra svampe
WO2019185726A1 (en) 2018-03-29 2019-10-03 Novozymes A/S Mannanase variants and polynucleotides encoding same
US11377648B2 (en) 2018-04-09 2022-07-05 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
CN112204137B (zh) 2018-04-19 2024-05-14 诺维信公司 稳定化的纤维素酶变体
US11661592B2 (en) 2018-04-19 2023-05-30 Novozymes A/S Stabilized endoglucanase variants
EP3794115A2 (en) 2018-05-18 2021-03-24 DSM IP Assets B.V. Mutant lipase and use thereof
EP3794114A2 (en) 2018-05-18 2021-03-24 DSM IP Assets B.V. Mutant lipase and use thereof
WO2019241132A1 (en) 2018-06-12 2019-12-19 Codexis, Inc. Engineered tyrosine ammonia lyase
WO2020002575A1 (en) 2018-06-28 2020-01-02 Novozymes A/S Polypeptides having pectin lyase activity and polynucleotides encoding same
CA3103721A1 (en) 2018-07-09 2020-01-16 Codexis, Inc. Engineered deoxyribose-phosphate aldolases
US11034948B2 (en) 2018-07-09 2021-06-15 Codexis, Inc. Engineered phosphopentomutase variant enzymes
SG11202012111UA (en) 2018-07-09 2021-01-28 Codexis Inc Engineered purine nucleoside phosphorylase variant enzymes
US11466259B2 (en) 2018-07-09 2022-10-11 Codexis, Inc. Engineered galactose oxidase variant enzymes
EP3820991A4 (en) 2018-07-09 2022-07-06 Codexis, Inc. MODIFIED VARIANT PANTOTHENATE KINASE ENZYMES
CN112672989A (zh) 2018-07-12 2021-04-16 科德克希思公司 工程化苯丙氨酸氨裂合酶多肽
WO2020012266A1 (en) 2018-07-12 2020-01-16 Novartis Ag Biocatalytic synthesis of olodanrigan (ema401) from 3-(2-(benzyloxy)-3-methoxyphenyl)propenoic acid with phenylalanine ammonia lyase
BR112021001661A8 (pt) 2018-07-30 2022-08-09 Codexis Inc Glicosiltransferase modificada, polinucleotídeo modificado, vetor, célula hospedeira, métodos para produzir pelo menos uma glicosiltransferase modificada, para produzir pelo menos uma variante de sacarose sintase, para glicosilação de um substrato, para produzir rebaudiosídeo m, rebaudiosídeo a e/ou rebaudiosídeo i e rebaudiosídeo d, composição, sacarose sintase modificada, pelo menos um rebaudiosídeo, rebaudiosídeo m, rebaudiosídeo a, rebaudiosídeo i, e, rebaudiosídeo d.
EP3830261A1 (en) 2018-08-02 2021-06-09 Novozymes A/S Preparation of combinatorial libraries of dna constructs using introns
EP3843552A1 (en) 2018-08-31 2021-07-07 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
EP3861008A1 (en) 2018-10-03 2021-08-11 Novozymes A/S Polypeptides having alpha-mannan degrading activity and polynucleotides encoding same
EP3864136A1 (en) 2018-10-09 2021-08-18 Novozymes A/S Modified filamentous fungal host cell
US11060075B2 (en) 2018-10-29 2021-07-13 Codexis, Inc. Engineered DNA polymerase variants
US20220010305A1 (en) 2018-10-31 2022-01-13 Novozymes A/S Genome Editing by Guided Endonuclease and Single-stranded Oligonucleotide
WO2020112911A1 (en) 2018-11-28 2020-06-04 Novozymes A/S Improved filamentous fungal host cells
BR112021010338A2 (pt) 2018-11-28 2021-11-16 Novozymes As Células hospedeiras fúngicas filamentosas modificadas
US20220145339A1 (en) 2018-12-10 2022-05-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for preparation of primary amine compounds
US20220064228A1 (en) 2018-12-12 2022-03-03 Novozymes A/S Methods For Increasing The Productivity Of A Filamentous Fungal Cell In The Production Of A Polypeptide
BR112021011384A2 (pt) 2018-12-12 2022-05-17 Novozymes As Polipeptídeo isolado, composição de enzimas, formulação de caldo inteiro ou composição de cultura de células, polinucleotídeo isolado, célula hospedeira recombinante, método de produção de um polipeptídeo, planta, parte da planta ou célula da planta transgênica, e, processos para degradação de um material celulósico ou hemicelulósico, para produção de um produto de fermentação e de fermentação de um material celulósico ou hemicelulósico
SG11202105668PA (en) 2018-12-14 2021-06-29 Codexis Inc Engineered tyrosine ammonia lyase
CA3123598A1 (en) 2018-12-20 2020-06-25 Codexis, Inc. Human alpha-galactosidase variants
EP3898985B1 (en) 2018-12-21 2023-02-08 Novozymes A/S Tandem protein expression
US11959111B2 (en) 2018-12-21 2024-04-16 Novozymes A/S Polypeptides having peptidoglycan degrading activity and polynucleotides encoding same
US20220112528A1 (en) 2019-01-11 2022-04-14 River Stone Biotech Aps Recombinant host cells with improved production of l-dopa, dopamine, s-noroclaurine or derivatives thereof
WO2020161354A1 (en) 2019-02-08 2020-08-13 Pili Recombinant host cells to produce anthraquinone derivatives
WO2020173817A1 (en) 2019-02-28 2020-09-03 Novozymes A/S Calcite binding proteins
EP3935157A2 (en) 2019-03-08 2022-01-12 Danisco US Inc. Fusion polypeptides
EP3942033A1 (en) 2019-03-18 2022-01-26 Novozymes A/S Polypeptides having pullulanase activity suitable for use in liquefaction
US10995325B2 (en) 2019-03-21 2021-05-04 Fornia Biosolutions, Inc. Additional phytase variants and methods
EP3946720A1 (en) 2019-03-27 2022-02-09 Bunge Global Innovation, LLC. Silica adsorbent treatment for removal of chlorophyll derivatives from triacylglycerol-based oils
EP3947442A2 (en) 2019-03-28 2022-02-09 Danisco US Inc. Engineered antibodies
EP3947619A1 (en) 2019-04-03 2022-02-09 Novozymes A/S Polypeptides having beta-glucanase activity, polynucleotides encoding same and uses thereof in cleaning and detergent compositions
WO2020207944A1 (en) 2019-04-10 2020-10-15 Novozymes A/S Polypeptide variants
BR112021020439A2 (pt) 2019-04-12 2022-05-24 Novozymes As Variantes estabilizadas de glicosídeo hidrolase
WO2020229191A1 (en) 2019-05-15 2020-11-19 Novozymes A/S Temperature-sensitive rna-guided endonuclease
AU2020286105A1 (en) 2019-05-27 2021-12-23 Octarine Bio Ivs Genetically modified host cells producing glycosylated cannabinoids.
WO2020260223A1 (en) 2019-06-24 2020-12-30 Novozymes A/S Alpha-amylase variants
WO2020264552A1 (en) 2019-06-24 2020-12-30 The Procter & Gamble Company Cleaning compositions comprising amylase variants
CN114207125A (zh) 2019-06-25 2022-03-18 诺维信公司 通过抑制条件性必需基因进行反向选择
EP3994255A1 (en) 2019-07-02 2022-05-11 Novozymes A/S Lipase variants and compositions thereof
US20220267783A1 (en) 2019-07-25 2022-08-25 Novozymes A/S Filamentous fungal expression system
WO2021018783A1 (en) 2019-07-26 2021-02-04 Novozymes A/S Modified filamentous fungal host cell
MX2022002473A (es) 2019-08-30 2022-08-02 Codexis Inc Variantes de lipasa modificadas geneticamente.
WO2021048172A2 (en) 2019-09-09 2021-03-18 River Stone Biotech Aps Delivery vehicle for in situ delivering of pharmaceutical agents
JP2022547523A (ja) 2019-09-12 2022-11-14 コデクシス, インコーポレイテッド 10-アセチル-3,7-ジヒドロキシフェノキサジンに対するペルオキシダーゼ活性
MX2022002834A (es) 2019-09-16 2022-04-06 Novozymes As Polipeptidos con actividad beta-glucanasa y polinucleotidos que los codifican.
US20210094986A1 (en) 2019-09-27 2021-04-01 The Procter & Gamble Company Consumer product compositions comprising fatty acid photodecarboxyalases
WO2021064068A1 (en) 2019-10-03 2021-04-08 Novozymes A/S Polypeptides comprising at least two carbohydrate binding domains
CA3155372A1 (en) 2019-10-28 2021-05-06 Sharief Barends Microbial host cells for the production of heterologous cyanuric acid hydrolases and biuret hydrolases
US20210139879A1 (en) 2019-10-31 2021-05-13 The Procter & Gamble Company Consumer Product Compositions Comprising P450 Fatty Acid Decarboxylases
WO2021122867A2 (en) 2019-12-19 2021-06-24 Novozymes A/S Xylanase variants and polynucleotides encoding same
BR112022011760A2 (pt) 2019-12-20 2022-08-30 Codexis Inc Fragmento de alfa glicosidase ácida recombinante e/ou de alfa glicosidase ácida recombinante biologicamente ativa, alfa glicosidase ácida recombinante, composição, sequência polinucleotídica recombinante, vetor de expressão, vetor de expressão pdh, célula hospedeira, método para produzir uma variante de alfa glicosidase ácida recombinante, variante de alfa glicosidase ácida recombinante, composição farmacêutica para o tratamento da doença de pompe, composição farmacêutica, método para tratar e/ou prevenir os sintomas da doença de pompe em um indivíduo, e, uso das composições
EP4077656A2 (en) 2019-12-20 2022-10-26 Novozymes A/S Polypeptides having proteolytic activity and use thereof
US20230242960A1 (en) 2020-01-24 2023-08-03 Novozymes A/S Mutants of a filamentous fungal cell having increased productivity in the production of a polypeptide
WO2021152120A1 (en) 2020-01-31 2021-08-05 Novozymes A/S Mannanase variants and polynucleotides encoding same
EP4097227A1 (en) 2020-01-31 2022-12-07 Novozymes A/S Mannanase variants and polynucleotides encoding same
WO2021163015A1 (en) 2020-02-10 2021-08-19 Novozymes A/S Process for producing ethanol from raw starch using alpha-amylase variants
WO2021163030A2 (en) 2020-02-10 2021-08-19 Novozymes A/S Polypeptides having alpha-amylase activity and polynucleotides encoding same
CA3166233A1 (en) 2020-02-10 2021-08-19 Sarah Schultheis ELLIOTT Alpha-amylase variants and polynucleotides encoding same
US20230220366A1 (en) 2020-02-26 2023-07-13 Novozymes A/S Polypeptide Variants
CN115427560A (zh) 2020-03-12 2022-12-02 诺维信公司 使用无催化活性rna指导的内切核酸酶的crispr-aid
WO2021202473A2 (en) 2020-03-30 2021-10-07 Danisco Us Inc Engineered antibodies
EP3892708A1 (en) 2020-04-06 2021-10-13 Henkel AG & Co. KGaA Cleaning compositions comprising dispersin variants
CN115210371A (zh) 2020-04-08 2022-10-18 诺维信公司 碳水化合物结合模块变体
EP4133064A2 (en) 2020-04-10 2023-02-15 Codexis, Inc. Engineered transaminase polypeptides
CA3175523A1 (en) 2020-04-13 2021-10-21 Antti Virtanen Methods, complexes and kits for detecting or determining an amount of a .beta.-coronavirus antibody in a sample
WO2021214059A1 (en) 2020-04-21 2021-10-28 Novozymes A/S Cleaning compositions comprising polypeptides having fructan degrading activity
US20230183759A1 (en) 2020-05-20 2023-06-15 Wisconsin Alumni Research Foundation Cells and methods for producing methyl ketones
EP4193149A1 (en) 2020-08-04 2023-06-14 Abbott Laboratories Improved methods and kits for detecting sars-cov-2 protein in a sample
US20220049230A1 (en) 2020-08-13 2022-02-17 Novozymes A/S Phytase variants and polynucleotides encoding same
CN116323889A (zh) 2020-08-25 2023-06-23 诺维信公司 家族44木葡聚糖酶变体
WO2022043563A1 (en) 2020-08-28 2022-03-03 Novozymes A/S Polyester degrading protease variants
WO2022047262A1 (en) 2020-08-28 2022-03-03 Codexis, Inc. Engineered protease variants
BR112023003643A2 (pt) 2020-08-28 2023-03-28 Codexis Inc Amilase recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, célula hospedeira, métodos para produzir uma amilase recombinante e para tratar e/ou prevenir os sintomas de insuficiência pancreática, composição farmacêutica para o tratamento de insuficiência pancreática, e, uso
US20220112446A1 (en) 2020-10-09 2022-04-14 The Procter & Gamble Company Cleaning composition comprising an alpha-dioxygenase
WO2022078910A1 (en) 2020-10-13 2022-04-21 Novozymes A/S Glycosyltransferase variants for improved protein production
US20240035005A1 (en) 2020-10-29 2024-02-01 Novozymes A/S Lipase variants and compositions comprising such lipase variants
EP4237555A1 (en) 2020-11-02 2023-09-06 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
EP4237430A1 (en) 2020-11-02 2023-09-06 Novozymes A/S Leader peptides and polynucleotides encoding the same
EP4026900A3 (en) 2020-12-17 2022-10-05 Fornia BioSolutions, Inc. Xylanase variants and methods
WO2022133289A2 (en) 2020-12-18 2022-06-23 Codexis, Inc. Engineered uridine phosphorylase variant enzymes
EP4023757A1 (en) 2020-12-29 2022-07-06 The Protein Brewery B.V. Methods for generating selection marker-free transformants of heterokaryotic organisms
EP4271998A1 (en) 2020-12-30 2023-11-08 Abbott Laboratories Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
AR124921A1 (es) 2021-02-18 2023-05-17 Novozymes As Polipéptidos inactivos que contienen hemo
WO2022189521A1 (en) 2021-03-12 2022-09-15 Novozymes A/S Polypeptide variants
WO2022194673A1 (en) 2021-03-15 2022-09-22 Novozymes A/S Dnase variants
EP4060036A1 (en) 2021-03-15 2022-09-21 Novozymes A/S Polypeptide variants
CA3199985A1 (en) 2021-03-15 2022-09-22 Lars Lehmann Hylling Christensen Cleaning compositions containing polypeptide variants
EP4314261A1 (en) 2021-04-02 2024-02-07 Codexis, Inc. Engineered acetate kinase variant enzymes
EP4314263A1 (en) 2021-04-02 2024-02-07 Codexis, Inc. Engineered adenylate kinase variant enzymes
WO2022212832A1 (en) 2021-04-02 2022-10-06 Codexis, Inc. Engineered cyclic gmp-amp synthase (cgas) variant enzymes
IL305922A (en) 2021-04-02 2023-11-01 Codexis Inc Transgenic enzymes of variant guanylate kinase
US20240150805A1 (en) 2021-05-07 2024-05-09 River Stone Biotech Aps Glycosylated Opioids
WO2022251056A1 (en) 2021-05-27 2022-12-01 Novozymes A/S Transcriptional regulators and polynucleotides encoding the same
EP4359518A1 (en) 2021-06-23 2024-05-01 Novozymes A/S Alpha-amylase polypeptides
WO2023006699A1 (en) 2021-07-30 2023-02-02 Københavns Universitet Cells and method for producing isoprenoid molecules with canonical and non-canonical structures
US20230089159A1 (en) 2021-09-16 2023-03-23 The Procter & Gamble Company Cleaning composition comprising an engineered fatty acid alpha-dioxygenase
WO2024015953A1 (en) 2022-07-15 2024-01-18 Danisco Us Inc. Methods for producing monoclonal antibodies
WO2024100063A1 (en) 2022-11-08 2024-05-16 River Stone Biotech Aps Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression
WO2024108175A2 (en) 2022-11-17 2024-05-23 Recombia Biosciences, Inc. Constructs and methods for biosynthesis of gastrodin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3937654A (en) * 1970-05-14 1976-02-10 Ranks Hovis Mcdougall Limited Production of edible protein substances
IE35176B1 (en) * 1970-05-14 1975-11-26 Ranks Hovis Mcdougall Ltd Improvements in the production of edible protein containing substances
US4163692A (en) * 1977-04-25 1979-08-07 E. I. Du Pont De Nemours And Company Low phosphate growth of fungal mycelia
US5364770A (en) * 1985-08-29 1994-11-15 Genencor International Inc. Heterologous polypeptides expressed in aspergillus
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
US5070020A (en) * 1988-05-09 1991-12-03 Eli Lilly And Company Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
GB8904762D0 (en) * 1989-03-02 1989-04-12 Glaxo Group Ltd Biological process
GB9011347D0 (en) * 1990-05-21 1990-07-11 Ici Plc Production of a proteinaceous composition
CA2069147A1 (en) * 1991-05-22 1992-11-23 Kazuaki Kitano Dna and its use
FR2681076B1 (fr) * 1991-09-06 1994-11-18 Sanofi Elf Adn recombinant codant pour une proteine a activite endochitinase.
US5360901A (en) * 1992-03-04 1994-11-01 Genencor International, Inc. Gene sequence encoding Aspergillus niger catalase-R

Also Published As

Publication number Publication date
EP1559776A3 (en) 2006-01-11
JPH10500024A (ja) 1998-01-06
DE69534185T2 (de) 2006-02-23
CN1151762A (zh) 1997-06-11
JP2001169791A (ja) 2001-06-26
EP0777737B1 (en) 2005-05-04
JP3167729B2 (ja) 2001-05-21
US5837847A (en) 1998-11-17
CN101659926A (zh) 2010-03-03
EP1559776A2 (en) 2005-08-03
EP0777737A1 (en) 1997-06-11
WO1996000787A1 (en) 1996-01-11
DE69534185D1 (de) 2005-06-09
FI965220A (fi) 1997-02-25
ATE294871T1 (de) 2005-05-15
AU2705895A (en) 1996-01-25
FI965220A0 (fi) 1996-12-27
JP3511005B2 (ja) 2004-03-29

Similar Documents

Publication Publication Date Title
FI119437B (fi) Ei-toksinen, ei-toksigeeninen, ei-patogeeninen Fusarium-ekspressiojärjestelmä ja siinä käytettäviä promoottereita ja terminaattoreita
JP5264825B2 (ja) 菌類細胞中で遺伝子を発現させるためのプロモーター
CA1341532C (en) Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
US5602004A (en) Thermophilic fungal expression system
US6060305A (en) Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system
WO1996034962A1 (en) Scytalidium catalase gene
WO2001068864A1 (en) Fungal transcriptional activator useful in methods for producing polypeptides
WO1998020136A1 (en) Glucose oxidases
JP2002526112A (ja) ポリペプチドの生成方法において有用な菌類転写活性化因子
US5667990A (en) Aspergillus expression system
JP2002515252A (ja) 糸状菌変異体細胞においてポリペプチドを生産するための方法
WO2000046375A2 (en) Methods for producing polypeptides in fungal cells
US5770371A (en) Modification of cryptic splice sites in heterologous genes expressed in fungi
AU690617B2 (en) (Aspergillus foetidus) expression system
JP4860820B2 (ja) シクロヘキサデプシペプチド欠損細胞におけるポリペプチドの産生方法
JP2000513588A (ja) Dna配列、これらのdnaの発現、該dnaによってコードされる好熱性ラッカーゼならびにその使用
US5922561A (en) Genes encoding signal recognition particle of Aspergillus niger
JP2000513223A (ja) 真菌中で発現される異種遺伝子中の陰性スプライス部位の変更

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 119437

Country of ref document: FI

MA Patent expired